Researcher profile · Semantic Scholar

A. Shone

h-index: 17
Works: 25
Citations: 1,350

Most-cited papers

Antimalarial pharmacology and therapeutics of atovaquone
G. Nixon, D. Moss, A. Shone, D. Lalloo +4 more
2013Journal of Antimicrobial Chemotherapy192 citations Open access
Semantic Scholar
Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria
G. Biagini, N. Fisher, A. Shone, M. Mubaraki +28 more
2012Proceedings of the National Academy of Sciences of the United States of America167 citations Open access
Semantic Scholar
Probing the validity of the probe-to-bone test in the diagnosis of osteomyelitis of the foot in diabetes.
A. Shone, J. Burnside, S. Chipchase, F. Game +1 more
2006Diabetes Care137 citations Open access
Semantic Scholar
Identification of a 1,2,4,5-tetraoxane antimalarial drug-development candidate (RKA 182) with superior properties to the semisynthetic artemisinins.
P. O'Neill, Richard K. Amewu, G. Nixon, Fatima Bousejra ElGarah +15 more
2010Angewandte Chemie129 citations
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Identification, Design and Biological Evaluation of Bisaryl Quinolones Targeting Plasmodium falciparum Type II NADH:Quinone Oxidoreductase (PfNDH2)
C. Pidathala, R. Amewu, Bénédicte Pacorel, G. Nixon +18 more
2012Journal of Medicinal Chemistry108 citations Open access
Semantic Scholar
Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century.
Paul M. O'Neill, B. Park, A. Shone, J. Maggs +20 more
2009Journal of Medicinal Chemistry88 citations Open access
Semantic Scholar
Two-step synthesis of achiral dispiro-1,2,4,5-tetraoxanes with outstanding antimalarial activity, low toxicity, and high-stability profiles.
G. Ellis, R. Amewu, Sunil Sabbani, Paul A. Stocks +14 more
2008Journal of Medicinal Chemistry78 citations
Semantic Scholar
Targeting the mitochondrial electron transport chain of Plasmodium falciparum: new strategies towards the development of improved antimalarials for the elimination era.
G. Nixon, C. Pidathala, A. Shone, Thomas Antoine +4 more
2013Future Medicinal Chemistry72 citations
Semantic Scholar
Semi-synthetic and synthetic 1,2,4-trioxaquines and 1,2,4-trioxolaquines: synthesis, preliminary SAR and comparison with acridine endoperoxide conjugates.
Nuna C. P. Araújo, Victoria E. Barton, Michael Jones, Paul A. Stocks +6 more
2009Bioorganic & Medicinal Chemistry Letters65 citations
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Synthesis, antimalarial activity, and preclinical pharmacology of a novel series of 4'-fluoro and 4'-chloro analogues of amodiaquine. Identification of a suitable "back-up" compound for N-tert-butyl isoquine.
P. O'Neill, A. Shone, Deborah Stanford, G. Nixon +25 more
2009Journal of Medicinal Chemistry58 citations Open access
Semantic Scholar
Discovery of Potent Small-Molecule Inhibitors of Multidrug-Resistant Plasmodium falciparum Using a Novel Miniaturized High-Throughput Luciferase-Based Assay
E. Lucumi, Claire Darling, Hyunil Jo, A. Napper +9 more
2010Antimicrobial Agents and Chemotherapy52 citations Open access
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Rational Design, Synthesis, and Biological Evaluation of Heterocyclic Quinolones Targeting the Respiratory Chain of Mycobacterium tuberculosis.
W. Hong, Peter D. Gibbons, S. Leung, R. Amewu +19 more
2017Journal of Medicinal Chemistry46 citations Open access
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Identification, Design and Biological Evaluation of Heterocyclic Quinolones Targeting Plasmodium falciparum Type II NADH:Quinone Oxidoreductase (PfNDH2)
S. Leung, Peter D. Gibbons, R. Amewu, G. Nixon +18 more
2012Journal of Medicinal Chemistry41 citations Open access
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Endoperoxide carbonyl falcipain 2/3 inhibitor hybrids: toward combination chemotherapy of malaria through a single chemical entity.
Peter D. Gibbons, Edite Verissimo, Nuna C. P. Araújo, Victoria E. Barton +16 more
2010Journal of Medicinal Chemistry36 citations
Semantic Scholar
The development of quinolone esters as novel antimalarial agents targeting the Plasmodium falciparum bc1 protein complex
R. Cowley, S. Leung, N. Fisher, M. Alhelal +7 more
201235 citations
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Comparative preclinical drug metabolism and pharmacokinetic evaluation of novel 4-aminoquinoline anti-malarials.
C. Davis, R. Bambal, G. Moorthy, Erin D. Hugger +5 more
2009Journal of Pharmacy and Science19 citations
Semantic Scholar
A novel drug for uncomplicated malaria: targeted high throughput screening (HTS) against the type II NADH:ubiquinone oxidoreductase (PfNdh2) of Plasmodium falciparum
S. Ward, N. Fisher, Alasdair Hill, A. Mbekeani +15 more
2010Malaria Journal17 citations Open access
Semantic Scholar
Identification of Novel Antimalarial Chemotypes via Chemoinformatic Compound Selection Methods for a High-Throughput Screening Program against the Novel Malarial Target, PfNDH2: Increasing Hit Rate via Virtual Screening Methods
Raman Sharma, A. S. Lawrenson, N. Fisher, A. Warman +19 more
2012Journal of Medicinal Chemistry6 citations Open access
Semantic Scholar
A multisystem investigation of raltegravir association with intestinal tissue: implications for pre-exposure prophylaxis and eradication.
D. Moss, P. Curley, A. Shone, M. Siccardi +1 more
2014Journal of Antimicrobial Chemotherapy5 citations Open access
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Corrigendum
G. Nixon, C. Pidathala, A. Shone
2016G3: Genes, Genomes, Genetics1 citations Open access
Semantic Scholar
The synthesis and metabolism of novel 4-aminoquinoline antimalarials
A. Shone
20071 citations
Semantic Scholar
A World Cafe Approach to Palliative Care and Planning for the Future in Fibrotic Lung Disease
Anneliese Russell, A. Shone, M. Love, D. Shanagher +5 more
2019Therapy0 citations
Semantic Scholar
Antimalarial Pharmacology and Therapeutics of Atovaquone 1 2
G. Nixon, D. Moss, A. Shone, D. Lalloo +4 more
20170 citations
Semantic Scholar
Multi-system investigation of the mechanisms for raltegravir association with intestinal tissue after oral administration
D. Moss, P. Curley, A. Shone, M. Siccardi +1 more
20130 citations
Semantic Scholar
Development of a novel drug for uncomplicated malaria targeting the mitochondrial NADH:quinone oxidoreductase
G. Biagini, Alasdair Hill, A. Mbekeani, A. Shone +15 more
2010Malaria Journal0 citations Open access
Semantic Scholar

N. Fisher

×12

Paul A. Stocks×12

Peter D. Gibbons×10

R. Amewu×9

Raman Sharma×9

C. Pidathala×8

A. Warman×7

N. Berry×7