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T. Nagatsu · SciRah

Researcher profile · Semantic Scholar

T. Nagatsu

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T. Nagatsu — researcher profile on SciRah

h-index: 79
Works: 712
Citations: 27K

Most-cited papers

Distribution of major histocompatibility complex class II-positive microglia and cytokine profile of Parkinson's disease brains
K. Imamura, N. Hishikawa, M. Sawada, T. Nagatsu +2 more
2003Acta Neuropathologica755 citations
Semantic Scholar
Inflammatory process in Parkinson's disease: role for cytokines.
T. Nagatsu, M. Sawada
2005Current pharmaceutical design430 citations
Semantic Scholar
Role of cytokines in inflammatory process in Parkinson's disease.
M. Sawada, K. Imamura, T. Nagatsu
2006Journal of neural transmission. Supplementum336 citations
Semantic Scholar
A link between stress and depression: Shifts in the balance between the kynurenine and serotonin pathways of tryptophan metabolism and the etiology and pathophysiology of depression
H. Miura, N. Ozaki, M. Sawada, Ken-ichi Isobe +2 more
2008Stress282 citations Open access
Semantic Scholar
p53 protein, interferon-γ, and NF-κB levels are elevated in the parkinsonian brain
M. Mogi, T. Kondo, Y. Mizuno, T. Nagatsu
2007226 citations
Semantic Scholar
Biochemistry of postmortem brains in Parkinson's disease: historical overview and future prospects.
T. Nagatsu, M. Sawada
2007Journal of neural transmission. Supplementum188 citations
Semantic Scholar
Human tyrosine hydroxylase in Parkinson’s disease and in related disorders
T. Nagatsu, A. Nakashima, H. Ichinose, Kazuto Kobayashi
2018Journal of neural transmission167 citations
Semantic Scholar
Cytosolic Catechols Inhibit α-Synuclein Aggregation and Facilitate the Formation of Intracellular Soluble Oligomeric Intermediates
J. Mazzulli, Amanda Mishizen, B. Giasson, D. Lynch +5 more
2006Journal of Neuroscience165 citations Open access
Semantic Scholar
Molecular mechanism of the relation of monoamine oxidase B and its inhibitors to Parkinson's disease: possible implications of glial cells.
T. Nagatsu, M. Sawada
2006Journal of neural transmission. Supplementum139 citations
Semantic Scholar
Progress in monoamine oxidase (MAO) research in relation to genetic engineering.
T. Nagatsu
2004Neurotoxicology133 citations
Semantic Scholar
p53 protein, interferon-gamma, and NF-kappaB levels are elevated in the parkinsonian brain.
M. Mogi, T. Kondo, Y. Mizuno, T. Nagatsu
2007Neuroscience Letters132 citations
Semantic Scholar
Cytokine production of activated microglia and decrease in neurotrophic factors of neurons in the hippocampus of Lewy body disease brains
K. Imamura, N. Hishikawa, K. Ono, Hiromi Suzuki +4 more
2005Acta Neuropathologica130 citations
Semantic Scholar
Neuromelanin in Parkinson’s Disease: Tyrosine Hydroxylase and Tyrosinase
T. Nagatsu, A. Nakashima, Hirohisa Watanabe, S. Ito +1 more
2022International Journal of Molecular Sciences128 citations Open access
Semantic Scholar
Cellular and Molecular Mechanisms of Parkinson’s Disease: Neurotoxins, Causative Genes, and Inflammatory Cytokines
T. Nagatsu, M. Sawada
2006Cellular and molecular neurobiology124 citations
Semantic Scholar
L-dopa therapy for Parkinson's disease: Past, present, and future
T. Nagatsu, M. Sawada
2009112 citations
Semantic Scholar
A collaborative study on the malignant syndrome in Parkinson's disease and related disorders.
H. Takubo, T. Harada, T. Hashimoto, Y. Inaba +9 more
2003Parkinsonism & Related Disorders106 citations
Semantic Scholar
Tyrosine hydroxylase (TH), its cofactor tetrahydrobiopterin (BH4), other catecholamine-related enzymes, and their human genes in relation to the drug and gene therapies of Parkinson’s disease (PD): historical overview and future prospects
T. Nagatsu, I. Nagatsu
2016Journal of neural transmission96 citations
Semantic Scholar
Intramuscular injection of AAV-GDNF results in sustained expression of transgenic GDNF, and its delivery to spinal motoneurons by retrograde transport.
Yan-Yan Lu, Li-Jun Wang, S. Muramatsu, K. Ikeguchi +9 more
2003Neurosciences research75 citations
Semantic Scholar
The catecholamine system in health and disease —Relation to tyrosine 3-monooxygenase and other catecholamine-synthesizing enzymes—
T. Nagatsu
2007Proceedings of the Japan Academy. Series B, Physical and biological sciences73 citations Open access
Semantic Scholar
Effects of Aging on Neuroprotective and Neurotoxic Properties of Microglia in Neurodegenerative Diseases
M. Sawada, H. Sawada, T. Nagatsu
2008Neurodegenerative Diseases71 citations
Semantic Scholar
Role of N-terminus of tyrosine hydroxylase in the biosynthesis of catecholamines
A. Nakashima, Nobuhiro Hayashi, Y. Kaneko, K. Mori +3 more
2009Journal of neural transmission65 citations
Semantic Scholar
Lewy bodies, iron, inflammation and neuromelanin: pathological aspects underlying Parkinson’s disease
P. Riederer, T. Nagatsu, M. Youdim, Maximilian Wulf +2 more
2023Journal of neural transmission59 citations Open access
Semantic Scholar
Prevention and treatment of malignant syndrome in Parkinson's disease: a consensus statement of the malignant syndrome research group.
S. Ikebe, T. Harada, T. Hashimoto, I. Kanazawa +9 more
2003Parkinsonism & Related Disorders58 citations
Semantic Scholar
The role of tyrosine hydroxylase as a key player in neuromelanin synthesis and the association of neuromelanin with Parkinson’s disease
T. Nagatsu, A. Nakashima, Hirohisa Watanabe, S. Ito +7 more
2023Journal of neural transmission52 citations Open access
Semantic Scholar
Phosphorylation of the N-terminal portion of tyrosine hydroxylase triggers proteasomal digestion of the enzyme.
A. Nakashima, K. Mori, Y. Kaneko, N. Hayashi +2 more
2011Biochemical and Biophysical Research Communications - BBRC42 citations
Semantic Scholar
Activated microglia affect the nigro‐striatal dopamine neurons differently in neonatal and aged mice treated with 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine
H. Sawada, R. Hishida, Y. Hirata, K. Ono +5 more
2007Journal of Neuroscience Research42 citations
Semantic Scholar
Molecular genetics of tyrosine 3-monooxygenase and inherited diseases.
Kazuto Kobayashi, T. Nagatsu
2005Biochemical and Biophysical Research Communications - BBRC42 citations
Semantic Scholar
Rapeseed oil ingestion and exacerbation of hypertension-related conditions in stroke prone spontaneously hypertensive rats.
Y. Naito, T. Nagata, Y. Takano, T. Nagatsu +1 more
2003Toxicology34 citations
Semantic Scholar
A possible pathophysiological role of tyrosine hydroxylase in Parkinson’s disease suggested by postmortem brain biochemistry: a contribution for the special 70th birthday symposium in honor of Prof. Peter Riederer
A. Nakashima, A. Ota, Y. Kaneko, K. Mori +2 more
2012Journal of neural transmission31 citations
Semantic Scholar
Catecholamine research : from molecular insights to clinical medicine
T. Nagatsu, T. Nagashima, R. Mccarty, D. Goldstein
200228 citations
Semantic Scholar
Rotenone and CCCP inhibit tyrosine hydroxylation in rat striatal tissue slices.
Y. Hirata, T. Nagatsu
2005Toxicology26 citations
Semantic Scholar
Inhibition of deubiquitinating activity of USP14 decreases tyrosine hydroxylase phosphorylated at Ser19 in PC12D cells.
A. Nakashima, S. Ohnuma, Y. Kodani, Y. Kaneko +3 more
2016Biochemical and Biophysical Research Communications - BBRC23 citations
Semantic Scholar
Regulation of oxidative stress in long‐lived lipopolysaccharide‐activated microglia
Y. Kaneko, A. Ota, A. Nakashima, K. Mori +2 more
2012Clinical and Experimental Pharmacology and Physiology23 citations
Semantic Scholar
The relationship between depression and regional cerebral blood flow in Parkinson’s disease and the effect of selegiline treatment
K. Imamura, N. Okayasu, T. Nagatsu
2011Acta Neurologica Scandinavica22 citations
Semantic Scholar
Catecholamines and Parkinson’s disease: tyrosine hydroxylase (TH) over tetrahydrobiopterin (BH4) and GTP cyclohydrolase I (GCH1) to cytokines, neuromelanin, and gene therapy: a historical overview
T. Nagatsu
2023Journal of neural transmission20 citations
Semantic Scholar
Cognitive behavioral therapy (CBT), acceptance and commitment therapy (ACT), and Morita therapy (MT); comparison of three established psychotherapies and possible common neural mechanisms of psychotherapies
J. Dijkstra, T. Nagatsu
2021Journal of neural transmission20 citations
Semantic Scholar
Identification by nano-LC-MS/MS of NT5DC2 as a protein binding to tyrosine hydroxylase: Down-regulation of NT5DC2 by siRNA increases catecholamine synthesis in PC12D cells.
A. Nakashima, Hisateru Yamaguchi, Y. Kodani, Y. Kaneko +4 more
2019Biochemical and Biophysical Research Communications - BBRC20 citations
Semantic Scholar
Microglial Activation in Neuroinflammation: Implications for the Etiology of Neurodegeneration
Y. Kaneko, A. Nakashima, K. Mori, T. Nagatsu +2 more
2012Neurodegenerative Diseases19 citations
Semantic Scholar
Effects of atypical antipsychotics and haloperidol on PC12 cells: only aripiprazole phosphorylates AMP-activated protein kinase
Goro Takami, M. Ota, A. Nakashima, Y. Kaneko +3 more
2010Journal of neural transmission18 citations
Semantic Scholar
Characterization of neuron-specific huntingtin aggregates in human huntingtin knock-in mice.
H. Sawada, H. Ishiguro, K. Nishii, Kouji Yamada +5 more
2007Neurosciences research18 citations
Semantic Scholar
Intracellular stability of tyrosine hydroxylase: phosphorylation and proteasomal digestion of the enzyme.
A. Nakashima, Y. Kaneko, Y. Kodani, K. Mori +3 more
2013Advances in Pharmacology17 citations
Semantic Scholar
Prolyl oligopeptidase and dipeptidyl peptidase II/dipeptidyl peptidase IV ratio in the cerebrospinal fluid in Parkinson’s disease: historical overview and future prospects
T. Nagatsu
2017Journal of neural transmission16 citations
Semantic Scholar
Immunocytochemical study of catecholaminergic neurons in the senescence-accelerated mouse (SAM-P8) brain
N. Karasawa, I. Nagatsu, Kazuyoshi Sakai, T. Nagatsu +2 more
2005Journal of neural transmission16 citations
Semantic Scholar
Lipopolysaccharide extends the lifespan of mouse primary-cultured microglia.
Y. Kaneko, A. Nakashima, K. Mori, T. Nagatsu +2 more
2009Brain Research15 citations
Semantic Scholar
NT5DC2 affects the phosphorylation of tyrosine hydroxylase regulating its catalytic activity
A. Nakashima, Hisateru Yamaguchi, Mii Kondo, Takahiro Furumura +6 more
2020Journal of neural transmission13 citations
Semantic Scholar
Effects of aripiprazole and clozapine on the treatment of glycolytic carbon in PC12 cells
A. Ota, A. Nakashima, Y. Kaneko, K. Mori +6 more
2012Journal of neural transmission13 citations
Semantic Scholar
Peripheral Lipopolysaccharide Administration Affects the Olfactory Dopamine System in Mice
A. Ota, K. Mori, Y. Kaneko, A. Nakashima +2 more
2008Annals of the New York Academy of Sciences13 citations
Semantic Scholar
RNAi of 14-3-3eta protein increases intracellular stability of tyrosine hydroxylase.
A. Nakashima, N. Hayashi, Y. Kaneko, K. Mori +3 more
2007Biochemical and Biophysical Research Communications - BBRC13 citations
Semantic Scholar
Deletion of N‐terminus of human tyrosine hydroxylase type 1 enhances stability of the enzyme in AtT‐20 cells
A. Nakashima, N. Hayashi, Y. Kaneko, K. Mori +3 more
2005Journal of Neuroscience Research12 citations
Semantic Scholar
Neuroprotective and Neurotoxic Phenotypes of Activated Microglia in Neonatal Mice with Respective MPTP- and Ethanol-Induced Brain Injury
H. Sawada, Hiromi Suzuki, T. Nagatsu, M. Sawada
2010Neurodegenerative Diseases11 citations
Semantic Scholar

Frequent co-authors

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A. Nakashima×19
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A. Nakashima — researcher profile on SciRah
A. Ota×16
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A. Ota — researcher profile on SciRah
Y. Kaneko×15
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Y. Kaneko — researcher profile on SciRah
M. Sawada×12
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M. Sawada — researcher profile on SciRah

×11

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K. Mori — researcher profile on SciRah

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I. Nagatsu — researcher profile on SciRah

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H. Nagasaki — researcher profile on SciRah

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K. Imamura — researcher profile on SciRah

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Y. Mizuno — researcher profile on SciRah

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H. Sawada — researcher profile on SciRah

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Y. Kodani — researcher profile on SciRah

Hiromi Suzuki×3

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Hiromi Suzuki — researcher profile on SciRah