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Da-Heng He · SciRah

Researcher profile · Semantic Scholar

Da-Heng He

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Da-Heng He — researcher profile on SciRah

h-index: 17
Works: 77
Citations: 1,151

Most-cited papers

Spermine synthase and MYC cooperate to maintain colorectal cancer cell survival by repressing Bim expression
Yu-Bin Guo, Q. Ye, Pan Deng, Ya-Nan Cao +10 more
2020Nature Communications134 citations Open access
Semantic Scholar
p300/CBP inhibition enhances the efficacy of programmed death-ligand 1 blockade treatment in prostate cancer
Jing-Hui Liu, Da-Heng He, Li-Jun Cheng, Chang-Kun Huang +11 more
2020Oncogene106 citations Open access
Semantic Scholar
Na/K-ATPase Y260 Phosphorylation–mediated Src Regulation in Control of Aerobic Glycolysis and Tumor Growth
Moumita Banerjee, Xiaoyu Cui, Zhichuan Li, Hui Yu +6 more
2018Scientific Reports105 citations Open access
Semantic Scholar
Inhibition of Fatty Acid Synthase Upregulates Expression of CD36 to Sustain Proliferation of Colorectal Cancer Cells
James Drury, P. Rychahou, Da-Heng He, N. Jafari +5 more
2020Frontiers in Oncology100 citations Open access
Semantic Scholar
Targeting Plk1 sensitizes pancreatic cancer to immune checkpoint therapy
Zhuang-Zhuang Zhang, Li-Jun Cheng, J. Li, Qi Qiao +14 more
2022Cancer Research64 citations Open access
Semantic Scholar
Upregulation of CD36, a Fatty Acid Translocase, Promotes Colorectal Cancer Metastasis by Increasing MMP28 and Decreasing E-Cadherin Expression
James Drury, P. Rychahou, Courtney O Kelson, Mariah E. Geisen +6 more
2022Cancers63 citations Open access
Semantic Scholar
Nitrogen-rich carbon-supported ultrafine MoC nanoparticles for the hydrotreatment of oleic acid into diesel-like hydrocarbons
Fei Wang, Wen-Juan Zhang, Jian-Chun Jiang, Jun-Ming Xu +7 more
202063 citations
Semantic Scholar
Combating acquired resistance to MAPK inhibitors in melanoma by targeting Abl1/2-mediated reactivation of MEK/ERK/MYC signaling
Rakshamani Tripathi, Zu-Long Liu, Aditi Jain, Anastasia Lyon +10 more
2020Nature Communications51 citations Open access
Semantic Scholar
The PLOD2/succinate axis regulates the epithelial–mesenchymal plasticity and cancer cell stemness
Yu-Xin Tong, Yifei Qi, G. Xiong, Jun-Yan Li +7 more
2023Proceedings of the National Academy of Sciences of the United States of America38 citations Open access
Semantic Scholar
Improved workflow for mass spectrometry–based metabolomics analysis of the heart
D. Andres, Lyndsay E. A. Young, S. Veeranki, T. Hawkinson +5 more
2020Journal of Biological Chemistry32 citations Open access
Semantic Scholar
The kinase PLK1 promotes the development of Kras/Tp53-mutant lung adenocarcinoma through transcriptional activation of the receptor RET
Yi-Fan Kong, Derek B. Allison, Qiongsi Zhang, Da-Heng He +9 more
2022Science Signaling30 citations Open access
Semantic Scholar
Sirtuin 1-mediated deacetylation of XPA DNA repair protein enhances its interaction with ATR protein and promotes cAMP-induced DNA repair of UV damage
Stuart G. Jarrett, Katharine M. Carter, Robert-Marlo Bautista, Da-Heng He +2 more
2018Journal of Biological Chemistry27 citations Open access
Semantic Scholar
Innate immune activation by checkpoint inhibition in human patient-derived lung cancer tissues
T. Fan, R. Higashi, Huan Song, S. Daneshmandi +7 more
2021eLife25 citations Open access
Semantic Scholar
Overexpression of Fatty Acid Synthase Upregulates Glutamine–Fructose-6-Phosphate Transaminase 1 and O-Linked N-Acetylglucosamine Transferase to Increase O-GlcNAc Protein Glycosylation and Promote Colorectal Cancer Growth
James Drury, Mariah E. Geisen, J. Tessmann, P. Rychahou +5 more
2024International Journal of Molecular Sciences24 citations Open access
Semantic Scholar
Elevating PLK1 overcomes BETi resistance in prostate cancer via triggering BRD4 phosphorylation-dependent degradation in mitosis
Yanquan Zhang, Ka-Wing Fong, Feng-Yi Mao, Rui-Xin Wang +14 more
2024Cell Reports22 citations Open access
Semantic Scholar
Tissue-Specific Downregulation of Fatty Acid Synthase Suppresses Intestinal Adenoma Formation via Coordinated Reprograming of Transcriptome and Metabolism in the Mouse Model of Apc-Driven Colorectal Cancer
James Drury, Lyndsay E. A. Young, Timothy L. Scott, Courtney O Kelson +9 more
2022International Journal of Molecular Sciences21 citations Open access
Semantic Scholar
Single-cell analysis identifies PLK1 as a driver of immunosuppressive tumor microenvironment in LUAD
Yi-Fan Kong, Chao-Hao Li, Jin-Peng Liu, Sai Wu +11 more
2024PLoS Genetics18 citations Open access
Semantic Scholar
The kinase PLK1 promotes Hedgehog signaling–dependent resistance to the antiandrogen enzalutamide in metastatic prostate cancer
Qiongsi Zhang, Jia Peng, Yanquan Zhang, Jing-Hui Liu +13 more
2025Science Signaling17 citations Open access
Semantic Scholar
Co‐Targeting Plk1 and DNMT3a in Advanced Prostate Cancer
Zhuang-Zhuang Zhang, Li-Jun Cheng, Qiongsi Zhang, Yi-Fan Kong +14 more
2021Advancement of science16 citations Open access
Semantic Scholar
Therapeutic targeting of the p300/CBP bromodomain enhances the efficacy of immune checkpoint blockade therapy
Jing-Hui Liu, Xin-Yi Wang, Da-Heng He, Hamed Maasoumyhaghighi +12 more
2025Oncogene15 citations Open access
Semantic Scholar
Predictive and targeting value of IGFBP-3 in therapeutically resistant prostate cancer.
P. Hensley, Zheng Cao, H. Pu, Haley Dicken +5 more
2019American journal of clinical and experimental urology15 citations
Semantic Scholar
Association Between Obesity and Histological Tumor Budding in Patients With Nonmetastatic Colon Cancer
Tong Gan, K. Schaberg, Da-Heng He, Akila Mansour +4 more
2021JAMA Network Open14 citations Open access
Semantic Scholar
Predictive value of phenotypic signatures of bladder cancer response to cisplatin-based neoadjuvant chemotherapy
P. Hensley, N. Kyprianou, Matthew S. Purdom, Da-Heng He +3 more
2019Urologic oncology14 citations Open access
Semantic Scholar
A kinome-wide CRISPR screen identifies CK1α as a target to overcome enzalutamide resistance of prostate cancer
Jing-Hui Liu, Yue Zhao, Da-Heng He, Katelyn Jones +10 more
2023Cell Reports Medicine13 citations Open access
Semantic Scholar
GSTM2 is a key molecular determinant of resistance to SG-ARIs
Chao-Hao Li, Jin-Peng Liu, Da-Heng He, Feng-Yi Mao +13 more
2022Oncogene12 citations Open access
Semantic Scholar
Inhibition of the erythropoietin-producing receptor EPHB4 antagonizes androgen receptor overexpression and reduces enzalutamide resistance
Chao-Hao Li, N. Lanman, Yi-Fan Kong, Da-Heng He +7 more
2020Journal of Biological Chemistry12 citations Open access
Semantic Scholar
Upregulation of Fatty Acid Synthase Increases Activity of β-Catenin and Expression of NOTUM to Enhance Stem-like Properties of Colorectal Cancer Cells
Courtney O Kelson, J. Tessmann, Mariah E. Geisen, Da-Heng He +4 more
2024Cells10 citations Open access
Semantic Scholar
Metformin in overcoming enzalutamide resistance in castration-resistant prostate cancer
Kendall Simpson, Derek B. Allison, Da-Heng He, Jin-Peng Liu +2 more
2024Journal of Pharmacology and Experimental Therapeutics9 citations Open access
Semantic Scholar
Perfluorooctanesulfonic acid exposure leads to downregulation of 3-hydroxy-3-methylglutaryl-CoA synthase 2 expression and upregulation of markers associated with intestinal carcinogenesis in mouse intestinal tissues
J. Tessmann, Pan Deng, Jerika Durham, Chang Li +9 more
2024Chemosphere9 citations Open access
Semantic Scholar
Potent Synergistic Effect on c-Myc Driven Colorectal Cancers Using a Novel Indole-Substituted Quinoline with a Plk1 Inhibitor
Yanqi Xie, Wen Zhang, Lichao Guo, Liliia M. Kril +12 more
2021Molecular Cancer Therapeutics9 citations Open access
Semantic Scholar
Phosphorylation of AHR by PLK1 promotes metastasis of LUAD via DIO2-TH signaling
Chao-Hao Li, Derek B. Allison, Da-Heng He, Feng-Yi Mao +15 more
2023PLoS Genetics8 citations Open access
Semantic Scholar
Downregulation of EZH2 inhibits epithelial–mesenchymal transition in enzalutamide-resistant prostate cancer
Zhuang-Zhuang Zhang, Xinyi Wang, Miyeong Kim, Da-Heng He +3 more
2023The Prostate8 citations
Semantic Scholar
Integrin α6β4 Upregulates PTPRZ1 Through UCHL1-Mediated Hif-1α Nuclear Accumulation to Promote Triple-Negative Breast Cancer Cell Invasive Properties
Min Chen, Parvanee A. Karimpour, A. Elliott, Da-Heng He +4 more
2024Cancers6 citations Open access
Semantic Scholar
Latexin regulates sex dimorphism in hematopoiesis via gender-specific differential expression of microRNA 98-3p and thrombospondin 1
Xiaoji Cui, Cui-Ping Zhang, Fang Wang, Xing-Hui Zhao +7 more
2023Cell Reports6 citations Open access
Semantic Scholar
The RelB-BLNK Axis Determines Cellular Response to a Novel Redox-Active Agent Betamethasone during Radiation Therapy in Prostate Cancer
L. Chaiswing, Fang-Fang Xu, Yanming Zhao, Jon S. Thorson +9 more
2022International Journal of Molecular Sciences6 citations Open access
Semantic Scholar
The cell cycle regulator PLK1 promotes murine melanoma progression by regulating the transcription factor BACH1
Feng-Yi Mao, Sai Wu, Derek B. Allison, Da-Heng He +8 more
2025PLoS Biology5 citations Open access
Semantic Scholar
Neurotensin promotes hepatic steatosis by regulating lipid uptake and mitochondrial adaptation in hepatocytes
Moumita Banerjee, Jun Song, Baoxiang Yan, Haoming Wu +13 more
2025Cell Death and Disease5 citations Open access
Semantic Scholar
PLK1 phosphorylates WRN at replication forks
Lei Wang, Da-Heng He, Qianjin Li, D. Orren +4 more
2024Journal of Pharmacology and Experimental Therapeutics5 citations
Semantic Scholar
Tumor Suppressor Par-4 Regulates Complement Factor C3 and Obesity
Nathalia Araujo, James Sledziona, S. Noothi, R. Burikhanov +20 more
2022Frontiers in Oncology5 citations Open access
Semantic Scholar
Hsp47 drives obesity-associated breast cancer progression by enhancing asporin deposition in adipose tissue
G. Xiong, Da-Heng He, Dana Napier, Jing Chen +8 more
2025Breast Cancer Research4 citations Open access
Semantic Scholar
Artesunate enhances the efficacy of enzalutamide in advanced prostate cancer
Xin-Yi Wang, Jing-Hui Liu, Feng-Yi Mao, Yi-Fan Kong +10 more
2025Journal of Biological Chemistry4 citations Open access
Semantic Scholar
ABL1/2 and DDR1 Drive MEKi Resistance in NRAS-Mutant Melanomas by Stabilizing RAF/MYC/ETS1 and Promoting RAF Homodimerization
Anastasia Lyon, Rakshamani Tripathi, Christina Meeks, Da-Heng He +8 more
2023Cancers4 citations Open access
Semantic Scholar
PLK1-mediated phosphorylation of PHGDH reprograms serine metabolism in advanced prostate cancer
Xiong-Jian Rao, Derek B. Allison, R. Flight, Penghui Lin +14 more
2025bioRxiv2 citations
Semantic Scholar
Colon cancer in Appalachian Kentucky: Unique genetic, microbiome and obesity findings in a cohort comparison
Ze-Ta Chow, Jin-Peng Liu, Da-Heng He, Chi Wang +20 more
2025HGG advances2 citations Open access
Semantic Scholar
Co‐Targeting Plk1 and DNMT3a in Advanced Prostate Cancer
Zhuang-Zhuang Zhang, Li-Jun Cheng, Qiongsi Zhang, Yi-Fan Kong +14 more
2022Advancement of science1 citations Open access
Semantic Scholar
Latexin regulates sex dimorphism in hematopoiesis via gender-specific differential expression of microRNA 98-3p and thrombospondin 1.
Xiaoji Cui, Cuiping Zhang, Fang Wang, Xing-Hui Zhao +7 more
2026Cell Reports0 citations Open access
Semantic Scholar
Abstract 6617: Targeting the PLK1-PRMT5 axis enhances radiosensitivity in prostate cancer.
Jia Peng, Xin-Yi Wang, Da-Heng He, Jian-Lin Wang +13 more
2026Cancer Research0 citations
Semantic Scholar
NHE1 sustains leukemia-propagating capacity and mitochondrial fitness in T-cell acute lymphoblastic leukemia
Majd A. Al-Hamaly, Meghan Haney, Yelena Chernyavskaya, Ty C. Cheatham +7 more
2026bioRxiv0 citations Open access
Semantic Scholar
Expression of the High Affinity Neurotensin Receptor Defines an Immune‑cold, Poor‑prognosis Colorectal Cancer Subtype.
Haoming Wu, Yang Wang, Jun Song, Baoxiang Yan +8 more
2026Annals of Surgery0 citations Open access
Semantic Scholar
Targeting ABL kinases overcomes melanoma immune evasion following resistance to MAPK inhibition
Rakshamani Tripathi, B. Kalal, Shirin Soni, Chezney Boothe +8 more
2026Nature Communications0 citations Open access
Semantic Scholar

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