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D. Fachinetti · SciRah

Researcher profile · Semantic Scholar

D. Fachinetti

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D. Fachinetti — researcher profile on SciRah

h-index: 37
Works: 83
Citations: 5,007

Most-cited papers

Topoisomerase I poisoning results in PARP-mediated replication fork reversal
A. Chaudhuri, Yoshitami Hashimoto, Raquel Herrador, K. Neelsen +5 more
2012Nature Structural &Molecular Biology508 citations Open access
Semantic Scholar
Inducible, reversible system for the rapid and complete degradation of proteins in mammalian cells
A. Holland, D. Fachinetti, Joo Seok Han, D. Cleveland
2012Proceedings of the National Academy of Sciences of the United States of America305 citations Open access
Semantic Scholar
The dark side of centromeres: types, causes and consequences of structural abnormalities implicating centromeric DNA
V. Barra, D. Fachinetti
2018Nature Communications299 citations Open access
Semantic Scholar
Exo1 processes stalled replication forks and counteracts fork reversal in checkpoint-defective cells.
Cecilia Cotta-Ramusino, D. Fachinetti, C. Lucca, Ylli Doksani +3 more
2005Molecules and Cells286 citations Open access
Semantic Scholar
A two-step mechanism for epigenetic specification of centromere identity and function
D. Fachinetti, H. D. Folco, Yael Nechemia-Arbely, Luis P. Valente +7 more
2013Nature Cell Biology270 citations Open access
Semantic Scholar
DNA sequence-specific binding of CENP-B enhances the fidelity of human centromere function
D. Fachinetti, Joo Seok Han, Moira A. McMahon, P. Ly +3 more
2015Developmental Cell254 citations Open access
Semantic Scholar
Selective Y centromere inactivation triggers chromosome shattering in micronuclei and repair by canonical NHEJ
P. Ly, Levi S. Teitz, Dong Hyun Kim, Ofer Shoshani +4 more
2016Nature Cell Biology250 citations Open access
Semantic Scholar
The N-Terminal Domain of cGAS Determines Preferential Association with Centromeric DNA and Innate Immune Activation in the Nucleus
Matteo Gentili, Xavier Lahaye, F. Nadalin, G. Nader +13 more
2019Cell Reports213 citations Open access
Semantic Scholar
Gene copy-number changes and chromosomal instability induced by aneuploidy confer resistance to chemotherapy.
M. Ippolito, Valentino Martis, Sara Martin, Andréa E. Tijhuis +9 more
2021Developmental Cell176 citations Open access
Semantic Scholar
Replication termination at eukaryotic chromosomes is mediated by Top2 and occurs at genomic loci containing pausing elements
D. Fachinetti, Rodrigo Bermejo, A. Cocito, S. Minardi +6 more
2010Molecules and Cells162 citations Open access
Semantic Scholar
The autoregulated instability of Polo-like kinase 4 limits centrosome duplication to once per cell cycle.
A. Holland, D. Fachinetti, Quan-Sheng Zhu, Manuel Bauer +3 more
2012Genes & Development152 citations Open access
Semantic Scholar
Genome-organizing factors Top2 and Hmo1 prevent chromosome fragility at sites of S phase transcription.
Rodrigo Bermejo, T. Capra, Víctor González-Huici, D. Fachinetti +7 more
2009Cell123 citations Open access
Semantic Scholar
Human chromosome‐specific aneuploidy is influenced by DNA‐dependent centromeric features
Marie Dumont, Riccardo Gamba, P. Gestraud, S. Klaasen +10 more
2019EMBO Journal113 citations Open access
Semantic Scholar
CENP-A is dispensable for mitotic centromere function after initial centromere/kinetochore assembly
Sebastian Hoffmann, Marie Dumont, V. Barra, P. Ly +5 more
2016Cell Reports110 citations Open access
Semantic Scholar
Live-cell micromanipulation of a genomic locus reveals interphase chromatin mechanics
Veer I. P. Keizer, Simon Grosse-Holz, M. Woringer, Laura Zambon +11 more
2021bioRxiv101 citations Open access
Semantic Scholar
Catalytic Assembly of the Mitotic Checkpoint Inhibitor BubR1-Cdc20 by Mad2-induced Functional Switch in Cdc20
Joo Seok Han, A. Holland, D. Fachinetti, Anita Kulukian +2 more
2013Molecules and Cells101 citations Open access
Semantic Scholar
CENP-A chromatin prevents replication stress at centromeres to avoid structural aneuploidy
Simona Giunta, Solène Hervé, Ryan R. White, Therese Wilhelm +8 more
2020Proceedings of the National Academy of Sciences of the United States of America89 citations Open access
Semantic Scholar
DNA replication acts as an error correction mechanism to maintain centromere identity by restricting CENP-A to centromeres
Yael Nechemia-Arbely, K. Miga, Ofer Shoshani, A. Aslanian +6 more
2019Nature Cell Biology86 citations Open access
Semantic Scholar
Centromeres are maintained by fastening CENP-A to DNA and directing an arginine anchor-dependent nucleosome transition
Lucie Y. Guo, P. K. Allu, Levani Zandarashvili, Kara L. McKinley +8 more
2017Nature Communications86 citations Open access
Semantic Scholar
Diverse mechanisms of centromere specification
B. Mellone, D. Fachinetti
2021Current Biology70 citations Open access
Semantic Scholar
α-amino trimethylation of CENP-A by NRMT is required for full recruitment of the centromere
K. Sathyan, D. Fachinetti, D. Foltz
2017Nature Communications69 citations Open access
Semantic Scholar
Short-term molecular consequences of chromosome mis-segregation for genome stability
Lorenza Garribba, Giuseppina De Feudis, Valentino Martis, M. Galli +18 more
2023bioRxiv65 citations Open access
Semantic Scholar
Human centromeric CENP-A chromatin is a homotypic, octameric nucleosome at all cell cycle points
Yael Nechemia-Arbely, D. Fachinetti, K. Miga, N. Sekulić +9 more
2017Journal of Cell Biology61 citations Open access
Semantic Scholar
CDK1-mediated CENP-C phosphorylation modulates CENP-A binding and mitotic kinetochore localization
Reito Watanabe, Masatoshi Hara, E. Okumura, Solène Hervé +3 more
2019Journal of Cell Biology56 citations Open access
Semantic Scholar
The N-Terminal Domain of cGAS Determines Preferential Association with Centromeric DNA and Innate Immune Activation in the Nucleus
Matteo Gentili, Xavier Lahaye, F. Nadalin, G. Nader +13 more
2019Cell Reports55 citations Open access
Semantic Scholar
Polo-like kinase 4 controls centriole duplication but does not directly regulate cytokinesis
A. Holland, D. Fachinetti, S. Da Cruz, Quan-Sheng Zhu +7 more
2012Molecular Biology of the Cell55 citations Open access
Semantic Scholar
Non-canonical functions of UHRF1 maintain DNA methylation homeostasis in cancer cells
Kosuke Yamaguchi, Xiaoying Chen, Brianna Rodgers, F. Miura +19 more
2023bioRxiv54 citations Open access
Semantic Scholar
From evolution to function: Two sides of the same CENP-B coin?
Riccardo Gamba, D. Fachinetti
2020Experimental Cell Research53 citations Open access
Semantic Scholar
Keeping the Centromere under Control: A Promising Role for DNA Methylation
A. Scelfo, D. Fachinetti
2019Cells53 citations Open access
Semantic Scholar
CENP-B-mediated DNA loops regulate activity and stability of human centromeres.
F. Chardon, A. Japaridze, Hannes Witt, Léonid Velikovsky +10 more
2022Molecules and Cells51 citations Open access
Semantic Scholar
CENP-A overexpression promotes aneuploidy with karyotypic heterogeneity
Roshan L. Shrestha, Austin Rossi, Darawalee Wangsa, Ann K. Hogan +12 more
2021Journal of Cell Biology48 citations Open access
Semantic Scholar
CENP-A modifications on Ser68 and Lys124 are dispensable for establishment, maintenance, and long-term function of human centromeres
D. Fachinetti, G. Logsdon, A. Abdullah, Evan B. Selzer +2 more
2017Developmental Cell46 citations Open access
Semantic Scholar
RAD51 protects abasic sites to prevent replication fork breakage.
Yodhara Wijesekara Hanthi, M. Ramirez-Otero, Robert Appleby, A. De Antoni +8 more
2024Molecules and Cells45 citations Open access
Semantic Scholar
CENP-A overexpression promotes distinct fates in human cells, depending on p53 status
Daniel Jeffery, A. Gatto, K. Podsypanina, Charlène Renaud-Pageot +5 more
2021Communications Biology44 citations Open access
Semantic Scholar
Specialized replication mechanisms maintain genome stability at human centromeres.
Andrea Scelfo, Annapaola Angrisani, Marco Grillo, Bethany M. Barnes +15 more
2024Molecules and Cells41 citations Open access
Semantic Scholar
Chromosome mis-segregation triggers cell cycle arrest through a mechanosensitive nuclear envelope checkpoint
Solène Hervé, Andrea Scelfo, Gabriele Bersano Marchisio, Marine Grison +14 more
2025Nature Cell Biology39 citations Open access
Semantic Scholar
Induction of spontaneous human neocentromere formation and long-term maturation
Marina Murillo-Pineda, Luis P. Valente, Marie Dumont, João F. Mata +2 more
2021Journal of Cell Biology39 citations Open access
Semantic Scholar
Bimodal activation of BubR1 by Bub3 sustains mitotic checkpoint signaling
Joo Seok Han, B. Vitre, D. Fachinetti, D. Cleveland
2014Proceedings of the National Academy of Sciences of the United States of America36 citations Open access
Semantic Scholar
Replicating centromeric chromatin: spatial and temporal control of CENP-A assembly
Yael Nechemia-Arbely, D. Fachinetti, D. Cleveland
2012Experimental Cell Research36 citations Open access
Semantic Scholar
Kronos scRT: a uniform framework for single-cell replication timing analysis
Stefano Gnan, Joseph M. Josephides, Xia Wu, M. Spagnuolo +7 more
2021Nature Communications28 citations Open access
Semantic Scholar
A genetic memory initiates the epigenetic loop necessary to preserve centromere position
Sebastian Hoffmann, H. M. Izquierdo, Riccardo Gamba, F. Chardon +7 more
2020EMBO Journal28 citations Open access
Semantic Scholar
DNA methylation influences human centromere positioning and function
Catalina Salinas-Luypaert, Danilo Dubocanin, R. Lee, Lorena Andrade Ruiz +18 more
2025Nature Genetics27 citations Open access
Semantic Scholar
Tunable DNMT1 degradation reveals DNMT1/DNMT3B synergy in DNA methylation and genome organization
Andrea Scelfo, V. Barra, Nezar Abdennur, G. Spracklin +15 more
2024Journal of Cell Biology25 citations Open access
Semantic Scholar
Centromere Dysfunction Compromises Mitotic Spindle Pole Integrity.
S. Gemble, A. Simon, Carole Pennetier, Marie Dumont +7 more
2019Current Biology25 citations Open access
Semantic Scholar
Plk1 protects kinetochore–centromere architecture against microtubule pulling forces
Robert F. Lera, Roshan X Norman, Marie Dumont, Alexandra Dennee +3 more
2019EMBO Reports25 citations Open access
Semantic Scholar
DNA Sequences in Centromere Formation and Function.
Marie Dumont, D. Fachinetti
2017Progress in molecular and subcellular biology25 citations
Semantic Scholar
Centromeric DNA amplification triggered by viral proteins activates nuclear cGAS.
Xavier Lahaye, Patrick Tran Van, Camellia Chakraborty, A. Shmakova +12 more
2025Cell20 citations
Semantic Scholar
Phosphorylation of CENP-A on serine 7 does not control centromere function
V. Barra, G. Logsdon, A. Scelfo, Sebastian Hoffmann +6 more
2019Nature Communications20 citations Open access
Semantic Scholar
Centromere: A Trojan horse for genome stability.
Andrea Scelfo, D. Fachinetti
2023DNA Repair16 citations Open access
Semantic Scholar
Heterochromatin boundaries maintain centromere position, size and number
Ben L. Carty, Danilo Dubocanin, Marina Murillo-Pineda, Marie Dumont +8 more
2025bioRxiv15 citations Open access
Semantic Scholar

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Joo Seok Han×4

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