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M. Palfreyman · SciRah

Researcher profile · Semantic Scholar

M. Palfreyman

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M. Palfreyman — researcher profile on SciRah

h-index: 31
Works: 134
Citations: 3,365

Most-cited papers

Simultaneous Determination of 3,4‐Dihydroxyphenylalanine, 5‐Hydroxytryptophan, Dopamine, 4‐Hydroxy‐3‐Methoxyphenylalanine, Norepinephrine, 3,4‐Dihydroxyphenylacetic Acid, Homovanillic Acid, Serotonin, and 5‐Hydroxyindoleacetic Acid in Rat Cerebrospinal Fluid and Brain by High‐Performance Liquid Chro
J. Wagner, P. Vitali, M. Palfreyman, M. Zraika +1 more
1982Journal of Neurochemistry336 citations
Semantic Scholar
Electroconvulsive Seizures Regulate Gene Expression of Distinct Neurotrophic Signaling Pathways
C. Altar, P. Laeng, L. Jurata, J. Brockman +6 more
2004Journal of Neuroscience332 citations Open access
Semantic Scholar
The role of 5-HT2A receptors in antipsychotic activity.
C. J. Schmidt, S. Sorensen, John H. Kenne, A. Carr +1 more
1995Life Science230 citations
Semantic Scholar
Normalizing Effects of EVP-6124, an Alpha-7 Nicotinic Partial Agonist, on Event-Related Potentials and Cognition: A Proof of Concept, Randomized Trial in Patients with Schizophrenia
S. Preskorn, M. Gawryl, N. Dgetluck, M. Palfreyman +2 more
2014Journal of Psychiatric Practice134 citations
Semantic Scholar
The pharmacology of GABA-transaminase inhibitors.
M. Palfreyman, Paul J. Schechter, W. Buckett, Guy P. Tell +1 more
1981Biochemical Pharmacology115 citations
Semantic Scholar
Enzyme-activated irreversible inhibitors of monoamine oxidase: phenylallylamine structure-activity relationships.
I. Mcdonald, J. Lacoste, P. Bey, M. Palfreyman +1 more
1985Journal of Medicinal Chemistry113 citations Open access
Semantic Scholar
Activity of 5,7-dichlorokynurenic acid, a potent antagonist at the N-methyl-D-aspartate receptor-associated glycine binding site.
B. Baron, B. Harrison, F. Miller, I. Mcdonald +5 more
1990Molecular Pharmacology108 citations
Semantic Scholar
Effect of acute and chronic MDL 73,147EF, a 5-HT3 receptor antagonist, on A9 and A10 dopamine neurons.
S. Sorensen, T. Humphreys, M. Palfreyman
1989European Journal of Pharmacology92 citations
Semantic Scholar
Curtatoxins. Neurotoxic insecticidal polypeptides isolated from the funnel-web spider Hololena curta.
Hololena Curta, A. Stapleton, D. T. Blankenship, B. Ackermann +6 more
1990Journal of Biological Chemistry82 citations Open access
Semantic Scholar
[3H]5,7-dichlorokynurenic acid, a novel radioligand labels NMDA receptor-associated glycine binding sites.
B. Baron, B. W. Siegel, A. L. Slone, B. L. Harrison +2 more
1991European Journal of Pharmacology71 citations
Semantic Scholar
Electrophysiological, biochemical and behavioral evidence for 5-HT2 and 5-HT3 mediated control of dopaminergic function
M. Palfreyman, C. J. Schmidt, S. Sorensen, M. W. Dudley +4 more
2005Psychopharmacology60 citations
Semantic Scholar
History of Serotonin and Serotonin Disorders
A. Sjoerdsma, M. Palfreyman
1990Annals of the New York Academy of Sciences59 citations
Semantic Scholar
Pharmacodynamics, pharmacokinetics, safety, and tolerability of encenicline, a selective α7 nicotinic receptor partial agonist, in single ascending-dose and bioavailability studies.
A. Barbier, M. Hilhorst, A. V. van Vliet, P. Snyder +7 more
2015Clinical Therapeutics50 citations Open access
Semantic Scholar
(E)-.beta.-(Fluoromethylene)-m-tyrosine: a substrate for aromatic L-amino acid decarboxylase liberating an enzyme-activated irreversible inhibitor of monoamine oxidase
I. Mcdonald, J. Lacoste, P. Bey, J. Wagner +2 more
198446 citations
Semantic Scholar
Inhibition of Monoamine Oxidase Selectively in Brain Monoamine Nerves Using the Bioprecursor (E‐β‐Fluoromethylene‐m‐Tyrosine (MDL 72394), a Substrate for Aromatic L‐Amino Acid Decarboxylase
M. Palfreyman, I. Mcdonald, J. Fozard, Y. Mély +5 more
1985Journal of Neurochemistry44 citations
Semantic Scholar
Potent indole- and quinoline-containing N-methyl-D-aspartate antagonists acting at the strychnine-insensitive glycine binding site.
B. Baron, B. L. Harrison, I. Mcdonald, B. Meldrum +6 more
1992Journal of Pharmacology and Experimental Therapeutics42 citations
Semantic Scholar
Pharmacological effects of MDL 11,939: A selective, centrally acting antagonist of 5‐HT2 receptors
M. W. Dudley, Norbert L. Wiech, F. Miller, A. Carr +6 more
198842 citations
Semantic Scholar
High-performance liquid chromatographic analysis of S-adenosylmethionine and its metabolites in rat tissues: interrelationship with changes in biogenic catechol levels following treatment with L-dopa.
J. Wagner, C. Danzin, Sylvie Huot-Olivier, N. Claverie +1 more
1984Journal of Chromatography A42 citations
Semantic Scholar
Total Synthesis and Preliminary Antibacterial Evaluation of the RNA Polymerase Inhibitors (±)-Myxopyronin A and B
T. Hu, Jennifer V. Schaus, Kelvin T. Lam, M. Palfreyman +3 more
199841 citations
Semantic Scholar
MDL 100,458 and MDL 102,288: two potent and selective glycine receptor antagonists with different functional profiles.
J. Kehne, Bruce M. Baron, B. L. Harrison, T. Mccloskey +7 more
1995European Journal of Pharmacology40 citations
Semantic Scholar
The effects of chronic treatment with amitriptyline and MDL 72394 on the control of 5-HT release in vivo.
A. Sleight, R. Smith, C. A. Marsden, M. Palfreyman
1989Neuropharmacology40 citations
Semantic Scholar
Inhibition of rat aorta semicarbazide-sensitive amine oxidase by 2-phenyl-3-haloallylamines and related compounds.
G. Lyles, C. M. Susan Marshall, I. Mcdonald, P. Bey +1 more
1987Biochemical Pharmacology39 citations
Semantic Scholar
MDL 72145, an Enzyme‐Activated Irreversible Inhibitor with Selectivity for Monoamine Oxidase Type B
M. Zreika, I. Mcdonald, P. Bey, M. Palfreyman
1984Journal of Neurochemistry39 citations
Semantic Scholar
Cerebrospinal fluid GABA as an index of brain GABA activity.
J. Grove, M. Palfreyman, Paul J. Schechter
1983Clinical neuropharmacology37 citations
Semantic Scholar
Value of monoamine metabolite determinations in CSF as an index of their concentrations in rat brain following various pharmacological manipulations.
M. Palfreyman, Stéphane Huot, J. Wagner
1982Journal of Pharmacological Methods37 citations
Semantic Scholar
Direct and allosteric control of glutamate receptors
M. Palfreyman, I. Reynolds, P. Skolnick
199436 citations
Semantic Scholar
Enzyme-activated antagonists of the strychnine-insensitive glycine/NMDA receptor.
F. Salituro, Ron Tomlinson, B. Baron, M. Palfreyman +5 more
1994Journal of Medicinal Chemistry36 citations
Semantic Scholar
Effects of γ-vinyl GABA on food intake of rats
S. Huot, M. Palfreyman
198230 citations
Semantic Scholar
MDL 72,974: a potent and selective enzyme-activated irreversible inhibitor of monoamine oxidase type B with potential for use in Parkinson's disease
M. Zreika, J. Fozard, M. W. Dudley, P. Bey +2 more
1989Journal of Neural Transmission - Parkinsons Disease and Dementia Section29 citations
Semantic Scholar
Design and early clinical evaluation of selective inhibitors of monoamine oxidase.
M. Palfreyman, I. Mcdonald, P. Bey, P. Schechter +1 more
1988Progress in Neuro-psychopharmacology and Biological Psychiatry27 citations
Semantic Scholar
Monoamine receptor sensitivity changes following chronic administration of MDL 72394, a site-directed inhibitor of monoamine oxidase.
M. Palfreyman, Anis K. Mir, M. Kubina, D. N. Middlemiss +3 more
1986European Journal of Pharmacology24 citations
Semantic Scholar
Haloallylamine inhibitors of MAO and SSAO and their therapeutic potential.
M. Palfreyman, I. Mcdonald, P. Bey, C. Danzin +2 more
1994Journal of neural transmission. Supplementum22 citations
Semantic Scholar
The rational design of suicide substrates of amine oxidases.
M. Palfreyman, I. Mcdonald, P. Bey, Charles Danzin +3 more
1986Biochemical Society Transactions21 citations
Semantic Scholar
Novel directions in antipsychotic target identification using gene arrays.
M. Palfreyman, D. Hook, L. Klimczak, Jeffery A. Brockman +2 more
2002Current Drug Targets - CNS & Neurological Disorders20 citations
Semantic Scholar
The primary in vitro anticancer activity of "half-mustard type" phenothiazines in NCI's revised anticancer screening paradigm.
M. A. Wuonola, M. Palfreyman, N. Motohashi, M. Kawase +3 more
1998Anticancer Research17 citations
Semantic Scholar
MDL 27,531 selectively reverses strychnine‐induced seizures in mice
J. Kehne, J. M. Kane, F. Miller, Herbert J. Ketteler +7 more
1992British Journal of Pharmacology17 citations Open access
Semantic Scholar
Dual enzyme-activated irreversible inhibition of monoamine oxidase
I. Mcdonald, J. Lacoste, P. Bey, J. Wagner +2 more
198617 citations
Semantic Scholar
A comparison of the effects of reversible and irreversible inhibitors of aromatic L-amino acid decarboxylase on the half-life and other pharmacokinetic parameters of oral L-3,4-dihydroxyphenylalanine.
N. Huebert, M. Palfreyman, K. Haegele
1983Drug Metabolism And Disposition17 citations
Semantic Scholar
Selective inhibition of monoamine oxidase type B by MDL 72145 increases the central effects of L‐DOPA without modifying its cardiovascular effects
J. Fozard, M. Palfreyman, M. Robin, M. Zreika
1986British Journal of Pharmacology13 citations Open access
Semantic Scholar
Total GABA and homocarnosine in CSF as indices of brain GABA concentrations.
M. Palfreyman, S. Huot, J. Grove
1983Neuroscience Letters12 citations
Semantic Scholar
Lactamimides: a novel chemical class of calcium antagonists with diltiazem-like properties.
M. Palfreyman, M. W. Dudley, Hsien C. Cheng, Anis K. Mir +4 more
1989Biochemical Pharmacology11 citations
Semantic Scholar
Synergistic interactions of repurposed drugs that inhibit Nsp1, a major virulence factor for COVID-19
H. Kao, A. Orry, M. Palfreyman, B. Porton
2022Scientific Reports10 citations Open access
Semantic Scholar
MDL 72,974A: a selective MAO-B inhibitor with potential for treatment of Parkinson's disease.
M. Palfreyman, I. Mcdonald, M. Zreika, G. Cremer +2 more
1993Journal of neural transmission. Supplementum9 citations
Semantic Scholar
Synthesis of (E)-β-fluoromethyleneglutamic acid
I. Mcdonald, M. Palfreyman, M. Jung, P. Bey
19859 citations
Semantic Scholar
Effect of chronic apomorphine on the development of denervation supersensitivity.
M. Robin, C. Forler, M. Palfreyman
1985Pharmacology, Biochemistry and Behavior9 citations
Semantic Scholar
A method for measuring monoamine turnover in animals using an irreversible inhibitor of aromatic L-amino acid decarboxylase, DL-alpha-mono fluoromethyldopa.
M. Palfreyman, M. Zreika, Robert Arbogast, J. Wagner
1984Journal of Pharmacological Methods9 citations
Semantic Scholar
Functional Genomics Conference: From Identifying Proteins to Faster Drug Discovery. March 10-11, 1998, Washington DC, USA.
M. Palfreyman
1998Expert Opinion on Investigational Drugs8 citations
Semantic Scholar
The functional consequences of inhibition of monoamine oxidase type B: comparison of the pharmacological properties ofl-deprenyl and MDL 72145
J. Fozard, M. Zreika, M. Robin, M. Palfreyman
1985Naunyn-Schmiedeberg's Archives of Pharmacology8 citations
Semantic Scholar
GABA and homocarnosine in CSF: The relationship to brain GABA content
P. Bőhlen, S. Huot, M. Mellet, M. Palfreyman
19808 citations
Semantic Scholar
Human tissue in target identification and drug discovery.
M. Palfreyman
2002Drug Discovery Today7 citations
Semantic Scholar

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P. Bey×12
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M. Zreika×12
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J. Fozard×6
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M. W. Dudley — researcher profile on SciRah

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S. Sorensen — researcher profile on SciRah

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F. Salituro — researcher profile on SciRah