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M. Dagnell · SciRah

Researcher profile · Semantic Scholar

M. Dagnell

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M. Dagnell — researcher profile on SciRah

h-index: 15
Works: 33
Citations: 1,637

Most-cited papers

FBXW7/hCDC4 is a general tumor suppressor in human cancer.
Shahab Akhoondi, Dahui Sun, N. von der Lehr, S. Apostolidou +22 more
2007Cancer Research501 citations
Semantic Scholar
Control of protein function through oxidation and reduction of persulfidated states
É. Dóka, T. Ida, M. Dagnell, Y. Abiko +15 more
2020Science Advances187 citations Open access
Semantic Scholar
12/15-lipoxygenase–derived lipid peroxides control receptor tyrosine kinase signaling through oxidation of protein tyrosine phosphatases
M. Conrad, Åsa Sandin, Heidi Förster, A. Seiler +8 more
2010Proceedings of the National Academy of Sciences of the United States of America105 citations Open access
Semantic Scholar
Selective activation of oxidized PTP1B by the thioredoxin system modulates PDGF-β receptor tyrosine kinase signaling
M. Dagnell, J. Frijhoff, I. Pader, M. Augsten +8 more
2013Proceedings of the National Academy of Sciences of the United States of America103 citations Open access
Semantic Scholar
The A to Z of Modulated Cell Patterning by Mammalian Thioredoxin Reductases
M. Dagnell, E. Schmidt, Elias S. J. Arnér
2017Free Radical Biology & Medicine88 citations Open access
Semantic Scholar
Hypoxia enhances platelet-derived growth factor signaling in the pulmonary vasculature by down-regulation of protein tyrosine phosphatases.
H. ten Freyhaus, M. Dagnell, M. Leuchs, M. Vantler +8 more
2011American Journal of Respiratory and Critical Care Medicine88 citations
Semantic Scholar
Cell transformation by FLT3 ITD in acute myeloid leukemia involves oxidative inactivation of the tumor suppressor protein-tyrosine phosphatase DEP-1/ PTPRJ.
R. Godfrey, Deepika Arora, Reinhard Bauer, Sabine Stopp +8 more
2012Blood87 citations
Semantic Scholar
Oxidation sensitivity of the catalytic cysteine of the protein-tyrosine phosphatases SHP-1 and SHP-2.
I. Weibrecht, Sylvia-Annette Böhmer, M. Dagnell, K. Kappert +2 more
2007Free Radical Biology & Medicine69 citations
Semantic Scholar
Regulation of Protein Tyrosine Phosphatase Oxidation in Cell Adhesion and Migration
J. Frijhoff, M. Dagnell, R. Godfrey, A. Östman
2014Antioxidants and Redox Signaling63 citations
Semantic Scholar
Irreversible TrxR1 inhibitors block STAT3 activity and induce cancer cell death
S. Busker, W. Qian, M. Haraldsson, B. Espinosa +9 more
2020Science Advances58 citations Open access
Semantic Scholar
Bicarbonate is essential for protein-tyrosine phosphatase 1B (PTP1B) oxidation and cellular signaling through EGF-triggered phosphorylation cascades
M. Dagnell, Q. Cheng, S. H. Rizvi, P. Pace +3 more
2019Journal of Biological Chemistry56 citations Open access
Semantic Scholar
Knockout of Mitochondrial Thioredoxin Reductase Stabilizes Prolyl Hydroxylase 2 and Inhibits Tumor Growth and Tumor-Derived Angiogenesis
Juliane Hellfritsch, Julian F. Kirsch, M. Schneider, Tamara Fluege +14 more
2015Antioxidants and Redox Signaling54 citations Open access
Semantic Scholar
The mitochondrial reactive oxygen species regulator p66Shc controls PDGF-induced signaling and migration through protein tyrosine phosphatase oxidation.
J. Frijhoff, M. Dagnell, M. Augsten, Elena Beltrami +2 more
2014Free Radical Biology & Medicine45 citations
Semantic Scholar
Thioredoxin reductase 1 and NADPH directly protect protein tyrosine phosphatase 1B from inactivation during H2O2 exposure
M. Dagnell, P. Pace, Q. Cheng, J. Frijhoff +4 more
2017Journal of Biological Chemistry42 citations Open access
Semantic Scholar
Hypoxia followed by re-oxygenation induces oxidation of tyrosine phosphatases.
Åsa Sandin, M. Dagnell, A. Gonon, J. Pernow +4 more
2011Cellular Signalling30 citations
Semantic Scholar
Redox regulation of PTPN22 affects the severity of T cell dependent autoimmune inflammation
Jaime James, Yifei Chen, Clara Magdalena Martínez Hernández, Florian Forster +11 more
2021bioRxiv12 citations Open access
Semantic Scholar
Qualitative Differences in Protection of PTP1B Activity by the Reductive Trx1 or TRP14 Enzyme Systems upon Oxidative Challenges with Polysulfides or H2O2 Together with Bicarbonate
M. Dagnell, Q. Cheng, Elias S. J. Arnér
2021Antioxidants11 citations Open access
Semantic Scholar
Redox regulation of PTPN22 affects the severity of T-cell-dependent autoimmune inflammation
Jaime James, Yifei Chen, Clara Magdalena Martínez Hernández, Florian Forster +11 more
2022eLife10 citations Open access
Semantic Scholar
Endogenous electrophiles and peroxymonocarbonate can link tyrosine phosphorylation cascades with the cytosolic TXNRD1 selenoprotein and the KEAP1/NRF2 system.
M. Dagnell, Elias S. J. Arnér
2024Current Opinion in Chemical Biology8 citations Open access
Semantic Scholar
Targeting density-enhanced phosphatase-1 (DEP-1) with antisense oligonucleotides improves the metabolic phenotype in high-fat diet-fed mice
J. Krüger, Manuela Trappiel, M. Dagnell, P. Stawowy +6 more
2013Cell Communication and Signaling7 citations Open access
Semantic Scholar
Intracellular enzymatic reducing systems control receptor tyrosine kinase signaling via PTP1B
Lucia Coppo, Wen-Chao Zhao, Qing Cheng, A. Scholz +2 more
2026Science Advances3 citations Open access
Semantic Scholar
Bicarbonate is required for hydrogen peroxide-dependent inactivation of PTP1B in presence of the Trx system and peroxiredoxin
M. Dagnell, Q. Cheng, P. Pace, M. Hampton +2 more
20183 citations
Semantic Scholar
Inhibition of protein tyrosine phosphatases enhances cerebral collateral growth in rats
I. Buschmann, D. Hackbusch, N. Gatzke, André Dülsner +5 more
2014Journal of molecular medicine3 citations
Semantic Scholar
Thioredoxin 1 Suppresses TXNIP-Driven Control of Glucose Metabolism in Human Cells
Shayida Maimaiti, M. Dagnell, Lucia Coppo, Wen-Chao Zhao +3 more
2026Antioxidants and Redox Signaling1 citations
Semantic Scholar
A katE katG double-knockout E. coli strain eliminates the risk of catalase contamination in recombinant proteins
A. Scholz, Lucia Coppo, E. Nolan, Michaella Hernandez +9 more
2026Applied Microbiology and Biotechnology1 citations Open access
Semantic Scholar
Patient-derived TXNIP-deficient primary cells exhibit NRF2 activation linked to upregulation of glyoxalase 1 (GLO1).
Shayida Maimaiti, M. Dagnell, Lucia Coppo, Elias S. J. Arnér
2025Free Radical Biology & Medicine1 citations Open access
Semantic Scholar
Targeting density-enhanced phosphatase-1 (DEP-1) with antisense oligonucleotides improves the metabolic phenotype in high-fat diet-fed mice
J. Krüger, Manuela Trappiel, M. Dagnell, P. Stawowy +6 more
2013Cell Communication and Signaling1 citations Open access
Semantic Scholar
Abstract 5774: Hypoxia Enhances Platelet-derived Growth Factor Signaling in the Pulmonary Vasculature by HIF-1 α -dependent Downregulation of Protein Tyrosine Phosphatases
H. Freyhaus, M. Leuchs, M. Dagnell, M. Vantler +7 more
2009Circulation1 citations
Semantic Scholar
84 - Thioredoxin Reductase 1 Directly Protects Protein Tyrosine Phosphatase 1B from Inactivation by H2O2
M. Dagnell, P. Pace, Q. Cheng, J. Frijhoff +4 more
20160 citations
Semantic Scholar
Abstract 17649: Inhibition of Src Homology 2 Domain-containing Phosphatase 1 (SHP-1) Increases Insulin Sensitivity in High-fat Diet-induced Insulin Resistant C57black6 Mice
J. Krüger, M. Dagnell, P. Stawowy, E. Caglayan +3 more
20140 citations
Semantic Scholar
Redox-regulation of PTPs; mechanisms and impact on PDGFR signaling
M. Dagnell
20130 citations
Semantic Scholar
phosphatase DEP-1 / PTPRJ oxidative inactivation of the tumor suppressor protein-tyrosine Cell transformation by FLT 3 ITD in acute myeloid leukemia involves
R. Godfrey, D. Arora, Reinhard Bauer, Sabine Stopp +8 more
20120 citations
Semantic Scholar
FLT3-ITD Mediated Transformation in Acute Myeloid Leukemia Involves Oxidation of the FLT3 Antagonist PTP, DEP-1: a Novel Redox Circuit in Cancer Cells
R. Godfrey, D. Arora, Reinhard Bauer, Sabine Stopp +6 more
20110 citations
Semantic Scholar

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