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Laetitia Laurent · SciRah

Researcher profile · Semantic Scholar

Laetitia Laurent

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Laetitia Laurent — researcher profile on SciRah

h-index: 19
Works: 39
Citations: 2,365

Most-cited papers

An atlas of genetic influences on osteoporosis in humans and mice
John A. Morris, J. Kemp, Scott E. Youlten, Laetitia Laurent +55 more
2018Nature Genetics694 citations Open access
Semantic Scholar
Induction of macrophage secretion of tumor necrosis factor alpha through Fcgamma receptor IIa engagement by rheumatoid arthritis-specific autoantibodies to citrullinated proteins complexed with fibrinogen.
C. Clavel, L. Nogueira, Laetitia Laurent, C. Iobagiu +3 more
2008Arthritis & Rheumatism304 citations
Semantic Scholar
A Neanderthal OAS1 isoform protects individuals of European ancestry against COVID-19 susceptibility and severity
Si-Rui Zhou, G. Butler-Laporte, T. Nakanishi, D. Morrison +37 more
2021Nature Medicine247 citations Open access
Semantic Scholar
IgM rheumatoid factor amplifies the inflammatory response of macrophages induced by the rheumatoid arthritis-specific immune complexes containing anticitrullinated protein antibodies
Laetitia Laurent, F. Anquetil, C. Clavel, N. Ndongo-Thiam +5 more
2014Annals of the Rheumatic Diseases127 citations
Semantic Scholar
Effects of prenatal maternal stress on serotonin and fetal development.
J. St-Pierre, Laetitia Laurent, S. King, C. Vaillancourt
2016Placenta123 citations
Semantic Scholar
Fcγ receptor profile of monocytes and macrophages from rheumatoid arthritis patients and their response to immune complexes formed with autoantibodies to citrullinated proteins
Laetitia Laurent, C. Clavel, O. Lemaire, F. Anquetil +6 more
2011Annals of the Rheumatic Diseases111 citations
Semantic Scholar
A second update on mapping the human genetic architecture of COVID-19
Masahiro Shea J. Mattia Christine Benjamin M. Mark Andrea G Kanai Andrews Cordioli Stevens Neale Daly Ganna Pa, Masahiro Shea J. Mattia Christine Benjamin M. Mark Andrea Kanai Andrews Cordioli Stevens Neale Daly Ganna, Masahiro Kanai, S. Andrews +496 more
2022Nature108 citations Open access
Semantic Scholar
Proteome-wide Mendelian randomization implicates nephronectin as an actionable mediator of the effect of obesity on COVID-19 severity
Satoshi Yoshiji, G. Butler-Laporte, Tian-Yuan Lu, J. Willett +27 more
2023Nature Metabolism90 citations Open access
Semantic Scholar
Loss of DGKε induces endothelial cell activation and death independently of complement activation.
S. Bruneau, M. Néel, L. Roumenina, Marie Frimat +3 more
2015Blood87 citations Open access
Semantic Scholar
The activating effect of IFN-γ on monocytes/macrophages is regulated by the LIF–trophoblast–IL-10 axis via Stat1 inhibition and Stat3 activation
Angham Dallagi, J. Girouard, Jovane Hamelin-Morrissette, R. Dadzie +5 more
2014Cellular & Molecular Immunology72 citations Open access
Semantic Scholar
Human placenta expresses both peripheral and neuronal isoform of tryptophan hydroxylase.
Laetitia Laurent, K. Deroy, J. St-Pierre, F. Côté +2 more
2017Biochimie56 citations
Semantic Scholar
Integrated immunovirological profiling validates plasma SARS-CoV-2 RNA as an early predictor of COVID-19 mortality
Elsa Brunet-Ratnasingham, S. Anand, P. Gantner, A. Dyachenko +39 more
2021medRxiv55 citations Open access
Semantic Scholar
Fluoxetine and its active metabolite norfluoxetine disrupt estrogen synthesis in a co-culture model of the feto-placental unit.
Andrée-Anne Hudon Thibeault, Laetitia Laurent, S. Vo Duy, S. Sauvé +4 more
2017Molecular and Cellular Endocrinology35 citations
Semantic Scholar
Human Primary Trophoblast Cell Culture Model to Study the Protective Effects of Melatonin Against Hypoxia/reoxygenation-induced Disruption.
Lucas Sagrillo-Fagundes, Hélène Clabault, Laetitia Laurent, Andrée-Anne Hudon-Thibeault +6 more
2016Journal of Visualized Experiments34 citations Open access
Semantic Scholar
Converging evidence from exome sequencing and common variants implicates target genes for osteoporosis
Si-Rui Zhou, O. Sosina, J. Bovijn, Laetitia Laurent +26 more
2023Nature Genetics28 citations Open access
Semantic Scholar
In utero exposure to venlafaxine, a serotonin-norepinephrine reuptake inhibitor, increases cardiac anomalies and alters placental and heart serotonin signaling in the rat.
Laetitia Laurent, Chun-Wei Huang, Sheila R. Ernest, A. Bérard +2 more
2016Birth defects research. Clinical and molecular teratology28 citations
Semantic Scholar
Prevention of lupus nephritis development in NZB/NZW mice by selective blockade of CD28
Laetitia Laurent, Awena Le Fur, Rozenn Le Bloas, M. Néel +5 more
2017European Journal of Immunology22 citations Open access
Semantic Scholar
Enhanced Renewal of Erythroid Progenitors in Myelodysplastic Anemia by Peripheral Serotonin.
D. Sibon, T. Coman, J. Rossignol, Mathilde Lamarque +19 more
2019Cell Reports21 citations Open access
Semantic Scholar
In Vitro Induction of Hypoxia/Reoxygenation on Placental Cells: A Suitable Model for Understanding Placental Diseases.
Lucas Sagrillo-Fagundes, Laetitia Laurent, Josianne Bienvenue-Pariseault, C. Vaillancourt
2018Methods in molecular biology21 citations
Semantic Scholar
Antagonist Anti-CD28 Therapeutics for the Treatment of Autoimmune Disorders
B. Vanhove, N. Poirier, F. Fakhouri, Laetitia Laurent +8 more
2017Antibodies16 citations Open access
Semantic Scholar
Circulating proteins to predict COVID-19 severity
Chen-Yang Su, Si-Rui Zhou, Edgar Gonzalez-Kozlova, G. Butler-Laporte +62 more
2023Scientific Reports15 citations Open access
Semantic Scholar
Circulating Proteins Influencing COVID-19 Susceptibility and Severity: a Mendelian Randomization Study
Sirui Zhou, G. Butler-Laporte, T. Nakanishi, D. Morrison +37 more
2020medRxiv13 citations Open access
Semantic Scholar
An Atlas of Human and Murine Genetic Influences on Osteoporosis
John A. Morris, J. Kemp, Scott E. Youlten, Laetitia Laurent +55 more
2018bioRxiv12 citations Open access
Semantic Scholar
Author Correction: An atlas of genetic influences on osteoporosis in humans and mice
John A. Morris, J. Kemp, Scott E. Youlten, Laetitia Laurent +79 more
2019Nature Genetics11 citations Open access
Semantic Scholar
Isolation and Purification of Villous Cytotrophoblast Cells from Term Human Placenta.
Hélène Clabault, Laetitia Laurent, J. Sanderson, C. Vaillancourt
2018Methods in molecular biology10 citations
Semantic Scholar
The dynamic changes and sex differences of 147 immune-related proteins during acute COVID-19 in 580 individuals
G. Butler-Laporte, Edgar Gonzalez-Kozlova, Chen-Yang Su, Si-Rui Zhou +61 more
2022Clinical Proteomics8 citations Open access
Semantic Scholar
Circulating proteins to predict adverse COVID-19 outcomes
Chen-Yang Su, Si-Rui Zhou, Edgar Gonzalez-Kozlova, G. Butler-Laporte +62 more
2021medRxiv7 citations Open access
Semantic Scholar
A Neanderthal OAS1 isoform Protects Against COVID-19 Susceptibility and Severity: Results from Mendelian Randomization and Case-Control Studies
Si-Rui Zhou, G. Butler-Laporte, T. Nakanishi, D. Morrison +37 more
20206 citations Open access
Semantic Scholar
Proteome-wide Mendelian randomization implicates nephronectin as an actionable mediator of the effect of obesity on COVID-19 severity
Satoshi Yoshiji, G. Butler-Laporte, Tian-Yuan Lu, J. Willett +26 more
2022medRxiv3 citations Open access
Semantic Scholar
A feto-placental co-culture model shows the complex disruptive effect of the antidepressant fluoxetine and its metabolite norfluoxetine on estrogen biosynthesis and serotonin transport
Laetitia Laurent, Andrée-Anne Hudon Thibeault, J. Sanderson, C. Vaillancourt
20153 citations
Semantic Scholar
MECP2 mutations rewire human ESC fate and bias cortical lineage commitment
Marion Guillon, Margaux Brin, Elodie Gabet, Justine Gromaire +10 more
2025bioRxiv1 citations Open access
Semantic Scholar
the 23 and Me Research Team, ... M. (2018). An atlas of genetic influences on osteoporosis in humans and mice. Nature Genetics
J. Morris, J. Kemp, Scott E. Youlten, Laetitia Laurent +62 more
20181 citations
Semantic Scholar
Cytokine profile of macrophages in vitro stimulated by ACPA immune complexes in the presence or absence of IgM rheumatoid factor
Laetitia Laurent, C. Clavel, F. Anquetil, J. Pasquali +2 more
20111 citations Open access
Semantic Scholar
Protocol for mechanical nuclei dissociation and isolation from frozen tissue and organoids for single-nucleus RNA sequencing
Marion Guillon, Margaux Brin, Laetitia Laurent, Anthony Flamier
2026STAR Protocols0 citations Open access
Semantic Scholar
Correction: The dynamic changes and sex differences of 147 immune-related proteins during acute COVID-19 in 580 individuals
G. Butler-Laporte, Edgar Gonzalez-Kozlova, Chen-Yang Su, Si-Rui Zhou +60 more
2022Clinical Proteomics0 citations Open access
Semantic Scholar
Exome sequencing of 300,000 individuals implicates target genes for osteoporosis
Si-Rui Zhou, O. Sosina, J. Bovijn, Laetitia Laurent +7 more
2022Bone Reports0 citations Open access
Semantic Scholar
Response to letter to the editor by Wise.
Laetitia Laurent, Chun-Wei Huang, Sheila R. Ernest, A. Bérard +2 more
2016Birth defects research. Clinical and molecular teratology0 citations
Semantic Scholar
Selective serotonin-reuptake inhibitors (SSRIs) induce the estrogen biosynthetic enzyme aromatase (CYP19) in trophoblast-like BeWo choriocarcinoma cells
Andrée-Anne Hudon-Thibeault, Laetitia Laurent, Thomas J. Sanderson, C. Vaillancourt
20140 citations
Semantic Scholar
Rheumatoid factor amplifies the macrophage secretion of TNFα induced by ACPA-citrullinated fibrinogen immune complexes
Laetitia Laurent, C. Clavel, J. Pasquali, G. Serre +1 more
20100 citations Open access
Semantic Scholar

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