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C. Siezen · SciRah

Researcher profile · Semantic Scholar

C. Siezen

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C. Siezen — researcher profile on SciRah

h-index: 19
Works: 30
Citations: 1,172

Most-cited papers

Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.
R. Janssen, L. Bont, C. Siezen, H. Hodemaekers +9 more
2007Journal of Infectious Diseases304 citations
Semantic Scholar
Opposing associations of serum n‐3 and n‐6 polyunsaturated fatty acids with colorectal adenoma risk: An endoscopy‐based case–control study
G. Pot, A. Geelen, E. V. van Heijningen, C. Siezen +2 more
2008International Journal of Cancer88 citations Open access
Semantic Scholar
Novel insight in the association between salmonellosis or campylobacteriosis and chronic illness, and the role of host genetics in susceptibility to these diseases
Y. Doorduyn, W. Van Pelt, C. Siezen, F. van der Horst +3 more
2007Epidemiology and Infection85 citations Open access
Semantic Scholar
Genetic Susceptibility to Respiratory Syncytial Virus Bronchiolitis in Preterm Children Is Associated With Airway Remodeling Genes and Innate Immune Genes
C. Siezen, L. Bont, H. Hodemaekers, M. Ermers +8 more
2009The Pediatric Infectious Disease Journal73 citations Open access
Semantic Scholar
Colorectal adenoma risk is modified by the interplay between polymorphisms in arachidonic acid pathway genes and fish consumption.
C. Siezen, A. V. van Leeuwen, Nicolien R. Kram, M. E. Luken +2 more
2004Carcinogenesis73 citations Open access
Semantic Scholar
Interleukin‐9 polymorphism in infants with respiratory syncytial virus infection: An opposite effect in boys and girls
A. Schuurhof, L. Bont, C. Siezen, H. Hodemaekers +5 more
2010Pediatric Pulmonology56 citations Open access
Semantic Scholar
Genetic variations in regulatory pathways of fatty acid and glucose metabolism are associated with obesity phenotypes: a population-based cohort study
S. W. van den Berg, M. Dollé, S. Imholz, D. van der A +8 more
2009International Journal of Obesity55 citations Open access
Semantic Scholar
Treatment with insulin (analogues) and breast cancer risk in diabetics; a systematic review and meta-analysis of in vitro, animal and human evidence
H. K. Bronsveld, B. ter Braak, Ø. Karlstad, P. Vestergaard +8 more
2015Breast Cancer Research53 citations Open access
Semantic Scholar
Polymorphisms in the genes involved in the arachidonic acid‐pathway, fish consumption and the risk of colorectal cancer
C. Siezen, H. Bueno-de-Mesquita, P. Peeters, Nicolien R. Kram +2 more
2006International Journal of Cancer48 citations Open access
Semantic Scholar
Tissue levels of fish fatty acids and risk of colorectal adenomas: a case–control study (Netherlands)
M. C. Busstra, C. Siezen, M. Grubben, H. V. van Kranen +2 more
2003Cancer Causes and Control46 citations Open access
Semantic Scholar
Protective effect of nonsteroidal anti-inflammatory drugs on colorectal adenomas is modified by a polymorphism in peroxisome proliferator-activated receptor δ
C. Siezen, M. Tijhuis, Nicolien R. Kram, E. V. van Soest +4 more
2006Pharmacogenetics & Genomics38 citations Open access
Semantic Scholar
Comparison of rat and rabbit embryo–fetal developmental toxicity data for 379 pharmaceuticals: on the nature and severity of developmental effects
P. Theunissen, S. Beken, B. Beyer, W. Breslin +24 more
2016Critical Reviews in Toxicology33 citations Open access
Semantic Scholar
Insulin-like growth factor 1 receptor activation promotes mammary gland tumor development by increasing glycolysis and promoting biomass production
B. ter Braak, C. Siezen, J. Lee, P. Rao +4 more
2017Breast Cancer Research32 citations Open access
Semantic Scholar
Mammary gland tumor promotion by chronic administration of IGF1 and the insulin analogue AspB10 in the p53R270H/+WAPCre mouse model
B. ter Braak, C. Siezen, E. Speksnijder, E. Koedoot +4 more
2015Breast Cancer Research29 citations Open access
Semantic Scholar
Comparing rat and rabbit embryo-fetal developmental toxicity data for 379 pharmaceuticals: on systemic dose and developmental effects
P. Theunissen, S. Beken, B. Beyer, W. Breslin +24 more
2016Critical Reviews in Toxicology28 citations Open access
Semantic Scholar
Development of tailored splice-switching oligonucleotides for progressive brain disorders in Europe: development, regulation, and implementation considerations
A. Aartsma-Rus, W. V. van Roon-Mom, M. Lauffer, C. Siezen +5 more
2023RNA: A publication of the RNA Society27 citations Open access
Semantic Scholar
Contribution of bi-allelic germline MUTYH mutations to early-onset and familial colorectal cancer and to low number of adenomatous polyps: case-series and literature review
Alain Knopperts, Maartje Nielsen, R. Niessen, C. Tops +11 more
2012Familial Cancer24 citations Open access
Semantic Scholar
Toll-Like Receptor 4 Polymorphism Associated with the Response to Whole-Cell Pertussis Vaccination in Children from the KOALA Study
Sander Banus, R. Bottema, C. Siezen, R. Vandebriel +8 more
2007Clinical and Vaccine Immunology24 citations Open access
Semantic Scholar
Classifying the adverse mitogenic mode of action of insulin analogues using a novel mechanism-based genetically engineered human breast cancer cell panel
B. ter Braak, C. Siezen, N. Kannegieter, E. Koedoot +2 more
2014Archives of Toxicology20 citations
Semantic Scholar
The pre‐ and post‐authorisation data published by the European medicines agency on the use of biologics during pregnancy and lactation
N. Ghalandari, R. Dolhain, J. Hazes, C. Siezen +4 more
2020British Journal of Clinical Pharmacology17 citations Open access
Semantic Scholar
Alternative signaling network activation through different insulin receptor family members caused by pro-mitogenic antidiabetic insulin analogues in human mammary epithelial cells
B. ter Braak, S. Wink, E. Koedoot, C. Pont +3 more
2015Breast Cancer Research10 citations Open access
Semantic Scholar
Developmental and Reproductive Toxicity Testing Strategies for Oligonucleotides: A Workshop Proceedings
Bethany R. Hannas, Sara M. Bender, E. Blasi, C. Bowman +20 more
2025Nucleic Acid Therapeutics5 citations Open access
Semantic Scholar
EMA commentary on the ICH guideline for testing for carcinogenicity of pharmaceuticals
J. W. van der Laan, Mikael Andersson, S. Beken, Milton Bonelli +8 more
2023British Journal of Clinical Pharmacology4 citations Open access
Semantic Scholar
Reduced Genotoxicity Testing Is Possible for Noncoding Oligonucleotide-Based Therapeutics Containing Well-Characterized Modifications: A European Regulatory Perspective
Clara Stock, B. Duijndam, C. Siezen, A. M. Pasmooij
2026Nucleic Acid Therapeutics0 citations Open access
Semantic Scholar
Insulin-like growth factor 1 receptor activation promotes mammary gland tumor development by increasing glycolysis and promoting biomass production
B. ter Braak, C. Siezen, J. Lee, P. Rao +4 more
2017Breast Cancer Research0 citations Open access
Semantic Scholar
Classifying the adverse mitogenic mode of action of insulin analogues using a novel mechanism-based genetically engineered human breast cancer cell panel
B. ter Braak, C. Siezen, N. Kannegieter, E. Koedoot +2 more
2014Archives of Toxicology0 citations
Semantic Scholar
Contribution of bi-allelic germline MUTYH mutations to early-onset and familial colorectal cancer and to low number of adenomatous polyps
A. Knopperts, M. Nielsen, R. Niessen, C. Tops +11 more
20130 citations
Semantic Scholar
Serum n-3 and n-6 polyunsaturated fatty acids and the risk of colorectal adenomas: an endoscopy-based case-control study
G. Pot, E. V. van Heijningen, A. Geelen, C. Siezen +2 more
20070 citations
Semantic Scholar
Low Penetrance Alleles in Colorectal Cancer: the arachidonic acid pathway
C. Siezen
20060 citations
Semantic Scholar
The association between fish consumption and the occurrence of colorectal adenomas is modified by genetic polymorphisms in PPRAdelta, COX-2 and cPLA2 genes
A. V. van Leeuwen, C. Siezen, Nicolien R. Kram, M. E. Luken +2 more
20040 citations
Semantic Scholar

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