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Dinesh Thummuri · SciRah

Researcher profile · Semantic Scholar

Dinesh Thummuri

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Dinesh Thummuri — researcher profile on SciRah

h-index: 28
Works: 48
Citations: 2,705

Most-cited papers

A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity
Sajid Khan, Xuan Zhang, D. Lv, Qi Zhang +21 more
2019Nature Medicine547 citations Open access
Semantic Scholar
Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity
Yonghan He, Xuan Zhang, Jian-Hui Chang, Ha-Neui Kim +18 more
2020Nature Communications244 citations Open access
Semantic Scholar
Development of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity,
D. Lv, Pratik Pal, Xin-Gui Liu, Yan-Nan Jia +20 more
2021Nature Communications133 citations Open access
Semantic Scholar
DT2216—a Bcl-xL-specific degrader is highly active against Bcl-xL-dependent T cell lymphomas
Yonghan He, R. Koch, Vivekananda Budamagunta, Pei-Yi Zhang +12 more
2020Journal of Hematology & Oncology112 citations Open access
Semantic Scholar
Thymoquinone prevents RANKL-induced osteoclastogenesis activation and osteolysis in an in vivo model of inflammation by suppressing NF-KB and MAPK Signalling.
Dinesh Thummuri, M. Jeengar, S. Shrivastava, H. Nemani +3 more
2015Pharmacological Research112 citations
Semantic Scholar
Discovery of PROTAC BCL-XL Degraders as Potent Anticancer Agents with Low On-target Platelet Toxicity
Xuan Zhang, Dinesh Thummuri, Xin-Gui Liu, Wan-Yi Hu +5 more
2020European journal of medicinal chemistry100 citations Open access
Semantic Scholar
Long-Term Gemcitabine Treatment Reshapes the Pancreatic Tumor Microenvironment and Sensitizes Murine Carcinoma to Combination Immunotherapy
D. Principe, Matthew Narbutis, Sandeep Kumar, Alex Park +11 more
2020Cancer Research98 citations Open access
Semantic Scholar
Cellular Senescence and Radiation-induced Pulmonary Fibrosis
Yonghan He, Dinesh Thummuri, Guangrong Zheng, P. Okunieff +3 more
2019Translational Research: The Journal of Laboratory and Clinical Medicine95 citations Open access
Semantic Scholar
Synthesis and biological evaluation of new benzimidazole-thiazolidinedione hybrids as potential cytotoxic and apoptosis inducing agents.
Pankaj Sharma, T. Srinivasa Reddy, Dinesh Thummuri, Kishna Ram Senwar +4 more
2016European journal of medicinal chemistry91 citations
Semantic Scholar
Uridine Ameliorates Dextran Sulfate Sodium (DSS)-Induced Colitis in Mice
M. Jeengar, Dinesh Thummuri, M. Magnusson, V. Naidu +1 more
2017Scientific Reports90 citations Open access
Semantic Scholar
Cardamonin, a chalcone, inhibits human triple negative breast cancer cell invasiveness by downregulation of Wnt/&bgr;‐catenin signaling cascades and reversal of epithelial–mesenchymal transition
S. Shrivastava, M. Jeengar, Dinesh Thummuri, A. Koval +3 more
2017Biofactors85 citations Open access
Semantic Scholar
Design and synthesis of dithiocarbamate linked β-carboline derivatives: DNA topoisomerase II inhibition with DNA binding and apoptosis inducing ability.
A. Kamal, M. Sathish, V. L. Nayak, V. Srinivasulu +6 more
2015Bioorganic & Medicinal Chemistry80 citations
Semantic Scholar
Carnosic acid attenuates RANKL-induced oxidative stress and osteoclastogenesis via induction of Nrf2 and suppression of NF-κB and MAPK signalling
Dinesh Thummuri, V. Naidu, P. Chaudhari
2017Journal of molecular medicine71 citations
Semantic Scholar
Design, synthesis and apoptosis inducing effect of novel (Z)-3-(3'-methoxy-4'-(2-amino-2-oxoethoxy)-benzylidene)indolin-2-ones as potential antitumour agents.
Kishna Ram Senwar, T. S. Reddy, Dinesh Thummuri, Pankaj Sharma +3 more
2016European journal of medicinal chemistry69 citations Open access
Semantic Scholar
Discovery of IAP-Recruiting BCL-XL PROTACs as Potent Degraders across Multiple Cancer Cell Lines
Xuan Zhang, Yonghan He, Pei-Yi Zhang, Vivekananda Budamagunta +7 more
2020European journal of medicinal chemistry64 citations Open access
Semantic Scholar
Utilizing PROTAC technology to address the on-target platelet toxicity associated with inhibition of BCL-XL
Xuan Zhang, Dinesh Thummuri, Yonghan He, Xin-Gui Liu +3 more
2019Chemical Communications64 citations Open access
Semantic Scholar
Overcoming Gemcitabine Resistance in Pancreatic Cancer Using the BCL-XL Specific Degrader DT2216
Dinesh Thummuri, Sajid Khan, Patrick W. Underwood, Pei-Yi Zheng +14 more
2021Molecular Cancer Therapeutics63 citations Open access
Semantic Scholar
New (E)-1-alkyl-1H-benzo[d]imidazol-2-yl)methylene)indolin-2-ones: Synthesis, in vitro cytotoxicity evaluation and apoptosis inducing studies.
Pankaj Sharma, Dinesh Thummuri, T. S. Reddy, Kishna Ram Senwar +4 more
2016European journal of medicinal chemistry60 citations
Semantic Scholar
Synthesis and biological evaluation of new rhodanine analogues bearing 2-chloroquinoline and benzo[h]quinoline scaffolds as anticancer agents.
V. Ramesh, Boddu Ananda Rao, Pankaj Sharma, B. Swarna +4 more
2014European journal of medicinal chemistry57 citations
Semantic Scholar
BCL-XL PROTAC degrader DT2216 synergizes with sotorasib in preclinical models of KRASG12C-mutated cancers
Sajid Khan, Janet S. Wiegand, Pei-Yi Zhang, Wan-Yi Hu +10 more
2022Journal of Hematology & Oncology49 citations Open access
Semantic Scholar
Discovery of a Novel BCL-XL PROTAC Degrader with Enhanced BCL-2 Inhibition
Pratik Pal, Dinesh Thummuri, D. Lv, Xin-Gui Liu +9 more
2021Journal of Medicinal Chemistry47 citations Open access
Semantic Scholar
XP-524 is a dual-BET/EP300 inhibitor that represses oncogenic KRAS and potentiates immune checkpoint inhibition in pancreatic cancer
D. Principe, R. Xiong, Yang-Feng Li, Thao N. D. Pham +13 more
2022Proceedings of the National Academy of Sciences of the United States of America45 citations Open access
Semantic Scholar
Abietic acid attenuates RANKL induced osteoclastogenesis and inflammation associated osteolysis by inhibiting the NF‐KB and MAPK signaling
Dinesh Thummuri, L. Guntuku, V. Challa, R. Ramavat +1 more
2018Journal of Cellular Physiology42 citations Open access
Semantic Scholar
Review on emu products for use as complementary and alternative medicine.
M. Jeengar, P. S. Kumar, Dinesh Thummuri, S. Shrivastava +3 more
2015Nutrition (Burbank, Los Angeles County, Calif.)42 citations
Semantic Scholar
IITZ-01, a novel potent lysosomotropic autophagy inhibitor, has single-agent antitumor efficacy in triple-negative breast cancer in vitro and in vivo
L. Guntuku, J. Gangasani, Dinesh Thummuri, Roshan M. Borkar +5 more
2018Oncogene40 citations
Semantic Scholar
Co-targeting BCL-XL and MCL-1 with DT2216 and AZD8055 synergistically inhibit small-cell lung cancer growth without causing on-target toxicities in mice
Sajid Khan, Patrick C. Kellish, N. Connis, Dinesh Thummuri +15 more
2022bioRxiv39 citations Open access
Semantic Scholar
Boswellia ovalifoliolata abrogates ROS mediated NF-κB activation, causes apoptosis and chemosensitization in Triple Negative Breast Cancer cells.
Dinesh Thummuri, M. Jeengar, S. Shrivastava, A. Areti +6 more
2014Environmental Toxicology and Pharmacology35 citations
Semantic Scholar
Preclinical drug metabolism and pharmacokinetics of salinomycin, a potential candidate for targeting human cancer stem cells.
Kahkashan Resham, P. Patel, Dinesh Thummuri, L. Guntuku +3 more
2015Chemico-Biological Interactions29 citations
Semantic Scholar
Design and synthesis of 4'-O-alkylamino-tethered-benzylideneindolin-2-ones as potent cytotoxic and apoptosis inducing agents.
Kishna Ram Senwar, T. S. Reddy, Dinesh Thummuri, Pankaj Sharma +3 more
2016Bioorganic & Medicinal Chemistry Letters21 citations
Semantic Scholar
Epigenetic regulation of protein tyrosine phosphatase PTPN12 in triple-negative breast cancer.
Dinesh Thummuri, Sandeep Kumar, S. Surapaneni, K. Tikoo
2015Life Science21 citations
Semantic Scholar
Polymeric Core–Shell Combinatorial Nanomedicine for Synergistic Anticancer Therapy
Asifkhan Shanavas, N. Jain, N. Kaur, Dinesh Thummuri +5 more
2019ACS Omega18 citations Open access
Semantic Scholar
Erratum to: Synthesis and characterization of new s-triazine bearing benzimidazole and benzothiazole derivatives as anticancer agents
G. J. Kumar, S. N. Kumar, Dinesh Thummuri, Lavanya Bindu Sree Adari +3 more
2015Medicinal Chemistry Research12 citations Open access
Semantic Scholar
Synthesis of some novel orcinol based coumarin triazole hybrids with capabilities to inhibit RANKL-induced osteoclastogenesis through NF-κB signaling pathway.
Boddu Rama Krishna, Dinesh Thummuri, V. Naidu, S. Ramakrishna +1 more
2018Bioorganic chemistry (Print)11 citations
Semantic Scholar
A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity
Sajid Khan, Xuan Zhang, D. Lv, Qi Zhang +21 more
2019Nature Medicine9 citations Open access
Semantic Scholar
Discovery of PZ671, a highly potent and in vivo active CRBN-recruiting Bcl-xL degrader
Pei-Yi Zhang, Dinesh Thummuri, Wan-Yi Hu, Sajid Khan +6 more
2025RSC Medicinal Chemistry6 citations Open access
Semantic Scholar
Discovery of XZ338, a highly potent BCL-XL degrader
Xuan Zhang, Dinesh Thummuri, Wan-Yi Hu, Xin-Gui Liu +4 more
2025European journal of medicinal chemistry6 citations Open access
Semantic Scholar
Discovery of Dual BCL-xL/BCL-w Degraders by Exploiting the Bis(sulfonyl)benzene Ring of ABT-263 as a Linkage Vector
S. K. Poddar, Yang Yang, Pratik Pal, Zeng Jin +12 more
2025Journal of Medicinal Chemistry4 citations
Semantic Scholar
Local administration of 4-Thiouridine, a novel molecule with potent anti-inflammatory properties, protects against experimental colitis and arthritis.
M. Jeengar, S. C. Narendra, Dinesh Thummuri, M. Magnusson +2 more
2020International Immunopharmacology3 citations
Semantic Scholar
DT2216, a Synthetic Proteolytic Selectively Targeting Bcl-XL for Ubiquitination and Degradation in Tumor Cells but Not in Platelets, Is a Safer and More Potent Antitumor Agent Than Navitoclax
Sajid Khan, Xuan Zhang, D. Lv, Yonghan He +8 more
2018Blood2 citations
Semantic Scholar
Abstract 955: Long-term gemcitabine treatment reshapes the pancreatic tumor microenvironment and sensitizes murine carcinoma to combination immunotherapy
D. Principe, Matthew Narbutis, Sandeep Kumar, Alex Park +11 more
2020Immunology1 citations
Semantic Scholar
P1 Piperlongumine inhibits growth potential of gastric cancer cells by targeting PI3K/Akt/mTOR signaling pathway
S. Shrivastava, M. Jeengar, Dinesh Thummuri, V. Naidu
20141 citations
Semantic Scholar
Correction to "Discovery of Dual BCL-xL/BCL-w Degraders by Exploiting the Bis(sulfonyl)benzene Ring of ABT-263 as a Linkage Vector".
S. K. Poddar, Yang Yang, Pratik Pal, Zeng Jin +12 more
2026Journal of Medicinal Chemistry0 citations Open access
Semantic Scholar
Abstract 5313: A BCL-XL PROTAC degrader DT2216 synergizes with KRASG12C inhibitors for effectively treating KRASG12C-mutated cancers
S. Khan, Janet S. Wiegand, Pei-Yi Zhang, Wan-Yi Hu +10 more
2022Cancer Research0 citations
Semantic Scholar
Erratum to: Synthesis and characterization of new s-triazine bearing benzimidazole and benzothiazole derivatives as anticancer agents
G. J. Kumar, S. N. Kumar, Dinesh Thummuri, Lavanya Bindu Sree Adari +3 more
2017Medicinal Chemistry Research0 citations Open access
Semantic Scholar
Multi-drug Adducts with Improved Compressibility and Synergistic Effects
Rajesh Thipparaboina, Dinesh Thummuri, R. Chavan, Naidu Vgm +1 more
20170 citations
Semantic Scholar
Uridine Ameliorates Dextran Sulfate Sodium (DSS)-Induced Colitis in Mice
M. Jeengar, Dinesh Thummuri, M. Magnusson, V. Naidu +1 more
2017Scientific Reports0 citations Open access
Semantic Scholar
Synthesis and characterization of new s-triazine bearing benzimidazole and benzothiazole derivatives as anticancer agents
G. J. Kumar, S. N. Kumar, Dinesh Thummuri, Lavanya Bindu Sree Adari +3 more
2015Medicinal Chemistry Research0 citations
Semantic Scholar
PROF. MANJEET SINGH PRIZE
V. Jain, A. Pareek, Y. Ratan, Nirmal Singh +3 more
2014Indian Journal of Pharmacology0 citations
Semantic Scholar

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