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D. Roche · SciRah

Researcher profile · Semantic Scholar

D. Roche

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D. Roche — researcher profile on SciRah

h-index: 15
Works: 71
Citations: 761

Most-cited papers

Exploring new targets and chemical space with affinity selection-mass spectrometry
R. Prudent, D. A. Annis, Peter J. Dandliker, J. Ortholand +1 more
2020Nature Reviews Chemistry90 citations
Semantic Scholar
Rhodium(III)-catalyzed allylic C-H bond amination. Synthesis of cyclic amines from ω-unsaturated N-sulfonylamines.
T. Cochet, V. Bellosta, D. Roche, J. Ortholand +2 more
2012Chemical Communications77 citations
Semantic Scholar
Isoform-selective ATAD2 chemical probe with novel chemical structure and unusual mode of action
A. Fernandez-Montalvan, M. Berger, Benno Kuropka, S. Koo +26 more
2017ACS Chemical Biology70 citations Open access
Semantic Scholar
Mild and regioselective oxidative bromination of anilines using potassium bromide and sodium perborate
D. Roche, K. Prasad, O. Repič, T. Blacklock
200055 citations
Semantic Scholar
Enantioselective acylation of β-aminoesters using penicillin G Acylase in organic solvents
D. Roche, K. Prasad, O. Repič
199944 citations
Semantic Scholar
Discovery of novel Cyclophilin D inhibitors starting from three dimensional fragments with millimolar potencies
U. Grädler, D. Schwarz, M. Blaesse, B. Leuthner +8 more
2019Bioorganic & Medicinal Chemistry Letters41 citations Open access
Semantic Scholar
1,4-Diazepane-2-ones as novel inhibitors of LFA-1.
S. Wattanasin, R. Albert, C. Ehrhardt, D. Roche +4 more
2003Bioorganic & Medicinal Chemistry Letters36 citations Open access
Semantic Scholar
Total syntheses of bengamides B and E.
F. Kinder, S. Wattanasin, R. Versace, K. Bair +11 more
2001Journal of Organic Chemistry28 citations
Semantic Scholar
Leucettinibs, a Class of DYRK/CLK Kinase Inhibitors Inspired by the Marine Sponge Natural Product Leucettamine B.
Emmanuel Deau, M. Lindberg, Frédéric Miege, D. Roche +5 more
2023Journal of Medicinal Chemistry27 citations Open access
Semantic Scholar
Discovery and structure-guided drug design of inhibitors of 11beta-hydroxysteroid-dehydrogenase type I based on a spiro-carboxamide scaffold.
Franck F. Lepifre, Serge Christmann-Franck, D. Roche, C. Leriche +7 more
2009Bioorganic & Medicinal Chemistry Letters27 citations Open access
Semantic Scholar
Design, synthesis and decoration of molecular scaffolds for exploitation in the production of alkaloid-like libraries.
Philip G. E. Craven, A. Aimon, Mark Dow, N. Fleury‐Brégeot +7 more
2015Bioorganic & Medicinal Chemistry25 citations
Semantic Scholar
Discovery and structure-activity relationships of pentanedioic acid diamides as potent inhibitors of 11beta-hydroxysteroid dehydrogenase type I.
D. Roche, D. Carniato, C. Leriche, Franck F. Lepifre +8 more
2009Bioorganic & Medicinal Chemistry Letters19 citations Open access
Semantic Scholar
Synthesis and biological properties of macrolactam analogs of the natural product macrolide (-)-A26771B.
S. Canova, Renaud H. M. Lepine, A. Thys, A. Baron +1 more
2011Bioorganic & Medicinal Chemistry Letters18 citations
Semantic Scholar
Rational Drug Design of Topically Administered Caspase 1 Inhibitors for the Treatment of Inflammatory Acne.
J. Fournier, L. Clary, Sandrine Chambon, Laurence Dumais +25 more
2018Journal of Medicinal Chemistry16 citations Open access
Semantic Scholar
An improved procedure of the Pechmann condensation in the synthesis of 8-ethyltrimethoxy-6H-benzo[d]naphtho[1,2-b]pyran-6-ones structurally related to the aglycon of gilvocarcins
D. Hua, S. Saha, D. Roche, J. Maeng +2 more
199216 citations
Semantic Scholar
Effect of a Phosphazene Base on the Diastereoselectivity of Addition of alpha-Sulfonyl Carbanions to Butyraldehyde and Isopropylideneglyceraldehyde.
A. Solladié-Cavallo*, D. Roche, J. Fischer, A. de Cian
1996Journal of Organic Chemistry15 citations
Semantic Scholar
Innovative approaches to the design and synthesis of small molecule libraries.
A. Nelson, D. Roche
2015Bioorganic & Medicinal Chemistry14 citations
Semantic Scholar
Structure-based design of 7-azaindole-pyrrolidine amides as inhibitors of 11β-hydroxysteroid dehydrogenase type I.
E. Valeur, Serge Christmann-Franck, Franck F. Lepifre, D. Carniato +10 more
2010Bioorganic & Medicinal Chemistry Letters14 citations Open access
Semantic Scholar
Therapeutic potential of compounds targeting SARS-CoV-2 helicase
Matthew T. J. Halma, M. Wever, S. Abeln, D. Roche +1 more
2022Frontiers in Chemistry13 citations Open access
Semantic Scholar
N-Formylsaccharin: A New Formylating Agent
T. Cochet, V. Bellosta, A. Greiner, D. Roche +1 more
201113 citations
Semantic Scholar
Novel 2,7-Diazaspiro[4,4]nonane Derivatives to Inhibit Mouse and Human Osteoclast Activities and Prevent Bone Loss in Ovariectomized Mice without Affecting Bone Formation.
L. Mounier, A. Morel, Y. Ferrandez, J. Morko +5 more
2020Journal of Medicinal Chemistry12 citations Open access
Semantic Scholar
Translation of innovative chemistry into screening libraries: an exemplar partnership from the European Lead Factory.
R. Morgentin, Mark Dow, A. Aimon, George Karageorgis +4 more
2018Drug Discovery Today11 citations Open access
Semantic Scholar
PS-SNAP, a practical polymer-supported nitrosation reagent in organic synthesis
D. Roche, C. Lardy, L. Tournier, M. Prunier +1 more
201011 citations
Semantic Scholar
Retention of Configuration in Displacement Reactions of 2-Chloro-1,3,2-oxazaphospholidin-2-one. Stereoselective 1,4-Addition Reaction of the Anion of Chiral 2-Propenylphosphonamide
D. Hua, J. Chen, S. Saha, Hui Wang +5 more
200210 citations
Semantic Scholar
New Caspase-1 inhibitor by scaffold hopping into bio-inspired 3D-fragment space.
A. Brethon, L. Chantalat, O. Christin, L. Clary +8 more
2017Bioorganic & Medicinal Chemistry Letters9 citations Open access
Semantic Scholar
(E)‐Dimethyl 2‐Oxopent‐3‐enylphosphonate: An Excellent Substrate for Cross‐Metathesis – Easy Access to Functionalized Heterocycles
T. Cochet, D. Roche, V. Bellosta, J. Cossy
20129 citations
Semantic Scholar
Efficient, mild, parallel and purification-free synthesis of aryl ethers via the Mitsunobu reaction
E. Valeur, D. Roche
20089 citations
Semantic Scholar
Synthesis of benzylated (R)- and as conformationally restricted building blocks for the preparation of E- and P-selectin antagonists
D. Roche, R. Bänteli, T. Winkler, Florence Casset +1 more
19987 citations
Semantic Scholar
Stereoselective synthesis of 2-amino-5-hydroxycaprolactams from l-glutamic acid
D. Roche, K. Prasad, O. Repič, T. Blacklock
20016 citations
Semantic Scholar
The Hydroxypinanone as Chiral Auxiliary in Michael Additions: an Inversion of Diastereoselectivity at Low Concentration of Enolate, a Substrate-Directed Approach
A. Solladié-Cavallo*, J. Koessler, Thomas Isarno, D. Roche +1 more
19975 citations
Semantic Scholar
Stereoselective synthesis of (4S,5R,6S)-4-(5,6-epoxy-6-phenyl)-γ-lactone
A. Solladié-Cavallo*, D. Roche, G. Bold, F. Acemoglu +3 more
19964 citations
Semantic Scholar
N-Formylsaccharin: A New Formylating Agent.
T. Cochet, V. Bellosta, A. Greiner, D. Roche +1 more
20113 citations
Semantic Scholar
Structure of cis,cis-4,6-diphenyl-2-(2-propenyl)-1,3-dioxa-2-phosphorinane 2-oxide.
D. Hua, D. Roche, S. Bharathi, X. Wu +1 more
1992Acta Crystallographica Section C: Crystal Structure Communications2 citations
Semantic Scholar
Structure of 8-ethyl-4,10,12-trimethoxy-6H-benzo[d]naphtho[1,2-b]pyran-6-one
P. Robinson, D. Hua, D. Roche, S. Saha
19912 citations
Semantic Scholar
Abstract 5084: Potent and isoform-selective ATAD2 bromodomain inhibitor with unprecedented chemical structure and mode of action
A. Fernandez-Montalvan, M. Berger, Benno Kuropka, S. Koo +23 more
20171 citations
Semantic Scholar
An expedient synthesis of non-racemic N-alkylated pyrrolidin-2,5-diones and piperidin-2,6-diones as peptidomimetics
A. Brethon, C. Bouix-Peter, L. Clary, J. Fournier +5 more
20161 citations
Semantic Scholar
Rhodium(III)-Catalyzed Allylic C—H Bond Amination. Synthesis of Cyclic Amines from ω-Unsaturated N-Sulfonylamines.
T. Cochet, V. Bellosta, D. Roche, J. Ortholand +2 more
20131 citations
Semantic Scholar
Stereoselective synthesis of (E)-N,N-diethyl-3-(imidazo[1,2-a]pyrid-2-yl)-2-(phenylsulfonyl)propenamide
S. Céard, D. Roche, V. Gaumet, D. Gardette +2 more
20021 citations
Semantic Scholar
Enantioselective Acylation of β-Aminoesters Using Penicillin G Acylase in Organic Solvents.
D. Roche, K. Prasad, O. Repič
19991 citations
Semantic Scholar
Synthesis of Benzylated (R)‐ and (S)‐Aminoethyl‐C‐α‐D‐mannosides as Conformationally Restricted Building Blocks for the Preparation of E‐ and P‐Selectin Antagonists.
D. Roche, Rolf Baenteli, T. Winkler, Florence Casset +1 more
19981 citations
Semantic Scholar
(E)-3-(4-Chlorophenyl)-3-cyclopropyl-2-(phenylthio)acrylonitrile
D. Roche, J. Métin, M. Madesclaire
19961 citations
Semantic Scholar
Structure of (2R,4R,5R)-2-chloro-3-isopropyl-4-methyl-5-phenyl-1,3,2-oxazaphospholidine 2-oxide
P. Robinson, D. Hua, D. Roche
19921 citations
Semantic Scholar
Chemiluminescence and radioimmunology compared for 10 allergens.
D. Roche, H. D. de Luca, N. Tugendhaft
1991Clinical Chemistry1 citations
Semantic Scholar
(Z)-Methyl 2-phenyl-2-(pyrid-4-yl)vinyl sulfoxide
M. Madesclaire, J. Métin, D. Roche, Annie Fauve
19901 citations
Semantic Scholar
Crystal structure of human Caspase-1 with (3S,6S,10aS)-N-((2S,3S)-2-hydroxy-5-oxotetrahydrofuran-3-yl)-6-(isoquinoline-1-carboxamido)-5-oxodecahydropyrrolo[1,2-a]azocine-3-carboxamide (PGE-3935199)
A. Brethon, L. Chantalat, O. Christin, L. Clary +8 more
20180 citations
Semantic Scholar
Crystal structure of human Caspase-1 with 2-((2-naphthoyl)-L-valyl)-4-hydroxy-N-((3S)-2-hydroxy-5-oxotetrahydrofuran-3-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide (Compound 1)
A. Brethon, L. Chantalat, O. Christin, L. Clary +8 more
20170 citations
Semantic Scholar
The metabolic sensors FXR (cid:1) , PGC-1 (cid:1) , and SIRT1 cooperatively regulate hepatitis B virus transcription
Claire Curtil, L. Enache, P. Radreau, Anne-Gaëlle Dron +6 more
20140 citations
Semantic Scholar
(E)‐Dimethyl 2‐Oxopent‐3‐enylphosphonate: An Excellent Substrate for Cross‐Metathesis — Easy Access to Functionalized Heterocycles.
T. Cochet, D. Roche, V. Bellosta, J. Cossy
20120 citations
Semantic Scholar
A Polymer-Supported Nitrosation Reagent of Amines
D. Roche, C. Lardy, L. Tournier, M. Prunier +1 more
20100 citations
Semantic Scholar
Mild and Regioselective Oxidative Bromination of Anilines Using Potassium Bromide and Sodium Perborate.
D. Roche, K. Prasad, O. Repič, T. Blacklock
20100 citations
Semantic Scholar

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