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N. Kosaka · SciRah

Researcher profile · Semantic Scholar

N. Kosaka

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N. Kosaka — researcher profile on SciRah

h-index: 56
Works: 125
Citations: 16K

Most-cited papers

Neutral Sphingomyelinase 2 (nSMase2)-dependent Exosomal Transfer of Angiogenic MicroRNAs Regulate Cancer Cell Metastasis
N. Kosaka, Haruhisa Iguchi, Keitaro Hagiwara, Y. Yoshioka +2 more
2013Journal of Biological Chemistry700 citations Open access
Semantic Scholar
Brain metastatic cancer cells release microRNA-181c-containing extracellular vesicles capable of destructing blood–brain barrier
Naoomi Tominaga, N. Kosaka, M. Ono, T. Katsuda +5 more
2015Nature Communications669 citations Open access
Semantic Scholar
Exosomes from bone marrow mesenchymal stem cells contain a microRNA that promotes dormancy in metastatic breast cancer cells
M. Ono, N. Kosaka, Naoomi Tominaga, Y. Yoshioka +6 more
2014Science Signaling638 citations
Semantic Scholar
Ultra-sensitive liquid biopsy of circulating extracellular vesicles using ExoScreen
Y. Yoshioka, N. Kosaka, Y. Konishi, Hideki Ohta +14 more
2014Nature Communications531 citations Open access
Semantic Scholar
Human adipose tissue-derived mesenchymal stem cells secrete functional neprilysin-bound exosomes
T. Katsuda, R. Tsuchiya, N. Kosaka, Y. Yoshioka +6 more
2013Scientific Reports523 citations Open access
Semantic Scholar
The therapeutic potential of mesenchymal stem cell‐derived extracellular vesicles
T. Katsuda, N. Kosaka, F. Takeshita, T. Ochiya
2013Proteomics388 citations
Semantic Scholar
Comparative marker analysis of extracellular vesicles in different human cancer types
Y. Yoshioka, Y. Konishi, N. Kosaka, T. Katsuda +2 more
2013Journal of Extracellular Vesicles379 citations Open access
Semantic Scholar
Bovine milk contains microRNA and messenger RNA that are stable under degradative conditions.
H. Izumi, N. Kosaka, Takashi Shimizu, K. Sekine +2 more
2012Journal of Dairy Science368 citations Open access
Semantic Scholar
Bovine milk exosomes contain microRNA and mRNA and are taken up by human macrophages.
H. Izumi, M. Tsuda, Yohei Sato, N. Kosaka +4 more
2015Journal of Dairy Science335 citations Open access
Semantic Scholar
Extracellular vesicles as biomarkers and therapeutic targets for cancer.
F. Urabe, N. Kosaka, Kagenori Ito, T. Kimura +2 more
2019American Journal of Physiology - Cell Physiology330 citations Open access
Semantic Scholar
The Progression of Liver Fibrosis Is Related with Overexpression of the miR-199 and 200 Families
Y. Murakami, H. Toyoda, Masami Tanaka, M. Kuroda +6 more
2011PLoS ONE296 citations Open access
Semantic Scholar
Versatile roles of extracellular vesicles in cancer.
N. Kosaka, Y. Yoshioka, Y. Fujita, T. Ochiya
2016Journal of Clinical Investigation288 citations Open access
Semantic Scholar
MicroRNA-143 regulates human osteosarcoma metastasis by regulating matrix metalloprotease-13 expression.
M. Osaki, F. Takeshita, Yui Sugimoto, N. Kosaka +9 more
2011Molecular Therapy285 citations Open access
Semantic Scholar
Competitive Interactions of Cancer Cells and Normal Cells via Secretory MicroRNAs*
N. Kosaka, Haruhisa Iguchi, Y. Yoshioka, Keitaro Hagiwara +2 more
2011Journal of Biological Chemistry265 citations Open access
Semantic Scholar
The Clinical Relevance of the miR-197/CKS1B/STAT3-mediated PD-L1 Network in Chemoresistant Non-small-cell Lung Cancer
Y. Fujita, S. Yagishita, Keitaro Hagiwara, Y. Yoshioka +10 more
2015Molecular Therapy249 citations Open access
Semantic Scholar
Cancer-secreted hsa-miR-940 induces an osteoblastic phenotype in the bone metastatic microenvironment via targeting ARHGAP1 and FAM134A
K. Hashimoto, Hiroki Ochi, Satoko Sunamura, N. Kosaka +11 more
2018Proceedings of the National Academy of Sciences of the United States of America238 citations Open access
Semantic Scholar
Suppression of autophagy by extracellular vesicles promotes myofibroblast differentiation in COPD pathogenesis
Y. Fujita, J. Araya, S. Ito, K. Kobayashi +6 more
2015Journal of Extracellular Vesicles219 citations Open access
Semantic Scholar
Extracellular vesicles in lung microenvironment and pathogenesis.
Y. Fujita, N. Kosaka, J. Araya, K. Kuwano +1 more
2015Trends in Molecular Medicine172 citations
Semantic Scholar
Exosomal miRNAs from Peritoneum Lavage Fluid as Potential Prognostic Biomarkers of Peritoneal Metastasis in Gastric Cancer
M. Tokuhisa, Y. Ichikawa, N. Kosaka, T. Ochiya +7 more
2015PLoS ONE169 citations Open access
Semantic Scholar
The roles of extracellular vesicles in cancer biology: Toward the development of novel cancer biomarkers
T. Katsuda, N. Kosaka, T. Ochiya
2014Proteomics154 citations
Semantic Scholar
Comprehensive miRNA Expression Analysis in Peripheral Blood Can Diagnose Liver Disease
Y. Murakami, H. Toyoda, T. Tanahashi, J. Tanaka +5 more
2012PLoS ONE154 citations Open access
Semantic Scholar
Trash or Treasure: extracellular microRNAs and cell-to-cell communication
N. Kosaka, Y. Yoshioka, Keitaro Hagiwara, Naoomi Tominaga +2 more
2013Frontiers in Genetics152 citations Open access
Semantic Scholar
Stilbene derivatives promote Ago2-dependent tumour-suppressive microRNA activity
Keitaro Hagiwara, N. Kosaka, Y. Yoshioka, Ryou-u Takahashi +2 more
2012Scientific Reports132 citations Open access
Semantic Scholar
miR‐148a plays a pivotal role in the liver by promoting the hepatospecific phenotype and suppressing the invasiveness of transformed cells
L. Gailhouste, L. Gomez-Santos, Keitaro Hagiwara, I. Hatada +8 more
2013Hepatology123 citations Open access
Semantic Scholar
RPN2-mediated glycosylation of tetraspanin CD63 regulates breast cancer cell malignancy
Naoomi Tominaga, Keitaro Hagiwara, N. Kosaka, Kimi Honma +2 more
2014Molecular Cancer120 citations Open access
Semantic Scholar
Therapeutic effects of microRNA-582-5p and -3p on the inhibition of bladder cancer progression.
K. Uchino, F. Takeshita, Ryou-u Takahashi, N. Kosaka +10 more
2013Molecular Therapy116 citations Open access
Semantic Scholar
Exploiting the message from cancer: the diagnostic value of extracellular vesicles for clinical applications
N. Kosaka, A. Kogure, Tomofumi Yamamoto, F. Urabe +3 more
2019Experimental and Molecular Medicine109 citations Open access
Semantic Scholar
Profiling of circulating microRNAs for prostate cancer biomarker discovery
Christa Haldrup, N. Kosaka, T. Ochiya, M. Borre +3 more
2014Drug Delivery and Translational Research103 citations
Semantic Scholar
Cross-talk between cancer cells and their neighbors via miRNA in extracellular vesicles: an emerging player in cancer metastasis
A. Kogure, N. Kosaka, T. Ochiya
2019Journal of Biomedical Sciences102 citations Open access
Semantic Scholar
Osteoblast-derived vesicles induce a switch from bone-formation to bone-resorption in vivo
Maki Uenaka, Erika Yamashita, J. Kikuta, Akito Morimoto +15 more
2022Nature Communications98 citations Open access
Semantic Scholar
Commitment of Annexin A2 in recruitment of microRNAs into extracellular vesicles
Keitaro Hagiwara, T. Katsuda, L. Gailhouste, N. Kosaka +1 more
2015FEBS Letters91 citations Open access
Semantic Scholar
Altered biodistribution of deglycosylated extracellular vesicles through enhanced cellular uptake
Nao Nishida-Aoki, Naoomi Tominaga, N. Kosaka, T. Ochiya
2020Journal of Extracellular Vesicles90 citations Open access
Semantic Scholar
PAI‐1, a target gene of miR‐143, regulates invasion and metastasis by upregulating MMP‐13 expression of human osteosarcoma
Mio Hirahata, M. Osaki, Y. Kanda, Yui Sugimoto +8 more
2016Cancer Medicine86 citations Open access
Semantic Scholar
On-Chip Immunoelectrophoresis of Extracellular Vesicles Released from Human Breast Cancer Cells
T. Akagi, Keio Kato, Masashi Kobayashi, N. Kosaka +2 more
2015PLoS ONE83 citations Open access
Semantic Scholar
UBL3 modification influences protein sorting to small extracellular vesicles
H. Ageta, N. Ageta-Ishihara, Keisuke Hitachi, Özge Karayel +18 more
2018Nature Communications78 citations Open access
Semantic Scholar
Latest advances in extracellular vesicles: from bench to bedside
Tomofumi Yamamoto, N. Kosaka, T. Ochiya
2019Science and Technology of Advanced Materials77 citations Open access
Semantic Scholar
Exosomal tumor-suppressive microRNAs as novel cancer therapy: "exocure" is another choice for cancer treatment.
N. Kosaka, F. Takeshita, Y. Yoshioka, Keitaro Hagiwara +3 more
2013Advanced Drug Delivery Reviews75 citations
Semantic Scholar
Clinical Relevance and Therapeutic Significance of MicroRNA‐133a Expression Profiles and Functions in Malignant Osteosarcoma‐Initiating Cells
T. Fujiwara, T. Katsuda, Keitaro Hagiwara, N. Kosaka +11 more
2014Stem Cells70 citations
Semantic Scholar
Time-Dependent Expression Profiles of microRNAs and mRNAs in Rat Milk Whey
H. Izumi, N. Kosaka, Takashi Shimizu, K. Sekine +2 more
2014PLoS ONE67 citations Open access
Semantic Scholar
Decoding the Secret of Cancer by Means of Extracellular Vesicles
N. Kosaka
2016Journal of Clinical Medicine64 citations Open access
Semantic Scholar
miR-26a regulates extracellular vesicle secretion from prostate cancer cells via targeting SHC4, PFDN4, and CHORDC1
F. Urabe, N. Kosaka, Yurika Sawa, Yusuke Yamamoto +5 more
2019Science Advances61 citations Open access
Semantic Scholar
Epithelial-mesenchymal transition transcription factors control pluripotent adult stem cell migration in vivo in planarians
Prasad Abnave, Ellen Aboukhatwa, N. Kosaka, James M. Thompson +2 more
2017Development61 citations Open access
Semantic Scholar
Expression Level of Urinary MicroRNA-146a-5p Is Increased in Patients With Bladder Cancer and Decreased in Those After Transurethral Resection.
Hideo Sasaki, M. Yoshiike, S. Nozawa, W. Usuba +9 more
2016Clinical Genitourinary Cancer59 citations
Semantic Scholar
A label-free electrical detection of exosomal microRNAs using microelectrode array.
T. Goda, K. Masuno, Junko Nishida, N. Kosaka +3 more
2012Chemical Communications59 citations
Semantic Scholar
Micromanaging Iron Homeostasis
Y. Yoshioka, N. Kosaka, T. Ochiya, Takashi Kato
2012Journal of Biological Chemistry57 citations Open access
Semantic Scholar
Dark side of the exosome: the role of the exosome in cancer metastasis and targeting the exosome as a strategy for cancer therapy.
N. Kosaka, Y. Yoshioka, Naoomi Tominaga, Keitaro Hagiwara +2 more
2014Future Oncology54 citations
Semantic Scholar
A paradigm shift for extracellular vesicles as small RNA carriers: from cellular waste elimination to therapeutic applications
Keitaro Hagiwara, T. Ochiya, N. Kosaka
2013Drug Delivery and Translational Research43 citations Open access
Semantic Scholar
Metastatic prostate cancer‐derived extracellular vesicles facilitate osteoclastogenesis by transferring the CDCP1 protein
F. Urabe, N. Kosaka, Yusuke Yamamoto, Kagenori Ito +5 more
2023Journal of Extracellular Vesicles41 citations Open access
Semantic Scholar
Extracellular vesicles: Toward a clinical application in urological cancer treatment
F. Urabe, N. Kosaka, T. Kimura, S. Egawa +1 more
2018International journal of urology41 citations Open access
Semantic Scholar
Functional analysis of exosomal microRNA in cell-cell communication research.
N. Kosaka, Y. Yoshioka, Keitaro Hagiwara, Naoomi Tominaga +1 more
2013Methods in molecular biology38 citations
Semantic Scholar

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T. Ochiya×48
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T. Ochiya — researcher profile on SciRah
Y. Yoshioka×22
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Y. Yoshioka — researcher profile on SciRah
Keitaro Hagiwara×13
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F. Takeshita×13
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T. Katsuda — researcher profile on SciRah

Naoomi Tominaga×7

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Ryou-u Takahashi×5

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F. Urabe — researcher profile on SciRah

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T. Kimura — researcher profile on SciRah

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