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Karen A. Smith · SciRah

Researcher profile · Semantic Scholar

Karen A. Smith

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Karen A. Smith — researcher profile on SciRah

h-index: 18
Works: 30
Citations: 1,680

Most-cited papers

Fibrotic extracellular matrix activates a profibrotic positive feedback loop.
Matthew Parker, D. Rossi, M. Peterson, Karen A. Smith +6 more
2014Journal of Clinical Investigation501 citations Open access
Semantic Scholar
Eukaryotic translation initiation factor 4E induced progression of primary human mammary epithelial cells along the cancer pathway is associated with targeted translational deregulation of oncogenic drivers and inhibitors.
Ola Larsson, Shu-Nan Li, Olga A. Issaenko, Svetlana V. Avdulov +4 more
2007Cancer Research161 citations Open access
Semantic Scholar
Metallothionein mRNA induction in HeLa cells in response to zinc or dexamethasone is a primary induction response
M. Karin, R. D. Andersen, E. Slater, Karen A. Smith +1 more
1980Nature160 citations
Semantic Scholar
Non-Toxic Chemical Interdiction of the Epithelial-to-Mesenchymal Transition by Targeting Cap-dependent Translation
Brahma Ghosh, A. Benyumov, P. Ghosh, Yan Jia +7 more
2009ACS Chemical Biology90 citations Open access
Semantic Scholar
miR-210 promotes IPF fibroblast proliferation in response to hypoxia.
Vidya Bodempudi, Polla J. Hergert, Karen A. Smith, H. Xia +6 more
2014American Journal of Physiology - Lung cellular and Molecular Physiology84 citations Open access
Semantic Scholar
Calcium-binding protein S100A4 confers mesenchymal progenitor cell fibrogenicity in idiopathic pulmonary fibrosis
H. Xia, A. Gilbertsen, J. Herrera, Emilian V. Racila +7 more
2017Journal of Clinical Investigation79 citations Open access
Semantic Scholar
IL-8 mediates idiopathic pulmonary fibrosis mesenchymal progenitor cell fibrogenicity
Libang Yang, J. Herrera, A. Gilbertsen, H. Xia +4 more
2017American Journal of Physiology - Lung cellular and Molecular Physiology79 citations Open access
Semantic Scholar
Identification of a cell-of-origin for fibroblasts comprising the fibrotic reticulum in idiopathic pulmonary fibrosis.
H. Xia, Vidya Bodempudi, A. Benyumov, Polla J. Hergert +15 more
2014American Journal of Pathology75 citations Open access
Semantic Scholar
Hypoxia enhances IPF mesenchymal progenitor cell fibrogenicity via the lactate/GPR81/HIF1α pathway
Libang Yang, A. Gilbertsen, H. Xia, A. Benyumov +5 more
2023JCI Insight70 citations Open access
Semantic Scholar
Low α(2)β(1) integrin function enhances the proliferation of fibroblasts from patients with idiopathic pulmonary fibrosis by activation of the β-catenin pathway.
H. Xia, J. Seeman, Jian Hong, Polla J. Hergert +7 more
2012American Journal of Pathology52 citations Open access
Semantic Scholar
Pathologic Regulation of Collagen I by an Aberrant Protein Phosphatase 2A/Histone Deacetylase C4/MicroRNA-29 Signal Axis in Idiopathic Pulmonary Fibrosis Fibroblasts.
Wajahat Khalil, H. Xia, Vidya Bodempudi, Judy Kahm +7 more
2015American Journal of Respiratory Cell and Molecular Biology49 citations Open access
Semantic Scholar
S-phase checkpoint controls mitosis via an APC-independent Cdc20p function
D. J. Clarke, Marisa Segal, Catherine A. Andrews, S. Rudyak +3 more
2003Nature Cell Biology49 citations
Semantic Scholar
Transforming Growth Factor-β1 Induced Epithelial Mesenchymal Transition is blocked by a chemical antagonist of translation factor eIF4E
Karen A. Smith, Bei-Yun Zhou, Svetlana V. Avdulov, A. Benyumov +8 more
2015Scientific Reports38 citations Open access
Semantic Scholar
Dicer1 Deficiency in the Idiopathic Pulmonary Fibrosis Fibroblastic Focus Promotes Fibrosis by Suppressing MicroRNA Biogenesis
J. Herrera, Daniel J. Beisang, M. Peterson, C. Forster +10 more
2018American Journal of Respiratory and Critical Care Medicine37 citations Open access
Semantic Scholar
High Glucose Levels Promote Switch to Synthetic Vascular Smooth Muscle Cells via Lactate/GPR81
Jing Yang, G. Gourley, A. Gilbertsen, Chi Chen +4 more
2024Cells27 citations Open access
Semantic Scholar
Hyaluronan/CD44 Axis Regulates S100A4 Mediated Mesenchymal Progenitor Cell Fibrogenicity in Idiopathic Pulmonary Fibrosis.
H. Xia, J. Herrera, Karen A. Smith, Libang Yang +5 more
2021American Journal of Physiology - Lung cellular and Molecular Physiology24 citations Open access
Semantic Scholar
A CD44/Brg1 nuclear complex confers mesenchymal progenitor cells with enhanced fibrogenicity in idiopathic pulmonary fibrosis
Libang Yang, H. Xia, Karen A. Smith, A. Gilbertsen +4 more
2021JCI Insight21 citations Open access
Semantic Scholar
Single-cell RNA sequencing reveals that lung mesenchymal progenitor cells in IPF exhibit pathological features early in their differentiation trajectory
Daniel J. Beisang, Karen A. Smith, Libang Yang, A. Benyumov +8 more
2020Scientific Reports19 citations Open access
Semantic Scholar
SFPQ Promotes Lung Cancer Malignancy via Regulation of CD44 v6 Expression
Libang Yang, Jianbo Yang, B. Jacobson, A. Gilbertsen +6 more
2022Frontiers in Oncology17 citations Open access
Semantic Scholar
eIF4E Threshold Levels Differ in Governing Normal and Neoplastic Expansion of Mammary Stem and Luminal Progenitor cells
Svetlana V. Avdulov, J. Herrera, Karen A. Smith, M. Peterson +10 more
2014Cancer Research16 citations Open access
Semantic Scholar
IL-8 Concurrently Promotes IPF MPC Senescence and PD-L1 Expression Enabling Escape from Immune Cell Surveillance.
Libang Yang, H. Xia, A. Gilbertsen, Karen A. Smith +3 more
2023American Journal of Physiology - Lung cellular and Molecular Physiology15 citations Open access
Semantic Scholar
Proteomic analysis of the IPF mesenchymal progenitor cell nuclear proteome identifies abnormalities in key nodal proteins that underlie their fibrogenic phenotype
Libang Yang, A. Gilbertsen, Karen A. Smith, H. Xia +3 more
2022Proteomics11 citations Open access
Semantic Scholar
Tumor Suppressors RBL1 and PTEN are Epigenetically Silenced in IPF5 Mesenchymal Progenitor Cells by a CD44/Brg1/PRMT5 Regulatory Complex.
Libang Yang, H. Xia, Karen A. Smith, A. Gilbertsen +4 more
2024American Journal of Physiology - Lung cellular and Molecular Physiology4 citations
Semantic Scholar
Calcium-binding protein S 100 A 4 confers mesenchymal progenitor cell fibrogenicity in idiopathic pulmonary fibrosis
H. Xia, A. Gilbertsen, J. Herrera, Emilian V. Racila +7 more
20192 citations
Semantic Scholar
IL-8 Mediates Idiopathic Pulmonary Fibrosis Mesenchymal
Libang Yang, J. Herrera, A. Gilbertsen, H. Xia +5 more
20171 citations
Semantic Scholar
Identi fi cation of a Cell-of-Origin for Fibroblasts Comprising the Fibrotic Reticulum in Idiopathic Pulmonary Fibrosis
H. Xia, Vidya Bodempudi, A. Benyumov, Polla J. Hergert +15 more
1 citations
Semantic Scholar
IPF Macrophage Crosstalk with IPF Mesenchymal Progenitor Cells Drives Fibrotic Progression
S. Khalil, H. Xia, Libang Yang, Karen A. Smith +3 more
20200 citations
Semantic Scholar
Single Cell Transcriptome Sequencing Identifies Pathogenic IPF Mesenchymal Progenitor Cells
Daniel J. Beisang, Karen A. Smith, A. Gilbertsen, A. Bunyemov +3 more
2019C64. PULMONARY FIBROSIS MODELS AND MECHANISTIC INSIGHTS0 citations
Semantic Scholar
Pathological Mesenchymal Progenitor Cells Reside In The Fibrotic Reticulum Of Idiopathic Pulmonary Fibrosis
C. Henke, H. Xia, Vidya Bodem, Polla J. Hergert +11 more
2012Asian Test Symposium0 citations
Semantic Scholar
A Genome-Wide Approach To Drug Development For Fibrosis
Jeff Braziunas, Matthew Parker, M. Peterson, Karen A. Smith +3 more
2012Asian Test Symposium0 citations
Semantic Scholar

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