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G. Beran · SciRah

Researcher profile · Semantic Scholar

G. Beran

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G. Beran — researcher profile on SciRah

h-index: 8
Works: 26
Citations: 1,030

Most-cited papers

Acquired resistance to mutant-selective EGFR inhibitor AZD9291 is associated with increased dependence on RAS signaling in preclinical models
C. Eberlein, Daniel B. Stetson, A. Markovets, K. Al-Kadhimi +19 more
2015Cancer Research296 citations Open access
Semantic Scholar
Transcriptional Pathway Signatures Predict MEK Addiction and Response to Selumetinib (AZD6244)
J. Dry, S. Pavey, C. Pratilas, C. Harbron +25 more
2010Cancer Research261 citations Open access
Semantic Scholar
Subtypes of primary colorectal tumors correlate with response to targeted treatment in colorectal cell lines
A. Schlicker, G. Beran, C. Chresta, Gael Mcwalter +9 more
2012BMC Medical Genomics256 citations Open access
Semantic Scholar
The MET Inhibitor AZD6094 (Savolitinib, HMPL-504) Induces Regression in Papillary Renal Cell Carcinoma Patient–Derived Xenograft Models
A. Schuller, E. Barry, Rhys D. O. Jones, Ryan E. Henry +15 more
2015Clinical Cancer Research71 citations Open access
Semantic Scholar
Whole transcriptome profiling of patient-derived xenograft models as a tool to identify both tumor and stromal specific biomarkers
J. Bradford, Mark Wappett, G. Beran, A. Logié +8 more
2016OncoTarget36 citations Open access
Semantic Scholar
Acquired savolitinib resistance in non-small cell lung cancer arises via multiple mechanisms that converge on MET-independent mTOR and MYC activation
Ryan E. Henry, E. Barry, Lillian Castriotta, B. Ladd +12 more
2016OncoTarget34 citations Open access
Semantic Scholar
Identification of a Subset of Human Non–Small Cell Lung Cancer Patients with High PI3Kβ and Low PTEN Expression, More Prevalent in Squamous Cell Carcinoma
M. Cumberbatch, Xi-Ming Tang, G. Beran, Sonia Eckersley +13 more
2013Clinical Cancer Research26 citations Open access
Semantic Scholar
Identification of Biomarkers in Human Head and Neck Tumor Cell Lines That Predict For In Vitro Sensitivity to Gefitinib
D. Hickinson, G. Marshall, G. Beran, M. Varella-Garcia +12 more
2009Clinical and Translational Science23 citations Open access
Semantic Scholar
Cabozantinib and Prostate Cancer: Inhibiting Seed and Disrupting Soil?
Richard J. Lee, Matthew R. Smith, T. Miller, G. Beran +8 more
2013Clinical Cancer Research8 citations Open access
Semantic Scholar
Abstract 3114: Targeting MET in preclinical models to support the clinical development of Volitinib in NSCLC
C. D'Cruz, M. Frigault, Ammar Adam, Minhui Shen +10 more
20145 citations
Semantic Scholar
Abstract 5365: Molecular and pharmacological (EGFRi, MEKi) characterisation of a colorectal cancer (CRC) cell line panel to evaluate cellular phenotype and efficacy of targeted therapies in CRC
C. Chresta, S. Runswick, G. Beran, Sara Davenport +2 more
20115 citations
Semantic Scholar
Abstract 2978: Generation of drug response data from 57 new patient-derived colon cancer xenografts and 3D cell cultures for systematic correlation with tumor biology within the OncoTrack* project
M. Rivera, Marlen Keil, K. Boehnke, M. Lange +15 more
20143 citations
Semantic Scholar
Abstract 761: Changing the paradigm for treating drug resistance in NSCLC: Novel combinations of AZD6094, a selective MET inhibitor, and an irreversible, selective (EGFRm/T790M) EGFRTKI, AZD9291
C. D'Cruz, E. Barry, Ryan E. Henry, Lillian Castriotta +9 more
20152 citations
Semantic Scholar
Fibroblast growth factor receptor 1 (FGFR1) gene copy number gain in adenocarcinoma and squamous cell carcinoma of the lung.
Xi-Ming Tang, Yuwen Xue, Xinying Su, Nusrat Harun +11 more
20131 citations
Semantic Scholar
Abstract 912: Targeting HER family signaling in low HER2-expressing breast cancer: activity of the selective and equipotent EGFR, HER2 and HER3 signaling inhibitor, AZD8931, in models of low HER2-expressing disease.
G. Marshall, S. Ashton, G. Speake, C. D'Cruz +6 more
20131 citations
Semantic Scholar
Abstract 5559: Reciprocal expression of miR-125b and miR-192/miR-200 families define clinically relevant sub-types of colorectal cancer with differential sensitivity to EGFR and MEK targeted agents
C. Chresta, A. Schlicker, G. Beran, G. Cerillo +2 more
20121 citations
Semantic Scholar
Acquired resistance to mutant-selective EGFR inhibitor AZD9291 is associated with increased dependence on RAS signaling in preclinical models
C. Eberlein, D. Stetson, Aleksandra A. Markovets, KatherineJ.Al +24 more
20150 citations
Semantic Scholar
Abstract LB-C22: Acquired resistance to the cMET inhibitor savolitinib in lung cancer models through EGFR/mTOR/MYC deregulation and adoption of PIM signaling
Ryan E. Henry, E. Barry, B. Ladd, A. Markovets +10 more
20150 citations
Semantic Scholar
Abstract 1477: Pharmacodynamic response and anti-tumor activity of the MET inhibitor AZD6094 in papillary renal cell carcinoma patient derived xenograft models
A. Schuller, E. Barry, Rhys D. O. Jones, M. Frigault +12 more
20150 citations
Semantic Scholar
Use of colorectal cancer subtypes identified through iterative clustering to predict response to therapy.
A. Schlicker, G. Beran, C. Chresta, Gael Mcwalter +9 more
2012Journal of Clinical Oncology0 citations
Semantic Scholar
Abstract 2995: Identifying subtypes of colorectal cancer tumors and cell lines with treatment relevance using iterative clustering (iNMF)
G. Beran, A. Schlicker, C. Chresta, Gael Mcwalter +9 more
20120 citations
Semantic Scholar
Abstract 4172: Identification of a low PTEN / high PI3Kα expressing subset of squamous non-small-cell lung cancer (NSCLC)
G. Beran, X. M. Tang, M. Cumberbatch, Sally Luke +10 more
20120 citations
Semantic Scholar
Abstract A13: Characterization of CRC primary explant models in comparison to standard human tumor cell-line-derived CRC xenografts.
D. Alférez, H. Brown, J. Dry, S. Runswick +11 more
20110 citations
Semantic Scholar
Abstract C2: Selection for combinational studies through biomarker stratification in colorectal patient-derived explant models.
Denis G. Alferez, J. Dry, Sarah V. Holt, Susie Weston +8 more
20110 citations
Semantic Scholar
Biologically driven interpretation reveals molecular signatures predictive of oncogenic addiction to MEK signaling and cell line response to the MEK1/2 inhibitor AZD6244 (ARRY-142886)
J. Dry, C. Harbron, M. Hickinson, A. Graham +9 more
20080 citations
Semantic Scholar

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