J. Eskildsen

Most-cited papers

1. The identification of AF38469: an orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin.

   T. J. Schrøder, Søren Christensen, Samsa Lindberg, M. Langgård +22 more

   2014Bioorganic & Medicinal Chemistry Letters46 citations Open access

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2. The synthesis and SAR of 2-arylsulfanylphenyl-1-oxyalkylamino acids as GlyT-1 inhibitors.

   G. Smith, G. Mikkelsen, J. Eskildsen, C. Bundgaard

   2006Bioorganic & Medicinal Chemistry Letters32 citations

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3. Discovery and optimization of Lu AF58801, a novel, selective and brain penetrant positive allosteric modulator of alpha-7 nicotinic acetylcholine receptors: attenuation of subchronic phencyclidine (PCP)-induced cognitive deficits in rats following oral administration.

   J. Eskildsen, J. Redrobe, Anette Graven Sams, K. Dekermendjian +6 more

   2014Bioorganic & Medicinal Chemistry Letters31 citations

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4. Identification of the first small-molecule ligand of the neuronal receptor sortilin and structure determination of the receptor–ligand complex

   J. Andersen, T. J. Schrøder, Søren Christensen, Dorthe Strandbygård +19 more

   2014Acta Crystallographica Section D: Biological Crystallography30 citations Open access

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5. Preparation and structural properties of 7,8-dioxa[6]helicenes and 7a,14c-dihydro-7,8-dioxa[6]helicenes.

   J. Eskildsen, F. Krebs, A. Faldt, P. Sommer-Larsen +1 more

   2001Journal of Organic Chemistry27 citations Open access

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6. Sequential functionalization of pyrazole 1-oxides via regioselective metalation: synthesis of 3,4,5-trisubstituted 1-hydroxypyrazoles.

   A. S. Paulson, J. Eskildsen, P. Vedsø, M. Begtrup

   2002Journal of Organic Chemistry23 citations

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7. Halogen dance in pyrazole 1-oxides: synthesis of pyrazolo[3,4-c]quinoline 1-oxides

   J. Eskildsen, Niels Østergaard, P. Vedsø, M. Begtrup

   200213 citations

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8. Synthesis of 2-Alkylpyrazole-1-oxides: A Facile Access to 1-Alkyl-5-halopyrazoles

   J. Eskildsen, P. Vedsø, M. Begtrup

   20017 citations

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9. AN IMPROVED SYNTHESIS OF 2,3-bis(BROMOMETHYL)-1,4-DIMETHOXYBENZENE

   J. Eskildsen, T. Christensen, T. Reenberg, Uffe S. Larsen +1 more

   20005 citations

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10. Acenaphtho[1,2‐b]pyrazine

    N. Thorup, J. Eskildsen, J. Christensen

    20061 citations

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11. Agonist Response Induced by Nicotinic α-7 Agonist is Inhibited by Antipsychotic Drugs

    K. Frederiksen, M. Jessen, J. F. Støier, K. Dekermendjian +4 more

    20140 citations Open access

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12. Antipsychotic compounds show inhibition of the human nicotinic acetylcholine α-7 receptor at high concentrations

    K. Frederiksen, C. Bundgaard, K. Dekermendjian, J. Redrobe +3 more

    20130 citations

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13. Discovery of Lu AF58801, a novel, selective and brain penetrant positive allosteric modulator of alpha-7 nicotinic acetylcholine receptors: Attenuation of subchronic phencyclidine (PCP)-induced cognitive deficits in rats following oral administration

    J. Bastlund, C. Bundgaard, K. Dekermendjian, R. Papke +3 more

    20130 citations

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14. Identification of histamine H3 receptor antagonists

    A. L. Del Tredici, J. Eskildsen, C. Andersen, Jian‐Nong Ma +11 more

    20070 citations

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15. 7,10-Diazafluoranthene (Acenaphtho[1,2-b]pyrazine)

    J. Eskildsen, J. Christensen

    20040 citations Open access

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