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Matthew L. Hirsch · SciRah

Researcher profile · Semantic Scholar

Matthew L. Hirsch

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Matthew L. Hirsch — researcher profile on SciRah

h-index: 30
Works: 76
Citations: 2,364

Most-cited papers

Integration of a CD19 CAR into the TCR Alpha Chain Locus Streamlines Production of Allogeneic Gene-Edited CAR T Cells
Daniel T. Macleod, J. Antony, Aaron J. Martin, R. Moser +16 more
2017Molecular Therapy248 citations Open access
Semantic Scholar
A survey of ex vivo/in vitro transduction efficiency of mammalian primary cells and cell lines with Nine natural adeno-associated virus (AAV1-9) and one engineered adeno-associated virus serotype
B. L. Ellis, Matthew L. Hirsch, Jenny C. Barker, J. Connelly +2 more
2013Virology Journal228 citations Open access
Semantic Scholar
Efficient retrograde neuronal transduction utilizing self-complementary AAV1.
Edmund R. Hollis, K. Kadoya, Matthew L. Hirsch, R. Samulski +1 more
2008Molecular Therapy113 citations Open access
Semantic Scholar
Double-stranded RNA innate immune response activation from long-term adeno-associated virus vector transduction.
Wen-Wei Shao, L. F. Earley, Zheng Chai, Xiao-Jing Chen +7 more
2018JCI Insight101 citations Open access
Semantic Scholar
Single Amino Acid Modification of Adeno-Associated Virus Capsid Changes Transduction and Humoral Immune Profiles
Chengwen Li, Nina DiPrimio, D. Bowles, Matthew L. Hirsch +5 more
2012Journal of Virology89 citations Open access
Semantic Scholar
Adeno-Associated Virus Type 2 (AAV2) Capsid-Specific Cytotoxic T Lymphocytes Eliminate Only Vector-Transduced Cells Coexpressing the AAV2 Capsid In Vivo
Chengwen Li, Matthew L. Hirsch, A. Asokan, Brian Zeithaml +3 more
2007Journal of Virology89 citations Open access
Semantic Scholar
Delivering Transgenic DNA Exceeding the Carrying Capacity of AAV Vectors
Matthew L. Hirsch, S. Wolf, R. Samulski
2016Methods in molecular biology82 citations Open access
Semantic Scholar
Cellular immune response to cryptic epitopes during therapeutic gene transfer
Chengwen Li, K. Goudy, Matthew L. Hirsch, A. Asokan +10 more
2009Proceedings of the National Academy of Sciences of the United States of America79 citations Open access
Semantic Scholar
Adeno-associated Virus as a Mammalian DNA Vector
M. Salganik, Matthew L. Hirsch, R. Samulski
201577 citations
Semantic Scholar
Little vector, big gene transduction: fragmented genome reassembly of adeno-associated virus.
Matthew L. Hirsch, M. Agbandje-McKenna, R. Samulski
2010Molecular Therapy74 citations Open access
Semantic Scholar
Adeno-associated virus capsid antigen presentation is dependent on endosomal escape.
Chengwen Li, Yi He, Sarah C. Nicolson, Matthew L. Hirsch +4 more
2013Journal of Clinical Investigation63 citations Open access
Semantic Scholar
Oversized AAV transductifon is mediated via a DNA-PKcs-independent, Rad51C-dependent repair pathway.
Matthew L. Hirsch, Chengwen Li, Isabella Bellon, C. Yin +4 more
2013Molecular Therapy62 citations Open access
Semantic Scholar
The prevalence of human parvovirus B19 DNA and antibodies in blood donors from four Chinese blood centers
Ling Ke, Miao He, Chang-Qing Li, Yu Liu +8 more
2011Transfusion53 citations
Semantic Scholar
A comparison of AAV strategies distinguishes overlapping vectors for efficient systemic delivery of the 6.2 kb Dysferlin coding sequence
M. Pryadkina, W. Lostal, N. Bourg, K. Charton +3 more
2015Molecular Therapy: Methods & Clinical Development52 citations Open access
Semantic Scholar
Viral Single-Strand DNA Induces p53-Dependent Apoptosis in Human Embryonic Stem Cells
Matthew L. Hirsch, B. Fagan, R. Dumitru, J. Bower +4 more
2011PLoS ONE52 citations Open access
Semantic Scholar
Direct Interaction of Human Serum Proteins with AAV Virions to Enhance AAV Transduction: Immediate Impact on Clinical Applications
Mei Wang, Junjiang Sun, Ashley J Crosby, Kenton T. Woodard +3 more
2016Gene Therapy50 citations Open access
Semantic Scholar
AAV Gene Therapy for MPS1-associated Corneal Blindness
M. Vance, Telmo Llanga, William D. Bennett, Kenton T. Woodard +7 more
2016Scientific Reports50 citations Open access
Semantic Scholar
Adeno-Associated Virus Mediated Gene Therapy for Corneal Diseases
P. Bastola, Liu-Jiang Song, B. Gilger, Matthew L. Hirsch
2020Pharmaceutics47 citations Open access
Semantic Scholar
Serotype survey of AAV gene delivery via subconjunctival injection in mice
Liu-Jiang Song, Telmo Llanga, Laura M. Conatser, V. Zaric +2 more
2018Gene Therapy47 citations
Semantic Scholar
Identification and Validation of Small Molecules That Enhance Recombinant Adeno-associated Virus Transduction following High-Throughput Screens
Sarah C. Nicolson, Chengwen Li, Matthew L. Hirsch, V. Setola +1 more
2016Journal of Virology46 citations Open access
Semantic Scholar
Development of Patient-specific AAV Vectors After Neutralizing Antibody Selection for Enhanced Muscle Gene Transfer.
Chengwen Li, Shu-Qing Wu, Blake H. Albright, Matthew L. Hirsch +6 more
2016Molecular Therapy46 citations Open access
Semantic Scholar
Cytotoxic-T-Lymphocyte-Mediated Elimination of Target Cells Transduced with Engineered Adeno-Associated Virus Type 2 Vector In Vivo
Chengwen Li, Matthew L. Hirsch, Nina DiPrimio, A. Asokan +3 more
2009Journal of Virology44 citations Open access
Semantic Scholar
Adeno-Associated Virus Vector Mediated Delivery of the HBV Genome Induces Chronic Hepatitis B Virus Infection and Liver Fibrosis in Mice
Lei Ye, Hai-Sheng Yu, Chengwen Li, Matthew L. Hirsch +4 more
2015PLoS ONE43 citations Open access
Semantic Scholar
AAV vector-meditated expression of HLA-G reduces injury-induced corneal vascularization, immune cell infiltration, and fibrosis
Matthew L. Hirsch, Laura M. Conatser, Sara M Smith, J. Salmon +4 more
2017Scientific Reports36 citations Open access
Semantic Scholar
Adeno-Associated Virus Vectors and Stem Cells: Friends or Foes?
Nolan J Brown, Liu-Jiang Song, N. Kollu, Matthew L. Hirsch
2017Human Gene Therapy35 citations Open access
Semantic Scholar
Three-dimensional multipotent progenitor cell aggregates for expansion, osteogenic differentiation and “in vivo” tracing with AAV vector serotype 6
J. Ferreira, Matthew L. Hirsch, Li Zhang, Yonsil Park +3 more
2012Gene Therapy35 citations Open access
Semantic Scholar
Intrastromal Gene Therapy Prevents and Reverses Advanced Corneal Clouding in a Canine Model of Mucopolysaccharidosis I.
K. Miyadera, Laura M. Conatser, Telmo Llanga, Kendall Carlin +7 more
2020Molecular Therapy34 citations Open access
Semantic Scholar
Structure-Based Designed Nano-Dysferlin Significantly Improves Dysferlinopathy in BLA/J Mice.
Telmo Llanga, Nadia Nagy, Laura M. Conatser, Catherine F. Dial +2 more
2017Molecular Therapy32 citations Open access
Semantic Scholar
AAV-mediated expression of HLA-G1/5 reduces severity of experimental autoimmune uveitis
Elizabeth Crabtree, Liu-Jiang Song, Telmo Llanga, J. Bower +4 more
2019Scientific Reports31 citations Open access
Semantic Scholar
AAV Recombineering with Single Strand Oligonucleotides
Matthew L. Hirsch, F. Storici, Chengwen Li, V. Choi +1 more
2009PLoS ONE30 citations Open access
Semantic Scholar
Hip region muscular dystrophy and emergence of motor deficits in dysferlin‐deficient Bla/J mice
Nadia Nagy, R. Nonneman, Telmo Llanga, Catherine F. Dial +10 more
2017Physiological Reports27 citations Open access
Semantic Scholar
Kinetics of Adeno-Associated Virus Serotype 2 (AAV2) and AAV8 Capsid Antigen Presentation In Vivo Are Identical
Yi He, M. Weinberg, Matthew L. Hirsch, Mark C. Johnson +3 more
2013Human Gene Therapy25 citations Open access
Semantic Scholar
Therapeutic Applications of Adeno-Associated Virus (AAV) Gene Transfer of HLA-G in the Eye
B. Gilger, Matthew L. Hirsch
2022International Journal of Molecular Sciences24 citations Open access
Semantic Scholar
Promyelocytic Leukemia Protein Is a Cell-Intrinsic Factor Inhibiting Parvovirus DNA Replication
A. M. Mitchell, Matthew L. Hirsch, Chengwen Li, R. Samulski
2013Journal of Virology24 citations Open access
Semantic Scholar
Little Vector, Big Gene Transduction: Fragmented Genome Reassembly of Adeno-associated Virus.
Matthew L. Hirsch, M. Agbandje-McKenna, R. Samulski
2010Molecular Therapy17 citations Open access
Semantic Scholar
Efficient Retrograde Neuronal Transduction Utilizing Self-complementary AAV1.
Edmund R. Hollis Ii, K. Kadoya, Matthew L. Hirsch, R. Samulski +1 more
2008Molecular Therapy17 citations Open access
Semantic Scholar
Inhibition of experimental autoimmune uveitis by intravitreal AAV-Equine-IL10 gene therapy
Elizabeth Crabtree, Katy Uribe, Sara M Smith, D. Roberts +6 more
2022PLoS ONE16 citations Open access
Semantic Scholar
Ocular Tolerability and Immune Response to Corneal Intrastromal AAV-IDUA Gene Therapy in New Zealand White Rabbits
Liu-Jiang Song, J. Bower, Telmo Llanga, J. Salmon +2 more
2020Molecular Therapy: Methods & Clinical Development16 citations Open access
Semantic Scholar
Harnessing the Natural Biology of Adeno-Associated Virus to Enhance the Efficacy of Cancer Gene Therapy
J. Bower, Liu-Jiang Song, P. Bastola, Matthew L. Hirsch
2021Viruses15 citations Open access
Semantic Scholar
Inhibition of antigen presentation during AAV gene therapy using virus peptides
Wen-Wei Shao, Xiao-Jing Chen, R. Samulski, Matthew L. Hirsch +1 more
2018Human Molecular Genetics14 citations Open access
Semantic Scholar
A Fixed-Depth Microneedle Enhances Reproducibility and Safety for Corneal Gene Therapy
B. Gilger, Elizabeth Crabtree, Liu-Jiang Song, Telmo Llanga +6 more
2019Cornea12 citations Open access
Semantic Scholar
Adeno-associated Virus as a Mammalian DNA Vector
M. Salganik, Matthew L. Hirsch, R. Samulski
2015Microbiology spectrum12 citations Open access
Semantic Scholar
Gene Delivery to Human Limbal Stem Cells Using Viral Vectors
Liu-Jiang Song, Zhen-Wei Song, Nate J. Fry, Laura M. Conatser +4 more
2019Human Gene Therapy11 citations Open access
Semantic Scholar
AAV Vectorization of DSB-mediated Gene Editing Technologies.
R. Moser, Matthew L. Hirsch
2016Current Gene Therapy11 citations
Semantic Scholar
A chimeric anti-vascularization immunomodulator prevents high-risk corneal transplantation rejection via ex vivo gene therapy
B. Gilger, Tomoko Hasegawa, R. B. Sutton, J. Bower +2 more
2024Molecular Therapy9 citations Open access
Semantic Scholar
Single Amino Acid Modiﬁcation of Adeno-Associated Virus Capsid Changes Transduction and Humoral Immune Proﬁles
Chengwen Li, Nina DiPrimio, D. Bowles, Matthew L. Hirsch +5 more
20129 citations
Semantic Scholar
Preparation and Administration of Adeno-associated Virus Vectors for Corneal Gene Delivery.
Liu-Jiang Song, J. Bower, Matthew L. Hirsch
2020Methods in molecular biology8 citations
Semantic Scholar
544. Comparison of AAV Serotype2 Transduction by Various Delivery Routes to the Mouse Eye
Kenton T. Woodard, M. Vance, B. Gilger, R. Samulski +1 more
20165 citations Open access
Semantic Scholar
AAV Vector Transduction Restriction and Attenuated Toxicity in hESCs via a Rationally Designed Inverted Terminal Repeat
Liu-Jiang Song, Nolan J Brown, J. Bower, R. Samulski +1 more
2022bioRxiv4 citations Open access
Semantic Scholar
Adeno-associated virus (AAV) gene delivery in stem cell therapy.
Nolan J Brown, Matthew L. Hirsch
2015Discover medicine4 citations
Semantic Scholar

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R. Samulski×19
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R. Samulski — researcher profile on SciRah
Chengwen Li×17
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Chengwen Li — researcher profile on SciRah
B. Gilger×12
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B. Gilger — researcher profile on SciRah
Liu-Jiang Song×12
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R. Samulski — researcher profile on SciRah

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Telmo Llanga×8

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Telmo Llanga — researcher profile on SciRah

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A. Asokan — researcher profile on SciRah

M. Agbandje-McKenna×5

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M. Agbandje-McKenna — researcher profile on SciRah

Laura M. Conatser×5

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Laura M. Conatser — researcher profile on SciRah

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J. Salmon — researcher profile on SciRah

Junjiang Sun×3

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Junjiang Sun — researcher profile on SciRah