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R. Fledrich · SciRah

Researcher profile · Semantic Scholar

R. Fledrich

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R. Fledrich — researcher profile on SciRah

h-index: 20
Works: 43
Citations: 1,839

Most-cited papers

A role for Schwann cell–derived neuregulin-1 in remyelination
R. Stassart, R. Fledrich, V. Velanac, B. G. Brinkmann +4 more
2012Nature Neuroscience281 citations Open access
Semantic Scholar
Schwann cell functions in peripheral nerve development and repair.
Mar Bosch-Queralt, R. Fledrich, R. Stassart
2023Neurobiology of Disease215 citations Open access
Semantic Scholar
Soluble neuregulin-1 modulates disease pathogenesis in rodent models of Charcot-Marie-Tooth disease 1A
R. Fledrich, R. Stassart, A. Klink, L. Rasch +10 more
2014Nature Medicine181 citations Open access
Semantic Scholar
Lithium enhances remyelination of peripheral nerves
Joelle Makoukji, Martin Belle, D. Meffre, R. Stassart +13 more
2012Proceedings of the National Academy of Sciences of the United States of America118 citations Open access
Semantic Scholar
Redefining the heterogeneity of peripheral nerve cells in health and autoimmunity
Jolien Wolbert, Xiao-Lin Li, Michael O. Heming, Anne K. Mausberg +10 more
2020Proceedings of the National Academy of Sciences of the United States of America115 citations Open access
Semantic Scholar
Targeting myelin lipid metabolism as a potential therapeutic strategy in a model of CMT1A neuropathy
R. Fledrich, T. Abdelaal, L. Rasch, V. Bansal +21 more
2018Nature Communications99 citations Open access
Semantic Scholar
Myelin insulation as a risk factor for axonal degeneration in autoimmune demyelinating disease
Erik Schäffner, Mar Bosch-Queralt, J. Edgar, M. Lehning +23 more
2021bioRxiv88 citations Open access
Semantic Scholar
Adipo-glial signaling mediates metabolic adaptation in peripheral nerve regeneration
V. Sundaram, V. Schütza, Nele H. Schröter, Aline Backhaus +24 more
2023Cell Metabolism81 citations Open access
Semantic Scholar
Proteome profile of peripheral myelin in healthy mice and in a neuropathy model
Sophie B. Siems, Olaf Jahn, Maria A. Eichel, N. Kannaiyan +10 more
2020eLife75 citations Open access
Semantic Scholar
AAV2/9-mediated silencing of PMP22 prevents the development of pathological features in a rat model of Charcot-Marie-Tooth disease 1 A
Benoît Gautier, Helene Hajjar, S. Soares, J. Berthelot +15 more
2021Nature Communications68 citations Open access
Semantic Scholar
Murine therapeutic models for Charcot-Marie-Tooth (CMT) disease.
R. Fledrich, R. Stassart, M. Sereda
2012British Medical Bulletin64 citations
Semantic Scholar
A rat model of Charcot-Marie-Tooth disease 1A recapitulates disease variability and supplies biomarkers of axonal loss in patients.
R. Fledrich, B. Schlotter‐Weigel, Tuuli J. Schnizer, Sven P. Wichert +10 more
2012Brain : a journal of neurology61 citations Open access
Semantic Scholar
The Wlds transgene reduces axon loss in a Charcot-Marie-Tooth disease 1A rat model and nicotinamide delays post-traumatic axonal degeneration.
Gerd Meyer zu Horste, T. Miesbach, Johanna Muller, R. Fledrich +4 more
2011Neurobiology of Disease57 citations Open access
Semantic Scholar
NRG1 type I dependent autoparacrine stimulation of Schwann cells in onion bulbs of peripheral neuropathies
R. Fledrich, Dagmar Akkermann, V. Schütza, T. Abdelaal +17 more
2019Nature Communications56 citations Open access
Semantic Scholar
Sodium-Dependent Vitamin C Transporter 2 Deficiency Causes Hypomyelination and Extracellular Matrix Defects in the Peripheral Nervous System
B. Gess, Dominik Röhr, R. Fledrich, M. Sereda +6 more
2011Journal of Neuroscience41 citations Open access
Semantic Scholar
Axo-glial interdependence in peripheral nerve development
R. Fledrich, Theresa Kungl, K. Nave, R. Stassart
2019Development40 citations
Semantic Scholar
CMTM6 expressed on the adaxonal Schwann cell surface restricts axonal diameters in peripheral nerves
Maria A. Eichel, Vasiliki-Ilya Gargareta, E. D'Este, R. Fledrich +12 more
2020Nature Communications38 citations Open access
Semantic Scholar
Biomarkers predict outcome in Charcot Marie Tooth Disease 1A
R. Fledrich, M. Mannil, Andreas Leha, Caroline Ehbrecht +25 more
2017Journal of Neurology Neurosurgery & Psychiatry27 citations Open access
Semantic Scholar
Proteolipid protein modulates preservation of peripheral axons and premature death when myelin protein zero is lacking
J. Patzig, K. Kusch, R. Fledrich, Maria A. Eichel +6 more
2016Glia25 citations
Semantic Scholar
Progesterone antagonist therapy in a Pelizaeus-Merzbacher mouse model.
T. Prukop, Dirk B Epplen, Tobias Nientiedt, Sven P. Wichert +7 more
2014American Journal of Human Genetics23 citations Open access
Semantic Scholar
Early targeting of endoneurial macrophages alleviates the neuropathy and affects abnormal Schwann cell differentiation in a mouse model of Charcot‐Marie‐Tooth 1A
D. Klein, J. Groh, Xi-Di Yuan, Kristina Berve +3 more
2022Glia16 citations Open access
Semantic Scholar
Hypoxia-induced conversion of sensory Schwann cells into repair cells is regulated by HDAC8
Nadège Hertzog, Mert Duman, Maëlle Bochud, Valérie Brügger-Verdon +10 more
2025Nature Communications15 citations Open access
Semantic Scholar
Myelinating Glia-Specific Deletion of Fbxo7 in Mice Triggers Axonal Degeneration in the Central Nervous System Together with Peripheral Neuropathy
Sabitha Joseph, Siv Vingill, Olaf Jahn, R. Fledrich +10 more
2019Journal of Neuroscience14 citations Open access
Semantic Scholar
Multi-omic identification of perineurial hyperplasia and lipid-associated nerve macrophages in human polyneuropathies
Michael O. Heming, Anna-Lena Börsch, Jolien Wolbert, Christian Thomas +26 more
2025Nature Communications11 citations Open access
Semantic Scholar
Targeting PI3K/Akt/mTOR signaling in rodent models of PMP22 gene-dosage diseases
Doris Krauter, D. Stausberg, Timon J Hartmann, Stefan Volkmann +9 more
2024EMBO Molecular Medicine10 citations Open access
Semantic Scholar
Targeted inactivation of the Septin2 and Septin9 genes in myelinating Schwann cells of mice
Ann-Kristin Martens, Michelle S Erwig, J. Patzig, R. Fledrich +2 more
2022Cytoskeleton5 citations Open access
Semantic Scholar
Myelinated peripheral axons are more vulnerable to mechanical trauma in a model of enlarged axonal diameters
Vasiliki-Ilya Gargareta, Stefan A Berghoff, Doris Krauter, Sophie Hümmert +6 more
2024Glia4 citations Open access
Semantic Scholar
Hyperactivity is a Core Endophenotype of Elevated Neuregulin-1 Signaling in Embryonic Glutamatergic Networks
T. Götze, M. C. Soto-Bernardini, Ming-Yue Zhang, Hendrik Mießner +16 more
2021Schizophrenia bulletin4 citations Open access
Semantic Scholar
Publisher Correction: NRG1 type I dependent autoparacrine stimulation of Schwann cells in onion bulbs of peripheral neuropathies
R. Fledrich, Dagmar Akkermann, V. Schütza, T. Abdelaal +17 more
2019Nature Communications3 citations Open access
Semantic Scholar
Multi-omic characterization of human sural nerves across polyneuropathies
Michael O. Heming, Jolien Wolbert, Anna-Lena Börsch, Christian Thomas +20 more
2024bioRxiv2 citations Open access
Semantic Scholar
Inversely proportional myelin growth due to altered Pmp22 gene dosage identifies PI3K/Akt/mTOR signaling as a novel therapeutic target in HNPP
Doris Krauter, D. Ewers, Timon J Hartmann, Stefan Volkmann +5 more
2021bioRxiv1 citations Open access
Semantic Scholar
Long term AAV2/9-mediated silencing of PMP22 prevents CMT1A disease in rats and validates skin biomarkers as treatment outcome measure
Benoît Gautier, Helene Hajjar, S. Soares, J. Berthelot +13 more
2020bioRxiv1 citations Open access
Semantic Scholar
Experimental Treatment of Acquired and Inherited Neuropathies
M. Sereda, R. Fledrich, R. Stassart
20141 citations
Semantic Scholar
Experimentelle Therapien bei hereditären Neuropathien
M. Sereda, B. Weiß, R. Fledrich, G. M. zu Horste +3 more
20091 citations
Semantic Scholar
A Multicenter Confirmatory Randomized-Controlled Study of rhNRGβ1 Protein Replacement Therapy in a Murine Model of NF2-related Schwannomatosis
Michael Reuter, Susann Groth, Johanna Schleep, L. Riecken +12 more
2026bioRxiv0 citations Open access
Semantic Scholar
Red Fluorescent Labeling of Myelin by Membrane‐Targeted tdTomato in Transgenic Mouse Lines
A. Reinert, U. Winkler, S. Goebbels, Lina Komarek +12 more
2026bioRxiv0 citations Open access
Semantic Scholar
High affinity cross-context cellular assays reveal novel protein-protein interactions of peripheral myelin protein of 22 kDa
D. Stausberg, S. Moshkovskii, Friederike A. Arlt, R. Fledrich +5 more
2025bioRxiv0 citations Open access
Semantic Scholar
Addendum: Myelin insulation as a risk factor for axonal degeneration in autoimmune demyelinating disease
Erik Schäffner, Mar Bosch-Queralt, Julia M Edgar, M. Lehning +23 more
2025Nature Neuroscience0 citations Open access
Semantic Scholar
Biomarker und Therapieansätze bei der Charcot-Marie-Tooth Erkrankung (CMT)
R. Fledrich, T. Prukop, S. Fritzsch, L. Reinecke +9 more
2019Nervenheilkunde0 citations
Semantic Scholar
Author response: Proteome profile of peripheral myelin in healthy mice and in a neuropathy model
Sophie B. Siems, Olaf Jahn, Maria A. Eichel, N. Kannaiyan +10 more
20190 citations Open access
Semantic Scholar
Biomarkers in Charcot-Marie-tooth disease 1a
R. Fledrich, M. Mannil, Andreas Leha, A. Solari +21 more
20160 citations
Semantic Scholar
Soluble Neuregulin-1 promotes Schwann cell differentiation in Charcot-Marie-Tooth disease 1 A
R. Fledrich, R. Stassart, A. Klink, L. Rasch +10 more
20140 citations
Semantic Scholar
Stassart et al., 2012SUPP
R. Stassart, R. Fledrich, V. Velanac, B. G. Brinkmann +4 more
20130 citations
Semantic Scholar

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