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Sandra Larkin · SciRah

Researcher profile · Semantic Scholar

Sandra Larkin

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Sandra Larkin — researcher profile on SciRah

h-index: 22
Works: 74
Citations: 1,778

Most-cited papers

Patterns of Arginine and Nitric Oxide in Patients With Sickle Cell Disease With Vaso-occlusive Crisis and Acute Chest Syndrome
C. Morris, F. Kuypers, Sandra Larkin, E. Vichinsky +1 more
2000Journal of pediatric hematology/oncology207 citations
Semantic Scholar
Arginine therapy: a novel strategy to induce nitric oxide production in sickle cell disease
C. Morris, F. Kuypers, Sandra Larkin, Nancy Sweeters +3 more
2000British Journal of Haematology152 citations
Semantic Scholar
Characterization of the phosphatidylserine-exposing subpopulation of sickle cells.
K. de Jong, Sandra Larkin, L. Styles, R. Bookchin +1 more
2001Blood124 citations Open access
Semantic Scholar
Hemolysis‐Associated Pulmonary Hypertension in Thalassemia
C. Morris, F. Kuypers, Gregory J. Kato, L. Lavrisha +3 more
2005Annals of the New York Academy of Sciences121 citations Open access
Semantic Scholar
Erythrocyte glutamine depletion, altered redox environment, and pulmonary hypertension in sickle cell disease.
C. Morris, Jung H. Suh, Ward Hagar, Sandra Larkin +7 more
2008Blood105 citations Open access
Semantic Scholar
Hydrolysis of Phosphatidylserine-exposing Red Blood Cells by Secretory Phospholipase A2 Generates Lysophosphatidic Acid and Results in Vascular Dysfunction*
N. A. Neidlinger, Sandra Larkin, Amrita Bhagat, G. Victorino +1 more
2006Journal of Biological Chemistry105 citations Open access
Semantic Scholar
Tropomodulin 1-null mice have a mild spherocytic elliptocytosis with appearance of tropomodulin 3 in red blood cells and disruption of the membrane skeleton.
J. Moyer, Roberta B. Nowak, Nancy E. Kim, Sandra Larkin +4 more
2010Blood84 citations Open access
Semantic Scholar
A pilot study of the short-term use of simvastatin in sickle cell disease: effects on markers of vascular dysfunction
C. Hoppe, F. Kuypers, Sandra Larkin, Ward Hagar +2 more
2011British Journal of Haematology78 citations Open access
Semantic Scholar
Transfusion prevents acute chest syndrome predicted by elevated secretory phospholipase A2
L. Styles, M. Abboud, Sandra Larkin, Margaret Lo +1 more
2007British Journal of Haematology75 citations
Semantic Scholar
Interaction of an annexin V homodimer (Diannexin) with phosphatidylserine on cell surfaces and consequent antithrombotic activity
F. Kuypers, Sandra Larkin, J. Emeis, A. Allison
2007Thrombosis and Haemostasis71 citations
Semantic Scholar
Simvastatin Reduces Vaso-occlusive Pain in Sickle Cell Anaemia: A Pilot Efficacy Trial
C. Hoppe, E. Jacob, L. Styles, F. Kuypers +2 more
2017British Journal of Haematology55 citations Open access
Semantic Scholar
Compromised Mitochondrial Fatty Acid Synthesis in Transgenic Mice Results in Defective Protein Lipoylation and Energy Disequilibrium
Stuart Smith, A. Witkowski, A. Moghul, Y. Yoshinaga +24 more
2012PLoS ONE53 citations Open access
Semantic Scholar
Human Term Placenta as a Source of Hematopoietic Cells
V. Serikov, Catherine Hounshell, Sandra Larkin, William Green +3 more
2009Experimental biology and medicine53 citations Open access
Semantic Scholar
Sildenafil therapy in thalassemia patients with Doppler-defined risk of pulmonary hypertension
C. Morris, Hae-Young Kim, J. Wood, J. Porter +15 more
2013Haematologica46 citations Open access
Semantic Scholar
Serum C-reactive protein parallels secretory phospholipase A2 in sickle cell disease patients with vasoocclusive crisis or acute chest syndrome.
Emilee Bargoma, J. Mitsuyoshi, Sandra Larkin, L. Styles +2 more
2005Blood39 citations Open access
Semantic Scholar
The Capacity of Red Blood Cells to Reduce Nitrite Determines Nitric Oxide Generation under Hypoxic Conditions
M. Fens, Sandra Larkin, B. Oronsky, J. Scicinski +2 more
2014PLoS ONE31 citations Open access
Semantic Scholar
Dysregulated Arginine Metabolism and Cardiopulmonary Dysfunction in Patients with Thalassaemia
Claudia R. Morris, Hae-Young Kim, E. Klings, J. Wood +14 more
2015British Journal of Haematology29 citations Open access
Semantic Scholar
Hereditary spherocytosis and elliptocytosis erythrocytes show a normal transbilayer phospholipid distribution.
K. de Jong, Sandra Larkin, S. Eber, P. Franck +2 more
1999Blood29 citations
Semantic Scholar
Postinjury serum secretory phospholipase A2 correlates with hypoxemia and clinical status at 72 hours.
N. A. Neidlinger, E. Hirvela, Ruby A. Skinner, Sandra Larkin +2 more
2005Journal of the American College of Surgeons27 citations
Semantic Scholar
Microparticles as Biomarkers of Osteonecrosis of the Hip in Sickle Cell Disease
A. Marsh, R. Schiffelers, F. Kuypers, Sandra Larkin +3 more
2014British Journal of Haematology25 citations Open access
Semantic Scholar
Blood draw site and analytic device influence hemoglobin measurements
David W. Killilea, F. Kuypers, Sandra Larkin, Kathleen Schultz
2022medRxiv22 citations Open access
Semantic Scholar
NO or No NO, Increased Reduction of Nitrite to Nitric Oxide by Modified Red Blood Cells
M. Fens, Sandra Larkin, C. Morris, Bill Fitch +3 more
201122 citations
Semantic Scholar
Hydroxycarbamide-Induced Changes in E/beta Thalassemia Red Blood Cells
S. Singer, E. Vichinsky, Sandra Larkin, N. Olivieri +2 more
2008American journal of hematology/oncology22 citations Open access
Semantic Scholar
Elevated tricuspid regurgitant jet velocity in sub-groups of thalassemia patients: insight into pathophysiology and the effect of splenectomy
S. Singer, F. Kuypers, Jeffery R. Fineman, G. Gildengorin +8 more
2014Annals of Hematology20 citations Open access
Semantic Scholar
Featured Article: Alterations of lecithin cholesterol acyltransferase activity and apolipoprotein A-I functionality in human sickle blood
E. Soupene, Mark S. Borja, Mauricio Borda, Sandra Larkin +1 more
2016Experimental biology and medicine19 citations Open access
Semantic Scholar
A look inside the mechanistic black box: Are red blood cells the critical effectors of RRx-001 cytotoxicity?
P. Cabrales, J. Scicinski, T. Reid, F. Kuypers +4 more
2016Medical Oncology16 citations
Semantic Scholar
Secretory phospholipase A2: a marker of infection in febrile children presenting to a pediatric ED,
Karim M. Mansour, F. Kuypers, Tammy Wang, A. M. Miller +2 more
2010American Journal of Emergency Medicine16 citations Open access
Semantic Scholar
Assessment of total and unbound cell-free heme in plasma of patients with sickle cell disease
Madhav Vissa, Sandra Larkin, E. Vichinsky, F. Kuypers +1 more
2023Experimental biology and medicine14 citations Open access
Semantic Scholar
Targeting tumor hypoxia with the epigenetic anticancer agent, RRx-001: a superagonist of nitric oxide generation
M. Fens, P. Cabrales, J. Scicinski, Sandra Larkin +6 more
2016Medical Oncology14 citations
Semantic Scholar
Implications for the Metabolic Fate of Oral Glutamine Supplementation within Plasma and Erythrocytes of Patients with Sickle Cell Disease: A Pharmacokinetics Study.
C. Morris, F. Kuypers, R. Hagar, Sandra Larkin +4 more
2022Complementary Therapies in Medicine11 citations Open access
Semantic Scholar
RBC deformability and amino acid concentrations after hypo-osmotic challenge may reflect chronic cell hydration status in healthy young men
J. Stookey, Alexis Klein, Janice Hamer, Christine Chi +7 more
2013Physiological Reports10 citations Open access
Semantic Scholar
The RoxyScan is a novel measurement of red blood cell deformability under oxidative and shear stress
Sandra Larkin, C. Hernández, E. V. van Beers, R. van Wijk +1 more
2024Scientific Reports9 citations Open access
Semantic Scholar
Metabolic Fate of Oral Glutamine Supplementation within Plasma and Erythrocytes of Patients with Sickle Cell Disease: Preliminary Pharmacokinetics Results
C. Morris, F. Kuypers, R. Hagar, M. Ansari +6 more
20108 citations
Semantic Scholar
Effect of voxelotor on cardiopulmonary testing in youths with sickle cell anemia in a pilot study
V. Phan, Jared A. Hershenson, L. Caldarera, Sandra Larkin +7 more
2023Pediatric Blood & Cancer7 citations Open access
Semantic Scholar
Featured Article: Depletion of HDL3 high density lipoprotein and altered functionality of HDL2 in blood from sickle cell patients
E. Soupene, Sandra Larkin, F. Kuypers
2017Experimental biology and medicine7 citations Open access
Semantic Scholar
FT-4202, a selective pyruvate kinase R activator for sickle cell disease.
A. Ericsson, D. Richard, E. Wilker, J. Lancia +13 more
2024Experimental Hematology6 citations Open access
Semantic Scholar
Highlight article: Vincristine-induced anemia in hereditary spherocytosis
Jennifer Michlitsch, Sandra Larkin, E. Vichinsky, F. Kuypers
2019Experimental biology and medicine6 citations Open access
Semantic Scholar
Pan-Selectin Antagonist Rivipansel (GMI-1070) Reduces Soluble E-Selectin Levels While Improving Clinical Outcomes in SCD Vaso-Occlusive Crisis
T. Wun, M. Telen, L. Krishnamurti, T. Mccavit +7 more
20146 citations
Semantic Scholar
Image‐Based Flow Cytometry and Angle‐Resolved Light Scattering to Define the Sickling Process
P. Goktas, Ilya O. Sukharevsky, Sandra Larkin, Frans A. Kuypers +2 more
2019Cytometry Part A5 citations Open access
Semantic Scholar
Sildenafil Therapy in Patients with Thalassemia and an Elevated Tricuspid Regurgitant Jet Velocity (TRV) On Doppler Echocardiography At Risk for Pulmonary Hypertension: Report From the Thalassemia Clinical Research Network
C. Morris, Hae-Young Kim, J. Wood, F. Trachtenberg +14 more
20124 citations
Semantic Scholar
The Effect of Thalassemia and Other RBC Hemolytic Disorders and Splenectomy on the Frequency of Pulmonary Hypertension
S. Singer, F. Kuypers, J. Fineman, Sandra Larkin +5 more
20103 citations
Semantic Scholar
The Effect of Short-Term Simvastatin On Markers of Vascular Dysfunction in Patients with Sickle Cell Disease (SCD).
C. Hoppe, K. Stewart, Annie Higa, Sandra Larkin +4 more
20093 citations
Semantic Scholar
Elevated Plasma Arginase Levels in Hemoglobinopathies.
Sandra Larkin, C. Morris, L. Styles, F. Kuypers
20053 citations
Semantic Scholar
Initial Results in a Phase 1b Trial of PB-04 in Sickle Cell Disease Demonstrate Fetal Hemoglobin Induction, Additive Activity with Hydroxyurea, and Improved Red Blood Cell Sickling Parameters
K. Kuo, S. Singer, G. Blyden, L. Bronte-Hall +11 more
2023Blood2 citations Open access
Semantic Scholar
Etavopivat, an Allosteric Activator of Pyruvate Kinase-R, Improves Sickle RBC Functional Health and Survival and Reduces Systemic Markers of Inflammation and Hypercoagulability in Patients with Sickle Cell Disease: An Analysis of Exploratory Studies in a Phase 1 Study
T. Kalfa, M. Telen, Santosh L. Saraf, R. Brown +7 more
2021Blood2 citations Open access
Semantic Scholar
The Effect of Voxelotor on Exercise Capacity of Youths with Sickle Cell Anemia
V. Phan, L. Caldarera, Ana Lucia Cortez, Kari Wheeler +8 more
2021Blood2 citations Open access
Semantic Scholar
Treatment with a Novel Dinitroazetidine, Abdnaz, Improves Nitrite Reductase Activity of Sickle Red Blood Cells
M. Fens, Sandra Larkin, W. Fitch, J. Scicinski +2 more
20122 citations
Semantic Scholar
Cardiopulmonary and Laboratory Profiling of Patients with Thalassemia At Risk for Pulmonary Hypertension: Report From the Thalassemia Clinical Research Network.
C. Morris, Hae-Young Kim, J. Wood, F. Trachtenberg +13 more
20122 citations
Semantic Scholar
Effects of Selectin Antagonist GMI-1070 on the Activation State of Leukocytes In Sickle Cell Patients Not In Crisis
S. Simon, S. Chase, Sandra Larkin, F. Kuypers +4 more
20102 citations
Semantic Scholar
Erythrocyte Glutathione Depletion Is Associated with Severity of Anemia and Pulmonary Hypertension in Patients with Sickle Cell Disease.
C. Morris, Jung H. Suh, Sandra Larkin, D. A. Bland +7 more
20062 citations
Semantic Scholar

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F. Kuypers×43
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F. Kuypers — researcher profile on SciRah
E. Vichinsky×15
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C. Morris×14
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L. Styles×10
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Jung H. Suh — researcher profile on SciRah

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E. Klings — researcher profile on SciRah

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M. Fens — researcher profile on SciRah

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S. Singer — researcher profile on SciRah

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