A. Accardi

Most-cited papers

Secondary active transport mediated by a prokaryotic homologue of ClC Cl- channels
A. Accardi, Christopher Miller
2004Nature609 citations
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Ca2+-dependent phospholipid scrambling by a reconstituted TMEM16 ion channel
Mattia Malvezzi, Madhavan Chalat, R. Janjusevic, A. Picollo +3 more
2013Nature Communications236 citations Open access
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Separate Ion Pathways in a Cl−/H+ Exchanger
A. Accardi, M. Walden, W. Nguitragool, H. Jayaram +2 more
2005The Journal of General Physiology209 citations Open access
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Ionic Currents Mediated by a Prokaryotic Homologue of CLC Cl− Channels
A. Accardi, L. Kolmakova-Partensky, C. Williams, Christopher Miller
2004The Journal of General Physiology150 citations Open access
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The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K
S. R. Bushell, A. Pike, M. Falzone, Nils J. G. Rorsman +19 more
2018Nature Communications144 citations Open access
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TMEM16 proteins: unknown structure and confusing functions
A. Picollo, Mattia Malvezzi, A. Accardi
2014Journal of Molecular Biology143 citations Open access
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Uncoupling and Turnover in a Cl−/H+ Exchange Transporter
M. Walden, A. Accardi, Fang Wu, Chen Xu +2 more
2007The Journal of General Physiology134 citations Open access
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Basis of substrate binding and conservation of selectivity in the CLC family of channels and transporters
A. Picollo, Mattia Malvezzi, J. Houtman, A. Accardi
2009Nature Structural &Molecular Biology108 citations Open access
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Purified TMEM16A is sufficient to form Ca2+-activated Cl− channels
H. Terashima, A. Picollo, A. Accardi
2013Proceedings of the National Academy of Sciences of the United States of America107 citations Open access
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Synergism between halide binding and proton transport in a CLC-type exchanger.
A. Accardi, S. Lobet, C. Williams, Christopher Miller +1 more
2006Journal of Molecular Biology107 citations Open access
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Ion permeation through a Cl−-selective channel designed from a CLC Cl−/H+ exchanger
H. Jayaram, A. Accardi, Fang Wu, C. Williams +1 more
2008Proceedings of the National Academy of Sciences of the United States of America103 citations Open access
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Known structures and unknown mechanisms of TMEM16 scramblases and channels
M. Falzone, Mattia Malvezzi, Byoung-Cheol Lee, A. Accardi
2018The Journal of General Physiology101 citations Open access
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CLC channels and transporters: proteins with borderline personalities
A. Accardi, A. Picollo
2010Biochimica et Biophysica Acta101 citations Open access
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Structural basis of Ca2+-dependent activation and lipid transport by a TMEM16 scramblase
M. Falzone, J. Rheinberger, Byoung-Cheol Lee, Thasin A. Peyear +7 more
2019eLife97 citations Open access
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Conformational Changes in the Pore of CLC-0
A. Accardi, M. Pusch
2003The Journal of General Physiology88 citations Open access
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Gating mechanism of the extracellular entry to the lipid pathway in a TMEM16 scramblase
Byoung-Cheol Lee, G. Khelashvili, M. Falzone, A. Menon +2 more
2018Nature Communications87 citations Open access
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Conformational changes required for H+/Cl– exchange mediated by a CLC transporter
D. Basílio, Kristina Noack, A. Picollo, A. Accardi
2014Nature Structural &Molecular Biology78 citations Open access
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The nhTMEM16 Scramblase Is Also a Nonselective Ion Channel.
Byoung-Cheol Lee, A. Menon, A. Accardi
2016Biophysical Journal76 citations Open access
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Synergistic substrate binding determines the stoichiometry of transport of a prokaryotic H+:Cl− exchanger
A. Picollo, Yanyan Xu, N. Johner, S. Bernèche +1 more
2012Nature Structural &Molecular Biology76 citations Open access
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Out-of-the-groove transport of lipids by TMEM16 and GPCR scramblases
Mattia Malvezzi, K. Andra, K. Pandey, Byoung-Cheol Lee +5 more
2018Proceedings of the National Academy of Sciences of the United States of America68 citations Open access
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Structure and gating of CLC channels and exchangers
A. Accardi
2015Journal of Physiology65 citations Open access
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Conformational changes in the C terminus of Shaker K+ channel bound to the rat Kvβ2-subunit
O. Sokolova, A. Accardi, David Gutierrez, A. Lau +2 more
2003Proceedings of the National Academy of Sciences of the United States of America65 citations Open access
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TMEM16 scramblases thin the membrane to enable lipid scrambling
M. Falzone, Zhan Feng, Omar E. Alvarenga, Yan-Gang Pan +5 more
2021Nature Communications54 citations Open access
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Nucleotide binding triggers a conformational change of the CBS module of the magnesium transporter CNNM2 from a twisted towards a flat structure
M. Corral-Rodríguez, M. Stuiver, G. Abascal-Palacios, T. Diercks +10 more
2014Biochemical Journal51 citations Open access
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PIP2-Mediated HCN3 Channel Gating Is Crucial for Rhythmic Burst Firing in Thalamic Intergeniculate Leaflet Neurons
Shui-Wang Ying, G. Tibbs, A. Picollo, S. Abbas +5 more
2011Journal of Neuroscience46 citations Open access
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Proton block of the CLC-5 Cl−/H+ exchanger
A. Picollo, Mattia Malvezzi, A. Accardi
2010The Journal of General Physiology32 citations Open access
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Lipids link ion channels and cancer
A. Accardi
2015Science31 citations Open access
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What biologists want from their chloride reporters – a conversation between chemists and biologists
M. Zajac, Kasturi Chakraborty, Sonali Saha, Vivek Mahadevan +4 more
2020Journal of Cell Science30 citations Open access
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Dynamic modulation of the lipid translocation groove generates a conductive ion channel in Ca2+-bound nhTMEM16
G. Khelashvili, M. Falzone, Xiaolu Cheng, Byoung-Cheol Lee +2 more
2019Nature Communications27 citations Open access
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Probing the conformation of a conserved glutamic acid within the Cl− pathway of a CLC H+/Cl− exchanger
M. Vien, D. Basílio, Lilia Leisle, A. Accardi
2017The Journal of General Physiology19 citations Open access
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Reconstitution of Proteoliposomes for Phospholipid Scrambling and Nonselective Channel Assays
M. Falzone, A. Accardi
2020Methods in molecular biology18 citations Open access
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Structural basis of pH-dependent activation in a CLC transporter
Eva Fortea, Sangyun Lee, Rahul Chadda, Yiorgos Argyros +8 more
2024Nature Structural & Molecular Biology17 citations
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Divergent Cl− and H+ pathways underlie transport coupling and gating in CLC exchangers and channels
Lilia Leisle, Yanyan Xu, Eva Fortea, J. Galpin +4 more
2019bioRxiv15 citations Open access
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Structural basis of closed groove scrambling by a TMEM16 protein
Zhan Feng, Omar E. Alvarenga, A. Accardi
2024Nature Structural & Molecular Biology14 citations Open access
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Backbone amides are determinants of Cl− selectivity in CLC ion channels
Lilia Leisle, Kin Lam, Sepehr Dehghani-Ghahnaviyeh, Eva Fortea +4 more
2022Nature Communications14 citations Open access
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Membrane Lipids Are Both the Substrates and a Mechanistically Responsive Environment of TMEM16 Scramblase Proteins
G. Khelashvili, Xiaolu Cheng, M. Falzone, M. Doktorova +2 more
2019Journal of Computational Chemistry14 citations Open access
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Divergent Cl- and H+ pathways underlie transport coupling and gating in CLC exchangers and channels
Lilia Leisle, Yanyan Xu, Eva Fortea, Sang-Yun Lee +5 more
2020eLife8 citations Open access
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A Proteoliposome-Based Efflux Assay to Determine Single-molecule Properties of Cl- Channels and Transporters.
D. Basílio, A. Accardi
2015Journal of Visualized Experiments5 citations Open access
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Mechanisms of Ion and Lipid Transport by TMEM16 Scramblases
Mattia Malvezzi, Byoung-Cheol Lee, M. Falzone, Ashley R. Brown +2 more
20164 citations Open access
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Not so transport incompetent after all: Revisiting a CLC-7 mutant sheds new mechanistic light on lysosomal physiology
A. Accardi
2021The Journal of General Physiology3 citations Open access
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Unveiling the Secret Lives of Glutamate Transporters: VGLUTs Engage in Multiple Transport Modes
A. Accardi
2014Neuron3 citations Open access
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To ATP or Not To ATP: This Is the Question
A. Accardi
2008The Journal of General Physiology3 citations Open access
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A quantitative flux assay for the study of reconstituted Cl- channels and transporters.
Eva Fortea, A. Accardi
2021Methods in Enzymology2 citations
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Cryo-EM structures reveal bilayer remodeling during Ca2+ activation of a TMEM16 scramblase
M. Falzone, J. Rheinberger, Byoung-Cheol Lee, Thasin A. Peyear +7 more
2018bioRxiv2 citations Open access
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BRIEF REPORT A Dystroglycan Mutation Associated with Limb-Girdle Muscular Dystrophy
Y. Hara, Burcu Balci-Hayta, Takako Yoshida-Moriguchi, M. Kanagawa +14 more
20112 citations
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Propofol rescues HCN1 epilepsy mutants and reveals non-canonical voltage-dependent gating in HCN channels
Elizabeth D. Kim, Xiao-An Wu, Sangyun Lee, G. Tibbs +6 more
2024Biophysical Journal1 citations Open access
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Revisiting the mechanism of TMEM16F phospholipid scramblase inhibition by small molecules
E. Di Zanni, Zhan Feng, A. Accardi
2022Biophysical Journal1 citations Open access
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Acknowledgment of Guest Editors, 2019
A. Accardi, T. Ackerman, David J. Adams, R. Adolphs +214 more
2019Proceedings of the National Academy of Sciences of the United States of America1 citations Open access
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Leukotriene B4 Activation of Arterial Smooth Muscle BK Channels
Kyuhan Kim, T. Squires, Siyoung Q. Choi, Andrew Kim +18 more
20131 citations
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Purification and Functional Reconstitution of the TMEM16A Ca2+ Activated Cl− Channel
H. Terashima, A. Picollo, A. Accardi
20131 citations Open access
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