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S. Simizu · SciRah

Researcher profile · Semantic Scholar

S. Simizu

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S. Simizu — researcher profile on SciRah

h-index: 35
Works: 138
Citations: 3,435

Most-cited papers

A small-molecule inhibitor shows that pirin regulates migration of melanoma cells.
I. Miyazaki, S. Simizu, H. Okumura, S. Takagi +1 more
2010Nature Chemical Biology108 citations
Semantic Scholar
RECK negatively regulates matrix metalloproteinase-9 transcription.
S. Takagi, S. Simizu, H. Osada
2009Cancer Research102 citations Open access
Semantic Scholar
Gilteritinib overcomes lorlatinib resistance in ALK-rearranged cancer
H. Mizuta, Koutaroh Okada, M. Araki, J. Adachi +20 more
2021Nature Communications95 citations Open access
Semantic Scholar
Discovery of a small molecule PDI inhibitor that inhibits reduction of HIV-1 envelope glycoprotein gp120.
Maola M. G. Khan, S. Simizu, N. Lai, M. Kawatani +2 more
2011ACS Chemical Biology70 citations Open access
Semantic Scholar
Integrin β1 is an essential factor in vasculogenic mimicry of human cancer cells
R. Kawahara, Y. Niwa, S. Simizu
2018Cancer Science54 citations Open access
Semantic Scholar
C-Mannosylation of thrombopoietin receptor (c-Mpl) regulates thrombopoietin-dependent JAK-STAT signaling.
Y. Sasazawa, Natsumi Sato, Takehiro Suzuki, N. Dohmae +1 more
2015Biochemical and Biophysical Research Communications - BBRC54 citations
Semantic Scholar
Determination of cathepsin V activity and intracellular trafficking by N‐glycosylation
Y. Niwa, Takehiro Suzuki, N. Dohmae, K. Umezawa +1 more
2012FEBS Letters47 citations Open access
Semantic Scholar
Identification of DPY19L3 as the C-mannosyltransferase of R-spondin1 in human cells
Y. Niwa, Takehiro Suzuki, N. Dohmae, S. Simizu
2016Molecular Biology of the Cell46 citations Open access
Semantic Scholar
Conophylline Protects Cells in Cellular Models of Neurodegenerative Diseases by Inducing Mammalian Target of Rapamycin (mTOR)-independent Autophagy*
Y. Sasazawa, Natsumi Sato, K. Umezawa, S. Simizu
2015Journal of Biological Chemistry46 citations Open access
Semantic Scholar
N-glycosylation is required for secretion and enzymatic activity of human hyaluronidase1
Yuki Goto, Y. Niwa, Takehiro Suzuki, Shiho Uematsu +2 more
2014FEBS Open Bio45 citations Open access
Semantic Scholar
Suppression of cellular invasion by glybenclamide through inhibited secretion of platelet‐derived growth factor in ovarian clear cell carcinoma ES‐2 cells
Tamami Yasukagawa, Y. Niwa, S. Simizu, K. Umezawa
2012FEBS Letters44 citations
Semantic Scholar
C-mannosylation of human hyaluronidase 1: possible roles for secretion and enzymatic activity.
Yuki Goto, Y. Niwa, Takehiro Suzuki, N. Dohmae +2 more
2014International Journal of Oncology42 citations Open access
Semantic Scholar
Polo-like kinase 1 phosphorylates and regulates Bcl-xL during pironetin-induced apoptosis
Yukiko Tamura, S. Simizu, Makoto Muroi, S. Takagi +3 more
2009Oncogene38 citations
Semantic Scholar
C‐mannosylation of R‐spondin3 regulates its secretion and activity of Wnt/β‐catenin signaling in cells
Miho Fujiwara, Shintaro Kato, Y. Niwa, Takehiro Suzuki +4 more
2016FEBS Letters37 citations Open access
Semantic Scholar
Involvement of autocrine CXCL12/CXCR4 system in the regulation of ovarian carcinoma cell invasion.
Nami Miyanishi, Yukino Suzuki, S. Simizu, Yoshiko Kuwabara +2 more
2010Biochemical and Biophysical Research Communications - BBRC36 citations
Semantic Scholar
Regulation of secretion and enzymatic activity of lipoprotein lipase by C-mannosylation.
S. Okamoto, T. Murano, Takehiro Suzuki, Shiho Uematsu +5 more
2017Biochemical and Biophysical Research Communications - BBRC35 citations
Semantic Scholar
Robust and Systematic Drug Screening Method Using Chemical Arrays and the Protein Library: Identification of Novel Inhibitors of Carbonic Anhydrase II
I. Miyazaki, S. Simizu, Harumi Ichimiya, M. Kawatani +1 more
2008Bioscience, biotechnology and biochemistry34 citations Open access
Semantic Scholar
Pirin regulates epithelial to mesenchymal transition independently of Bcl3‐Slug signaling
K. Komai, Y. Niwa, Y. Sasazawa, S. Simizu
2015FEBS Letters33 citations Open access
Semantic Scholar
Opposing roles for SNAP23 in secretion in exocrine and endocrine pancreatic cells
Masataka Kunii, M. Ohara-Imaizumi, Noriko Takahashi, Masaki Kobayashi +20 more
2016Journal of Cell Biology28 citations Open access
Semantic Scholar
O‐fucosylation of CCN1 is required for its secretion
Y. Niwa, Takehiro Suzuki, N. Dohmae, S. Simizu
2015FEBS Letters26 citations
Semantic Scholar
Involvement of DNA binding domain in the cellular stability and importin affinity of NF-κB component RelB.
M. Takeiri, Kana Horie, D. Takahashi, M. Watanabe +3 more
2012Organic and biomolecular chemistry26 citations
Semantic Scholar
Protein disulfide isomerase-mediated disulfide bonds regulate the gelatinolytic activity and secretion of matrix metalloproteinase-9.
Maola M. G. Khan, S. Simizu, Takehiro Suzuki, A. Masuda +4 more
2012Experimental Cell Research26 citations
Semantic Scholar
Therapeutic activity of plant-derived alkaloid conophylline on metabolic syndrome and neurodegenerative disease models
K. Umezawa, I. Kojima, S. Simizu, Yin-Zhi Lin +4 more
2017Human Cell24 citations
Semantic Scholar
Involvement of NF-κB-mediated expression of galectin-3-binding protein in TNF-α-induced breast cancer cell adhesion.
Naruto Noma, S. Simizu, Y. Kambayashi, Y. Kabe +2 more
2012Oncology Report24 citations Open access
Semantic Scholar
Cleavable linker for photo-cross-linked small-molecule affinity matrix.
N. Kanoh, H. Takayama, K. Honda, T. Moriya +4 more
2010Bioconjugate chemistry24 citations
Semantic Scholar
The potential of protein disulfide isomerase as a therapeutic drug target.
Maola M. G. Khan, S. Simizu, M. Kawatani, H. Osada
2011Oncology Research21 citations Open access
Semantic Scholar
C‑mannosylation of R‑spondin2 activates Wnt/β‑catenin signaling and migration activity in human tumor cells.
H. Mizuta, K. Kuga, Takehiro Suzuki, Y. Niwa +2 more
2019International Journal of Oncology20 citations Open access
Semantic Scholar
Development of a Vaccinia H1‐Related (VHR) Phosphatase Inhibitor with a Nonacidic Phosphate‐Mimicking Core Structure
Go Hirai, A. Tsuchiya, Yusuke Koyama, Yuko Otani +5 more
2011ChemMedChem20 citations
Semantic Scholar
Tyrosinase suppresses vasculogenic mimicry in human melanoma cells
Hiroki Kamo, R. Kawahara, S. Simizu
2022Oncology Letters19 citations Open access
Semantic Scholar
Regulation of N-glycosylation and secretion of Isthmin-1 by its C-mannosylation.
S. Yoshimoto, K. Katayama, Takehiro Suzuki, N. Dohmae +1 more
2021Biochimica et Biophysica Acta - General Subjects19 citations
Semantic Scholar
Dpy-19 like 3-mediated C-mannosylation and expression levels of RPE-spondin in human tumor cell lines.
S. Morishita, Takehiro Suzuki, Y. Niwa, N. Dohmae +1 more
2017Oncology Letters19 citations Open access
Semantic Scholar
Deamino-hydroxy-phoslactomycin B, a biosynthetic precursor of phoslactomycin, induces myeloid differentiation in HL-60 cells.
S. Simizu, Takayuki Teruya, Toshihiko Nogawa, Harumi Aono +4 more
2009Biochemical and Biophysical Research Communications - BBRC18 citations
Semantic Scholar
C-Mannosylation: Previous Studies and Future Research Perspectives
Y. Niwa, S. Simizu
2018Trends in glycoscience and glycotechnology17 citations Open access
Semantic Scholar
The Mammalian Sterile 20–like 1 Kinase Controls Selective CCR7-Dependent Functions in Human Dendritic Cells
Jesús Torres-Bacete, C. Delgado-Martín, C. Gómez-Moreira, S. Simizu +1 more
2015Journal of Immunology17 citations Open access
Semantic Scholar
Determination of topological structure of ARL6ip1 in cells: Identification of the essential binding region of ARL6ip1 for conophylline
M. Kuroda, Shintaro Funasaki, Tsuyoshi Saitoh, Y. Sasazawa +3 more
2013FEBS Letters17 citations Open access
Semantic Scholar
Methionine aminopeptidase-2 is a pivotal regulator of vasculogenic mimicry
Shota Shimizu, R. Kawahara, S. Simizu
2021Oncology Report16 citations Open access
Semantic Scholar
Inhibition of MMP-2-Mediated Mast Cell Invasion by NF-κB Inhibitor DHMEQ in Mast Cells
Naruto Noma, M. Asagiri, M. Takeiri, Saori Ohmae +6 more
2015International Archives of Allergy and Immunology16 citations Open access
Semantic Scholar
N-Glycosylation of extracellular matrix protein 1 (ECM1) regulates its secretion, which is unrelated to lipoid proteinosis
Shiho Uematsu, Yuki Goto, Takehiro Suzuki, Y. Sasazawa +2 more
2014FEBS Open Bio16 citations Open access
Semantic Scholar
Regulation of granulocyte colony-stimulating factor receptor-mediated granulocytic differentiation by C-mannosylation.
Kei Otani, Y. Niwa, Takehiro Suzuki, Natsumi Sato +3 more
2018Biochemical and Biophysical Research Communications - BBRC15 citations
Semantic Scholar
Identification of seco‐clavilactone B as a small‐molecule actin polymerization inhibitor
S. Miyazaki, Y. Sasazawa, Takuma Mogi, Takehiro Suzuki +4 more
2016FEBS Letters15 citations
Semantic Scholar
Requirement of the conserved, hydrophobic C-terminus region for the activation of heparanase.
N. Lai, S. Simizu, Daiki Morisaki, Makoto Muroi +1 more
2008Experimental Cell Research15 citations
Semantic Scholar
Identification of madangamine A as a novel lysosomotropic agent to inhibit autophagy.
Kazuki Miura, Sayaka Kawano, Takahiro Suto, Takaaki Sato +2 more
2021Bioorganic & Medicinal Chemistry14 citations
Semantic Scholar
Unified Total Synthesis of Madangamine Alkaloids
Takahiro Suto, Y. Yanagita, Yoshiyuki Nagashima, S. Takikawa +6 more
2019Bulletin of the Chemical Society of Japan14 citations
Semantic Scholar
Synthesis and evaluation of biological activities of vibsanin A analogs.
Wataru Matsuki, S. Miyazaki, Keisuke Yoshida, Akihiro Ogura +3 more
2017Bioorganic & Medicinal Chemistry Letters14 citations
Semantic Scholar
Identification of a molecular target of kurahyne, an apoptosis-inducing lipopeptide from marine cyanobacterial assemblages.
Arihiro Iwasaki, O. Ohno, Shun Katsuyama, M. Morita +5 more
2015Bioorganic & Medicinal Chemistry Letters14 citations Open access
Semantic Scholar
Isolation of a novel paxilline analog pyrapaxilline from fungus that inhibits LPS-induced NO production
Chino Matsui, Y. Ikeda, H. Iinuma, N. Kushida +3 more
2014Journal of antibiotics (Tokyo. 1968)14 citations
Semantic Scholar
Migracins A and B, new inhibitors of cancer cell migration, produced by Streptomyces sp.
Yuhei Arai, H. Iinuma, Y. Ikeda, M. Igarashi +5 more
2012Journal of antibiotics (Tokyo. 1968)14 citations
Semantic Scholar
The fibrinogen C-terminal domain is seldom C-mannosylated but its C-mannosylation is important for the secretion of microfibril-associated glycoprotein 4.
Y. Osada, Takehiro Suzuki, H. Mizuta, Kento Mori +3 more
2020Biochimica et Biophysica Acta - General Subjects13 citations
Semantic Scholar
Structure–Affinity Relationship Study of Bleomycins and Shble Protein by Use of a Chemical Array
I. Miyazaki, H. Okumura, S. Simizu, Y. Takahashi +4 more
2009ChemBioChem13 citations
Semantic Scholar
Identification of a novel compound that inhibits osteoclastogenesis by suppressing nucleoside transporters
Shun Katsuyama, Kumi Sugino, Y. Sasazawa, Yoshihiko Nakano +6 more
2016FEBS Letters12 citations Open access
Semantic Scholar

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