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Stephen B. Helliwell · SciRah

Researcher profile · Semantic Scholar

Stephen B. Helliwell

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Stephen B. Helliwell — researcher profile on SciRah

h-index: 22
Works: 35
Citations: 3,316

Most-cited papers

Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo
William E. Dowdle, B. Nyfeler, Jane Nagel, R. Elling +43 more
2014Nature Cell Biology731 citations
Semantic Scholar
TOR1 and TOR2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologues in yeast.
Stephen B. Helliwell, Philipp Wagner, J. Kunz, M. Deuter‐Reinhard +2 more
1994Molecular Biology of the Cell403 citations Open access
Semantic Scholar
Components of a Ubiquitin Ligase Complex Specify Polyubiquitination and Intracellular Trafficking of the General Amino Acid Permease
Stephen B. Helliwell, S. Losko, C. Kaiser
2001Journal of Cell Biology285 citations Open access
Semantic Scholar
Protein–Protein Interactions of ESCRT Complexes in the Yeast Saccharomyces cerevisiae
K. Bowers, Jillian M Lottridge, Stephen B. Helliwell, Lisa M. Goldthwaite +2 more
2004Traffic : the International Journal of Intracellular Transport200 citations
Semantic Scholar
TOR2 is part of two related signaling pathways coordinating cell growth in Saccharomyces cerevisiae.
Stephen B. Helliwell, I. Howald, N. Barbet, Michael N. Hall
1998Genetics193 citations
Semantic Scholar
The Rho1 effector Pkc1, but not Bni1, mediates signalling from Tor2 to the actin cytoskeleton.
Stephen B. Helliwell, A. Schmidt, Y. Ohya, M. Hall
1998Current Biology172 citations Open access
Semantic Scholar
High-resolution chemical dissection of a model eukaryote reveals targets, pathways and gene functions.
D. Hoepfner, Stephen B. Helliwell, H. Sadlish, S. Schuierer +31 more
2014Microbiology Research153 citations Open access
Semantic Scholar
Yeast Protein Kinases and the RHO1 Exchange Factor TUS1 Are Novel Components of the Cell Integrity Pathway in Yeast
T. Schmelzle, Stephen B. Helliwell, M. Hall
2002Molecular and Cellular Biology150 citations Open access
Semantic Scholar
Eap1p, a Novel Eukaryotic Translation Initiation Factor 4E-Associated Protein in Saccharomyces cerevisiae
G. Cosentino, T. Schmelzle, Ashkan Haghighat, Stephen B. Helliwell +2 more
2000Molecular and Cellular Biology140 citations Open access
Semantic Scholar
Evidence for a functionally relevant rocaglamide binding site on the eIF4A:RNA complex
H. Sadlish, Gabriela Galicia-Vázquez, C. G. Paris, Thomas Aust +12 more
2013ACS Chemical Biology112 citations Open access
Semantic Scholar
Genome-wide CRISPR screen for PARKIN regulators reveals transcriptional repression as a determinant of mitophagy
Christoph Potting, C. Crochemore, F. Moretti, Florian Nigsch +15 more
2017Proceedings of the National Academy of Sciences of the United States of America91 citations Open access
Semantic Scholar
Single-cell and bulk transcriptomics of the liver reveals potential targets of NASH with fibrosis
Zhong-Yi Wang, A. Keogh, Annick Waldt, Rachel Cuttat +15 more
2021Scientific Reports90 citations Open access
Semantic Scholar
Target of Rapamycin Complex 2 Regulates Actin Polarization and Endocytosis via Multiple Pathways*
Delphine Rispal, S. Eltschinger, M. Stahl, Stefania Vaga +7 more
2015Journal of Biological Chemistry90 citations Open access
Semantic Scholar
TORC2 signaling pathway guarantees genome stability in the face of DNA strand breaks.
K. Shimada, I. Filipuzzi, M. Stahl, Stephen B. Helliwell +6 more
2013Molecules and Cells89 citations Open access
Semantic Scholar
NPR1 Kinase and RSP5-BUL1/2 Ubiquitin Ligase Control GLN3-dependent Transcription in Saccharomyces cerevisiae*
J. Crespo, Stephen B. Helliwell, C. Wiederkehr, P. Demougin +3 more
2004Journal of Biological Chemistry52 citations Open access
Semantic Scholar
CLN3 expression is sufficient to restore G1-to-S-phase progression in Saccharomyces cerevisiae mutants defective in translation initiation factor eIF4E.
Parisa Danaie, Michael Altmann, Michael N. Hall, H. Trachsel +1 more
1999Biochemical Journal51 citations Open access
Semantic Scholar
Preferential amplification of a human mitochondrial DNA deletion in vitro and in vivo
O. Russell, Isabelle Fruh, Pavandeep K. Rai, D. Marcellin +13 more
2018Scientific Reports41 citations Open access
Semantic Scholar
Tor Controls Translation Initiation and Early G1 Progression
Stephen B. Helliwell, N. Barbet, Ulrich Schneider, Ian Stansfield +2 more
199640 citations
Semantic Scholar
Pmr1, a Golgi Ca2+/Mn2+-ATPase, is a regulator of the target of rapamycin (TOR) signaling pathway in yeast
Gina Devasahayam, Danilo Ritz, Stephen B. Helliwell, D. Burke +1 more
2006Proceedings of the National Academy of Sciences of the United States of America38 citations Open access
Semantic Scholar
Stendomycin selectively inhibits tIM23-dependent mitochondrial protein import
I. Filipuzzi, Janos Steffen, Mitchel Germain, Laetitia Goepfert +9 more
2017Nature Chemical Biology31 citations Open access
Semantic Scholar
Target of rapamycin complex 2–dependent phosphorylation of the coat protein Pan1 by Akl1 controls endocytosis dynamics in Saccharomyces cerevisiae
Clélia Bourgoint, Delphine Rispal, M. Berti, I. Filipuzzi +3 more
2018Journal of Biological Chemistry30 citations Open access
Semantic Scholar
Auxin-Inducible Depletion of the Essentialome Suggests Inhibition of TORC1 by Auxins and Inhibition of Vrg4 by SDZ 90-215, a Natural Antifungal Cyclopeptide
Nathan A. Snyder, A. Kim, L. Kester, A. Gale +5 more
2019G3: Genes, Genomes, Genetics22 citations Open access
Semantic Scholar
High-Resolution Genetics Identifies the Lipid Transfer Protein Sec14p as Target for Antifungal Ergolines
I. Filipuzzi, S. Cotesta, Francesca Perruccio, B. Knapp +10 more
2016PLoS Genetics22 citations Open access
Semantic Scholar
An Integrated Approach for Identification and Target Validation of Antifungal Compounds Active against Erg11p
D. Hoepfner, Shantanu Karkare, Stephen B. Helliwell, Martin J. Pfeifer +12 more
2012Antimicrobial Agents and Chemotherapy21 citations Open access
Semantic Scholar
FR171456 is a specific inhibitor of mammalian NSDHL and yeast Erg26p
Stephen B. Helliwell, Shantanu Karkare, M. Bergdoll, A. Rahier +30 more
2015Nature Communications19 citations Open access
Semantic Scholar
Defining a longevity biotechnology company
Nicola Boekstein, N. Barzilai, André Bertram, Joe Betts-Lacroix +14 more
2023Nature Biotechnology14 citations
Semantic Scholar
Two low complexity ultra-high throughput methods to identify diverse chemically bioactive molecules using Saccharomyces cerevisiae.
Katarina Petrovic, Martin J. Pfeifer, C. Parker, S. Schuierer +5 more
2017Microbiology Research9 citations Open access
Semantic Scholar
A Lys27‐to‐Glu27 mutation in the human insulin‐like growth factor‐1 prevents disulfide linked dimerization and allows secretion of BiP when expressed in yeast
B. Chaudhuri, Stephen B. Helliwell, John P. Priestle
1991FEBS Letters8 citations
Semantic Scholar
A novel Kex2 enzyme can process the proregion of the yeast alpha-factor leader in the endoplasmic reticulum instead of in the Golgi.
Bhabatosh Chaudhuri, Sarah E. Latham, Stephen B. Helliwell, Peter Seeboth
1992Biochemical and Biophysical Research Communications - BBRC7 citations
Semantic Scholar
Loss of cytoplasmic actin filaments raises nuclear actin levels to drive INO80C-dependent chromosome fragmentation
Verena Hurst, C. Gerhold, Cleo V D Tarashev, K. Challa +8 more
2024Nature Communications6 citations Open access
Semantic Scholar
TORC2 inhibition triggers yeast chromosome fragmentation through misregulated Base Excision Repair of clustered oxidation events
K. Shimada, Cleo V D Tarashev, Stephanie Bregenhorn, C. Gerhold +6 more
2024Nature Communications5 citations Open access
Semantic Scholar
Development of Treatments and Therapies to Target Mitochondrial Dysfunction
Stephen B. Helliwell
20161 citations
Semantic Scholar
The Target of Rapamycin Complex 2-dependent phosphorylation of Pan1 by Akl1 controls endocytosis dynamics.
Clélia Bourgoint, Delphine Rispal, M. Berti, I. Filipuzzi +3 more
20180 citations
Semantic Scholar
Hoepfneretal NonAzoleERG11 AAC2012
D. Hoepfner, Shantanu Karkare, Stephen B. Helliwell, Martin J. Pfeifer +12 more
20130 citations
Semantic Scholar
NPR1 kinase and RSP5-BUL1/2 ubiquitin ligase control GLN3-dependent transcription in S. cerevisiae
J. Crespo, Stephen B. Helliwell, C. Wiederkehr, P. Demougin +4 more
20040 citations
Semantic Scholar

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