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O. Brück · SciRah

Researcher profile · Semantic Scholar

O. Brück

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O. Brück — researcher profile on SciRah

h-index: 26
Works: 96
Citations: 2,133

Most-cited papers

Phenotype-based drug screening reveals association between venetoclax response and differentiation stage in acute myeloid leukemia
H. Kuusanmäki, Aino-Maija Leppä, P. Pölönen, M. Kontro +11 more
2019Haematologica165 citations Open access
Semantic Scholar
The Multi-modality Cell Segmentation Challenge: Towards Universal Solutions
Jun Ma, Ronald Xie, Shamini Ayyadhury, Cheng Ge +36 more
2023Nature Methods164 citations Open access
Semantic Scholar
Immunogenomic landscape of hematological malignancies
O. Dufva, P. Pölönen, O. Brück, M. Keränen +21 more
2018bioRxiv161 citations Open access
Semantic Scholar
Implementing a Functional Precision Medicine Tumor Board for Acute Myeloid Leukemia
D. Malani, Ashwini Kumar, O. Brück, M. Kontro +23 more
2021Cancer Discovery157 citations Open access
Semantic Scholar
Immune cell constitution in the tumor microenvironment predicts the outcome in diffuse large B-cell lymphoma
M. Autio, S. Leivonen, O. Brück, S. Mustjoki +6 more
2020Haematologica137 citations Open access
Semantic Scholar
Immune cell contexture in the bone marrow tumor microenvironment impacts therapy response in CML
O. Brück, Sami Blom, O. Dufva, Riku Turkki +9 more
2018Leukemia97 citations Open access
Semantic Scholar
PD-L1+ tumor-associated macrophages and PD-1+ tumor-infiltrating lymphocytes predict survival in primary testicular lymphoma
M. Pollari, O. Brück, T. Pellinen, P. Vähämurto +7 more
2018Haematologica86 citations Open access
Semantic Scholar
Single-cell characterization of anti–LAG-3 and anti–PD-1 combination treatment in patients with melanoma
Jani Huuhtanen, H. Kasanen, K. Peltola, T. Lönnberg +16 more
2023Journal of Clinical Investigation81 citations Open access
Semantic Scholar
Fibroblast subsets in non-small cell lung cancer: associations with survival, mutations, and immune features.
T. Pellinen, L. Paavolainen, A. Martín-Bernabé, Renata Papatella Araujo +14 more
2022Journal of the National Cancer Institute69 citations Open access
Semantic Scholar
Lumican is upregulated in osteoarthritis and contributes to TLR4-induced pro-inflammatory activation of cartilage degradation and macrophage polarization.
G. Barreto, B. Senturk, L. Colombo, O. Brück +4 more
2019Osteoarthritis and Cartilage69 citations Open access
Semantic Scholar
Immune profiles in acute myeloid leukemia bone marrow associate with patient age, T-cell receptor clonality, and survival.
O. Brück, O. Dufva, Helena R Hohtari, Sami Blom +13 more
2020Blood Advances65 citations Open access
Semantic Scholar
Immune cell constitution in bone marrow microenvironment predicts outcome in adult ALL
Helena R Hohtari, O. Brück, Sami Blom, Riku Turkki +6 more
2019Leukemia57 citations Open access
Semantic Scholar
T-cell inflamed tumor microenvironment predicts favorable prognosis in primary testicular lymphoma
S. Leivonen, M. Pollari, O. Brück, T. Pellinen +7 more
2018Haematologica57 citations Open access
Semantic Scholar
Somatic STAT3 mutations in Felty syndrome: an implication for a common pathogenesis with large granular lymphocyte leukemia
P. Savola, O. Brück, T. Olson, T. Kelkka +7 more
2017Haematologica57 citations Open access
Semantic Scholar
Somatic mutations in lymphocytes in patients with immune-mediated aplastic anemia
S. Lundgren, M. Keränen, M. Kankainen, Jani Huuhtanen +15 more
2021Leukemia51 citations Open access
Semantic Scholar
Machine Learning of Bone Marrow Histopathology Identifies Genetic and Clinical Determinants in Patients with MDS.
O. Brück, Susanna Lallukka-Brück, Helena R Hohtari, A. Ianevski +7 more
2021Cancer Discovery51 citations Open access
Semantic Scholar
Characterization of polydactyly chondrocytes and their use in cartilage engineering
E. Cavalli, Clara Levinson, M. Hertl, N. Broguiere +8 more
2019Scientific Reports49 citations Open access
Semantic Scholar
Clinical Impact of Immune Cells and Their Spatial Interactions in Diffuse Large B-Cell Lymphoma Microenvironment
M. Autio, S. Leivonen, O. Brück, M. Karjalainen-Lindsberg +2 more
2021Clinical Cancer Research47 citations Open access
Semantic Scholar
Dasatinib Reversibly Disrupts Endothelial Vascular Integrity by Increasing Non-Muscle Myosin II Contractility in a ROCK-Dependent Manner
A. Kreutzman, Beatriz Colom-Fernández, Ana Marcos Jímenez, M. Ilander +13 more
2017Clinical Cancer Research45 citations Open access
Semantic Scholar
Prognostic Impact of Tumor-Associated Macrophages on Survival Is Checkpoint Dependent in Classical Hodgkin Lymphoma
K. Karihtala, S. Leivonen, O. Brück, M. Karjalainen-Lindsberg +3 more
2020Cancers42 citations Open access
Semantic Scholar
A bibliometric analysis of the gender gap in the authorship of leading medical journals
O. Brück
2023Communications Medicine37 citations Open access
Semantic Scholar
Spatial immunoprofiling of the intratumoral and peritumoral tissue of renal cell carcinoma patients
O. Brück, Moon H. Lee, Riku Turkki, Ilona Uski +8 more
2021Modern Pathology30 citations Open access
Semantic Scholar
A bibliometric analysis of geographic disparities in the authorship of leading medical journals
O. Brück
2023Communications Medicine29 citations Open access
Semantic Scholar
Epigenetic modifier gene mutations in chronic myeloid leukemia (CML) at diagnosis are associated with risk of relapse upon treatment discontinuation
Shady Adnan Awad, O. Brück, N. Shanmuganathan, Timo Jarvinen +9 more
2022Blood Cancer Journal29 citations Open access
Semantic Scholar
Immunogenomic Landscape of Hematological Malignancies.
O. Dufva, P. Pölönen, O. Brück, M. Keränen +21 more
2020Cancer Cell28 citations Open access
Semantic Scholar
Prognostic implications of tumor-infiltrating T cells in early-stage endometrial cancer
M. Mendiola, T. Pellinen, J. Ramon-Patino, A. Berjón +11 more
2021Modern Pathology27 citations Open access
Semantic Scholar
T and NK cell abundance defines two distinct subgroups of renal cell carcinoma
Moon-Hee Lee, P. Järvinen, H. Nísen, O. Brück +7 more
2022Oncoimmunology26 citations Open access
Semantic Scholar
STAT3 Mutation Is Associated with STAT3 Activation in CD30+ ALK− ALCL
E. Andersson, O. Brück, T. Braun, S. Mannisto +7 more
2020Cancers26 citations Open access
Semantic Scholar
Somatic mTOR mutation in clonally expanded T lymphocytes associated with chronic graft versus host disease
Daehong Kim, Giljun Park, Jani Huuhtanen, S. Lundgren +19 more
2020Nature Communications23 citations Open access
Semantic Scholar
Age-associated changes in the immune system may influence the response to anti-PD1 therapy in metastatic melanoma patients
H. Kasanen, M. Hernberg, S. Mäkelä, O. Brück +5 more
2020Cancer Immunology and Immunotherapy21 citations Open access
Semantic Scholar
Computational textural mapping harmonises sampling variation and reveals multidimensional histopathological fingerprints
Otso Brummer, P. Pölönen, S. Mustjoki, O. Brück
2023British Journal of Cancer19 citations Open access
Semantic Scholar
An immunity and pyroptosis gene-pair signature predicts overall survival in acute myeloid leukemia
Weikaixin Kong, Li-Ye He, Jie Zhu, O. Brück +4 more
2022Leukemia19 citations Open access
Semantic Scholar
Integrative Analysis of Histological Textures and Lymphocyte Infiltration in Renal Cell Carcinoma using Deep Learning
Otso Brummer, P. Pölönen, S. Mustjoki, O. Brück
2022bioRxiv16 citations Open access
Semantic Scholar
Systematic drug screening reveals specific vulnerabilities and co-resistance patterns in endocrine-resistant breast cancer
Sara Kangaspeska, S. Hultsch, A. Jaiswal, H. Edgren +5 more
2016BMC Cancer13 citations Open access
Semantic Scholar
Characterization of tumor microenvironment and cell interaction patterns in testicular and diffuse large B-cell lymphomas
M. Autio, O. Brück, M. Pollari, M. Karjalainen-Lindsberg +6 more
2024Haematologica11 citations Open access
Semantic Scholar
E‐cadherin is a robust prognostic biomarker in colorectal cancer and low expression is associated with sensitivity to inhibitors of topoisomerase, aurora, and HSP90 in preclinical models
J. Bruun, P. Eide, C. Bergsland, O. Brück +9 more
2021Molecular Oncology11 citations Open access
Semantic Scholar
European health regulations reduce registry-based research
O. Brück, E. Sanmark, V. Ponkilainen, A. Bützow +3 more
2024Health Research Policy and Systems7 citations Open access
Semantic Scholar
Real-world evidence of multiple myeloma treated from 2013 to 2019 in the Hospital District of Helsinki and Uusimaa, Finland.
Johanna Vikkula, K. Uusi-Rauva, T. Ranki, I. Toppila +6 more
2023Future Oncology6 citations
Semantic Scholar
Granulocyte abundance and maturation state at diagnosis predicts treatment-free remission in CML
Mikko Purhonen, Mikael Tatun, Katariina Luukkainen, Kevin Hung +18 more
2025Leukemia5 citations Open access
Semantic Scholar
Single-Cell Characterization of the Immune and Leukemic Cells Following Anti-TIM3 and Hypomethylating Agent Combination Therapy in Patients with AML or MDS
Jani Huuhtanen, O. Brück, K. Peltonen, A. Kreutzman +16 more
2021Blood5 citations Open access
Semantic Scholar
Tumor cell FAP orchestrates EMT and immune suppression in aggressive localized ccRCC
T. Pellinen, L. Luomala, K. Mattila, A. Hemmes +13 more
2026Theranostics4 citations Open access
Semantic Scholar
Copy number alterations define outcome in Philadelphia chromosome-positive acute lymphoblastic leukemia
Helena R Hohtari, N. Pallisgaard, M. Kankainen, P. Ellonen +10 more
2022Haematologica4 citations Open access
Semantic Scholar
Machine Learning of Bone Marrow Histopathology Identifies Genetic and Clinical 1 Determinants in MDS Patients
O. Brück, Susanna Lallukka-Brück, Helena R Hohtari, Aleksandr +8 more
20214 citations
Semantic Scholar
Anti-PD1 therapy increases peripheral blood NKT cells and chemokines in metastatic melanoma patients
Henna Hakanen, M. Hernberg, S. Mäkelä, B. Yadav +6 more
2018Annals of Oncology4 citations Open access
Semantic Scholar
Fibroblast Activation Protein Defines an Aggressive, Immunosuppressive EMT-associated Tumor Subtype in Highly Inflamed Localized Clear Cell Renal Cell Carcinoma
T. Pellinen, L. Luomala, K. Mattila, A. Hemmes +12 more
2025bioRxiv3 citations Open access
Semantic Scholar
Evaluating Pediatric Reference Ranges for Extended Immunophenotyping from a Finnish Cohort against Published References
Elli Äärimaa, Anssi Kesäläinen, Samuel Askeli, Anne Toivonen +10 more
2025Journal of Clinical Immunology3 citations Open access
Semantic Scholar
Real‐world experience of novel multiple myeloma treatments in a large, single‐center cohort in Finland
H. Loponen, Juha Mehtälä, T. Ylisaukko-oja, O. Brück +4 more
2023eJHaem3 citations Open access
Semantic Scholar
Abstract A130: Metastatic melanoma patients responding to PD1 therapy have higher proportion of peripheral blood NKT-cells
Henna Hakanen, M. Hernberg, S. Mäkelä, B. Yadav +6 more
2019Maintenance of Immune Balance: Effects of Targeted and Immune Therapies3 citations
Semantic Scholar
Fibroblast activation protein defines aggressive EMT-associated cancer cell state and prognosis in localized ccRCC
T. Pellinen, L. Luomala, K. Mattila, A. Hemmes +12 more
3 citations
Semantic Scholar
Enhancing Severe Neutropenia Prediction: PKPD‐Informed Labeling for Machine Learning Models Trained on Real‐World Data
Conor J O'Hanlon, Jonas Denck, Elif Ozkirimli, Stefanie Bendels +6 more
2025Clinical pharmacology and therapy2 citations Open access
Semantic Scholar

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Jani Huuhtanen — researcher profile on SciRah

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