Researcher profile · Semantic Scholar

N. Sphyris

h-index: 19
Works: 27
Citations: 1,842

Most-cited papers

Epithelial-mesenchymal transition and cancer stem cells: a dangerously dynamic duo in breast cancer progression
Caitlin D. May, N. Sphyris, K. Evans, S. Werden +2 more
2011Breast Cancer Research334 citations Open access
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FOXC2 expression links epithelial-mesenchymal transition and stem cell properties in breast cancer
B. Hollier, A. Tinnirello, S. Werden, K. Evans +12 more
2013Cancer Research274 citations Open access
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Apc-mutant cells deploy Notum to bias clonal competition and drive cancer
D. Flanagan, Nalle Pentinmikko, Kalle Luopajärvi, Nicky J. Willis +32 more
2021Nature208 citations Open access
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GSK3β regulates epithelial-mesenchymal transition and cancer stem cell properties in triple-negative breast cancer
G. Vijay, N. Zhao, P. den Hollander, M. Toneff +17 more
2019Breast Cancer Research132 citations Open access
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Epigenetic silencing of microRNA-203 is required for EMT and cancer stem cell properties
J. Taube, G. Malouf, Emily Lu, N. Sphyris +12 more
2013Scientific Reports127 citations Open access
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GD3 Synthase regulates epithelial-mesenchymal transition and metastasis in breast cancer
T. R. Sarkar, V. Battula, S. Werden, G. Vijay +8 more
2014Oncogene117 citations Open access
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Mutational Analysis of the Ricinus Lectin B-chains
N. Sphyris, J. M. Lord, R. Wales, L. M. Roberts
1995Journal of Biological Chemistry81 citations Open access
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Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis
Joshua D. G. Leach, N. Vlahov, Petros K Tsantoulis, R. Ridgway +28 more
2021Nature Communications78 citations Open access
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The H3K27me3-demethylase KDM6A is suppressed in breast cancer stem-like cells, and enables the resolution of bivalency during the mesenchymal-epithelial transition
J. Taube, N. Sphyris, Kelsey S. Johnson, Keighley N Reisenauer +10 more
2017OncoTarget64 citations Open access
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EMT-induced metabolite signature identifies poor clinical outcome
S. Bhowmik, E. Ramirez-Peña, James M. Arnold, V. Putluri +6 more
2015OncoTarget58 citations Open access
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Phosphorylation of serine 367 of FOXC2 by p38 regulates ZEB1 and breast cancer metastasis, without impacting primary tumor growth
Sj Werden, N. Sphyris, Tr Sarkar, A. Paranjape +13 more
2016Oncogene57 citations Open access
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The MDM2 Ubiquitination Signal in the DNA-Binding Domain of p53 Forms a Docking Site for Calcium Calmodulin Kinase Superfamily Members
Ashley L. Craig, Jennifer A. Chrystal, Jennifer A. Fraser, N. Sphyris +5 more
2007Molecular and Cellular Biology57 citations Open access
Semantic Scholar
Mathematical modelling of phenotypic plasticity and conversion to a stem-cell state under hypoxia
A. Dhawan, S. A. Madani Tonekaboni, J. Taube, Stephen Hu +3 more
2016Scientific Reports47 citations Open access
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Subversion of Niche-Signalling Pathways in Colorectal Cancer: What Makes and Breaks the Intestinal Stem Cell
N. Sphyris, M. Hodder, O. Sansom
2021Cancers40 citations Open access
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FOXC2 regulates the G2/M transition of stem cell-rich breast cancer cells and sensitizes them to PLK1 inhibition
M. Pietilä, G. Vijay, R. Soundararajan, Xian-Yan Yu +3 more
2016Scientific Reports34 citations Open access
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Improved Retention of Zymogen Granules in Cultured Murine Pancreatic Acinar Cells and Induction of Acinar-Ductal Transdifferentiation In Vitro
N. Sphyris, C. Logsdon, D. Harrison
2005Pancreas34 citations
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pIgR: frenemy of inflammation, EMT, and HCC progression.
N. Sphyris, Sendurai A Mani
2011Journal of the National Cancer Institute22 citations Open access
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p53 deficiency exacerbates pleiotropic mitotic defects, changes in nuclearity and polyploidy in transdifferentiating pancreatic acinar cells
N. Sphyris, D. Harrison
2005Oncogene19 citations Open access
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p73α is a candidate effector in the p53 independent apoptosis pathway of cisplatin damaged primary murine colonocytes
A. Oniscu, N. Sphyris, R. Morris, S. Bader +1 more
2004Journal of Clinical Pathology19 citations Open access
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Glutathione and p53 independently mediate responses against oxidative stress in ES cells.
J. P. Coe, I. Rahman, N. Sphyris, A. Clarke +1 more
2002Free Radical Biology & Medicine13 citations
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GD2 and GD3 synthase: novel drug targets for cancer therapy
N. Sphyris, T. R. Sarkar, V. Battula, M. Andreeff +1 more
2015Molecular & Cellular Oncology10 citations Open access
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The importance of the epithelial-mesenchymal transition in breast cancer
N. Sphyris, Sendurai A Mani
20097 citations
Semantic Scholar
Induction of p21 and nuclear accumulation of TAp73alpha and c-abl during apoptosis of cisplatin-treated primary pancreatic acinar cells.
N. Sphyris, R. Morris, D. Harrison
2004International Journal of Oncology6 citations
Semantic Scholar
Carcinoma cells that have undergone an epithelial-mesenchymal transition differentiate into endothelial cells and contribute to tumor growth
N. Sphyris, C. King, J. Hoar, S. Werden +4 more
2021OncoTarget5 citations Open access
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Notum inhibits local Wnt signalling to increase the competitiveness of Apc -mutant clones
D. Flanagan, Nalle Pentinmikko, Kalle Luopajärvi, Nicky J. Willis +33 more
20210 citations
Semantic Scholar
The role of effective energy restriction on metastatic tumor growth
T. R. Sarkar, N. Sphyris, Emily Schmitt, Garhett L. Wyatt +2 more
20180 citations
Semantic Scholar
Studies on agglutinin from Ricinus communis : comparison with ricin.
N. Sphyris
19940 citations
Semantic Scholar

Jeffrey T. Chang

×5

G. Vijay×5

D. Harrison×5

M. Hodder×4

O. Sansom×4

R. Soundararajan×4

V. Battula×3

J. Rosen×3