H. Rubin

Most-cited papers

1. Synergistic mechanisms in carcinogenesis by polycyclic aromatic hydrocarbons and by tobacco smoke: a bio-historical perspective with updates.

   H. Rubin

   2001Carcinogenesis256 citations Open access

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2. Cell aging in vivo and in vitro.

   H. Rubin

   1997Mechanisms of Ageing and Development244 citations

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3. Cancer as a dynamic developmental disorder.

   H. Rubin

   1985Cancer Research223 citations

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4. Central role for magnesium in coordinate control of metabolism and growth in animal cells.

   H. Rubin

   1975Proceedings of the National Academy of Sciences of the United States of America188 citations Open access

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5. The disparity between human cell senescence in vitro and lifelong replication in vivo

   H. Rubin

   2002Nature Biotechnology173 citations

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6. Magnesium: The missing element in molecular views of cell proliferation control.

   H. Rubin

   2005Bioessays103 citations

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7. What keeps cells in tissues behaving normally in the face of myriad mutations?

   H. Rubin

   2006Bioessays101 citations Open access

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8. The logic of the Membrane, Magnesium, Mitosis (MMM) model for the regulation of animal cell proliferation.

   H. Rubin

   2007Archives of Biochemistry and Biophysics96 citations

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9. Cancer cachexia: Its correlations and causes

   H. Rubin

   2003Proceedings of the National Academy of Sciences of the United States of America87 citations Open access

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10. Evidence that intracellular magnesium is present in cells at a regulatory concentration for protein synthesis.

    M. Terasaki, H. Rubin

    1985Proceedings of the National Academy of Sciences of the United States of America81 citations Open access

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11. Selected cell and selective microenvironment in neoplastic development.

    H. Rubin

    2001Cancer Research76 citations

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12. Magnesium deprivation reproduces the coordinate effects of serum removal or cortisol addition on transport and metabolism in chick embryo fibroblasts

    H. Rubin

    1976Journal of Cellular Physiology74 citations

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13. THE ROLE OF MAGNESIUM IN CELL PROLIFERATION AND TRANSFORMATION

    H. Sanui, H. Rubin

    198272 citations

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14. Coordinate control of collagen synthesis and cell growth in chick embryo fibroblasts and the effect of viral transformation on collagen synthesis

    J. Kamine, H. Rubin

    1977Journal of Cellular Physiology66 citations

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15. Central roles of Mg2+ and MgATP2- in the regulation of protein synthesis and cell proliferation: significance for neoplastic transformation.

    H. Rubin

    2005Advances in Cancer Research60 citations

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16. Mutual potentiation by magnesium and calcium of growth in animal cells.

    H. Rubin, T. Koide

    1976Proceedings of the National Academy of Sciences of the United States of America60 citations Open access

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17. The early history of tumor virology: Rous, RIF, and RAV

    H. Rubin

    2011Proceedings of the National Academy of Sciences of the United States of America59 citations Open access

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18. Is somatic mutation the major mechanism of malignant transformation?

    H. Rubin

    1980Journal of the National Cancer Institute56 citations Open access

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19. The significance of biological heterogeneity

    H. Rubin

    1990Cancer Metastasis Review53 citations

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20. Telomerase and cellular lifespan: Ending the debate?

    H. Rubin

    1998Nature Biotechnology50 citations

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21. Hormonal control of hyaluronic acid production in fibroblasts and its relation to nucleic acid and protein synthesis

    D. Moscatelli, H. Rubin

    1977Journal of Cellular Physiology50 citations

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22. Increased hyaluronic acid production on stimulation of DNA synthesis in chick embryo fibroblasts

    D. Moscatelli, H. Rubin

    1975Nature49 citations

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23. Differential effects of glucocorticoids on DNA synthesis in normal and virus-transformed chick embryo cells

    D. Fodge, H. Rubin

    1975Nature48 citations

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24. Selective clonal expansion and microenvironmental permissiveness in tobacco carcinogenesis

    H. Rubin

    2002Oncogene46 citations

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25. Early cellular responses to diverse growth stimuli independent of protein and RNA synthesis

    H. Rubin, T. Koide

    1975Journal of Cellular Physiology45 citations

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26. Microenvironmental regulation of the initiated cell.

    H. Rubin

    2003Advances in Cancer Research43 citations

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27. Complexes of inorganic pyrophosphate, orthophosphate, and calcium as stimulants of 3T3 cell multiplication.

    H. Rubin, H. Sanui

    1977Proceedings of the National Academy of Sciences of the United States of America43 citations Open access

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28. Fields and field cancerization: The preneoplastic origins of cancer

    H. Rubin

    2011Bioessays42 citations

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29. Cell–cell contact interactions conditionally determine suppression and selection of the neoplastic phenotype

    H. Rubin

    2008Proceedings of the National Academy of Sciences of the United States of America41 citations Open access

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30. Promise and problems in relating cellular senescence in vitro to aging in vivo.

    H. Rubin

    2002Archives of gerontology and geriatrics (Print)39 citations

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31. The role of selection in progressive neoplastic transformation.

    H. Rubin

    2001Advances in Cancer Research39 citations

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32. Degrees and kinds of selection in spontaneous neoplastic transformation: an operational analysis.

    H. Rubin

    2005Proceedings of the National Academy of Sciences of the United States of America38 citations Open access

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33. Multistage carcinogenesis in cell culture.

    H. Rubin

    2001Developments in Biologicals35 citations

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34. Correlated effects of external magnesium on cation content and DNA synthesis in cultured chicken embryo fibroblasts

    H. Sanui, H. Rubin

    1977Journal of Cellular Physiology34 citations

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35. Antagonistic effects of insulin and cortisol on coordinate control of metabolism and growth in cultured fibroblasts

    H. Rubin

    1977Journal of Cellular Physiology33 citations

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36. Deprivation of glutamine in cell culture reveals its potential for treating cancer

    H. Rubin

    2019Proceedings of the National Academy of Sciences of the United States of America27 citations Open access

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37. On the nature of enduring modifications induced in cells and organisms.

    H. Rubin

    1990American Journal of Physiology27 citations

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38. Ordered heterogeneity and its decline in cancer and aging.

    H. Rubin

    2007Advances in Cancer Research26 citations

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39. Growth stimulatory precipitates of CA2+ and pyrophosphate

    D. F. Bowen-Pope, H. Rubin

    1983Journal of Cellular Physiology26 citations

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40. Contact interactions between cells that suppress neoplastic development: can they also explain metastatic dormancy?

    H. Rubin

    2008Advances in Cancer Research25 citations

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41. Effect of magnesium content on density-dependent regulation of the onset of DNA synthesis in transformed 3T3 cells.

    H. Rubin

    1982Cancer Research25 citations

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42. Magnesium required for serum-stimulation of growth in cultures of chick embryo fibroblasts

    J. Kamine, H. Rubin

    1976Nature24 citations

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43. Neoplastic development: paradoxical relation between impaired cell growth at low population density and excessive growth at high density.

    H. Rubin, Adam Yao, Ming Chow

    1995Proceedings of the National Academy of Sciences of the United States of America23 citations Open access

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44. Specificity of the requirements for magnesium and calcium in the growth and metabolism of chick embryo fibroblasts

    H. Rubin

    1977Journal of Cellular Physiology23 citations

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45. Maintenance of multiplication rate stability by cell populations in the face of heterogeneity among individual cells.

    R. Grundel, H. Rubin

    1988Journal of Cell Science21 citations

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46. Mutations and oncogenes — cause or effect

    H. Rubin

    1984Nature21 citations

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47. Glucose utilization, pH reduction and density dependent inhibition in cultures of chick embryo fibroblasts

    D. Fodge, H. Rubin

    1975Journal of Cellular Physiology21 citations

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48. Promotion and selection by serum growth factors drive field cancerization, which is anticipated in vivo by type 2 diabetes and obesity

    H. Rubin

    2013Proceedings of the National Academy of Sciences of the United States of America18 citations Open access

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49. Systemic effects of cancer: role of multiple proteases and their toxic peptide products.

    H. Rubin

    2005Medical Science Monitor18 citations

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50. Mg2+ as activator of uridine phosphorylation in coordination with other cellular responses to growth factors.

    C. Vidair, H. Rubin

    2005Proceedings of the National Academy of Sciences of the United States of America18 citations Open access

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