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Ru-Fu Chen · SciRah

Researcher profile · Semantic Scholar

Ru-Fu Chen

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Ru-Fu Chen — researcher profile on SciRah

h-index: 45
Works: 260
Citations: 6,618

Most-cited papers

Excessive miR-25-3p maturation via N6-methyladenosine stimulated by cigarette smoke promotes pancreatic cancer progression
Jia-Liang Zhang, Ruihong Bai, Mei Li, Hui-Lin Ye +24 more
2019Nature Communications330 citations Open access
Semantic Scholar
Exosomal long noncoding RNA LNMAT2 promotes lymphatic metastasis in bladder cancer.
Chang-Hao Chen, Yu-Ming Luo, Wang He, Yue Zhao +8 more
2019Journal of Clinical Investigation307 citations Open access
Semantic Scholar
Cross-tissue human fibroblast atlas reveals myofibroblast subtypes with distinct roles in immune modulation.
Yang Gao, Jia-Na Li, W. Cheng, T. Diao +13 more
2024Cancer Cell278 citations Open access
Semantic Scholar
Laparoscopic versus open pancreatoduodenectomy for pancreatic or periampullary tumours: a multicentre, open-label, randomised controlled trial.
Min Wang, De-Wei Li, Ru-Fu Chen, Xiao-Bing Huang +33 more
2021The Lancet Gastroenterology and Hepatology165 citations
Semantic Scholar
circNFIB1 inhibits lymphangiogenesis and lymphatic metastasis via the miR-486-5p/PIK3R1/VEGF-C axis in pancreatic cancer
Yao Kong, Yu-Ting Li, Yu-Ming Luo, Jiang Zhu +6 more
2020Molecular Cancer160 citations Open access
Semantic Scholar
circFARP1 enables cancer-associated fibroblasts to promote gemcitabine resistance in pancreatic cancer via the LIF/STAT3 axis
Chong-Hui Hu, Ren-Peng Xia, Xiang Zhang, Tingting Li +7 more
2022Molecular Cancer135 citations Open access
Semantic Scholar
Integrated single-cell and spatial transcriptomics uncover distinct cellular subtypes involved in neural invasion in pancreatic cancer.
Min-Min Chen, Qin-Hang Gao, Hui-Heng Ning, Kang Chen +12 more
2025Cancer Cell121 citations Open access
Semantic Scholar
Circular RNA circBFAR promotes the progression of pancreatic ductal adenocarcinoma via the miR-34b-5p/MET/Akt axis
Xiaofeng Guo, Quan-Bo Zhou, Dan Su, Yu-Ming Luo +8 more
2020Molecular Cancer111 citations Open access
Semantic Scholar
CSTF2 mediated mRNA N6-methyladenosine modification drives pancreatic ductal adenocarcinoma m6A subtypes
Yanfen Zheng, Xing-Yang Li, S. Deng, Hong-Zhe Zhao +17 more
2023Nature Communications93 citations Open access
Semantic Scholar
Cancer-Associated Fibroblasts Foster a High-Lactate Microenvironment to Drive Perineural Invasion in Pancreatic Cancer
Ting-Ting Li, Chong-Hui Hu, Tian-Hao Huang, Yu Zhou +10 more
2025Cancer Research84 citations Open access
Semantic Scholar
Cancer-associated fibroblasts-mediated ATF4 expression promotes malignancy and gemcitabine resistance in pancreatic cancer via the TGF-β1/SMAD2/3 pathway and ABCC1 transactivation
Lusheng Wei, Qing Lin, Yanan Lu, Guolin Li +4 more
2021Cell Death and Disease80 citations Open access
Semantic Scholar
lncRNA-PLACT1 sustains activation of NF-κB pathway through a positive feedback loop with IκBα/E2F1 axis in pancreatic cancer
Xiaofan Ren, Chang-Hao Chen, Yu-Ming Luo, Ming-Yang Liu +7 more
2020Molecular Cancer77 citations Open access
Semantic Scholar
LINC00842 inactivates transcription co-regulator PGC-1α to promote pancreatic cancer malignancy through metabolic remodelling
Xu-Dong Huang, L. Pan, Z. Zuo, Mei Li +20 more
2021Nature Communications70 citations Open access
Semantic Scholar
Inflammatory cytokine-regulated tRNA-derived fragment tRF-21 suppresses pancreatic ductal adenocarcinoma progression.
L. Pan, Xu-Dong Huang, Ze Liu, Ying Ye +19 more
2021Journal of Clinical Investigation70 citations Open access
Semantic Scholar
Super-enhancer RNA m^6A promotes local chromatin accessibility and oncogene transcription in pancreatic ductal adenocarcinoma
Rui Li, Hong-Zhe Zhao, Xudong Huang, Jia-Liang Zhang +14 more
2023Nature Genetics69 citations
Semantic Scholar
Tumor-neuroglia interaction promotes pancreatic cancer metastasis
D. Su, Xiaofeng Guo, Leyi Huang, Hui-Lin Ye +4 more
2020Theranostics69 citations Open access
Semantic Scholar
Extracellular vesicle–packaged PIAT from cancer-associated fibroblasts drives neural remodeling by mediating m5C modification in pancreatic cancer mouse models
Shang-You Zheng, Chong-Hui Hu, Qing Lin, Ting-Ting Li +9 more
2024Science Translational Medicine64 citations
Semantic Scholar
Cancer-associated fibroblast-induced lncRNA UPK1A-AS1 confers platinum resistance in pancreatic cancer via efficient double-strand break repair
Xiang Zhang, Shang-You Zheng, Chong-Hui Hu, Guolin Li +8 more
2022Oncogene64 citations Open access
Semantic Scholar
Macrophage-expressed CD51 promotes cancer stem cell properties via the TGF-β1/smad2/3 axis in pancreatic cancer.
Bin Zhang, Hui-Lin Ye, Xiaofan Ren, Shang-You Zheng +10 more
2019Cancer Letters64 citations
Semantic Scholar
Practice Patterns and Perioperative Outcomes of Laparoscopic Pancreaticoduodenectomy in China
Min Wang, B. Peng, Jianhua Liu, Xin-Min Yin +29 more
2019Annals of Surgery62 citations
Semantic Scholar
Single-cell RNA sequencing reveals spatiotemporal heterogeneity and malignant progression in pancreatic neuroendocrine tumor
Yu Zhou, S. Liu, Chao Liu, Jia-Bin Yang +5 more
2021International Journal on Biological Sciences59 citations Open access
Semantic Scholar
circCUL2 induces an inflammatory CAF phenotype in pancreatic ductal adenocarcinoma via the activation of the MyD88-dependent NF-κB signaling pathway
Shang-You Zheng, Chong-Hui Hu, Hongcao Lin, Guolin Li +6 more
2022Journal of experimental & clinical cancer research : CR58 citations Open access
Semantic Scholar
The Role of APAL/ST8SIA6-AS1 lncRNA in PLK1 Activation and Mitotic Catastrophe of Tumor Cells.
Man-Li Luo, Jing-Jing Li, Liping Shen, Junjun Chu +6 more
2019Journal of the National Cancer Institute56 citations Open access
Semantic Scholar
Extracellular vesicle-packaged circBIRC6 from cancer-associated fibroblasts induce platinum resistance via SUMOylation modulation in pancreatic cancer
Shang-You Zheng, Qing Tian, Yuan Yuan, Shu-Xin Sun +9 more
2023Journal of experimental & clinical cancer research : CR55 citations Open access
Semantic Scholar
KRAS mutant–driven SUMOylation controls extracellular vesicle transmission to trigger lymphangiogenesis in pancreatic cancer
Yu-Ming Luo, Zhi-Hua Li, Yao Kong, Wang He +8 more
2022Journal of Clinical Investigation51 citations Open access
Semantic Scholar
QDPR deficiency drives immune suppression in pancreatic cancer.
Ji Liu, Xiao-Wei He, S. Deng, Sihan Zhao +17 more
2024Cell Metabolism41 citations Open access
Semantic Scholar
Glycolysis reprogramming in CAFs promotes oxaliplatin resistance in pancreatic cancer through circABCC4 mediated PKM2 nuclear translocation
Rihua He, Chong-Hui Hu, Yuan Yuan, Ting-Ting Li +7 more
2025Cell Death and Disease38 citations Open access
Semantic Scholar
Crosstalk between cancer cells and the nervous system
Meng Huang, Gu Gong, Yicheng Deng, Xinmiao Long +4 more
2023Medicine Advances38 citations Open access
Semantic Scholar
Standard pancreatoduodenectomy versus extended pancreatoduodenectomy with modified retroperitoneal nerve resection in patients with pancreatic head cancer: a multicenter randomized controlled trial
Qing Lin, Shang-You Zheng, Xianjun Yu, Mei-Fu Chen +20 more
2022Cancer Communications36 citations Open access
Semantic Scholar
Mutant KRAS Mediates circARFGEF2 Biogenesis to Promote Lymphatic Metastasis of Pancreatic Ductal Adenocarcinoma
Yao Kong, Yu-Ming Luo, Shang-You Zheng, Jia-Bin Yang +10 more
2023Cancer Research34 citations Open access
Semantic Scholar
N6-methyladenosine–Mediated Upregulation of WTAPP1 Promotes WTAP Translation and Wnt Signaling to Facilitate Pancreatic Cancer Progression
Junge Deng, Jia-Liang Zhang, Ying Ye, Kai-Jing Liu +15 more
2021Cancer Research32 citations Open access
Semantic Scholar
LLGL1 Regulates Gemcitabine Resistance by Modulating the ERK-SP1-OSMR Pathway in Pancreatic Ductal Adenocarcinoma
Yinxin Zhu, Chi H. Li, Guolin Li, Huiyi Feng +7 more
2020Cellular and Molecular Gastroenterology and Hepatology26 citations Open access
Semantic Scholar
Association of genetic risk and lifestyle with pancreatic cancer and their age dependency: a large prospective cohort study in the UK Biobank
Liangtang Zeng, Zhuo Wu, Jia-Bin Yang, Yu Zhou +1 more
2023BMC Medicine23 citations Open access
Semantic Scholar
Genome-wide identification and characterization of circular RNA m6A modification in pancreatic cancer
Ying Ye, Weiyi Feng, Jia-Liang Zhang, Kai-Yu Zhu +15 more
2021Genome Medicine23 citations Open access
Semantic Scholar
LncRNA BCAN-AS1 stabilizes c-Myc via N^6-methyladenosine-mediated binding with SNIP1 to promote pancreatic cancer
Guandi Wu, Jiachun Su, Lingxing Zeng, S. Deng +14 more
2023Cell Death and Differentiation22 citations Open access
Semantic Scholar
Total laparoscopic pancreaticoduodenectomy versus open pancreaticoduodenectomy (TJDBPS01): study protocol for a multicentre, randomised controlled clinical trial
Hang Zhang, Yechen Feng, Junfang Zhao, Ru-Fu Chen +17 more
2020BMJ Open22 citations Open access
Semantic Scholar
EIF4E-mediated biogenesis of circPHF14 promotes the growth and metastasis of pancreatic ductal adenocarcinoma via Wnt/β-catenin pathway
Zhou Fang, Zhuo Wu, Chao Yu, Qing-Yu Xie +2 more
2025Molecular Cancer21 citations Open access
Semantic Scholar
Effect of Laparoscopic and Open Pancreaticoduodenectomy for Pancreatic or Periampullary Tumors
Tingting Qin, Hang Zhang, Shu-Tao Pan, Jun Liu +29 more
2023Annals of Surgery20 citations Open access
Semantic Scholar
Guidelines for the diagnosis and treatment of pancreatic cancer in China (2021)
Yinmo Yang, Xue-Li Bai, Da-Peng Bian, Shouwang Cai +46 more
2021Zhonghua wai ke za zhi [Chinese journal of surgery]20 citations Open access
Semantic Scholar
Textbook outcome as a composite outcome measure in laparoscopic pancreaticoduodenectomy: a multicenter retrospective cohort study
Yi Wu, B. Peng, Jianhua Liu, Xin-Min Yin +17 more
2023International Journal of Surgery19 citations Open access
Semantic Scholar
Experts' consensus on intraoperative radiotherapy for pancreatic cancer.
Ye-Xiong Li, Q. Feng, Jing Jin, S. Shi +13 more
2019Cancer Letters19 citations Open access
Semantic Scholar
A randomised, multicentre trial of somatostatin to prevent clinically relevant postoperative pancreatic fistula in intermediate-risk patients after pancreaticoduodenectomy
Zhe Cao, Jiang-Dong Qiu, Junchao Guo, G. Xiong +11 more
2021Journal of gastroenterology18 citations
Semantic Scholar
Lactylation-driven NSUN2-mediated RNA m5C modification promotes perineural invasion in pancreatic cancer
Tian-Hao Huang, Chong-Hui Hu, Hui-Mou Chen, Hong-Hui Jiang +12 more
2026Theranostics17 citations Open access
Semantic Scholar
Nudt21-mediated alternative polyadenylation of MZT1 3′UTR contributes to pancreatic cancer progression
Yu Zhou, Jia-Bin Yang, Leyi Huang, Chao Liu +3 more
2024iScience16 citations Open access
Semantic Scholar
N4-acetylcytidine modification of ITGB5 mRNA mediated by NAT10 promotes perineural invasion in pancreatic ductal adenocarcinoma
Leyi Huang, Yanan Lu, Rihua He, Xiaofeng Guo +7 more
2025Journal of experimental & clinical cancer research : CR14 citations Open access
Semantic Scholar
HNF1A regulates oxaliplatin resistance in pancreatic cancer by targeting 53BP1
Ren-Peng Xia, Chong-Hui Hu, Yuancheng Ye, Xiang Zhang +5 more
2023International Journal of Oncology14 citations Open access
Semantic Scholar
Cancer-associated fibroblast-derived circKLHL24 drives perineural invasion in pancreatic cancer via dual regulation of the sec31a-CXCL12 axis
Ting-Ting Li, Rihua He, Qing Tian, Tian-Hao Huang +9 more
2025Journal of experimental & clinical cancer research : CR12 citations Open access
Semantic Scholar
KHSRP Stabilizes m6A-Modified Transcripts to Activate FAK Signaling and Promote Pancreatic Ductal Adenocarcinoma Progression.
Zilan Xu, Yifan Zhou, Shao-Qiu Liu, Hong-Zhe Zhao +18 more
2024Cancer Research12 citations
Semantic Scholar
Correction: Cancer-associated fibroblasts promote progression and gemcitabine resistance via the SDF-1/SATB-1 pathway in pancreatic cancer
Lusheng Wei, Hui-Lin Ye, Guolin Li, Yuanting Lu +6 more
2021Cell Death and Disease11 citations Open access
Semantic Scholar
A novel anastomosis technique facilitates pancreaticojejunostomy in total laparoscopic pancreaticoduodenectomy (with video)
Yu Zhou, Jia-Bin Yang, Lusheng Wei, Qing Lin +5 more
2021Langenbeck's archives of surgery (Print)10 citations
Semantic Scholar

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