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C. Simonaro · SciRah

Researcher profile · Semantic Scholar

C. Simonaro

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C. Simonaro — researcher profile on SciRah

h-index: 22
Works: 74
Citations: 2,157

Most-cited papers

Mechanism of glycosaminoglycan-mediated bone and joint disease: implications for the mucopolysaccharidoses and other connective tissue diseases.
C. Simonaro, M. D'Angelo, Xing-Xuan He, E. Eliyahu +3 more
2008American Journal of Pathology207 citations Open access
Semantic Scholar
Involvement of the Toll-like receptor 4 pathway and use of TNF-α antagonists for treatment of the mucopolysaccharidoses
C. Simonaro, Y. Ge, E. Eliyahu, Xingxuan He +2 more
2009Proceedings of the National Academy of Sciences of the United States of America184 citations Open access
Semantic Scholar
Joint and Bone Disease in Mucopolysaccharidoses VI and VII: Identification of New Therapeutic Targets and BioMarkers Using Animal Models
C. Simonaro, M. D'Angelo, M. Haskins, E. Schuchman
2005Pediatric Research162 citations
Semantic Scholar
The demographics and distribution of type B Niemann-Pick disease: novel mutations lead to new genotype/phenotype correlations.
C. Simonaro, R. Desnick, M. McGovern, M. Wasserstein +1 more
2002American Journal of Human Genetics154 citations Open access
Semantic Scholar
Oral glycotoxins are a modifiable cause of dementia and the metabolic syndrome in mice and humans
W. Cai, J. Uribarri, Li Zhu, Xue Chen +9 more
2014Proceedings of the National Academy of Sciences of the United States of America152 citations Open access
Semantic Scholar
Articular Chondrocytes from Animals with a Dermatan Sulfate Storage Disease Undergo a High Rate of Apoptosis and Release Nitric Oxide and Inflammatory Cytokines: A Possible Mechanism Underlying Degenerative Joint Disease in the Mucopolysaccharidoses
C. Simonaro, M. Haskins, E. Schuchman
2001Laboratory Investigation148 citations Open access
Semantic Scholar
Acid sphingomyelinase deficiency: prevalence and characterization of an intermediate phenotype of Niemann-Pick disease.
M. Wasserstein, A. Aron, S. Brodie, C. Simonaro +2 more
2006Jornal de Pediatria120 citations
Semantic Scholar
Insertional mutagenesis of the mouse acid ceramidase gene leads to early embryonic lethality in homozygotes and progressive lipid storage disease in heterozygotes.
Chi-Ming Li, Jae-Ho Park, C. Simonaro, Xing-Xuan He +10 more
2002Genomics114 citations
Semantic Scholar
Systemic ceramide accumulation leads to severe and varied pathological consequences
A. Alayoubi, J. C. Wang, Bryan C Y Au, S. Carpentier +15 more
2013EMBO Molecular Medicine101 citations Open access
Semantic Scholar
Pentosan Polysulfate: A Novel Therapy for the Mucopolysaccharidoses
E. Schuchman, Y. Ge, Alon Lai, Y. Borisov +7 more
2013PLoS ONE95 citations Open access
Semantic Scholar
Anti-TNF-Alpha Therapy Enhances the Effects of Enzyme Replacement Therapy in Rats with Mucopolysaccharidosis Type VI
E. Eliyahu, Theodore S. Wolfson, Y. Ge, K. J. Jepsen +2 more
2011PLoS ONE68 citations Open access
Semantic Scholar
Imprinting at the SMPD1 locus: implications for acid sphingomyelinase-deficient Niemann-Pick disease.
C. Simonaro, Jae-Ho Park, E. Eliyahu, N. Shtraizent +2 more
2006American Journal of Human Genetics66 citations Open access
Semantic Scholar
Identification and characterization of the molecular lesion causing mucopolysaccharidosis type I in cats.
Xing-Xuan He, Chi-Ming Li, C. Simonaro, Qi Wan +3 more
1999Molecular Genetics and Metabolism49 citations
Semantic Scholar
Identification and Characterization of Eight Novel SMPD1 Mutations Causing Types A and B Niemann-Pick Disease
J. Desnick, Jungmin Kim, Xing-Xuan He, M. Wasserstein +2 more
2010Molecular Medicine47 citations Open access
Semantic Scholar
Lysosomes, Lysosomal Storage Diseases, and Inflammation:
C. Simonaro
201646 citations Open access
Semantic Scholar
Dose Responsive Effects of Subcutaneous Pentosan Polysulfate Injection in Mucopolysaccharidosis Type VI Rats and Comparison to Oral Treatment
M. Frohbergh, Y. Ge, Fan-Li Meng, N. Karabul +5 more
2014PLoS ONE44 citations Open access
Semantic Scholar
Enzyme replacement therapy for Farber disease: Proof-of-concept studies in cells and mice
Xing-Xuan He, Shaalee Dworski, Changzhi Zhu, Victor A. DeAngelis +4 more
2017BBA Clinical42 citations Open access
Semantic Scholar
Treatment with pentosan polysulphate in patients with MPS I: results from an open label, randomized, monocentric phase II study
J. Hennermann, Seyfullah Gökce, A. Sólyom, E. Mengel +2 more
2016Journal of Inherited Metabolic Disease41 citations
Semantic Scholar
Pentosan Polysulfate: Oral Versus Subcutaneous Injection in Mucopolysaccharidosis Type I Dogs
C. Simonaro, S. Tomatsu, Tracey U. Sikora, F. Kubaski +8 more
2016PLoS ONE36 citations Open access
Semantic Scholar
Autologous transplantation of retrovirally transduced bone marrow or neonatal blood cells into cats can lead to long-term engraftment in the absence of myeloablation
C. Simonaro, M. Haskins, J. Abkowitz, D. Brooks +3 more
1999Gene Therapy36 citations
Semantic Scholar
Mucopolysaccharidosis type VI in rats: isolation of cDNAs encoding arylsulfatase B, chromosomal localization of the gene, and identification of the mutation.
T. Kunieda, C. Simonaro, Midori Yoshida, H. Ikadai +3 more
1995Genomics34 citations
Semantic Scholar
Cartilage and chondrocyte pathology in the mucopolysaccharidoses: The role of glycosaminoglycan-mediated inflammation
C. Simonaro
2010Journal of Pediatric Rehabilitation Medicine32 citations Open access
Semantic Scholar
Acid Ceramidase Maintains the Chondrogenic Phenotype of Expanded Primary Chondrocytes and Improves the Chondrogenic Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells
C. Simonaro, S. Sachot, Y. Ge, Xing-Xuan He +8 more
2013PLoS ONE22 citations Open access
Semantic Scholar
Efficacy of pentosan polysulfate in in vitro models of lysosomal storage disorders: Fabry and Gaucher Disease
A. Crivaro, J. Mucci, C. Bondar, M. Ormazabal +3 more
2019PLoS ONE20 citations Open access
Semantic Scholar
Acid Ceramidase Protects Against Hepatic Ischemia/Reperfusion Injury by Modulating Sphingolipid Metabolism and Reducing Inflammation and Oxidative Stress
Yuan Jiang, Xing-Xuan He, C. Simonaro, Bin Yi +1 more
2021Frontiers in Cell and Developmental Biology17 citations Open access
Semantic Scholar
N-acetylgalactosamine-4-sulfatase: identification of four new mutations within the conserved sulfatase region causing mucopolysaccharidosis type VI.
C. Simonaro, E. Schuchman
1995Biochimica et Biophysica Acta15 citations Open access
Semantic Scholar
Pentosan Polysulfate Treatment of Mucopolysaccharidosis Type IIIA Mice.
Ningning Guo, Victor A. DeAngelis, Changzhi Zhu, E. Schuchman +1 more
2019JIMD Reports14 citations Open access
Semantic Scholar
Safety Study of Sodium Pentosan Polysulfate for Adult Patients with Mucopolysaccharidosis Type II
K. Orii, A. Lim, S. Tomatsu, Molly Stapleton +5 more
2019Diagnostics14 citations Open access
Semantic Scholar
Acid Ceramidase Treatment Enhances the Outcome of Autologous Chondrocyte Implantation in a Rat Osteochondral Defect Model
M. Frohbergh, J. Guevara, Ronald P. Grelsamer, M. Barbe +3 more
2015Osteoarthritis and Cartilage13 citations Open access
Semantic Scholar
New paradigms for the treatment of lysosomal storage diseases: targeting the endocannabinoid system as a therapeutic strategy
E. Schuchman, M. D. Ledesma, C. Simonaro
2021Orphanet Journal of Rare Diseases8 citations Open access
Semantic Scholar
Growth Plate Pathology in the Mucopolysaccharidosis Type VI Rat Model—An Experimental and Computational Approach
J. Guevara-Morales, M. Frohbergh, H. Castro-Abril, J. Vaca-González +4 more
2020Diagnostics6 citations Open access
Semantic Scholar
Polyarticular arthritis as presenting feature of farber disease: a lysosomal storage disease involving inflammation
A. Sólyom, N. Karabul, B. Hügle, C. Simonaro +1 more
2014Pediatric Rheumatology Online Journal6 citations Open access
Semantic Scholar
Two Siblings with Niemann-Pick Disease (NPD) Type B: Clinical Findings and Novel Mutations of the Acid Sphingomyelinase Gene
Z. Gucev, V. Tasic, N. Pop-Jordanova, A. Jančevska +2 more
2013Indian Journal of Pediatrics6 citations
Semantic Scholar
The genetics of sphingolipid hydrolases and sphingolipid storage diseases.
E. Schuchman, C. Simonaro
2013Handbook of Experimental Pharmacology6 citations
Semantic Scholar
Uteroplacental blood flow in pregnant women with hypertension and recurrent spontaneous abortion.
N. Chianchiano, C. Rossi, G. Bertolino, C. Simonaro +2 more
1991Acta Europaea fertilitatis4 citations
Semantic Scholar
A New Fluorescent Method to Detect Sulfamidase Activity in Blood, Tissue Extracts and Dried Blood Spots
Xing-Xuan He, E. Schuchman, C. Simonaro
2021Journal of Inborn Errors of Metabolism and Screening3 citations Open access
Semantic Scholar
Identification and Characterization of Eight Novel SMPD 1 Mutations Causing Types A and B Niemann-Pick Disease
J. Desnick, Jungmin Kim, Xing-Xuan He, M. Wasserstein +2 more
20183 citations
Semantic Scholar
Pentosan polysulfate and neuroinflammation in mice with mucopolysaccharidosis type IIIA mice
C. Simonaro, Ningning Guo, E. Schuchman
20162 citations
Semantic Scholar
Acid ceramidase deficiency: Clinical implications of an emerging phenotypic spectrum and potential therapies
A. Sólyom, C. Simonaro, Xing-Xuan He, E. Schuchman
20152 citations
Semantic Scholar
A63: Treatment of Arthritis in Animal Models of the Mucopolysaccharidoses Using a Novel Anti‐Inflammatory Drug, Pentosan Polysulfate
C. Simonaro, M. Frohbergh, Y. Ge, Fan-Li Meng +1 more
20142 citations
Semantic Scholar
91. Mechanism of glycosaminoglycan-mediated bone and joint disease in the mucopolysaccharidoses
C. Simonaro, M. Haskins, E. Schuchman
20082 citations
Semantic Scholar
[The role of heparin sulfate in the treatment of pregnant women with circulatory deficiency syndrome].
M. A. Palmeri, N. Chianchiano, C. Simonaro, A. Perino
1996Minerva Ginecologica2 citations
Semantic Scholar
Endocannabinoid receptor 2 is a potential biomarker and therapeutic target for the lysosomal storage disorders
C. Simonaro, M. Yasuda, E. Schuchman
2024Journal of Inherited Metabolic Disease1 citations Open access
Semantic Scholar
Modulation of the endocannabinoid receptor CB2 as a novel treatment for the lysosomal diseases
C. Simonaro, Xing-Xuan He, Victor A. DeAngelis, Changzhi Zhu +1 more
20211 citations
Semantic Scholar
Evaluation of pentosan polysulfate in mucopolysaccharidosis type IIIA mice
C. Simonaro, Ningning Guo, Victor A. DeAngelis, S. Tomatsu +1 more
20171 citations
Semantic Scholar
Safety study of sodium pentosan polysulfate for adult patients with mucopolysaccharidosis type II
K. Orii, S. Tomatsu, Yasuyuki Suzuki, A. Sólyom +5 more
20161 citations
Semantic Scholar
Treatment with pentosan polysulphate in patients with mucopolysaccharidosis type I: Results from an open label, randomized, monocentric phase 2 study
J. Hennermann, Seyfullah Goekce, A. Sólyom, E. Mengel +2 more
20161 citations
Semantic Scholar
Bone Tissue Engineering: Nanomedicine Approaches
M. Frohbergh, P. Newman, C. Simonaro, H. Zreiqat
20151 citations
Semantic Scholar
Pentosan polysulfate: New mechanistic insights and treatment of the mucopolysaccharidoses
C. Simonaro, S. Tomatsu, Y. Ge, Fan-Li Meng +7 more
20151 citations
Semantic Scholar
THU0361 Bone and Joint Disease in Mucopolysaccharidosis Involves Tlr4-Related Inflammation and Improves upon Treatment with Pentosan Polysulphate
C. Simonaro, M. Frohbergh, Y. Ge, Fan-Li Meng +5 more
20141 citations
Semantic Scholar

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