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R. Kolesnick · SciRah

Researcher profile · Semantic Scholar

R. Kolesnick

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R. Kolesnick — researcher profile on SciRah

h-index: 88
Works: 255
Citations: 34K

Most-cited papers

Interleukin-22 Promotes Intestinal Stem Cell-Mediated Epithelial Regeneration
C. Lindemans, M. Calafiore, Anna M. Mertelsmann, M. O'Connor +23 more
2015Nature1,041 citations Open access
Semantic Scholar
Interleukin-22 protects intestinal stem cells from immune-mediated tissue damage and regulates sensitivity to graft vs. host disease
A. Hanash, J. Dudakov, Guoqiang Hua, M. O'Connor +19 more
2012Immunity592 citations Open access
Semantic Scholar
A rectal cancer organoid platform to study individual responses to chemoradiation
K. Ganesh, Chao Wu, K. O'Rourke, Bryan C. Szeglin +46 more
2019Nature Medicine485 citations Open access
Semantic Scholar
Small-molecule MAPK inhibitors restore radioiodine incorporation in mouse thyroid cancers with conditional BRAF activation.
D. Chakravarty, E. Santos, Mabel Ryder, J. Knauf +11 more
2011Journal of Clinical Investigation368 citations Open access
Semantic Scholar
CERAMIDE-RICH PLATFORMS IN TRANSMEMBRANE SIGNALING
Branka Stancevic, R. Kolesnick
2010FEBS Letters299 citations Open access
Semantic Scholar
Ceramide synthases 2, 5, and 6 confer distinct roles in radiation-induced apoptosis in HeLa cells
Judith Mesicek, Hyunmi Lee, Taya Feldman, Xue-Jun Jiang +5 more
2010Cellular Signalling223 citations Open access
Semantic Scholar
BASIC AND TRANSLATIONAL — ALIMENTARY TRACT Crypt Base Columnar Stem Cells in Small Intestines of Mice Are Radioresistant
Guoqiang Hua, T. Thin, Regina Feldman, A. Haimovitz-Friedman +3 more
2012167 citations
Semantic Scholar
Mitochondrial Ceramide-Rich Macrodomains Functionalize Bax upon Irradiation
Hyunmi Lee, Jimmy A. Rotolo, Judith Mesicek, Tuula Peñate-Medina +11 more
2011PLoS ONE155 citations Open access
Semantic Scholar
T-cell-derived Interferon-γ programs stem cell death in immune-mediated intestinal damage
S. Takashima, M. L. Martin, S. Jansen, Y. Fu +19 more
2019Science immunology135 citations Open access
Semantic Scholar
Anti-ceramide antibody prevents the radiation gastrointestinal syndrome in mice.
Jimmy A. Rotolo, Branka Stancevic, J. Zhang, Guoqiang Hua +10 more
2012Journal of Clinical Investigation134 citations Open access
Semantic Scholar
Endothelial Membrane Remodeling Is Obligate for Anti-Angiogenic Radiosensitization during Tumor Radiosurgery
J. Truman, M. Garcia-Barros, M. Kaag, D. Hambardzumyan +5 more
2010PLoS ONE128 citations Open access
Semantic Scholar
The Unconventional Role of Acid Sphingomyelinase in Regulation of Retinal Microangiopathy in Diabetic Human and Animal Models
Madalina Opreanu, M. Tikhonenko, Svetlana N. Bozack, T. Lydic +9 more
2011Diabetes103 citations Open access
Semantic Scholar
C16:0-Ceramide Signals Insulin Resistance
T. Hla, R. Kolesnick
2014Cell Metabolism94 citations Open access
Semantic Scholar
Phase III Multi-Center, Prospective, Randomized Trial Comparing Single Dose 24 Gy Radiotherapy to a 3-Fraction SBRT Regimen in the Treatment of Oligometastatic Cancer
M. Zelefsky, Y. Yamada, C. Greco, E. Lis +8 more
2021International Journal of Radiation Oncology, Biology, Physics84 citations Open access
Semantic Scholar
Sphingosine-1-phosphate activates the AKT pathway to protect small intestines from radiation-induced endothelial apoptosis.
S. Bonnaud, C. Niaudet, F. Legoux, I. Corre +6 more
2010Cancer Research83 citations Open access
Semantic Scholar
Acid sphingomyelinase.
Brian D. Henry, Regan Ziobro, K. A. Becker, R. Kolesnick +1 more
2013Handbook of Experimental Pharmacology80 citations
Semantic Scholar
Single-dose radiotherapy disables tumor cell homologous recombination via ischemia/reperfusion injury
Sahra Bodo, C. Campagne, T. Thin, D. Higginson +27 more
2019Journal of Clinical Investigation68 citations Open access
Semantic Scholar
Impact of Stromal Sensitivity on Radiation Response of Tumors Implanted in SCID Hosts Revisited
M. Garcia-Barros, T. Thin, J. Maj, C. Cordon-Cardo +3 more
2010Cancer Research66 citations Open access
Semantic Scholar
Logarithmic expansion of LGR5+ cells in human colorectal cancer
M. L. Martin, Z. Zeng, M. Adileh, A. Jacobo +8 more
2017Cellular Signalling58 citations Open access
Semantic Scholar
Axitinib sensitization of high Single Dose Radiotherapy
Shyam S. Rao, Chris Thompson, Jin Cheng, A. Haimovitz-Friedman +3 more
2014Radiotherapy and Oncology53 citations Open access
Semantic Scholar
Distinct Levels of Radioresistance in Lgr5+ Colonic Epithelial Stem Cells versus Lgr5+ Small Intestinal Stem Cells
Guoqiang Hua, Chu Wang, Yan Pan, Z. Zeng +6 more
2017Cancer Research51 citations Open access
Semantic Scholar
A Ceramide-binding C1 Domain Mediates Kinase Suppressor of Ras Membrane Translocation
Xianglei Yin, M. Zafrullah, Hyunmi Lee, A. Haimovitz-Friedman +2 more
2009Cellular Physiology and Biochemistry50 citations Open access
Semantic Scholar
Targeting acid sphingomyelinase reduces cardiac ceramide accumulation in the post-ischemic heart
Martina Klevstig, M. Ståhlman, A. Lundqvist, Margareta Scharin Täng +7 more
2016Journal of Molecular and Cellular Cardiology49 citations Open access
Semantic Scholar
Organoids reveal that inherent radiosensitivity of small and large intestinal stem cells determines organ sensitivity
M. L. Martin, M. Adileh, Kuo-Shun Hsu, Guoqiang Hua +11 more
2019Cancer Research45 citations Open access
Semantic Scholar
Fusion of lysosomes to plasma membrane initiates radiation-induced apoptosis
Charles S Ferranti, Jin Cheng, Chris Thompson, J. Zhang +4 more
2020Journal of Cell Biology44 citations Open access
Semantic Scholar
Colorectal cancer develops inherent radiosensitivity that can be predicted using patient-derived organoids
Kuo-Shun Hsu, M. Adileh, M. L. Martin, V. Makarov +13 more
2022Cancer Research43 citations Open access
Semantic Scholar
Establishing estrogen-responsive mouse mammary organoids from single Lgr5+ cells,,
Li-Xing Zhang, M. Adileh, M. L. Martin, Stefan Klingler +5 more
2016Cellular Signalling42 citations Open access
Semantic Scholar
Phenotype-Oriented Ablation of Oligometastatic Cancer with Single Dose Radiation Therapy.
C. Greco, O. Parés, N. Pimentel, V. Louro +10 more
2019International Journal of Radiation Oncology, Biology, Physics41 citations
Semantic Scholar
Sphingolipid Abnormalities in Cancer Multidrug Resistance: Chicken or Egg?
Wing-Kee Lee, R. Kolesnick
2017Cellular Signalling40 citations Open access
Semantic Scholar
Accelerated Hematopoietic Toxicity by High Energy 56Fe Radiation
Kamal Datta, S. Suman, D. Trani, Kathryn Doiron +5 more
2011International Journal of Radiation Biology40 citations Open access
Semantic Scholar
Timing of lethality from gastrointestinal syndrome in mice revisited.
Jimmy A. Rotolo, R. Kolesnick, Z. Fuks
2009International Journal of Radiation Oncology, Biology, Physics39 citations
Semantic Scholar
Cytolytic T cells induce ceramide-rich platforms in target cell membranes to initiate graft-versus-host disease.
Jimmy A. Rotolo, Branka Stancevic, Sydney X. Lu, J. Zhang +8 more
2009Blood30 citations Open access
Semantic Scholar
It takes a CAD to kill a tumor cell with a LMP.
E. Gulbins, R. Kolesnick
2013Cancer Cell28 citations Open access
Semantic Scholar
Regulation of Ceramide Synthase-Mediated Crypt Epithelium Apoptosis by DNA Damage Repair Enzymes
Jimmy A. Rotolo, Judith Mesicek, J. Maj, J. Truman +3 more
2010Cancer Research28 citations Open access
Semantic Scholar
Regulation of ceramide generation during macrophage apoptosis by ASMase and de novo synthesis
Shih-Wei Wang, Payman Hojabrpour, Peng Zhang, R. Kolesnick +3 more
2015Biochimica et Biophysica Acta27 citations Open access
Semantic Scholar
Adenoviral Transduction of Human Acid Sphingomyelinase into Neo-Angiogenic Endothelium Radiosensitizes Tumor Cure
Branka Stancevic, N. Varda‐Bloom, Jin Cheng, John D. Fuller +10 more
2013PLoS ONE27 citations Open access
Semantic Scholar
Acid sphingomyelinase deactivation post-ischemia promotes brain angiogenesis and remodeling by small extracellular vesicles
Ayan Mohamud Yusuf, N. Hagemann, Xiaoni Zhang, M. Zafar +17 more
2022Basic Research in Cardiology25 citations Open access
Semantic Scholar
Using ASMase Knockout Mice to Model Human Diseases
Guoqiang Hua, R. Kolesnick
2012Handbook of Experimental Pharmacology24 citations
Semantic Scholar
Orthovoltage X-rays exhibit increased efficacy compared to γ-rays in preclinical irradiation
B. Bell, Justin Vercellino, N. Brodin, C. Velten +17 more
2022Cancer Research23 citations Open access
Semantic Scholar
Anti-ceramide single-chain variable fragment mitigates radiation GI syndrome mortality independent of DNA repair
Jimmy A. Rotolo, C. Fong, Sahra Bodo, Prashanth K. B. Nagesh +7 more
2021JCI Insight23 citations Open access
Semantic Scholar
Targeting acid sphingomyelinase with anti-angiogenic chemotherapy
Jeanna Jacobi, M. Garcia-Barros, Shyam Rao, Jimmy A. Rotolo +9 more
2016Cellular Signalling23 citations Open access
Semantic Scholar
Marked elevations in lung and plasma ceramide in COVID-19 linked to microvascular injury
I. Petrache, E. Pujadas, Aditya Ganju, K. Serban +10 more
2023JCI Insight22 citations Open access
Semantic Scholar
Alpha Particles Induce Apoptosis through the Sphingomyelin Pathway
Jonathan H Seideman, Branka Stancevic, Jimmy A. Rotolo, M. McDevitt +3 more
2011Radiation Research22 citations Open access
Semantic Scholar
Kinase Suppressor of Ras Transphosphorylates c-Raf-1
M. Zafrullah, Xianglei Yin, A. Haimovitz-Friedman, Z. Fuks +1 more
2009Biochemical and Biophysical Research Communications - BBRC20 citations Open access
Semantic Scholar
Homozygous Smpd1 deficiency aggravates brain ischemia/ reperfusion injury by mechanisms involving polymorphonuclear neutrophils, whereas heterozygous Smpd1 deficiency protects against mild focal cerebral ischemia
N. Hagemann, Ayan Mohamud Yusuf, C. Martiny, Xiaoni Zhang +5 more
2020Basic Research in Cardiology19 citations Open access
Semantic Scholar
Gemcitabine kills proliferating endothelial cells exclusively via acid sphingomyelinase activation
A. V. van Hell, A. Haimovitz-Friedman, Z. Fuks, W. Tap +1 more
2017Cellular Signalling18 citations Open access
Semantic Scholar
Radiation-induced gastrointestinal (GI) syndrome as a function of age
Hongyan Li, Herman Kucharavy, Carla Hajj, Liyang Zhao +7 more
2023Cell Death Discovery15 citations Open access
Semantic Scholar
Targeting Homologous Recombination in Notch-Driven C. elegans Stem Cell and Human Tumors
Xin-Zhu Deng, David Michaelson, J. Tchieu, Jin Cheng +10 more
2015PLoS ONE15 citations Open access
Semantic Scholar
Intestinal Acid Sphingomyelinase Protects From Severe Pathogen-Driven Colitis
J. Meiners, Vittoria Palmieri, R. Klopfleisch, J. Ebel +12 more
2019Frontiers in Immunology14 citations Open access
Semantic Scholar
Ceramide as an endothelial cell surface receptor and a lung-specific lipid vascular target for circulating ligands
Daniela I. Staquicini, M. Cardó-Vila, Jimmy A. Rotolo, F. Staquicini +25 more
2023Proceedings of the National Academy of Sciences of the United States of America11 citations Open access
Semantic Scholar

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Z. Fuks×27
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A. Haimovitz-Friedman×19
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Jimmy A. Rotolo×13
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Jimmy A. Rotolo — researcher profile on SciRah
Guoqiang Hua×10
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M. L. Martin — researcher profile on SciRah

Branka Stancevic×6

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Branka Stancevic — researcher profile on SciRah

John D. Fuller×6

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M. Adileh — researcher profile on SciRah

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P. Paty — researcher profile on SciRah

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E. Gulbins — researcher profile on SciRah

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Regina Feldman — researcher profile on SciRah