O. Tighe

Most-cited papers

1. Phenotypic characterization of spatial cognition and social behavior in mice with 'knockout' of the schizophrenia risk gene neuregulin 1.

   C. O'Tuathaigh, D. Babovic, Gerard J. O'Sullivan, J. Clifford +4 more

   2007Neuroscience239 citations Open access

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2. Colorectal

   N. Williams, M. Bennett, O. Tighe, H. Mulcahy +20 more

   2020Nature reviews: Gastroenterology & hepatology215 citations Open access

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3. Gene expression differences between the microsatellite instability (MIN) and chromosomal instability (CIN) phenotypes in colorectal cancer revealed by high-density cDNA array hybridization

   Donncha S. Dunican, P. Mcwilliam, O. Tighe, A. Parle‐McDermott +1 more

   2002Oncogene122 citations Open access

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4. Chronic Adolescent Exposure to Δ-9-Tetrahydrocannabinol in COMT Mutant Mice: Impact on Psychosis-Related and Other Phenotypes

   C. O'Tuathaigh, M. Hryniewiecka, Á. Behan, O. Tighe +7 more

   2010Neuropsychopharmacology98 citations Open access

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5. Phenotypic characterization of cognition and social behavior in mice with heterozygous versus homozygous deletion of catechol-O-methyltransferase.

   D. Babovic, C. O'Tuathaigh, A. O'Connor, Gerard J. O'Sullivan +6 more

   2008Neuroscience89 citations

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6. Sexually dimorphic changes in the exploratory and habituation profiles of heterozygous neuregulin-1 knockout mice

   C. O'Tuathaigh, Gerard J. O'Sullivan, A. Kinsella, R. Harvey +3 more

   2006NeuroReport87 citations

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7. Phenotypic effects of repeated psychosocial stress during adolescence in mice mutant for the schizophrenia risk gene neuregulin-1: a putative model of gene × environment interaction.

   L. Desbonnet, C. O'Tuathaigh, G. Clarke, C. O'Leary +8 more

   2012Brain, behavior, and immunity80 citations

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8. Schizophrenia‐related endophenotypes in heterozygous neuregulin‐1 ‘knockout’ mice

   C. O'Tuathaigh, Michael K. Harte, C. O'Leary, Gerard J. O'Sullivan +8 more

   2010European Journal of Neuroscience78 citations

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9. Topographical evaluation of the phenotype of spontaneous behaviour in mice with targeted gene deletion of the D1A dopamine receptor: paradoxical elevation of grooming syntax.

   J. Clifford, O. Tighe, D. Croke, D. Sibley +2 more

   1998Neuropharmacology78 citations

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10. Genetic basis of transferase-deficient galactosaemia in Ireland and the population history of the Irish Travellers

    M. Murphy, B. McHugh, O. Tighe, P. Mayne +3 more

    1999European Journal of Human Genetics75 citations

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11. Phenotypic effects of maternal immune activation and early postnatal milieu in mice mutant for the schizophrenia risk gene neuregulin-1.

    C. O'Leary, L. Desbonnet, N. Clarke, E. Petit +5 more

    2014Neuroscience68 citations

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12. Conservation of behavioural topography to dopamine D1-like receptor agonists in mutant mice lacking the D1A receptor implicates a D1-like receptor not coupled to adenylyl cyclase.

    J. Clifford, O. Tighe, D. Croke, A. Kinsella +3 more

    1999Neuroscience66 citations

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13. Congenic D1A Dopamine Receptor Mutants: Ethologically Based Resolution of Behavioural Topography Indicates Genetic Background as a Determinant of Knockout Phenotype

    Fergal N. Mcnamara, J. Clifford, O. Tighe, A. Kinsella +3 more

    2003Neuropsychopharmacology61 citations

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14. Genetic vs. pharmacological inactivation of COMT influences cannabinoid-induced expression of schizophrenia-related phenotypes.

    C. O'Tuathaigh, G. Clarke, J. Walsh, L. Desbonnet +9 more

    2012International Journal of Neuropsychopharmacology60 citations Open access

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15. Exploratory and habituation phenotype of heterozygous and homozygous COMT knockout mice.

    D. Babovic, C. O'Tuathaigh, Gerard J. O'Sullivan, J. Clifford +6 more

    2007Behavioural Brain Research50 citations Open access

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16. Replication error phenotype, clinicopathological variables, and patient outcome in Dukes' B stage II (T3,N0,M0) colorectal cancer

    B. Curran, K. Lenehan, H. Mulcahy, O. Tighe +5 more

    2000Gut42 citations Open access

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17. Ethological resolution of behavioural topography and D1‐like versus D2‐like agonist responses in congenic D5 dopamine receptor mutants: Identification of D5:D2‐like interactions

    Gerard J. O'Sullivan, A. Kinsella, David R. Sibley, O. Tighe +2 more

    2005Synapse41 citations

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18. Comparative, Topographically-Based Evaluation of Behavioural Phenotype and Specification of D1-Like:D2 Interactions in a Line of Incipient Congenic Mice with D2 Dopamine Receptor ‘Knockout’

    J. Clifford, A. Kinsella, O. Tighe, M. Rubinstein +4 more

    2001Neuropsychopharmacology41 citations Open access

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19. Serial analysis of gene expression identifies putative metastasis-associated transcripts in colon tumour cellines

    A. Parle‐McDermott, P. Mcwilliam, O. Tighe, Donncha S. Dunican +1 more

    2000British Journal of Cancer41 citations Open access

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20. Phenotypic, ethologically based resolution of spontaneous and D2‐like vs D1‐like agonist‐induced behavioural topography in mice with congenic D3 dopamine receptor “knockout”

    Fergal N. Mcnamara, J. Clifford, O. Tighe, A. Kinsella +4 more

    2002Synapse35 citations

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21. Genetic diversity within the R408W phenylketonuria mutation lineages in Europe

    O. Tighe, Donncha S. Dunican, C. O'Neill, G. Bertorelle +24 more

    2003Human Mutation34 citations Open access

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22. Physiological and behavioural responsivity to stress and anxiogenic stimuli in COMT-deficient mice.

    L. Desbonnet, O. Tighe, M. Karayiorgou, J. Gogos +2 more

    2012Behavioural Brain Research33 citations

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23. Phenotypic resolution of spontaneous and D1-like agonist-induced orofacial movement topographies in congenic dopamine D1A receptor 'knockout' mice.

    Katsunori Tomiyama, Fergal N. Mcnamara, J. Clifford, A. Kinsella +5 more

    2002Neuropharmacology32 citations Open access

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24. Topographical Assessment of Ethological and Dopamine Receptor Agonist-Induced Behavioral Phenotype in Mutants with Congenic DARPP-32 ‘Knockout’

    R. Nally, Fergal N. Mcnamara, J. Clifford, A. Kinsella +5 more

    2003Neuropsychopharmacology26 citations

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25. Gene expression differences between the microsatellite instability (MIN) and chromosomal instability (CIN) phenotypes in colorectal cancer revealed by high-density cDNA array hybridization

    Donncha S. Dunican, P. Mcwilliam, O. Tighe, A. Parle‐McDermott +1 more

    2002Oncogene26 citations Open access

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26. Disruption of thermal nociceptive behaviour in mice mutant for the schizophrenia-associated genes NRG1, COMT and DISC1.

    J. Walsh, O. Tighe, D. Lai, R. Harvey +4 more

    2010Brain Research23 citations

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27. The role of human demographic history in determining the distribution and frequency of transferase-deficient galactosaemia mutations

    Jonathan M. Flanagan, G. McMahon, S. H. Brendan Chia, P. Fitzpatrick +18 more

    2010Heredity22 citations Open access

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28. Epistatic and Independent Effects on Schizophrenia-Related Phenotypes Following Co-disruption of the Risk Factors Neuregulin-1 × DISC1

    C. O'Tuathaigh, F. Fumagalli, L. Desbonnet, F. Pérez-Brangulí +14 more

    2017Schizophrenia bulletin21 citations Open access

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29. Confirmation That the Renin Gene Distal Enhancer Polymorphism REN-5312C/T Is Associated With Increased Blood Pressure

    C. Vangjeli, N. Clarke, Ursula Quinn, P. Dicker +4 more

    2010Circulation: Cardiovascular Genetics21 citations Open access

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30. Comparative phenotypic resolution of spontaneous, D2‐like and D1‐like agonist‐induced orofacial movement topographies in congenic mutants with dopamine D2 vs. D3 receptor “knockout”

    Katsunori Tomiyama, Fergal N. Mcnamara, J. Clifford, A. Kinsella +9 more

    2004Synapse20 citations Open access

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31. The mutation spectrum of hyperphenylalaninaemia in the Republic of Ireland: the population history of the Irish revisited

    K. O'Donnell, C. O'Neill, O. Tighe, G. Bertorelle +3 more

    2002European Journal of Human Genetics20 citations Open access

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32. Hypercholesterolaemia: simvastatin and pravastatin alter cholesterol metabolism by different mechanisms.

    D. Owens, P. Collins, Alan H. Johnson, O. Tighe +2 more

    1991Biochimica et Biophysica Acta18 citations

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33. Dysregulation of Specialized Delay/Interference-Dependent Working Memory Following Loss of Dysbindin-1A in Schizophrenia-Related Phenotypes

    E. Petit, Z. Michalak, Rachel Cox, C. O'Tuathaigh +14 more

    2017Neuropsychopharmacology17 citations Open access

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34. Ethologically Based Resolution of D2-Like Dopamine Receptor Agonist-versus Antagonist-Induced Behavioral Topography in Dopamine- and Adenosine 3′,5′-Monophosphate-Regulated Phosphoprotein of 32 kDa “Knockout” Mutants Congenic on the C57BL/6 Genetic Background

    R. Nally, A. Kinsella, O. Tighe, D. Croke +3 more

    2004Journal of Pharmacology and Experimental Therapeutics15 citations

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35. Ethological resolution of behavioral topography and D2‐like vs. D1‐like agonist responses in congenic D4 dopamine receptor “knockouts”: Identification of D4:D1‐like interactions

    Gerard J. O'Sullivan, A. Kinsella, D. Grandy, O. Tighe +2 more

    2006Synapse12 citations

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36. Educating pharmacy students through a pandemic: Reflecting on our COVID-19 experience

    J. Strawbridge, J. Hayden, T. Robson, M. Flood +11 more

    2021Research in Social and Administrative Pharmacy11 citations Open access

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37. Associations between single-nucleotide polymorphisms of ADIPOQ, serum adiponectin and increased type 2 diabetes mellitus risk in Bahraini individuals.

    F. Al Hannan, P. O'Farrell, M. Morgan, O. Tighe +1 more

    2016Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit9 citations Open access

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38. Phenotype of spontaneous orofacial dyskinesia in neuregulin-1 'knockout' mice.

    Katsunori Tomiyama, C. O'Tuathaigh, Gerard J. O'Sullivan, A. Kinsella +6 more

    2009Progress in Neuro-psychopharmacology and Biological Psychiatry9 citations

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39. Altered cytokine profile, pain sensitivity, and stress responsivity in mice with co‐disruption of the developmental genes Neuregulin‐1 × DISC1

    L. Desbonnet, Rachel Cox, O. Tighe, Donna Lai +3 more

    2017Behavioural Brain Research8 citations Open access

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40. Behavioral analysis of multiple D1-like dopamine receptor subtypes: new agents and studies in transgenic mice with D1A receptor knockout.

    J. Waddington, A. Deveney, J. Clifford, O. Tighe +3 more

    1998Advances in Pharmacology7 citations

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41. Frequency distribution of the Los Angeles and Duarte galactose-1-phosphate uridyltransferase variant alleles in the Irish population.

    O. Tighe, J. M. Flanagan, F. Kernan, C. O'Neill +3 more

    2004Molecular Genetics and Metabolism5 citations

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42. Irish society of gastroenterology

    L. Cotter, M. Healy, M. Buckley, C. Ó'Moráin +166 more

    19925 citations

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43. Acute stress in adolescence vs early adulthood following selective deletion of dysbindin-1A: Effects on anxiety, cognition and other schizophrenia-related phenotypes

    L. Desbonnet, C. O'Tuathaigh, C. O'Leary, Rachel Cox +4 more

    2019Journal of Psychopharmacology4 citations

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44. Disruption of orofacial movement topographies in congenic mutants with dopamine D5 but not D4 receptor or DARPP-32 transduction 'knockout'.

    Katsunori Tomiyama, Yasuyuki Makihara, Hiroshi Yamamoto, Gerard J. O'Sullivan +9 more

    2006European Neuropsychopharmacology4 citations Open access

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45. Identification of sequence variation in the galactose-1-phosphate uridyl transferase gene by dHPLC.

    J. M. Flanagan, O. Tighe, C. O'Neill, E. Naughten +2 more

    2004Molecular Genetics and Metabolism4 citations

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46. Disruption of orofacial movement topographies in congenic mutants with dopamine D 5 but not D 4 receptor or DARPP-32 transduction ' knockout '

    Yasuyuki Makihara, Hiroshi Yamamoto, Gerard J. O'Sullivan, R. Nally +8 more

    20153 citations

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47. P.2.27 Topographical evaluation of spontaneous and agonist-induced behaviour in mutants with congenic dopamine D4 versus D5 receptor knockout

    Gerard J. O'Sullivan, D. Croke, O. Tighe, A. Kinsella +5 more

    20042 citations

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48. Rapid detection of the R408W and I65T mutations in phenylketonuria by glycosylase mediated polymorphism detection

    K. O'Donnell, O. Tighe, C. O'Neill, E. Naughten +4 more

    2001Human Mutation2 citations Open access

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49. Identification of a novel PKD1 mutation in an Irish autosomal dominant polycystic kidney disease kindred.

    O. Tighe, Michael Carmody, D. Croke

    1998Biochemical Society Transactions2 citations

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50. High-dose bupivacaine remotely loaded into multivesicular liposomes demonstrates slow drug release without systemic toxic plasma concentrations after subcutaneous administration in humans

    J. Walsh, O. Tighe, M. Karayiorgou, A. Joseph +5 more

    20101 citations

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