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M. Opravil · SciRah

Researcher profile · Semantic Scholar

M. Opravil

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M. Opravil — researcher profile on SciRah

h-index: 46
Works: 149
Citations: 8,309

Most-cited papers

Clinical progression and virological failure on highly active antiretroviral therapy in HIV-1 patients : a prospective cohort study
B. Ledergerber, M. Egger, M. Opravil, A. Telenti +8 more
1999984 citations
Semantic Scholar
CD4 T-lymphocyte recovery in individuals with advanced HIV-1 infection receiving potent antiretroviral therapy for 4 years: the Swiss HIV Cohort Study.
G. Kaufmann, L. Perrin, G. Pantaleo, M. Opravil +9 more
2003Archives of Internal Medicine435 citations Open access
Semantic Scholar
Characteristics, determinants, and clinical relevance of CD4 T cell recovery to <500 cells/microL in HIV type 1-infected individuals receiving potent antiretroviral therapy.
G. Kaufmann, H. Furrer, B. Ledergerber, L. Perrin +7 more
2005Clinical Infectious Diseases342 citations Open access
Semantic Scholar
Bosentan for the treatment of human immunodeficiency virus-associated pulmonary arterial hypertension.
O. Sitbon, V. Gressin, R. Speich, P. Macdonald +6 more
2004American Journal of Respiratory and Critical Care Medicine263 citations Open access
Semantic Scholar
Hyperlactatemia and antiretroviral therapy: the Swiss HIV Cohort Study.
K. Boubaker, M. Flepp, P. Sudre, H. Furrer +10 more
2001Clinical Infectious Diseases243 citations Open access
Semantic Scholar
Impact of drug resistance mutations on virologic response to salvage therapy. Swiss HIV Cohort Study.
P. Lorenzi, M. Opravil, B. Hirschel, J. Chave +6 more
1999AIDS (London)210 citations Open access
Semantic Scholar
Pulmonary arterial hypertension related to HIV infection: improved hemodynamics and survival associated with antiretroviral therapy.
J. Zuber, A. Calmy, J. Evison, B. Hasse +8 more
2004Clinical Infectious Diseases207 citations Open access
Semantic Scholar
Frequent chronic hepatitis B virus infection in HIV-infected patients positive for antibody to hepatitis B core antigen only
M. Hofer, H. Joller-Jemelka, P. Grob, R. Lüthy +2 more
2005European Journal of Clinical Microbiology and Infectious Diseases197 citations
Semantic Scholar
Updated European Recommendations for the Clinical Use of HIV Drug Resistance Testing
A. Vandamme, A. Sönnerborg, M. Ait-Khaled, J. Albert +43 more
2004Antiviral Therapy186 citations Open access
Semantic Scholar
Abnormalities of body fat distribution in HIV-infected persons treated with antiretroviral drugs: The Swiss HIV Cohort Study.
E. Bernasconi, K. Boubaker, C. Junghans, M. Flepp +9 more
2002Journal of Acquired Immune Deficiency Syndromes148 citations Open access
Semantic Scholar
A randomized trial of simplified maintenance therapy with abacavir, lamivudine, and zidovudine in human immunodeficiency virus infection.
M. Opravil, B. Hirschel, A. Lazzarin, H. Furrer +12 more
2002Journal of Infectious Diseases148 citations Open access
Semantic Scholar
Tenofovir Use is associated with a Reduction in Calculated Glomerular Filtration Rates in the Swiss HIV Cohort Study
C. Fux, M. Simcock, M. Wolbers, H. Bucher +7 more
2007Antiviral Therapy138 citations Open access
Semantic Scholar
Clinical efficacy of early initiation of HAART in patients with asymptomatic HIV infection and CD4 cell count > 350 × 106/l
M. Opravil, B. Ledergerber, H. Furrer, B. Hirschel +7 more
2002AIDS (London)135 citations
Semantic Scholar
Natural history of HIV-associated pulmonary arterial hypertension: trends in the HAART era
M. Opravil, D. Séréni
2008AIDS (London)122 citations Open access
Semantic Scholar
Nevirapine versus Atazanavir/Ritonavir, Each Combined with Tenofovir Disoproxil Fumarate/Emtricitabine, in Antiretroviral-Naive HIV-1 Patients: The Arten Trial
V. Soriano, K. Arastéh, Horacio Migrone, T. Lutz +9 more
2011Antiviral Therapy111 citations
Semantic Scholar
Higher CNS Penetration-Effectiveness of Long-term Combination Antiretroviral Therapy Is Associated With Better HIV-1 Viral Suppression in Cerebrospinal Fluid
A. Cusini, P. Vernazza, S. Yerly, L. Decosterd +12 more
2013Journal of Acquired Immune Deficiency Syndromes101 citations Open access
Semantic Scholar
Clinical and laboratory guidelines for the use of HIV-1 drug resistance testing as part of treatment management: recommendations for the European setting. The EuroGUidelines Group for HIV resistance.
Miller, A. Vandamme, C. Loveday, S. Staszewski +48 more
2001AIDS (London)101 citations
Semantic Scholar
Time of initiation of antiretroviral therapy: impact on HIV-1 viraemia
S. Yerly, L. Kaiser, T. Perneger, R. Cone +5 more
2000AIDS (London)92 citations
Semantic Scholar
Tenofovir use is Associated with an Increase in Serum Alkaline Phosphatase in the Swiss HIV Cohort Study
C. Fux, A. Rauch, M. Simcock, H. Bucher +7 more
2008Antiviral Therapy89 citations Open access
Semantic Scholar
Progression of Liver Fibrosis in HIV/HCV Co-Infection: A Comparison between Non-Invasive Assessment Methods and Liver Biopsy
P. Schmid, A. Bregenzer, M. Huber, A. Rauch +5 more
2015PLoS ONE88 citations Open access
Semantic Scholar
Stopping primary prophylaxis in HIV-1-infected patients at high risk of toxoplasma encephalitis. Swiss HIV Cohort Study.
H. Furrer, M. Opravil, E. Bernasconi, A. Telenti +1 more
2000The Lancet84 citations
Semantic Scholar
Effect of Individual Cognitive Behaviour Intervention on Adherence to Antiretroviral Therapy: Prospective Randomized Trial
R. Weber, L. Christen, S. Christen, Simone Tschopp +6 more
2004Antiviral Therapy82 citations Open access
Semantic Scholar
Incidence and Predictors of Virologic Failure of Antiretroviral Triple-Drug Therapy in a Community-Based Cohort
D. París, B. Ledergerber, Rainer Weber, J. Jost +4 more
1999AIDS Research and Human Retroviruses80 citations
Semantic Scholar
Phase II study of vicriviroc versus efavirenz (both with zidovudine/lamivudine) in treatment-naive subjects with HIV-1 infection.
R. Landovitz, J. Angel, C. Hoffmann, H. Horst +4 more
2008Journal of Infectious Diseases77 citations Open access
Semantic Scholar
Residual Cell-Associated Unspliced HIV-1 Rna in Peripheral Blood of Patients on Potent Antiretroviral Therapy Represents Intracellular Transcripts
M. Fischer, J. Wong, D. Russenberger, B. Joos +6 more
2001Antiviral Therapy69 citations Open access
Semantic Scholar
Highly Sensitive Methods for Quantitation of Human Immunodeficiency Virus Type 1 RNA from Plasma, Cells, and Tissues
M. Fischer, W. Huber, A. Kallivroussis, P. Ott +4 more
1999Journal of Clinical Microbiology67 citations Open access
Semantic Scholar
Adverse Events to Antiretrovirals in the Swiss HIV Cohort Study: Effect on Mortality and Treatment Modification
O. Keiser, J. Fellay, M. Opravil, H. Hirsch +6 more
2007Antiviral Therapy66 citations Open access
Semantic Scholar
Effect of Baseline CD4 Cell Count on the Efficacy and Safety of Peginterferon Alfa-2a (40KD) Plus Ribavirin in Patients With HIV/Hepatitis C Virus Coinfection
M. Opravil, J. Sasadeusz, D. Cooper, J. Rockstroh +6 more
2008Journal of Acquired Immune Deficiency Syndromes64 citations Open access
Semantic Scholar
Regression of HIV-associated pulmonary arterial hypertension and long-term survival during antiretroviral therapy.
R. Speich, R. Jenni, M. Opravil, R. Jaccard
2001Swiss medical weekly61 citations
Semantic Scholar
Antiretroviral treatment monitoring with an improved HIV‐1 p24 antigen test: an inexpensive alternative to tests for viral RNA
J. Schüpbach, J. Böni, M. Flepp, Z. Tomasik +2 more
2001Journal of Medical Virology58 citations
Semantic Scholar
Acute interstitial nephritis of HIV-positive patients under atazanavir and tenofovir therapy in a retrospective analysis of kidney biopsies
S. Schmid, M. Opravil, M. Möddel, M. Huber +6 more
2007Virchows Archiv57 citations Open access
Semantic Scholar
Meta-analysis of randomized controlled trials of simplified versus continued protease inhibitor-based antiretroviral therapy in HIV-1-infected patients
H. Bucher, A. Kofler, R. Nüesch, James B. Young +2 more
2003AIDS (London)54 citations Open access
Semantic Scholar
Impact of occasional short interruptions of HAART on the progression of HIV infection: results from a cohort study
P. Taffé, M. Rickenbach, B. Hirschel, M. Opravil +6 more
2002AIDS (London)53 citations Open access
Semantic Scholar
CD4+ T cell count recovery in HIV type 1-infected patients is independent of class of antiretroviral therapy.
N. Khanna, M. Opravil, H. Furrer, M. Cavassini +6 more
2008Clinical Infectious Diseases50 citations Open access
Semantic Scholar
Importance of Baseline Prognostic Factors With Increasing Time Since Initiation of Highly Active Antiretroviral Therapy: Collaborative Analysis of Cohorts of HIV-1-Infected Patients
J. Sterne, M. May, C. Sabin, Andrew N. Phillips +496 more
2007Journal of Acquired Immune Deficiency Syndromes49 citations Open access
Semantic Scholar
Diffusion-Weighted MR Imaging of Intramedullary Spinal Cord Abscess
E. Dörflinger-Hejlek, E. C. Kirsch, H. Reiter, M. Opravil +1 more
2010American Journal of Neuroradiology46 citations Open access
Semantic Scholar
Optimized virus disruption improves detection of HIV‐1 p24 in particles and uncovers a p24 reactivity in patients with undetectable HIV‐1 RNA under long‐term HAART
J. Schüpbach, Z. Tomasik, M. Knuchel, M. Opravil +3 more
2006Journal of Medical Virology45 citations
Semantic Scholar
Quantification of In Vivo Replicative Capacity of HIV‐1 in Different Compartments of Infected Cells
G. A. Funk, M. Fischer, Eda Joos, M. Opravil +3 more
2001Journal of Acquired Immune Deficiency Syndromes44 citations
Semantic Scholar
Attenuated and nonproductive viral transcription in the lymphatic tissue of HIV-1-infected patients receiving potent antiretroviral therapy.
M. Fischer, B. Joos, J. Wong, P. Ott +4 more
2004Journal of Infectious Diseases42 citations Open access
Semantic Scholar
Eligibility for and Outcome of Hepatitis C Treatment of HIV-Coinfected Individuals in Clinical Practice: The Swiss HIV Cohort Study
A. Zinkernagel, V. von Wyl, B. Ledergerber, M. Rickenbach +8 more
2006Antiviral Therapy41 citations Open access
Semantic Scholar
HIV-1 p24 antigen is a significant inverse correlate of CD4 T-cell change in patients with suppressed viremia under long-term antiretroviral therapy.
J. Schüpbach, J. Böni, L. R. Bisset, Z. Tomasik +4 more
2003Journal of Acquired Immune Deficiency Syndromes41 citations Open access
Semantic Scholar
Treatment initiation with zidovudine-containing potent antiretroviral therapy impairs CD4 cell count recovery but not clinical efficacy
A. Huttner, G. Kaufmann, M. Battegay, R. Weber +1 more
2007AIDS (London)40 citations Open access
Semantic Scholar
Discontinuation of primary prophylaxis in HIV-infected patients at high risk of Pneumocystis carinii pneumonia: prospective multicentre study
H. Furrer, M. Opravil, M. Rossi, E. Bernasconi +7 more
2001AIDS (London)35 citations Open access
Semantic Scholar
Refining Abacavir Hypersensitivity Diagnoses using a Structured Clinical Assessment and Genetic Testing in the Swiss HIV Cohort Study
A. Rauch, D. Nolan, C. Thurnheer, C. Fux +6 more
2008Antiviral Therapy34 citations Open access
Semantic Scholar
Long-term hydroxyurea in combination with didanosine and stavudine for the treatment of HIV-1 infection
O. Rutschmann, P. Vernazza, H. Bucher, M. Opravil +8 more
2000AIDS (London)34 citations Open access
Semantic Scholar
Impact of Genotypic Resistance Testing on Selection of Salvage Regimen in Clinical Practice
Stefan Haupts, B. Ledergerber, J. Böni, J. Schüpbach +8 more
2002Antiviral Therapy33 citations Open access
Semantic Scholar
Effects of Early Antiretroviral Treatment on HIV‐1 RNA in Blood and Lymphoid Tissue: A Randomized Trial of Double Versus Triple Therapy
M. Opravil, R. Cone, M. Fischer, P. Vernazza +9 more
2000Journal of Acquired Immune Deficiency Syndromes33 citations Open access
Semantic Scholar
The SPICE Study: 48‐Week Activity of Combinations of Saquinavir Soft Gelatin and Nelfinavir With and Without Nucleoside Analogues
G. Moyle, A. Pozniak, M. Opravil, N. Clumeck +8 more
2000Journal of Acquired Immune Deficiency Syndromes31 citations
Semantic Scholar
Equal amounts of intracellular and virion-enclosed hepatitis C virus RNA are associated with peripheral-blood mononuclear cells in vivo.
P. Kaiser, Barbara Niederost, B. Joos, V. von Wyl +4 more
2006Journal of Infectious Diseases29 citations Open access
Semantic Scholar
HIV-specific cellular immune response is inversely correlated with disease progression as defined by decline of CD4+ T cells in relation to HIV RNA load.
A. Oxenius, D. Price, M. Hersberger, E. Schlaepfer +9 more
2004Journal of Infectious Diseases28 citations Open access
Semantic Scholar

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