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N. Gotoh · SciRah

Researcher profile · Semantic Scholar

N. Gotoh

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N. Gotoh — researcher profile on SciRah

h-index: 37
Works: 113
Citations: 6,536

Most-cited papers

Substrate Specificities of MexAB-OprM, MexCD-OprJ, and MexXY-OprM Efflux Pumps in Pseudomonas aeruginosa
N. Masuda, E. Sakagawa, S. Ohya, N. Gotoh +2 more
2000Antimicrobial Agents and Chemotherapy699 citations Open access
Semantic Scholar
Characterization of MexE–MexF–OprN, a positively regulated multidrug efflux system of Pseudomonas aeruginosa
T. K. ̈hler, M. Michéa-Hamzehpour, U. Henze, N. Gotoh +2 more
1997Molecular Microbiology595 citations Open access
Semantic Scholar
Overexpression of the mexC–mexD–oprJ efflux operon in nfxB‐type multidrug‐resistant strains of Pseudomonas aeruginosa
K. Poole, N. Gotoh, Hideto Tsujimoto, Qi-Xun Zhao +6 more
1996Molecular Microbiology483 citations
Semantic Scholar
Contribution of the MexX-MexY-OprM Efflux System to Intrinsic Resistance in Pseudomonas aeruginosa
N. Masuda, E. Sakagawa, S. Ohya, N. Gotoh +2 more
2000Antimicrobial Agents and Chemotherapy284 citations Open access
Semantic Scholar
Multidrug Efflux Systems Play an Important Role in the Invasiveness of Pseudomonas aeruginosa
Y. Hirakata, R. Srikumar, K. Poole, N. Gotoh +5 more
2002Journal of Experimental Medicine275 citations Open access
Semantic Scholar
Carbapenem Resistance Mechanisms in Pseudomonas aeruginosa Clinical Isolates
H. Pai, Jong-Won Kim, Jungmin Kim, Ji Hyang Lee +2 more
2001Antimicrobial Agents and Chemotherapy241 citations Open access
Semantic Scholar
Molecular Mechanisms of Fluoroquinolone Resistance in Pseudomonas aeruginosa Isolates from Cystic Fibrosis Patients
S. Jalal, O. Ciofu, N. Høiby, N. Gotoh +1 more
2000Antimicrobial Agents and Chemotherapy231 citations Open access
Semantic Scholar
Expression of Pseudomonas aeruginosa Multidrug Efflux Pumps MexA-MexB-OprM and MexC-MexD-OprJ in a Multidrug-Sensitive Escherichia coli Strain
R. Srikumar, T. Kon, N. Gotoh, K. Poole
1998Antimicrobial Agents and Chemotherapy192 citations Open access
Semantic Scholar
Genome Evolution and Plasticity of Serratia marcescens, an Important Multidrug-Resistant Nosocomial Pathogen
Atsushi Iguchi, Y. Nagaya, E. Pradel, T. Ooka +12 more
2014Genome Biology and Evolution189 citations Open access
Semantic Scholar
MexXY-OprM Efflux Pump Is Necessary for Adaptive Resistance of Pseudomonas aeruginosa to Aminoglycosides
D. Hocquet, C. Vogne, F. El Garch, A. Véjux +4 more
2003Antimicrobial Agents and Chemotherapy183 citations Open access
Semantic Scholar
Multidrug efflux in intrinsic resistance to trimethoprim and sulfamethoxazole in Pseudomonas aeruginosa
T. Köhler, M. Kok, M. Michéa-Hamzehpour, P. Plésiat +4 more
1996Antimicrobial Agents and Chemotherapy153 citations Open access
Semantic Scholar
Pseudomonas aeruginosa Reveals High Intrinsic Resistance to Penem Antibiotics: Penem Resistance Mechanisms and Their Interplay
K. Okamoto, N. Gotoh, Takeshi Nishino
2001Antimicrobial Agents and Chemotherapy138 citations Open access
Semantic Scholar
On the mechanism of substrate specificity by resistance nodulation division (RND)‐type multidrug resistance pumps: the large periplasmic loops of MexD from Pseudomonas aeruginosa are involved in substrate recognition
W. Mao, M. S. Warren, D. S. Black, T. Satou +4 more
2002Molecular Microbiology135 citations
Semantic Scholar
Induction of mexCD-oprJ operon for a multidrug efflux pump by disinfectants in wild-type Pseudomonas aeruginosa PAO1.
Yuji Morita, Takeshi Murata, Takehiko Mima, S. Shiota +5 more
2003Journal of Antimicrobial Chemotherapy129 citations
Semantic Scholar
Characterization of the MexC-MexD-OprJ Multidrug Efflux System in ΔmexA-mexB-oprM Mutants of Pseudomonas aeruginosa
N. Gotoh, Hideto Tsujimoto, M. Tsuda, K. Okamoto +4 more
1998Antimicrobial Agents and Chemotherapy116 citations Open access
Semantic Scholar
Increased prevalence and clonal dissemination of multidrug-resistant Pseudomonas aeruginosa with the blaIMP-1 gene cassette in Hiroshima.
Syuntaro Kouda, M. Ohara, M. Onodera, Y. Fujiue +11 more
2009Journal of Antimicrobial Chemotherapy114 citations
Semantic Scholar
The outer membrane protein OprM of Pseudomonas aeruginosa is encoded by oprK of the mexA-mexB-oprK multidrug resistance operon
N. Gotoh, Hideto Tsujimoto, K. Poole, J. Yamagishi +1 more
1995Antimicrobial Agents and Chemotherapy102 citations Open access
Semantic Scholar
Interplay between Chromosomal β-Lactamase and the MexAB-OprM Efflux System in Intrinsic Resistance to β-Lactams inPseudomonas aeruginosa
N. Masuda, N. Gotoh, C. Ishii, E. Sakagawa +2 more
1999Antimicrobial Agents and Chemotherapy101 citations Open access
Semantic Scholar
RND type efflux pump system MexAB-OprM of pseudomonas aeruginosa selects bacterial languages, 3-oxo-acyl-homoserine lactones, for cell-to-cell communication
Shuta Minagawa, Hiroyuki Inami, Tomohisa Kato, Shinji Sawada +5 more
2012BMC Microbiology99 citations Open access
Semantic Scholar
Quantitative correlation between susceptibility and OprJ production in NfxB mutants of Pseudomonas aeruginosa
N. Masuda, N. Gotoh, Satoshi Ohya, Takeshi Nishino
1996Antimicrobial Agents and Chemotherapy99 citations Open access
Semantic Scholar
nfxC-type quinolone resistance in a clinical isolate of Pseudomonas aeruginosa
Hideyuki Fukuda, M. Hosaka, Shizuko Iyobe, N. Gotoh +2 more
1995Antimicrobial Agents and Chemotherapy94 citations Open access
Semantic Scholar
Translocation of Pseudomonas aeruginosa from the Intestinal Tract Is Mediated by the Binding of ExoS to an Na,K-ATPase Regulator, FXYD3
Jun Okuda, Naoki Hayashi, M. Okamoto, Shinji Sawada +3 more
2010Infection and Immunity81 citations Open access
Semantic Scholar
Measurement of Pseudomonas aeruginosa multidrug efflux pumps by quantitative real-time polymerase chain reaction.
K. Yoneda, H. Chikumi, T. Murata, N. Gotoh +4 more
2005FEMS Microbiology Letters81 citations
Semantic Scholar
Substrate-Dependent Utilization of OprM or OpmH by the Pseudomonas aeruginosa MexJK Efflux Pump
R. Chuanchuen, T. Murata, N. Gotoh, H. Schweizer
2005Antimicrobial Agents and Chemotherapy80 citations Open access
Semantic Scholar
Alterations of susceptibility of Pseudomonas aeruginosa by overproduction of multidrug efflux systems, MexAB-OprM, MexCD-OprJ, and MexXY/OprM to carbapenems: substrate specificities of the efflux systems
K. Okamoto, N. Gotoh, T. Nishino
2002Journal of Infection and Chemotherapy73 citations
Semantic Scholar
Subunit swapping in the Mex-extrusion pumps in Pseudomonas aeruginosa.
Hiroshi Yoneyama, A. Ocaktan, N. Gotoh, Takeshi Nishino +1 more
1998Biochemical and Biophysical Research Communications - BBRC64 citations
Semantic Scholar
Pseudomonas aeruginosa Las quorum sensing autoinducer suppresses growth and biofilm production in Legionella species.
S. Kimura, K. Tateda, Y. Ishii, M. Horikawa +4 more
2009Microbiology62 citations Open access
Semantic Scholar
The hemolytic and cytolytic activities of Serratia marcescens phospholipase A (PhlA) depend on lysophospholipid production by PhlA
K. Shimuta, M. Ohnishi, S. Iyoda, N. Gotoh +2 more
2009BMC Microbiology61 citations Open access
Semantic Scholar
Extrusion of Penem Antibiotics by Multicomponent Efflux Systems MexAB-OprM, MexCD-OprJ, and MexXY-OprM of Pseudomonas aeruginosa
K. Okamoto, N. Gotoh, T. Nishino
2002Antimicrobial Agents and Chemotherapy58 citations Open access
Semantic Scholar
Functional replacement of OprJ by OprM in the MexCD-OprJ multidrug efflux system of Pseudomonas aeruginosa.
N. Gotoh, Hideto Tsujimoto, Atsuko Nomura, K. Okamoto +2 more
1998FEMS Microbiology Letters58 citations
Semantic Scholar
Classification of OprD sequence and correlation with antimicrobial activity of carbapenem agents in Pseudomonas aeruginosa clinical isolates collected in Japan
Yumiko Sanbongi, Atsuyuki Shimizu, Takahisa Suzuki, H. Nagaso +3 more
2009Microbiology and immunology51 citations Open access
Semantic Scholar
Global population structure of the Serratia marcescens complex and identification of hospital-adapted lineages in the complex
Tomoyuki D Ono, I. Taniguchi, Keiji Nakamura, D. Nagano +14 more
2022Microbial Genomics49 citations Open access
Semantic Scholar
Purification of a 54-kilodalton protein (OprJ) produced in NfxB mutants of Pseudomonas aeruginosa and production of a monoclonal antibody specific to OprJ
M. Hosaka, N. Gotoh, Takeshi Nishino
1995Antimicrobial Agents and Chemotherapy43 citations Open access
Semantic Scholar
Interplay between chromosomal beta-lactamase and the MexAB-OprM efflux system in intrinsic resistance to beta-lactams in Pseudomonas aeruginosa.
N. Masuda, N. Gotoh, C. Ishii, E. Sakagawa +2 more
1999Antimicrobial Agents and Chemotherapy37 citations
Semantic Scholar
Relationship of Virulence Factors and Clinical Features in Keratitis Caused by Pseudomonas aeruginosa.
Naoko Oka, Takashi Suzuki, E. Ishikawa, Satoshi Yamaguchi +3 more
2015Investigative Ophthalmology and Visual Science33 citations Open access
Semantic Scholar
Characterization of outer membrane efflux proteins OpmE, OpmD and OpmB of Pseudomonas aeruginosa: molecular cloning and development of specific antisera.
T. Murata, N. Gotoh, T. Nishino
2002FEMS Microbiology Letters33 citations
Semantic Scholar
Hypersusceptibility of the Pseudomonas aeruginosa nfxB Mutant to β-Lactams Due to Reduced Expression of the AmpC β-Lactamase
N. Masuda, E. Sakagawa, S. Ohya, N. Gotoh +1 more
2001Antimicrobial Agents and Chemotherapy33 citations Open access
Semantic Scholar
Hyperoxia exaggerates bacterial dissemination and lethality in Pseudomonas aeruginosa pneumonia.
Y. Kikuchi, K. Tateda, E. Fuse, T. Matsumoto +6 more
2009Pulmonary Pharmacology & Therapeutics31 citations
Semantic Scholar
Molecular Characterization of Imipenem‐Resistant Pseudomonas aeruginosa in Hiroshima, Japan
M. Ohara, S. Kouda, M. Onodera, Y. Fujiue +12 more
2007Microbiology and immunology31 citations Open access
Semantic Scholar
Pseudomonas aeruginosa MucD protease mediates keratitis by inhibiting neutrophil recruitment and promoting bacterial survival.
Yujin Mochizuki, Takashi Suzuki, Naoko Oka, Yuan Zhang +4 more
2014Investigative Ophthalmology and Visual Science28 citations
Semantic Scholar
The substrate specificity of tripartite efflux systems of Pseudomonas aeruginosa is determined by the RND component.
T. Murata, Misato Kuwagaki, Tomoko Shin, N. Gotoh +1 more
2002Biochemical and Biophysical Research Communications - BBRC28 citations
Semantic Scholar
Pseudomonas aeruginosa injects type III effector ExoS into epithelial cells through the function of type IV pili
Naoki Hayashi, H. Nishizawa, Seiya Kitao, Sakurako Deguchi +4 more
2015FEBS Letters27 citations Open access
Semantic Scholar
Diffusion of macrolide antibiotics through the outer membrane of Moraxella catarrhalis
Hideto Tsujimoto, N. Gotoh, T. Nishino
1999Journal of Infection and Chemotherapy26 citations
Semantic Scholar
Topological analysis of an RND family transporter, MexD of Pseudomonas aeruginosa
N. Gotoh, Toshiyuki Kusumi, Hideto Tsujimoto, T. Wada +1 more
1999FEBS Letters26 citations Open access
Semantic Scholar
Rapid identification of mutations in a multidrug efflux pump in Pseudomonas aeruginosa
S. Jalal, Gunnar Wretlind, N. Gotoh, B. Wretlind
1999Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS)25 citations
Semantic Scholar
Degradation of interleukin 8 by the serine protease MucD of Pseudomonas aeruginosa
Jun Okuda, Naoki Hayashi, Soichi Tanabe, S. Minagawa +1 more
2011Journal of Infection and Chemotherapy24 citations
Semantic Scholar
Influence of OprM expression on multiple antibiotic resistance in Pseudomonas aeruginosa
Kendy K. Y. Wong, K. Poole, N. Gotoh, R. Hancock
1997Antimicrobial Agents and Chemotherapy22 citations Open access
Semantic Scholar
Protein D2 porin of the Pseudomonas aeruginosa outer membrane bears the protease activity
Eisaku Yoshihara, N. Gotoh, T. Nishino, T. Nakae
1996FEBS Letters21 citations Open access
Semantic Scholar
Isolation and characterization of the outer-membrane proteins of Burkholderia (Pseudomonas) pseudomallei.
N. Gotoh, Nicholas J. White, W. Chaowagul, Donald E. Woods
1994Microbiology21 citations Open access
Semantic Scholar
Potent In Vitro Antibacterial Activity of DS-8587, a Novel Broad-Spectrum Quinolone, against Acinetobacter baumannii
Saito Higuchi, Yoshikuni Onodera, M. Chiba, K. Hoshino +1 more
2013Antimicrobial Agents and Chemotherapy20 citations Open access
Semantic Scholar

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