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T. Druck · SciRah

Researcher profile · Semantic Scholar

T. Druck

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T. Druck — researcher profile on SciRah

h-index: 45
Works: 108
Citations: 8,263

Most-cited papers

The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers.
M. Ohta, H. Inoue, M. Cotticelli, K. Kastury +8 more
1996Cell1,058 citations Open access
Semantic Scholar
Cloning, Characterization, and Chromosomal Localization of a Human 5‐HT6 Serotonin Receptor
R. Kohen, Mark A. Metcalf, N. Khan, T. Druck +6 more
1996Journal of Neurochemistry374 citations Open access
Semantic Scholar
Characterization of the Mammalian YAP (Yes-associated Protein) Gene and Its Role in Defining a Novel Protein Module, the WW Domain (*)
M. Sudol, P. Bork, A. Einbond, K. Kastury +4 more
1995Journal of Biological Chemistry353 citations Open access
Semantic Scholar
Cloning and characterization of two members of the vertebrate Dlx gene family.
A. Simeone, D. Acampora, M. Pannese, M. D'Esposito +6 more
1994Proceedings of the National Academy of Sciences of the United States of America277 citations Open access
Semantic Scholar
Functional association between Wwox tumor suppressor protein and p73, a p53 homolog.
R. Aqeilan, Y. Pekarsky, Juan José Herrero, Alexey Palamarchuk +7 more
2004Proceedings of the National Academy of Sciences of the United States of America255 citations Open access
Semantic Scholar
The FHIT gene at 3p14.2 is abnormal in breast carcinomas.
Massimo Negrini, Carmen Monaco, Igor Vŏrechovský, M. Ohta +4 more
1996Cancer Research227 citations
Semantic Scholar
The cloning of a receptor-type protein tyrosine phosphatase expressed in the central nervous system.
J. B. Levy, Peter Canoll, O. Silvennoinen, G. Barnea +6 more
1993Journal of Biological Chemistry224 citations Open access
Semantic Scholar
Structure and expression of the human FHIT gene in normal and tumor cells.
T. Druck, P. Hadaczek, Tie-Bo Fu, M. Ohta +12 more
1997Cancer Research211 citations
Semantic Scholar
Fragile genes as biomarkers: epigenetic control of WWOX and FHIT in lung, breast and bladder cancer
D. Iliopoulos, G. Guler, Shuang-Yin Han, D. Johnston +6 more
2005Oncogene191 citations
Semantic Scholar
The tumor spectrum in FHIT-deficient mice
N. Zanesi, V. Fidanza, L. Fong, R. Mancini +6 more
2001Proceedings of the National Academy of Sciences of the United States of America175 citations Open access
Semantic Scholar
Chromosomal mapping of members of the cdc2 family of protein kinases, cdk3, cdk6, PISSLRE, and PITALRE, and a cdk inhibitor, p27Kip1, to regions involved in human cancer.
F. Bullrich, T. Maclachlan, N. Sang, T. Druck +7 more
1995Cancer Research143 citations
Semantic Scholar
Muir-Torre-like syndrome in Fhit-deficient mice.
L. Fong, V. Fidanza, N. Zanesi, L. Lock +9 more
2000Proceedings of the National Academy of Sciences of the United States of America138 citations Open access
Semantic Scholar
Sequence of the FRA3B common fragile region: implications for the mechanism of FHIT deletion.
H. Inoue, Hideshi Ishii, H. Alder, Eric L. Snyder +3 more
1997Proceedings of the National Academy of Sciences of the United States of America130 citations Open access
Semantic Scholar
Cancer-specific chromosome alterations in the constitutive fragile region FRA3B.
K. Mimori, T. Druck, H. Inoue, H. Alder +4 more
1999Proceedings of the National Academy of Sciences of the United States of America128 citations Open access
Semantic Scholar
Potential gastrointestinal tumor suppressor locus at the 3p14.2 FRA3B site identified by homozygous deletions in tumor cell lines.
K. Kastury, R. Baffa, T. Druck, M. Ohta +8 more
1996Cancer Research116 citations
Semantic Scholar
A role for the WWOX gene in prostate cancer.
H. Qin, D. Iliopoulos, S. Semba, M. Fabbri +6 more
2006Cancer Research110 citations
Semantic Scholar
Fragile histidine triad expression delays tumor development and induces apoptosis in human pancreatic cancer.
K. Dumon, Hideshi Ishii, A. Vecchione, F. Trapasso +9 more
2001Cancer Research105 citations
Semantic Scholar
Structure and expression pattern of human ALR, a novel gene with strong homology to ALL-1 involved in acute leukemia and to Drosophila trithorax
R. Prasad, A. Zhadanov, Y. Sedkov, F. Bullrich +8 more
1997Oncogene105 citations Open access
Semantic Scholar
Retroposition in a family of carcinoma-associated antigen genes
A. Linnenbach, B. Seng, Shuang Wu, S. Robbins +4 more
1993Molecular and Cellular Biology105 citations Open access
Semantic Scholar
Common regions of deletion in chromosome regions 3p12 and 3p14.2 in primary clear cell renal carcinomas.
J. Lubiński, Piotr Hadaczek, J. Podolski, A. Tołoczko +4 more
1994Cancer Research103 citations
Semantic Scholar
Positions of chromosome 3p14.2 fragile sites (FRA3B) within the FHIT gene.
D. Zimonjic, T. Druck, M. Ohta, K. Kastury +3 more
1997Cancer Research99 citations
Semantic Scholar
Inhibition of Breast Cancer Cell Growth In vitro and In vivo: Effect of Restoration of Wwox Expression
D. Iliopoulos, M. Fabbri, T. Druck, H. Qin +2 more
2007Clinical Cancer Research90 citations
Semantic Scholar
Roles of FHIT and WWOX fragile genes in cancer.
D. Iliopoulos, G. Guler, Shuang-Yin Han, T. Druck +3 more
2006Cancer Letters78 citations
Semantic Scholar
Sequence conservation at human and mouse orthologous common fragile regions, FRA3B/FHIT and Fra14A2/Fhit
T. Shiraishi, T. Druck, K. Mimori, J. Flomenberg +5 more
2001Proceedings of the National Academy of Sciences of the United States of America77 citations Open access
Semantic Scholar
Absence or reduction of Fhit expression in most clear cell renal carcinomas.
P. Hadaczek, Z. Siprashvili, M. Markiewski, W. Domagala +6 more
1998Cancer Research77 citations
Semantic Scholar
Nitrilase and Fhit homologs are encoded as fusion proteins in Drosophila melanogaster and Caenorhabditis elegans.
Y. Pekarsky, M. Campiglio, Z. Siprashvili, T. Druck +10 more
1998Proceedings of the National Academy of Sciences of the United States of America76 citations Open access
Semantic Scholar
Identification of a conserved family of Meis1-related homeobox genes.
S. Steelman, J. Moskow, K. Muzynski, C. North +5 more
1997Genome Research72 citations Open access
Semantic Scholar
Expression of FRA16D/WWOX and FRA3B/FHIT genes in hematopoietic malignancies.
H. Ishii, A. Vecchione, Yutaka Furukawa, K. Sutheesophon +10 more
2003Molecular Cancer Research71 citations
Semantic Scholar
Loss of heterozygosity at the familial RCC t(3;8) locus in most clear cell renal carcinomas.
T. Druck, K. Kastury, Piotr Hadaczek, J. Podolski +8 more
1995Cancer Research70 citations
Semantic Scholar
Epigenetic modulation of endogenous tumor suppressor expression in lung cancer xenografts suppresses tumorigenicity
J. Cantor, D. Iliopoulos, Atul S. Rao, T. Druck +8 more
2007International Journal of Cancer67 citations Open access
Semantic Scholar
Fhit modulation of the Akt-survivin pathway in lung cancer cells: Fhit-tyrosine 114 (Y114) is essential
S. Semba, F. Trapasso, M. Fabbri, K. A. McCorkell +9 more
2006Oncogene66 citations
Semantic Scholar
The FHIT gene, a multiple tumor suppressor gene encompassing the carcinogen sensitive chromosome fragile site, FRA3B.
K. Huebner, P. Hadaczek, Z. Siprashvili, T. Druck +1 more
1997Biochimica et Biophysica Acta64 citations
Semantic Scholar
The BAX gene maps to the glioma candidate region at 19q13.3, but is not altered in human gliomas.
D. Chou, T. Miyashita, H. Mohrenweiser, K. Ueki +6 more
1996Cancer Genetics and Cytogenetics62 citations
Semantic Scholar
Assignment of DAP1 and DAPK--genes that positively mediate programmed cell death triggered by IFN-gamma--to chromosome regions 5p12.2 and 9q34.1, respectively.
E. Feinstein, T. Druck, K. Kastury, Hanna Berissi +4 more
1995Genomics61 citations
Semantic Scholar
Chromosome locations of human EMX and OTX genes.
K. Kastury, T. Druck, K. Huebner, Cosimo Barletta +4 more
1994Genomics61 citations
Semantic Scholar
Fhit-deficient normal and cancer cells are mitomycin C and UVC resistant
M. Ottey, S.-Y. Han, T. Druck, Bl Barnoski +6 more
2004British Journal of Cancer58 citations Open access
Semantic Scholar
Wwox-Brca1 interaction: Role in DNA repair pathway choice
M. Schrock, B. Batar, Jaeho Lee, T. Druck +9 more
2016Oncogene52 citations Open access
Semantic Scholar
Fhit–Fdxr interaction in the mitochondria: modulation of reactive oxygen species generation and apoptosis in cancer cells
T. Druck, Douglas G. Cheung, Dongju Park, F. Trapasso +11 more
2019Cell Death and Disease50 citations Open access
Semantic Scholar
Biological Functions of Mammalian Nit1, the Counterpart of the Invertebrate NitFhit Rosetta Stone Protein, a Possible Tumor Suppressor*
S. Semba, Shuang-Yin Han, H. Qin, K. A. McCorkell +6 more
2006Journal of Biological Chemistry50 citations Open access
Semantic Scholar
Cloning of cDNAs encoding the human BAG1 protein and localization of the human BAG1 gene to chromosome 9p12.
S. Takayama, K. Kochel, S. Irie, J. Inazawa +5 more
1996Genomics48 citations Open access
Semantic Scholar
Fhit modulates the DNA damage checkpoint response.
H. Ishii, K. Mimori, H. Inoue, Taeko Inageta +9 more
2006Cancer Research47 citations Open access
Semantic Scholar
Molecular alterations to human chromosome 3p loci in neuroendocrine lung tumors
A. Kovatich, D. Friedland, T. Druck, P. Hadaczek +4 more
1998Cancer47 citations Open access
Semantic Scholar
Structure of the human receptor tyrosine phosphatase gamma gene (PTPRG) and relation to the familial RCC t(3;8) chromosome translocation.
K. Kastury, M. Ohta, J. Lasota, D. Moir +4 more
1996Genomics42 citations
Semantic Scholar
The human eps15 gene, encoding a tyrosine kinase substrate, is conserved in evolution and maps to 1p31-p32.
W. T. Wong, M. H. Kraus, F. Carlomagno, A. Zelano +4 more
1994Oncogene42 citations
Semantic Scholar
Complementary DNA cloning of the alternatively expressed endothelial cell glycoprotein Ib beta (GPIb beta) and localization of the GPIb beta gene to chromosome 22.
M. D. Kelly, D. Essex, Sandor S. Shapiro, F. J. Meloni +3 more
1994Journal of Clinical Investigation39 citations Open access
Semantic Scholar
Gene structure, promoter activity, and chromosomal location of the DR-nm23 gene, a related member of the nm23 gene family.
Robert J. Martinez, Donatella Venturelli, Danilo Perrotti, M. Veronese +4 more
1997Cancer Research38 citations
Semantic Scholar
FHITness and cancer.
T. Druck, L. Berk, K. Huebner
1998Oncology Research36 citations
Semantic Scholar
Evolutionary conservation of the EPS8 gene and its mapping to human chromosome 12q23-q24.
W. T. Wong, F. Carlomagno, T. Druck, C. Barletta +4 more
1994Oncogene36 citations
Semantic Scholar
The leukemia inhibitory factor receptor (LIFR) gene is located within a cluster of cytokine receptor loci on mouse chromosome 15 and human chromosome 5p12-p13.
D. Gearing, T. Druck, K. Huebner, J. Overhauser +3 more
1993Genomics35 citations
Semantic Scholar
Hits, Fhits and Nits: Beyond enzymatic function
K. Huebner, J. Saldivar, Jin Sun, Hidetaka Shibata +1 more
2010Advances in Enzyme Regulation34 citations Open access
Semantic Scholar

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