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F. Hyland · SciRah

Researcher profile · Semantic Scholar

F. Hyland

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F. Hyland — researcher profile on SciRah

h-index: 4
Works: 62
Citations: 290

Most-cited papers

Development and Validation of a Scalable Next-Generation Sequencing System for Assessing Relevant Somatic Variants in Solid Tumors
D. Hovelson, A. Mcdaniel, A. Cani, Bryan W. Johnson +29 more
2015Neoplasia207 citations Open access
Semantic Scholar
A scalable solution for tumor mutational burden from formalin-fixed, paraffin-embedded samples using the Oncomine Tumor Mutation Load Assay.
R. Chaudhary, L. Quagliata, Jermann Philip Martin, I. Alborelli +6 more
2018Translational Lung Cancer Research40 citations Open access
Semantic Scholar
Challenges in bioinformatics approaches to tumor mutation burden analysis
F. Fenizia, R. Pasquale, R. E. Abate, M. Lambiase +6 more
2021Oncology Letters7 citations Open access
Semantic Scholar
Haplotype Analysis of the T-Cell Receptor Beta (TCRB) Locus by Long-amplicon TCRB Repertoire Sequencing
T. Looney, D. Duose, G. Lowman, E. Linch +17 more
2019Journal of Immunotherapy and Precision Oncology7 citations Open access
Semantic Scholar
Validation of a targeted next-generation sequencing panel for tumor mutation burden analysis: results from the Onconetwork Immuno-Oncology Consortium.
F. Fenizia, I. Alborelli, J. L. Costa, C. Vollbrecht +18 more
2021Journal of Molecular Diagnostics4 citations Open access
Semantic Scholar
Estimating tumor mutation burden using next-generation sequencing assay.
R. Chaudhary, John W. Bishop, A. Broomer, D. Cyanam +4 more
20174 citations
Semantic Scholar
Abstract 158: Custom primer design pipeline and analysis workflow for targeted methylation sequencing using NGS Ion AmpliSeq technology
Zun-Ping Luo, Loni Pickle, Andrew Hatch, Aren Ewing +4 more
2020Molecular and Cellular Biology / Genetics3 citations
Semantic Scholar
Somatic mutation burden in cancer samples determined by targeted next generation sequencing.
D. Cyanam, A. Broomer, D. Mandelman, R. Chaudhary +7 more
20173 citations
Semantic Scholar
Abstract 764: Fully automated sample-to-report NGS workflow for comprehensive genomic profiling for myeloid neoplasms
Marina Sedova, Alexy Ongpin, Jennifer M. Burke, Collyn Seeger +7 more
2022Cancer Research2 citations
Semantic Scholar
Haplotype Analysis of the TRB Locus by TCRB Repertoire Sequencing
T. Looney, D. Duose, G. Lowman, E. Linch +17 more
2018bioRxiv2 citations Open access
Semantic Scholar
Abstract 3622: Complete workflow for detection of low frequency somatic mutations from cell-free DNA using Ion Torrent™ platforms
Jian Gu, D. Brinza, A. Mongan, Richard Chien +3 more
20162 citations
Semantic Scholar
Abstract 2402: A research approach for the detection of somatic mutations at 0.5% frequency from cfDNA and cTc DNA using a multiplex sequencing assay targeting 2000 tumor mutations
D. Brinza, Dalia M. Dhingra, C. Scafe, Richard Chien +1 more
20152 citations
Semantic Scholar
Fully Automated Workflows Quantify and Report Key T-Cell and B-Cell Receptor Biomarkers Relevant to Immuno-Oncology and Heme-Oncology Research
S. Sarda, G. Lowman, Michelle A. Toro, Loni Pickle +2 more
2021Blood1 citations Open access
Semantic Scholar
Abstract 1207: Custom next-generation sequencing primer designs for targeted sequencing of multi strain viral targets
R. Singh, Na Li, Zun-Ping Luo, Anna M. McGeachy +3 more
2020Epidemiology1 citations
Semantic Scholar
Abstract 1701: Improvement of tumor mutation burden measurement by removal of deaminated bases in FFPE DNA
W. Tom, R. Chaudhary, V. Mittal, D. Cyanam +6 more
2019Molecular and Cellular Biology / Genetics1 citations
Semantic Scholar
Abstract 4668: Evidence for antigen-driven TCRB chain convergence in the tumor infiltrating T cell repertoire of 85 research subjects with melanoma
T. Looney, S. Glenn, S. Pabla, J. Conroy +8 more
2018Immunology1 citations
Semantic Scholar
Comprehensive detection of ctDNA variants at 0.1% allelic frequency using a broad targeted NGS panel for liquid biopsy research.
Richard Chien, D. Brinza, Jian Gu, Dalia M. Dhingra +10 more
20171 citations
Semantic Scholar
Abstracts from the 4th ImmunoTherapy of Cancer Conference
J. Ženka, V. Caisová, O. Uher, P. Nedbalova +298 more
2017Journal of Immunotherapy for Cancer1 citations Open access
Semantic Scholar
The Oncomine Cancer Research Panel, a scalable next-generation sequencing system for relevant somatic variant assessment in solid tumors.
D. Hovelson, A. Cani, A. Mcdaniel, Bryan W. Johnson +16 more
20151 citations
Semantic Scholar
P46.07 An Extended Targeted RNA Sequencing for Fusion Detection with Oncomine Comprehensive Assay Plus
A. Marcovitz, Rajesh Gottimukkala, G. Bee, J. Kilzer +9 more
20210 citations Open access
Semantic Scholar
Abstract 2079: Prediction of DDR and other mutation signatures using targeted panels for FFPE samples
F. Hyland, Ajithavalli Chellappan, Chintan N. Vora, Shilpa Nair +3 more
2021Molecular and Cellular Biology/Genetics0 citations
Semantic Scholar
Abstract 6472: Clonal lineage and somatic hypermutation analysis of chronic lymphocytic leukemia by long-amplicon IGH chain sequencing
Jayde Chang, Z. Davis, G. Quest, Harriet Feilloter +5 more
2020Endocrinology0 citations
Semantic Scholar
Abstract 3118: Next generation sequencing assay for detection of gene fusions and exon deletion events in tissue and liquid biopsy samples at very low frequency
Rajesh Gottimukkala, F. Hyland, A. Marcovitz, J. Schageman +7 more
2020Clinical Trials0 citations
Semantic Scholar
680 Automated Ion torrent based solution enables accurate gut microbiome quantification of bacterial species relevant to research in cancer and its response to immunotherapy
S. Sarda, David Merrill, Heesun Shin, Anna M. McGeachy +5 more
20200 citations Open access
Semantic Scholar
Abstract 5472: Development of customizable targeted RNA fusion panels using a novel automated high-multiplexing primer design strategy
Na Li, Antonio Martínez-Alcántara, Aren Ewing, Rajesh Gottimukkala +2 more
2020Clinical research0 citations
Semantic Scholar
Abstract 3305: Comparative analysis of RNA versus DNA as input material for IGH repertoire sequencing based detection of rare clonal B cells at a frequency of 10E-6
Michelle A. Toro, Loni Pickle, Jayde Chang, T. Looney +3 more
2020Immunology0 citations
Semantic Scholar
Abstract 170: Development and analytical validation of a novel next-generation DNA sequencing assay, the oncomine lymphoma panel, to detect SNV, insertion, deletion and copy number variants in 25 Lymphoma genes in FFPE samples
F. Hyland, C. Scafe, Yun Zhu, Chenchen Yang +6 more
2020Molecular and Cellular Biology / Genetics0 citations
Semantic Scholar
Abstract 1326: A novel system that produces pre-qualified cancer NGS panels with customizable content
Steve Roman, C. Scafe, Yun Zhu, Fernando Farfán +9 more
2020Molecular and Cellular Biology / Genetics0 citations
Semantic Scholar
Abstract 4279: Automated TRB locus haplotype analysis by long-amplicon TCRB chain sequencing for immune-related adverse events biomarker research
Jennifer M. Burke, Frances Chan, Jia-Jie Huang, Marina Sedova +2 more
2020Clinical Trials0 citations
Semantic Scholar
Abstract 177: RNA sequencing based gene fusion detection with oncomine comprehensive assay plus
A. Marcovitz, Rajesh Gottimukkala, G. Bee, J. Kilzer +8 more
2020Molecular and Cellular Biology / Genetics0 citations
Semantic Scholar
Abstract 3347: Characterization of gut microbiota and identification of key bacterial species associated with immune response using a new Ion Torrent next-generation sequencing assay
S. Sarda, David Merrill, Heesun Shin, Anna M. McGeachy +5 more
2020Immunology0 citations
Semantic Scholar
Peripheral blood TCRB chain convergence and clonal expansion following cytomegalovirus infection: Implications for the biomarker use of TCR-seq.
T. Looney, Jian-Ping Zheng, D. Topacio-Hall, G. Lowman +1 more
2019Journal of Clinical Oncology0 citations
Semantic Scholar
Development of a comprehensive next-generation targeted sequencing assay for detection of gene-fusions in solid tumors
V. Mittal, S. Myrand, D. Cyanam, P. Williams +10 more
2019Annals of Oncology0 citations Open access
Semantic Scholar
Optimized IGH Chain Sequencing for Detection of Very Low Frequency B Cell Malignancies from RNA or DNA Input
T. Looney, Michelle A. Toro, G. Lowman, Jayde Chang +3 more
2019Blood0 citations Open access
Semantic Scholar
Abstract 5132: Assessing tumor mutational burden and profiling variants from FFPE samples using a PCR-based next-generation sequencing assay
R. Chaudhary, C. Scafe, D. Cyanam, V. Mittal +4 more
2019Molecular and Cellular Biology / Genetics0 citations
Semantic Scholar
T cell repertoire convergence and clonal expansion in cytomegalovirus infection: Implications for the biomarker use of TCR-seq
T. Looney, D. Topacio-Hall, G. Lowman, F. Hyland
2019European Journal of Cancer0 citations
Semantic Scholar
Long-Amplicon Sequencing of Rearranged IGH Chains Enables Simultaneous Measurement of Somatic Hypermutation and Isotype in Chronic Lymphocytic Leukemia
T. Looney, G. Lowman, Loni Pickle, Jayde Chang +3 more
2019Blood0 citations Open access
Semantic Scholar
Insights into the tumor microenvironment and human TRBV gene polymorphism revealed by long-amplicon immune repertoire sequencing
G. Lowman, T. Looney, A. Glavin, E. Linch +14 more
20180 citations
Semantic Scholar
Long-amplicon TCRβ repertoire sequencing to reveal human T-cell receptor variable gene polymorphism: Implications for the prediction and interpretation of immunotherapy outcome.
T. Looney, A. Glavin, S. Pabla, S. Glenn +10 more
20180 citations
Semantic Scholar
Abstract 2267: A novel method for classification of microsatellite instability (MSI) using the Oncomine Tumor Mutation Load assay
A. Pankov, S. El-Difrawy, W. Tom, J. Conroy +5 more
2018Bioinformatics and Systems Biology0 citations
Semantic Scholar
Estimating mutation load at 5% LOD from FFPE samples using a targeted next-generation sequencing assay.
R. Chaudhary, D. Cyanam, V. Mittal, W. Tom +3 more
20180 citations
Semantic Scholar
T cell receptor beta immune repertoire sequencing in FFPE preserved samples: Increasing flexibility and applicability for immuno-oncology studies.
L. Miller, E. Linch, Jian-Ping Zheng, D. Topacio-Hall +4 more
20180 citations
Semantic Scholar
Abstract 580: A method for estimating mutation load from tumor research samples using a targeted next-generation sequencing panel
R. Chaudhary, D. Cyanam, V. Mittal, W. Tom +3 more
2018Clinical research0 citations
Semantic Scholar
Abstract 3994: Using NGS to characterize 40 NSCLC tumor with gene expression and tumor infiltrating T cell repertoire profiling from FFPE and matched Fresh Frozen samples
A. Mongan, G. Lowman, Yuan-Chieh Ku, T. Looney +3 more
20170 citations
Semantic Scholar
Abstract B17: Validation of targeted gene expression profiling panel for identifying biomarker signatures of immunotherapy responders
A. Pankov, Yong-Ming A. Sun, Yuan-Chieh Ku, W. Tom +5 more
20170 citations
Semantic Scholar
Abstract 1631: Sequencing the circulating and infiltrating T-cell repertoire on the Ion S5TM
G. Lowman, E. Linch, L. Miller, D. Topacio-Hall +7 more
20170 citations
Semantic Scholar
Abstract 3567: Sequencing the human TCRβ repertoire on the Ion S5™ System
D. Topacio-Hall, T. Looney, Yong-Ming A. Sun, L. Miller +6 more
20170 citations
Semantic Scholar
Abstract 5364: A targeted NGS solution to evaluate gene expression signature of the tumor microenvironment from 40 NSCLC FFPE and matched fresh frozen samples
Yuan-Chieh Ku, W. Tom, Yong-Ming A. Sun, A. Pankov +4 more
20170 citations
Semantic Scholar
Verification of targeted gene expression profiling panel for identifying biomarker signatures for immunotherapy research.
A. Pankov, Yuan-Chieh Ku, W. Tom, Jian-Ping Zheng +5 more
20170 citations
Semantic Scholar
Tracking the interplay between circulating and tumor-infiltrating T cells using AmpliSeq-based Ion Torrent TCRβ immune repertoire sequencing.
T. Looney, G. Lowman, E. Linch, D. Topacio +7 more
20170 citations
Semantic Scholar

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