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J. Graff · SciRah

Researcher profile · Semantic Scholar

J. Graff

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J. Graff — researcher profile on SciRah

h-index: 22
Works: 51
Citations: 1,686

Most-cited papers

Clopidogrel but not aspirin reduces P‐selectin expression and formation of platelet‐leukocyte aggregates in patients with atherosclerotic vascular disease *
U. Klinkhardt, R. Bauersachs, Jan Adams, J. Graff +2 more
2003Clinical pharmacology and therapy212 citations
Semantic Scholar
Effects of the Oral, Direct Factor Xa Inhibitor Rivaroxaban on Platelet‐Induced Thrombin Generation and Prothrombinase Activity 1
J. Graff, N. von Hentig, F. Misselwitz, D. Kubitza +3 more
2007Journal of clinical pharmacology150 citations
Semantic Scholar
Anticoagulant Therapy with the Oral Direct Factor Xa Inhibitors Rivaroxaban, Apixaban and Edoxaban and the Thrombin Inhibitor Dabigatran Etexilate in Patients with Hepatic Impairment
J. Graff, S. Harder
2013Clinical Pharmacokinetics129 citations
Semantic Scholar
Clopidogrel, but not abciximab, reduces platelet leukocyte conjugates and P‐selectin expression in a human ex vivo in vitro model
U. Klinkhardt, J. Graff, S. Harder
2002Clinical pharmacology and therapy112 citations
Semantic Scholar
Genetic variants altering dopamine D2 receptor expression or function modulate the risk of opiate addiction and the dosage requirements of methadone substitution
A. Doehring, N. von Hentig, J. Graff, S. Salamat +4 more
2009Pharmacogenetics & Genomics108 citations
Semantic Scholar
Oral Plasma Kallikrein Inhibitor for Prophylaxis in Hereditary Angioedema
E. Aygören-Pürsün, A. Bygum, V. Grivcheva-Panovska, M. Magerl +29 more
2018New England Journal of Medicine102 citations Open access
Semantic Scholar
Novel oral anticoagulants: clinical pharmacology, indications and practical considerations
S. Harder, J. Graff
2013European Journal of Clinical Pharmacology99 citations
Semantic Scholar
Anti‐inflammatory effects of clopidogrel intake in renal transplant patients: Effects on platelet‐leukocyte interactions, platelet CD40 ligand expression, and proinflammatory biomarkers
J. Graff, S. Harder, O. Wahl, E. Scheuermann +1 more
2005Clinical pharmacology and therapy72 citations
Semantic Scholar
Transition from argatroban to oral anticoagulation with phenprocoumon or acenocoumarol: effects on prothrombin time, activated partial thromboplastin time, and Ecarin Clotting Time
S. Harder, J. Graff, U. Klinkhardt, N. von Hentig +4 more
2004Thrombosis and Haemostasis64 citations
Semantic Scholar
Effects of selective COX‐2 inhibition on prostanoids and platelet physiology in young healthy volunteers
J. Graff, C. Skarke, U. Klinkhardt, B. Watzer +4 more
2007Journal of Thrombosis and Haemostasis58 citations Open access
Semantic Scholar
Close relationship between the platelet activation marker CD62 and the granular release of platelet-derived growth factor.
J. Graff, U. Klinkhardt, V. Schini-Kerth, S. Harder +3 more
2002Journal of Pharmacology and Experimental Therapeutics58 citations
Semantic Scholar
Mobilization of hematopoietic stem cells with the novel CXCR4 antagonist POL6326 (balixafortide) in healthy volunteers—results of a dose escalation trial
D. Karpova, S. Bräuninger, E. Wiercinska, Ariane Krämer +11 more
2017Journal of Translational Medicine53 citations Open access
Semantic Scholar
Effects of parecoxib and dipyrone on platelet aggregation in patients undergoing meniscectomy: a double-blind, randomized, parallel-group study.
J. Graff, M. Arabmotlagh, R. Cheung, G. Geisslinger +1 more
2007Clinical Therapeutics47 citations
Semantic Scholar
Ex vivo–in vitro interaction between aspirin, clopidogrel, and the glycoprotein IIb/IIIa inhibitors abciximab and SR121566A
U. Klinkhardt, Carl M. Kirchmaier, D. Westrup, J. Graff +3 more
2000Clinical pharmacology and therapy40 citations
Semantic Scholar
Effects of antiplatelet agents on platelet-induced thrombin generation.
W. Wegert, J. Graff, D. Kaiser, H. Breddin +2 more
2002International journal of clinical pharmacology and therapeutics36 citations
Semantic Scholar
In vitro dose response to different GPIIb/IIIa-antagonists: inter-laboratory comparison of various platelet function tests.
S. Harder, U. Klinkhardt, J. Graff, D. Westrup +7 more
2001Thrombosis Research30 citations
Semantic Scholar
Prophylaxis of hereditary angioedema attacks: A randomized trial of oral plasma kallikrein inhibition with avoralstat.
E. Aygören-Pürsün, M. Magerl, J. Graff, I. Martínez-Saguer +11 more
2016Journal of Allergy and Clinical Immunology28 citations
Semantic Scholar
Induction of central signalling pathways and select functional effects in human platelets by β‐boswellic acid
Daniel Poeckel, L. Tausch, Anja Altmann, Christian Feisst +4 more
2005British Journal of Pharmacology28 citations Open access
Semantic Scholar
Immunosuppressive therapy regimen and platelet activation in renal transplant patients
J. Graff, U. Klinkhardt, S. Harder, W. Wegert +3 more
2002Clinical pharmacology and therapy28 citations
Semantic Scholar
Platelet-leucocyte adhesion markers before and after the initiation of antiretroviral therapy with HIV protease inhibitors.
N. von Hentig, Ann-Kristin Förster, Karina Kuczka, U. Klinkhardt +5 more
2008Journal of Antimicrobial Chemotherapy24 citations
Semantic Scholar
Differential in vitro effects of the platelet glycoprotein IIb/IIIa inhibitors abixicimab or SR121566A on platelet aggregation, fibrinogen binding and platelet secretory parameters.
Ute Klinkhardt, Carl M. Kirchmaier, Dagmar Westrup, H. Breddin +4 more
2000Thrombosis Research24 citations
Semantic Scholar
Significant effects of tipranavir on platelet aggregation and thromboxane B2 formation in vitro and in vivo.
J. Graff, N. von Hentig, Karina Kuczka, C. Angioni +4 more
2007Journal of Antimicrobial Chemotherapy23 citations Open access
Semantic Scholar
Multiple dose escalation study investigating the pharmacodynamics, safety, and pharmacokinetics of BAY 59-7939 an oral, direct Factor Xa inhibitor in healthy male subjects
S. Harder, J. Graff, N. von Hentig, F. Misselwitz +6 more
200321 citations
Semantic Scholar
Monitoring effects of direct FXa-inhibitors with a new one-step prothrombinase-induced clotting time (PiCT) assay: comparative in vitro investigation with heparin, enoxaparin, fondaparinux and DX 9065a.
J. Graff, B. Picard-Willems, S. Harder
2007International journal of clinical pharmacology and therapeutics20 citations
Semantic Scholar
Pharmacodynamic profile of antiplatelet agents: marked differences between single versus costimulation with platelet activators.
J. Graff, U. Klinkhardt, S. Harder
2004Thrombosis Research17 citations
Semantic Scholar
Anti-GPVI Fab SAR264565 effectively blocks GPVI function in ex vivo human platelets under arterial shear in a perfusion chamber
P. Florian, P. Wonerow, S. Harder, Karina Kuczka +2 more
2017European Journal of Clinical Pharmacology14 citations
Semantic Scholar
Levodopa pharmacokinetic‐pharmacodynamic modeling and 6‐[18F]levodopa positron emission tomography in patients with Parkinson's disease
M. Dietz, S. Harder, J. Graff, G. Kunig +3 more
2001Clinical pharmacology and therapy13 citations
Semantic Scholar
Pharmacokinetic Analysis of Mycophenolate Mofetil and Enteric-Coated Mycophenolate Sodium in Calcineurin Inhibitor–Free Renal Transplant Recipients
J. Graff, E. Scheuermann, G. Brandhorst, M. Oellerich +1 more
2016Therapeutic Drug Monitoring12 citations
Semantic Scholar
Pharmacodynamic characterization of the interaction between abciximab or tirofiban with unfractionated or a low molecular weight heparin in healthy subjects.
U. Klinkhardt, J. Graff, D. Westrup, Carl M. Kirchmaier +3 more
2001British Journal of Clinical Pharmacology11 citations Open access
Semantic Scholar
Does Early Clinical Manifestation of Hereditary Angioedema (HAE) Influence the Clinical Course of the Disease
I. Martínez-Saguer, J. Graff, E. Rusicke, E. Aygören-Pürsün +2 more
201310 citations
Semantic Scholar
Effect of oestrogen or cyproterone acetate treatment on adrenocortical function in prostate carcinoma patients.
T. Schurmeyer, J. Graff, T. Senge, E. Nieschlag
1986Acta Endocrinologica9 citations
Semantic Scholar
Abstracts from the 10th C1-inhibitor deficiency workshop
A. Schmaier, M. Cicardi, A. Reshef, D. Moldovan +337 more
2017Allergy, Asthma & Clinical Immunology8 citations Open access
Semantic Scholar
Pharmacodynamic characterization of the interaction between the glycoprotein IIb/IIIa inhibitor YM337 and unfractionated heparin and aspirin in humans.
J. Graff, U. Klinkhardt, D. Westrup, C. Kirchmaier +2 more
2003British Journal of Clinical Pharmacology7 citations Open access
Semantic Scholar
Potent Stem Cell Mobilization with the Novel CXCR4 Antagonist POL6326 - Results of a Phase IIa Dose Escalation Study in Comparison to G-CSF
D. Karpova, Susanne Brauninger, E. Wiercinska, Ariane Kraemer +9 more
20155 citations
Semantic Scholar
Efficacy Correlates with Plasma Levels in Opus-1, a Proof-of-Concept Study of Oral Kallikrein Inhibitor BCX4161 As a Prophylaxis Against Attacks of Hereditary Angioedema (HAE)
E. Aygören-Pürsün, M. Magerl, J. Graff, I. Martínez-Saguer +12 more
20155 citations Open access
Semantic Scholar
Platelet CD62 expression and PDGFAB secretion in patients undergoing PTCA and treatment with abciximab.
J. Graff, D. Andries, M. Elsner, Dagmar Westrup +4 more
2001British Journal of Clinical Pharmacology5 citations Open access
Semantic Scholar
BCX4161, an Oral Kallikrein Inhibitor, Showed Significant Benefits on Reducing Disease Burden and Improving Quality of Life in Subjects with Hereditary Angioedema in the Opus-1 Study
M. Magerl, E. Aygören-Pürsün, J. Graff, I. Martínez-Saguer +12 more
20154 citations
Semantic Scholar
Role of the retention test Homburg in evaluating platelet hyperactivity and in monitoring therapy with antiplatelet drugs.
B. Krischek, W. Brannath, U. Klinkhardt, J. Graff +6 more
2005Seminars in Thrombosis and Hemostasis3 citations
Semantic Scholar
Investigation of the PADA as a method for monitoring GPIIb/IIIa inhibitors and other antiplatelet agents.
J. Graff, S. Harder
2005Seminars in Thrombosis and Hemostasis2 citations
Semantic Scholar
Ex vivo/In vitro Interaction between ASA, Clopidogrel and GPIIb/IIIa-Inhibitors
C. Kirchmaier, D. Westrup, J. Graff, R. Mahnel +3 more
19992 citations
Semantic Scholar
Platelet activation markers after conversion from azathioprine to sirolimus based immunosuppression in renal transplant recipients.
J. Graff, S. Harder, C. Reiche, E. Scheuermann +1 more
2012International journal of clinical pharmacology and therapeutics1 citations
Semantic Scholar
Effects of P2Y12 inhibition on platelet function in renal transplant patients
J. Graff, Ute Klinkhardt, J. Gossmann, O. Wahl +1 more
20041 citations
Semantic Scholar
University of Southern Denmark Oral plasma kallikrein inhibitor for prophylaxis in hereditary angioedema Aygören-Pürsün,
E. Aygören-Pürsün, A. Bygum, V. Grivcheva-Panovska, M. Magerl +27 more
20180 citations
Semantic Scholar
Anti-GPVI Fab SAR264565 effectively blocks GPVI function in ex vivo human platelets under arterial shear in a perfusion chamber
P. Florian, P. Wonerow, S. Harder, Karina Kuczka +2 more
2017European Journal of Clinical Pharmacology0 citations
Semantic Scholar
PHARMOCOKINETICS OF MYCOPHENOLATE MOFETIL AND ENTERIC-COATED MYCOPHENOLATE SODIUM IN CALCINEURININHIBITOR-FREE TREATED RENAL TRANSPLANTAT PATIENTS: 183
J. Gossmann, J. Graff, I. Dragutinović, G. Brandhorst +2 more
20100 citations Open access
Semantic Scholar
Argatroban
J. Graff, S. Harder
2006Deutsche Medizinische Wochenschrift0 citations
Semantic Scholar
Role of the Retention Test Homburg in Evaluating Platelet Hyperactivity and in Monitoring Therapy with Antiplatelet Drugs
B. Krischek, W. Brannath, Ute Klinkhardt, J. Graff +6 more
20050 citations
Semantic Scholar
Inflammatory parameters in renal transplant patients before and after P2Y12 inhibition
J. Graff
20050 citations
Semantic Scholar
Investigation of the PADA as a Method for Monitoring GPIIb/IIIa Inhibitors and Other Antiplatelet Agents
J. Graff, S. Harder
20050 citations
Semantic Scholar
Effects of argatroban alone or in combination with phen‐procoumon or acenocoumarol on PT, APTT and ecarin clotting time
Ute Klinkhardt, J. Graff, H. Breddin, S. Harder
20030 citations
Semantic Scholar

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