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A. Ambrogelly · SciRah

Researcher profile · Semantic Scholar

A. Ambrogelly

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A. Ambrogelly — researcher profile on SciRah

h-index: 26
Works: 52
Citations: 2,424

Most-cited papers

Natural expansion of the genetic code.
A. Ambrogelly, S. Palioura, D. Söll
2007Nature Chemical Biology332 citations
Semantic Scholar
An aminoacyl-tRNA synthetase that specifically activates pyrrolysine.
C. Polycarpo, A. Ambrogelly, A. Bérubé, SusAnn M. Winbush +4 more
2004Proceedings of the National Academy of Sciences of the United States of America201 citations Open access
Semantic Scholar
Efficient, chemoenzymatic process for manufacture of the Boceprevir bicyclic [3.1.0]proline intermediate based on amine oxidase-catalyzed desymmetrization.
Tao Li, Jack Liang, A. Ambrogelly, T. Brennan +11 more
2012Journal of the American Chemical Society163 citations
Semantic Scholar
Pyrrolysine analogues as substrates for pyrrolysyl‐tRNA synthetase
C. Polycarpo, S. Herring, A. Bérubé, John L. Wood +2 more
2006FEBS Letters160 citations Open access
Semantic Scholar
Pyrrolysine is not hardwired for cotranslational insertion at UAG codons
A. Ambrogelly, Sarath B. Gundllapalli, S. Herring, C. Polycarpo +2 more
2007Proceedings of the National Academy of Sciences of the United States of America128 citations Open access
Semantic Scholar
Separation of mAbs molecular variants by analytical hydrophobic interaction chromatography HPLC: overview and applications
Mark A Haverick, S. Mengisen, M. Shameem, A. Ambrogelly
2014mAbs122 citations Open access
Semantic Scholar
Developability studies before initiation of process development
Xiaoyu Yang, Wei Xu, Svetlana Dukleska, S. Benchaar +12 more
2013mAbs108 citations Open access
Semantic Scholar
Analytical comparability study of recombinant monoclonal antibody therapeutics
A. Ambrogelly, Stephen Gozo, Amit Katiyar, Shara M. Dellatore +12 more
2018mAbs82 citations Open access
Semantic Scholar
Distinct genetic code expansion strategies for selenocysteine and pyrrolysine are reflected in different aminoacyl-tRNA formation systems
Jing Yuan, P. O'Donoghue, A. Ambrogelly, Sarath B. Gundllapalli +4 more
2010FEBS Letters80 citations Open access
Semantic Scholar
Functional convergence of two lysyl-tRNA synthetases with unrelated topologies
T. Terada, O. Nureki, R. Ishitani, A. Ambrogelly +3 more
2002Nature Structural Biology80 citations
Semantic Scholar
Activation of the pyrrolysine suppressor tRNA requires formation of a ternary complex with class I and class II lysyl-tRNA synthetases.
C. Polycarpo, A. Ambrogelly, B. Ruan, D. Tumbula-Hansen +6 more
2003Molecules and Cells78 citations Open access
Semantic Scholar
Cysteine Activation Is an Inherent in Vitro Property of Prolyl-tRNA Synthetases*
I. Ahel, C. Stathopoulos, A. Ambrogelly, A. Sauerwald +3 more
2002Journal of Biological Chemistry76 citations Open access
Semantic Scholar
Orthologs of a novel archaeal and of the bacterial peptidyl–tRNA hydrolase are nonessential in yeast
G. Rosas-Sandoval, A. Ambrogelly, Jesse Rinehart, David Wei +5 more
2002Proceedings of the National Academy of Sciences of the United States of America68 citations Open access
Semantic Scholar
Recognition of pyrrolysine tRNA by the Desulfitobacterium hafniense pyrrolysyl-tRNA synthetase
S. Herring, A. Ambrogelly, C. Polycarpo, D. Söll
2007Nucleic Acids Research64 citations Open access
Semantic Scholar
Adding pyrrolysine to the Escherichia coli genetic code
O. Namy, Yu Zhou, Sarath B. Gundllapalli, C. Polycarpo +4 more
2007FEBS Letters61 citations Open access
Semantic Scholar
Assessment of AMBRTM as a model for high-throughput cell culture process development strategy
S. Moses, M. Manahan, A. Ambrogelly, Wai-Lam W. Ling
201260 citations Open access
Semantic Scholar
The amino‐terminal domain of pyrrolysyl‐tRNA synthetase is dispensable in vitro but required for in vivo activity
S. Herring, A. Ambrogelly, Sarath B. Gundllapalli, P. O'Donoghue +2 more
2007FEBS Letters59 citations Open access
Semantic Scholar
Functional Annotation of Class I Lysyl-tRNA Synthetase Phylogeny Indicates a Limited Role for Gene Transfer
A. Ambrogelly, D. Korencić, M. Ibba
2002Journal of Bacteriology42 citations Open access
Semantic Scholar
Comprehensive Analysis of the Therapeutic IgG4 Antibody Pembrolizumab: Hinge Modification Blocks Half Molecule Exchange In Vitro and In Vivo.
Xiaoyu Yang, Feng-Qiang Wang, Ying Zhang, Larry Wang +11 more
2015Journal of Pharmacy and Science39 citations
Semantic Scholar
Analysis and purification of IgG4 bispecific antibodies by a mixed-mode chromatography.
Xiaoyu Yang, Ying Zhang, Feng-Qiang Wang, Larry Wang +3 more
2015Analytical Biochemistry35 citations
Semantic Scholar
Characterization of antibody variants during process development: The tale of incomplete processing of N-terminal secretion peptide
A. Ambrogelly, Yan-Hui Liu, Hong Li, S. Mengisen +3 more
2012mAbs34 citations Open access
Semantic Scholar
Translation termination in pyrrolysine-utilizing archaea
E. Alkalaeva, B. Eliseev, A. Ambrogelly, P. Vlasov +5 more
2009FEBS Letters31 citations Open access
Semantic Scholar
tRNA Recognition by Glutamyl-tRNA Reductase*
Lennart Randau, S. Schauer, A. Ambrogelly, J. C. Salazar +5 more
2004Journal of Biological Chemistry31 citations Open access
Semantic Scholar
Enlarging the repertoire of therapeutic monoclonal antibodies platforms: domesticating half molecule exchange to produce stable IgG4 and IgG1 bispecific antibodies.
Xiaoyu Yang, A. Ambrogelly
2014Current Opinion in Biotechnology30 citations
Semantic Scholar
Aminoacyl-tRNA Synthesis by Pre-Translational Amino Acid Modification
Liang Feng, Kelly Sheppard, S. Namgoong, A. Ambrogelly +4 more
2004RNA Biology29 citations Open access
Semantic Scholar
A one-step method for in vitro production of tRNA transcripts.
D. Korencić, D. Söll, A. Ambrogelly
2002Nucleic Acids Research27 citations Open access
Semantic Scholar
Methanocaldococcus jannaschii Prolyl-tRNA Synthetase Charges tRNAPro with Cysteine*
A. Ambrogelly, I. Ahel, C. Polycarpo, Shipra Bunjun-Srihari +7 more
2002Journal of Biological Chemistry25 citations Open access
Semantic Scholar
Ultrafast and high-throughput N-glycan analysis for monoclonal antibodies
Xiaoyu Yang, Sunnie Kim, Richard Ruzanski, Yuetian Chen +8 more
2016mAbs23 citations Open access
Semantic Scholar
A Bacterial Ortholog of Class II Lysyl-tRNA Synthetase Activates Lysine
A. Ambrogelly, P. O'Donoghue, D. Söll, Sharath Moses
2010FEBS Letters21 citations Open access
Semantic Scholar
Asymmetric behavior of archaeal prolyl‐tRNA synthetase
A. Ambrogelly, S. Kamtekar, C. Stathopoulos, D. Kennedy +1 more
2005FEBS Letters15 citations Open access
Semantic Scholar
A high throughput ultra performance size exclusion chromatography assay for the analysis of aggregates and fragments of monoclonal antibodies
X. Mou, Xiaoyu Yang, Hong Li, A. Ambrogelly +1 more
201414 citations Open access
Semantic Scholar
Transfer RNA recognition by class I lysyl‐tRNA synthetase from the Lyme disease pathogen Borrelia burgdorferi
A. Ambrogelly, M. Frugier, M. Ibba, D. Söll +1 more
2005FEBS Letters14 citations
Semantic Scholar
Isolation and characterization of a monoclonal antibody containing an extra heavy-light chain Fab arm
Daniel Boyd, A. Ebrahimi, S. Ronan, B. Mickus +4 more
2018mAbs13 citations Open access
Semantic Scholar
Cysteinyl‐tRNA formation and prolyl‐tRNA synthetase
C. Jacquin-Becker, I. Ahel, A. Ambrogelly, B. Ruan +2 more
2002FEBS Letters12 citations
Semantic Scholar
Screening of Reducing Agents for the PEGylation of Recombinant Human IL-10
A. Ambrogelly, Collette Cutler, Brittany C. Paporello
2013The Protein Journal11 citations
Semantic Scholar
Genomics and the evolution of aminoacyl-tRNA synthesis.
B. Ruan, I. Ahel, A. Ambrogelly, H. Becker +14 more
2001Acta Biochimica Polonica11 citations Open access
Semantic Scholar
Misacylation of pyrrolysine tRNA in vitro and in vivo
Sarath B. Gundllapalli, A. Ambrogelly, T. Umehara, Darrick Li +2 more
2008FEBS Letters10 citations Open access
Semantic Scholar
Quantification of a recombinant antigen in an immuno-stimulatory whole yeast cell-based therapeutic vaccine.
Jenny Wang, D. Stenzel, Ally Liu, Deng-Feng Liu +2 more
2018Analytical Biochemistry9 citations
Semantic Scholar
The Different Colors of mAbs in Solution
A. Ambrogelly
2021Antibodies7 citations Open access
Semantic Scholar
Taking the Hinge off: An Approach to Effector-Less Monoclonal Antibodies
Jamie Valeich, Daniel Boyd, Manu Kanwar, D. Stenzel +5 more
2020Antibodies7 citations Open access
Semantic Scholar
Class I Lysyl-tRNA Synthetases
A. Ambrogelly, D. Söll, O. Nureki, S. Yokoyama +1 more
20136 citations
Semantic Scholar
Features of Aminoacyl-tRNA Synthesis Unique to Archaea
C. Polycarpo, Kelly Sheppard, Lennart Randau, A. Ambrogelly +11 more
20073 citations
Semantic Scholar
A path to building quality during monoclonal antibody candidate selection
A. Ambrogelly, Valentyn Antochshuk, Shuangping Shi, Zhong Liu +1 more
20152 citations
Semantic Scholar
Effect of pegylation on self-association of IFN-α2b.
A. Mohs, A. Ambrogelly, Xiaoyu Yang, Mark A Haverick +3 more
2014Molecular Pharmaceutics1 citations
Semantic Scholar
IL-10 mono- and diPEGylated and their uses
S. Blaisdell, Collette Cutler, Brittany C. Paporello, A. Ambrogelly
20090 citations
Semantic Scholar
The production and use of mono-and di-PEG-IL-10
S. Blaisdell, Collette Cutler, Brittany C. Paporello, A. Ambrogelly
20090 citations
Semantic Scholar
Aminoacyl‐tRNAs: Deciphering and Defining the Genetic Message
A. Ambrogelly, J. C. Salazar, Kelly Sheppard, C. Polycarpo +5 more
20070 citations
Semantic Scholar
Recognition in vitro of the suppressor tRNAPyl by the class II‐like Pyrrolsyl‐tRNA Synthetase
S. Herring, Darrick Li, A. Ambrogelly, C. Polycarpo +1 more
20060 citations
Semantic Scholar
Mischarging of M. barkeri tRNAPyl with alanine and serine in vitro
Darrick Li, C. Polycarpo, A. Ambrogelly, D. Söll
20060 citations
Semantic Scholar
Minireview Cysteinyl-tRNA formation and prolyl-tRNA synthetase
C. Jacquin-Becker, I. Ahel, A. Ambrogelly, B. Ruan +1 more
20020 citations
Semantic Scholar

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