Skip to content

Home Search Authors Pakistan News Saved

SciRah

SciRah does not host or store research papers. Results come live from free, official scholarly APIs, and every paper links back to its original source.

Data sources

OpenAlex
Semantic Scholar
Crossref
CORE
arXiv
PubMed

Privacy policy Terms of service

A. Siraki · SciRah

Researcher profile · Semantic Scholar

A. Siraki

Share profile

A. Siraki — researcher profile on SciRah

h-index: 29
Works: 89
Citations: 3,213

Most-cited papers

Aldehyde Sources, Metabolism, Molecular Toxicity Mechanisms, and Possible Effects on Human Health
P. O'Brien, A. Siraki, N. Shangari
2005Critical Reviews in Toxicology702 citations
Semantic Scholar
Dietary flavonoid iron complexes as cytoprotective superoxide radical scavengers.
M. Moridani, J. Pourahmad, H. Bui, A. Siraki +1 more
2003Free Radical Biology & Medicine250 citations
Semantic Scholar
The many roles of myeloperoxidase: From inflammation and immunity to biomarkers, drug metabolism and drug discovery
A. Siraki
2021Redox Biology128 citations Open access
Semantic Scholar
A conceptual framework for predicting the toxicity of reactive chemicals: modeling soft electrophilicity
T. Schultz, R. Carlson, M. Cronin, Joop L. M. Hermens +6 more
2006SAR and QSAR in environmental research (Print)128 citations
Semantic Scholar
Molecular cytotoxic mechanisms of anticancer hydroxychalcones.
O. Sabzevari, G. Galati, M. Moridani, A. Siraki +1 more
2004Chemico-Biological Interactions128 citations
Semantic Scholar
Endogenous and endobiotic induced reactive oxygen species formation by isolated hepatocytes.
A. Siraki, J. Pourahmad, T. Chan, Sumsullah Khan +1 more
2002Free Radical Biology & Medicine121 citations
Semantic Scholar
Comprehensive in vitro characterization of PD-L1 small molecule inhibitors
A. Ganesan, Marawan Ahmed, Isobel S. Okoye, E. Arutyunova +25 more
2019Scientific Reports118 citations Open access
Semantic Scholar
Quantitative structure toxicity relationships for phenols in isolated rat hepatocytes.
M. Moridani, A. Siraki, P. O'Brien
2003Chemico-Biological Interactions95 citations
Semantic Scholar
Application of quantitative structure-toxicity relationships for the comparison of the cytotoxicity of 14 p-benzoquinone congeners in primary cultured rat hepatocytes versus PC12 cells.
A. Siraki, T. Chan, P. O'Brien
2004Toxicological Sciences86 citations Open access
Semantic Scholar
Differential eNOS-signalling by platelet subpopulations regulates adhesion and aggregation
A. Radziwon-Balicka, G. Lesyk, Valentina Back, T. Fong +13 more
2017Cardiovascular Research69 citations Open access
Semantic Scholar
Interactions of the antioxidant enzymes NAD(P)H: Quinone oxidoreductase 1 (NQO1) and NRH: Quinone oxidoreductase 2 (NQO2) with pharmacological agents, endogenous biochemicals and environmental contaminants.
Md. Harunur Rashid, D. Babu, A. Siraki
2021Chemico-Biological Interactions59 citations
Semantic Scholar
Immunolocalization of hypochlorite-induced, catalase-bound free radical formation in mouse hepatocytes.
M. Bonini, A. Siraki, B. Atanassov, R. Mason
2007Free Radical Biology & Medicine58 citations Open access
Semantic Scholar
β-Caryophyllene Induces Apoptosis and Inhibits Angiogenesis in Colorectal Cancer Models
S. Dahham, Y. Tabana, M. Asif, Marawan Ahmed +7 more
2021International Journal of Molecular Sciences55 citations Open access
Semantic Scholar
Target identification of small molecules: an overview of the current applications in drug discovery
Yasser Tabana, Dinesh Babu, Richard P Fahlman, A. Siraki +1 more
2023BMC Biotechnology53 citations Open access
Semantic Scholar
Quantitative structure toxicity relationships for catechols in isolated rat hepatocytes.
M. Moridani, A. Siraki, Tatiana Chevaldina, Hugh Scobie +1 more
2004Chemico-Biological Interactions51 citations
Semantic Scholar
Prooxidant activity of free radicals derived from phenol-containing neurotransmitters.
A. Siraki, P. O'Brien
2002Toxicology49 citations
Semantic Scholar
Caution for the routine use of phenol red - It is more than just a pH indicator.
Andrew G M Morgan, D. Babu, B. Reiz, R. Whittal +2 more
2019Chemico-Biological Interactions48 citations
Semantic Scholar
Reversing T-cell exhaustion in immunotherapy: a review on current approaches and limitations
Y. Tabana, T. Moon, A. Siraki, S. Elahi +1 more
2021Expert opinion on therapeutic targets44 citations
Semantic Scholar
Isoniazid and host immune system interactions: A proposal for a novel comprehensive mode of action
Saifur R. Khan, Y. Manialawy, A. Siraki
2019British Journal of Pharmacology42 citations Open access
Semantic Scholar
N-OXIDATION OF AROMATIC AMINES BY INTRACELLULAR OXIDASES
A. Siraki, T. Chan, G. Galati, S. Teng +1 more
2002Drug metabolism reviews (Softcover ed.)42 citations
Semantic Scholar
Machine learning in toxicological sciences: opportunities for assessing drug toxicity
L. Tonoyan, A. Siraki
2024Frontiers in Drug Discovery40 citations Open access
Semantic Scholar
Application of quantitative structure-toxicity relationships for acute NSAID cytotoxicity in rat hepatocytes.
A. Siraki, Tatiana Chevaldina, P. O'Brien
2005Chemico-Biological Interactions40 citations
Semantic Scholar
Current status and future prospects of toxicogenomics in drug discovery.
Saifur R. Khan, Argishti Baghdasarian, R. Fahlman, K. Michail +1 more
2014Drug Discovery Today38 citations
Semantic Scholar
2-Methoxyestradiol protects against pressure overload-induced left ventricular hypertrophy
Zaid H. Maayah, Jody Levasseur, Ramanaguru Siva Piragasam, Ghada Abdelhamid +4 more
2018Scientific Reports37 citations Open access
Semantic Scholar
Modulating carbonyl cytotoxicity in intact rat hepatocytes by inhibiting carbonyl metabolizing enzymes. II. Aromatic aldehydes.
H. Niknahad, A. Shuhendler, G. Galati, A. Siraki +3 more
2003Chemico-Biological Interactions35 citations
Semantic Scholar
Free radical production from the interaction of 2-chloroethyl vesicants (mustard gas) with pyridine nucleotide-driven flavoprotein electron transport systems
A. Brimfield, A. Mancebo, Ronald P. Mason, J.-J. Jiang +2 more
2008Toxicology and Applied Pharmacology33 citations Open access
Semantic Scholar
The role of cytochrome P450 1B1 and its associated mid-chain hydroxyeicosatetraenoic acid metabolites in the development of cardiac hypertrophy induced by isoproterenol
Zaid H. Maayah, H. Althurwi, Ahmed A. El-Sherbeni, Ghada Abdelhamid +2 more
2017Molecular and Cellular Biochemistry32 citations
Semantic Scholar
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
Saifur R. Khan, Andrew G M Morgan, K. Michail, Nutan Srivastava +3 more
2016Biochemical Pharmacology31 citations
Semantic Scholar
Accelerated cytotoxicity mechanism screening using drug metabolising enzyme modulators.
P. O'Brien, A. Siraki
2005Current drug metabolism30 citations
Semantic Scholar
Aminoglutethimide-induced protein free radical formation on myeloperoxidase: a potential mechanism of agranulocytosis.
A. Siraki, M. Bonini, Jinjie Jiang, M. Ehrenshaft +1 more
2007Chemical Research in Toxicology29 citations Open access
Semantic Scholar
Characterization of Mechanisms of Glutathione Conjugation with Halobenzoquinones in Solution and HepG2 Cells.
Wei Wang, Yi-chao Qian, Jinhua Li, N. Aljuhani +3 more
2018Environmental Science and Technology28 citations
Semantic Scholar
Treatment of a mixture of pharmaceuticals, herbicides and perfluorinated compounds by powdered activated carbon and ozone: Synergy, catalysis and insights into non-free OH contingent mechanisms.
Mirna Alameddine, A. Siraki, L. Tonoyan, Mohamed Gamal El-Din
2021Science of the Total Environment27 citations
Semantic Scholar
Procainamide, but not N-acetylprocainamide, induces protein free radical formation on myeloperoxidase: a potential mechanism of agranulocytosis.
A. Siraki, L. Deterding, M. Bonini, Jinjie Jiang +3 more
2008Chemical Research in Toxicology25 citations Open access
Semantic Scholar
1.14 – Free Radicals and Reactive Oxygen Species☆
A. Siraki
201824 citations
Semantic Scholar
Anti-inflammatory and antioxidant properties of a novel resveratrol-salicylate hybrid analog.
Fahad S. Aldawsari, R. P. Aguiar, L. A. M. Wiirzler, R. Aguayo-Ortiz +5 more
2016Bioorganic & Medicinal Chemistry Letters24 citations Open access
Semantic Scholar
Superoxide radical scavenging and attenuation of hypoxia-reoxygenation injury by neurotransmitter ferric complexes in isolated rat hepatocytes.
A. Siraki, J. Smythies, P. O'Brien
2000Neuroscience Letters22 citations
Semantic Scholar
Scavenging of free-radical metabolites of aniline xenobiotics and drugs by amino acid derivatives: toxicological implications of radical-transfer reactions.
K. Michail, Argishti Baghdasarian, Malyaj Narwaley, N. Aljuhani +1 more
2013Chemical Research in Toxicology21 citations
Semantic Scholar
Effect of Plasma-Activated Water Bubbles on Fusarium graminearum, Deoxynivalenol, and Germination of Naturally Infected Barley during Steeping
Ehsan Feizollahi, U. Basu, R. Fredua-Agyeman, Brasathe Jeganathan +5 more
2023Toxins19 citations Open access
Semantic Scholar
Tackling Immune Targets for Breast Cancer: Beyond PD-1/PD-L1 Axis
Y. Tabana, Isobel S. Okoye, A. Siraki, S. Elahi +1 more
2021Frontiers in Oncology19 citations Open access
Semantic Scholar
Quantitative structure-toxicity relationships by accelerated cytotoxicity mechanism screening.
A. Siraki, Tatiana Chevaldina, M. Moridani, P. O'Brien
2004Current opinion in drug discovery & development19 citations
Semantic Scholar
Proteomic profile of aminoglutethimide-induced apoptosis in HL-60 cells: Role of myeloperoxidase and arylamine free radicals.
Saifur R. Khan, Argishti Baghdasarian, Prarthna H Nagar, R. Fahlman +4 more
2015Chemico-Biological Interactions18 citations
Semantic Scholar
Post-trapping derivatization of radical-derived EPR-silent adducts: application to free radical detection by HPLC/UV in chemical, biochemical, and biological systems and comparison with EPR spectroscopy.
K. Michail, A. Siraki
2012Analytical Chemistry18 citations
Semantic Scholar
Modulating carbonyl cytotoxicity in intact rat hepatocytes by inhibiting carbonyl-metabolizing enzymes. I. Aliphatic alkenals.
H. Niknahad, A. Siraki, A. Shuhendler, Sumsullah Khan +5 more
2003Chemico-Biological Interactions16 citations
Semantic Scholar
Induction of quinone oxidoreductase 1 enzyme by Rhazya stricta through Nrf2-dependent mechanism.
M. El Gendy, B. Ali, K. Michail, A. Siraki +1 more
2012Journal of Ethnopharmacology15 citations
Semantic Scholar
INVESTIGATING THE MECHANISMS OF AROMATIC AMINE-INDUCED PROTEIN FREE RADICAL FORMATION BY QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIPS (QSARs): IMPLICATIONS FOR DRUG-INDUCED AGRANULOCYTOSIS
A. Siraki, Jinjie Jiang, R. Mason
2010Chemical Research in Toxicology15 citations Open access
Semantic Scholar
Phenylbutazone Oxidation via Cu,Zn-SOD Peroxidase Activity: An EPR Study.
N. Aljuhani, R. Whittal, Saifur R. Khan, A. Siraki
2015Chemical Research in Toxicology14 citations
Semantic Scholar
Free Radical Metabolites in Arylamine Toxicity
A. Siraki
201314 citations
Semantic Scholar
Heating of consumer cannabis oils can lead to free radical initiated degradation, causing CBD and THC depletion.
L. Tonoyan, D. Babu, B. Reiz, T. Le +1 more
2022Free Radical Biology & Medicine13 citations
Semantic Scholar
Cytoprotective effect of isoniazid against H2O2 derived injury in HL-60 cells.
Saifur R. Khan, N. Aljuhani, Andrew G M Morgan, Argishti Baghdasarian +2 more
2016Chemico-Biological Interactions13 citations
Semantic Scholar
Drug-induced protein free radical formation is attenuated by unsaturated fatty acids by scavenging drug-derived phenyl radical metabolites.
Malyaj Narwaley, K. Michail, Pratik Arvadia, A. Siraki
2011Chemical Research in Toxicology13 citations
Semantic Scholar

Frequent co-authors

Invite them to SciRah by sharing their profile.

P. O'Brien×16
Invite
P. O'Brien — researcher profile on SciRah
K. Michail×7
Invite
K. Michail — researcher profile on SciRah
N. Aljuhani×7
Invite
N. Aljuhani — researcher profile on SciRah
Saifur R. Khan×6
Invite
Saifur R. Khan — researcher profile on SciRah

×5

Invite

M. Moridani — researcher profile on SciRah

Invite

D. Babu — researcher profile on SciRah

Invite

G. Galati — researcher profile on SciRah

Invite

Y. Tabana — researcher profile on SciRah

Invite

K. Barakat — researcher profile on SciRah

Invite

A. El-Kadi — researcher profile on SciRah

Invite

R. Mason — researcher profile on SciRah

Invite

L. Tonoyan — researcher profile on SciRah