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J. Arolas · SciRah

Researcher profile · Semantic Scholar

J. Arolas

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J. Arolas — researcher profile on SciRah

h-index: 20
Works: 81
Citations: 1,237

Most-cited papers

Folding of small disulfide-rich proteins: clarifying the puzzle.
J. Arolas, F. Avilés, Jui-Yoa Chang, S. Ventura
2006TIBS -Trends in Biochemical Sciences. Regular ed159 citations Open access
Semantic Scholar
Metallocarboxypeptidases: emerging drug targets in biomedicine.
J. Arolas, J. Vendrell, F. Avilés, L. Fricker
2007Current pharmaceutical design110 citations
Semantic Scholar
A Carboxypeptidase Inhibitor from the Tick Rhipicephalus bursa
J. Arolas, J. Lorenzo, A. Rovira, J. Castellá +2 more
2005Journal of Biological Chemistry91 citations Open access
Semantic Scholar
Structural basis for the sheddase function of human meprin β metalloproteinase at the plasma membrane
J. Arolas, C. Broder, T. Jefferson, T. Guevara +5 more
2012Proceedings of the National Academy of Sciences of the United States of America79 citations Open access
Semantic Scholar
Structure, function and latency regulation of a bacterial enterotoxin potentially derived from a mammalian adamalysin/ADAM xenolog
T. Goulas, J. Arolas, F. Gomis-Rüth
2011Proceedings of the National Academy of Sciences of the United States of America74 citations Open access
Semantic Scholar
The three-dimensional structures of tick carboxypeptidase inhibitor in complex with A/B carboxypeptidases reveal a novel double-headed binding mode.
J. Arolas, G. Popowicz, J. Lorenzo, C. Sommerhoff +3 more
2005Journal of Molecular Biology61 citations
Semantic Scholar
Mammalian metallopeptidase inhibition at the defense barrier of Ascaris parasite
Laura Sanglas, F. X. Avilés, R. Huber, F. Gomis-Rüth +1 more
2009Proceedings of the National Academy of Sciences of the United States of America49 citations Open access
Semantic Scholar
Structure of activated thrombin-activatable fibrinolysis inhibitor, a molecular link between coagulation and fibrinolysis.
Laura Sanglas, Z. Valnickova, J. Arolas, I. Pallarès +6 more
2008Molecules and Cells43 citations Open access
Semantic Scholar
Multiple stable conformations account for reversible concentration-dependent oligomerization and autoinhibition of a metamorphic metallopeptidase.
M. Lopez-pelegrin, N. Cerdà‐Costa, A. Cintas-pedrola, Fátima Herranz-Trillo +4 more
2014Angewandte Chemie41 citations Open access
Semantic Scholar
The pCri System: A Vector Collection for Recombinant Protein Expression and Purification
T. Goulas, A. Cuppari, R. García-Castellanos, S. Snipas +3 more
2014PLoS ONE36 citations Open access
Semantic Scholar
A Novel Family of Soluble Minimal Scaffolds Provides Structural Insight into the Catalytic Domains of Integral Membrane Metallopeptidases*
M. Lopez-pelegrin, N. Cerdà‐Costa, F. Martínez-Jiménez, A. Cintas-pedrola +6 more
2013Journal of Biological Chemistry35 citations Open access
Semantic Scholar
Multiple Architectures and Mechanisms of Latency in Metallopeptidase Zymogens.
J. Arolas, T. Goulas, A. Cuppari, F. Gomis-Rüth
2018Chemical Reviews32 citations Open access
Semantic Scholar
The structure of the catalytic domain of Tannerella forsythia karilysin reveals it is a bacterial xenolog of animal matrix metalloproteinases
N. Cerdà‐Costa, T. Guevara, A. Karim, M. Ksiazek +4 more
2010Molecular Microbiology31 citations Open access
Semantic Scholar
Structural evidence for standard-mechanism inhibition in metallopeptidases from a complex poised to resynthesize a peptide bond.
J. Arolas, T. Botelho, A. Vilcinskas, F. Gomis-Rüth
2011Angewandte Chemie27 citations
Semantic Scholar
Role of Kinetic Intermediates in the Folding of Leech Carboxypeptidase Inhibitor*
J. Arolas, Sílvia Bronsoms, J. Lorenzo, F. Avilés +2 more
2004Journal of Biological Chemistry26 citations Open access
Semantic Scholar
Order from disorder in the sarcomere: FATZ forms a fuzzy but tight complex and phase-separated condensates with α-actinin
A. Sponga, J. Arolas, Thomas C. Schwarz, C. Jeffries +23 more
2021Science Advances24 citations Open access
Semantic Scholar
NMR structural characterization and computational predictions of the major intermediate in oxidative folding of leech carboxypeptidase inhibitor.
J. Arolas, L. D'silva, G. Popowicz, F. Avilés +2 more
2005Structure22 citations Open access
Semantic Scholar
Insights into the molecular inactivation mechanism of human activated thrombin‐activatable fibrinolysis inhibitor
Laura Sanglas, J. Arolas, Z. Valnickova, F. Avilés +2 more
2010Journal of Thrombosis and Haemostasis21 citations Open access
Semantic Scholar
Designing out disulfide bonds of leech carboxypeptidase inhibitor: implications for its folding, stability and function.
J. Arolas, Virginia Castillo, Sílvia Bronsoms, F. Avilés +1 more
2009Journal of Molecular Biology21 citations
Semantic Scholar
Scrambled Isomers as Key Intermediates in the Oxidative Folding of Ligand Binding Module 5 of the Low Density Lipoprotein Receptor*
X. Arias-Moreno, J. Arolas, F. Avilés, J. Sancho +1 more
2008Journal of Biological Chemistry21 citations Open access
Semantic Scholar
Calcium modulates the domain flexibility and function of an α-actinin similar to the ancestral α-actinin
N. Pinotsis, K. Zielińska, Mrigya Babuta, J. Arolas +11 more
2020Proceedings of the National Academy of Sciences of the United States of America20 citations Open access
Semantic Scholar
The NMR structure and dynamics of the two-domain tick carboxypeptidase inhibitor reveal flexibility in its free form and stiffness upon binding to human carboxypeptidase B.
D. Pantoja-Uceda, J. Arolas, P. García, E. López-Hernández +3 more
2008Biochemistry20 citations Open access
Semantic Scholar
Secondary binding site of the potato carboxypeptidase inhibitor. Contribution to its structure, folding, and biological properties.
J. Arolas, J. Lorenzo, A. Rovira, J. Vendrell +2 more
2004Biochemistry20 citations
Semantic Scholar
A Novel Mechanism of Latency in Matrix Metalloproteinases*
M. Lopez-pelegrin, M. Ksiazek, A. Karim, T. Guevara +3 more
2015Journal of Biological Chemistry19 citations Open access
Semantic Scholar
Study of a major intermediate in the oxidative folding of leech carboxypeptidase inhibitor: contribution of the fourth disulfide bond.
J. Arolas, G. Popowicz, Sílvia Bronsoms, F. Avilés +3 more
2005Journal of Molecular Biology18 citations
Semantic Scholar
Oxidative folding and structural analyses of a Kunitz-related inhibitor and its disulfide intermediates: functional implications.
Sílvia Bronsoms, D. Pantoja-Uceda, D. Gabrijelcic‐Geiger, Laura Sanglas +4 more
2011Journal of Molecular Biology15 citations Open access
Semantic Scholar
Deciphering the Structural Basis That Guides the Oxidative Folding of Leech-derived Tryptase Inhibitor*
D. Pantoja-Uceda, J. Arolas, F. Avilés, J. Santoro +2 more
2009Journal of Biological Chemistry15 citations Open access
Semantic Scholar
Oxidative Folding of Leech-Derived Tryptase Inhibitor Via Native Disulfide-Bonded Intermediates
J. Arolas, Sílvia Bronsoms, F. Avilés, S. Ventura +1 more
2008Antioxidants and Redox Signaling13 citations
Semantic Scholar
Structure–Function Analysis of the Short Splicing Variant Carboxypeptidase Encoded by Drosophila melanogaster silver
S. Tanco, J. Arolas, T. Guevara, J. Lorenzo +2 more
2010Journal of Molecular Biology12 citations Open access
Semantic Scholar
A unique network of attack, defence and competence on the outer membrane of the periodontitis pathogen Tannerella forsythia
M. Ksiazek, T. Goulas, D. Mizgalska, A. Rodríguez-Banqueri +19 more
2022Chemical Science11 citations Open access
Semantic Scholar
Ultratight crystal packing of a 10 kDa protein.
S. Trillo-Muyo, A. Jasilionis, M. Domagalski, M. Chruszcz +5 more
2013Acta Crystallographica Section D: Biological Crystallography11 citations Open access
Semantic Scholar
Protease Inhibitors as Models for the Study of Oxidative Folding
J. Arolas, S. Ventura
2011Antioxidants and Redox Signaling11 citations Open access
Semantic Scholar
Flexibility of the Thrombin-activatable Fibrinolysis Inhibitor Pro-domain Enables Productive Binding of Protein Substrates*
Z. Valnickova, Laura Sanglas, J. Arolas, S. Petersen +5 more
2010Journal of Biological Chemistry9 citations Open access
Semantic Scholar
Characterizing the Tick Carboxypeptidase Inhibitor
J. Arolas, Sílvia Bronsoms, S. Ventura, F. Avilés +1 more
2006Journal of Biological Chemistry9 citations Open access
Semantic Scholar
Structural basis for latency and function of immune inhibitor A metallopeptidase, a modulator of the Bacillus anthracis secretome
J. Arolas, T. Goulas, A. Pomerantsev, S. Leppla +1 more
2016Structure8 citations Open access
Semantic Scholar
The NMR Structures of the Major Intermediates of the Two-domain Tick Carboxypeptidase Inhibitor Reveal Symmetry in Its Folding and Unfolding Pathways*
J. Arolas, D. Pantoja-Uceda, S. Ventura, F. Blanco +1 more
2008Journal of Biological Chemistry8 citations Open access
Semantic Scholar
Expression and purification of integral membrane metallopeptidase HtpX.
J. Arolas, R. García-Castellanos, T. Goulas, Y. Akiyama +1 more
2014Protein Expression and Purification7 citations Open access
Semantic Scholar
Mechanism of action of a Janus-faced single-domain protein inhibitor simultaneously targeting two peptidase classes
S. Trillo-Muyo, S. Martínez-Rodríguez, J. Arolas, F. Gomis-Rüth
20136 citations Open access
Semantic Scholar
Insights into the two-domain architecture of the metallocarboxypeptidase inhibitor from the Ascaris parasite inferred from the mechanism of its oxidative folding.
J. Arolas, Laura Sanglas, J. Lorenzo, Sílvia Bronsoms +1 more
2009Biochemistry4 citations
Semantic Scholar
Cytotoxicity studies of [PtCl2(H2bim)] (H2bim = 2,2′-biimidazole): Study of its interaction with a small protein PCI (potato carboxypeptidase inhibitor)
Yolanda Parajó, J. Arolas, V. Moreno, A. Sánchez-gonzález +4 more
20093 citations
Semantic Scholar
Recombinant expression of disulfide-rich proteins: carboxypeptidase inhibitors as model proteins
Laura Sanglas, Sílvia Bronsoms, J. Arolas, J. Lorenzo +1 more
20061 citations Open access
Semantic Scholar
Sarcomeric Protein Fatz Forms a Tight Fuzzy Complex with α-Actinin and Phase-Separates in Vitro
A. Sponga, J. Arolas, Thomas C. Schwarz, C. Jeffries +8 more
20210 citations Open access
Semantic Scholar
Crystal structure of sarcomeric protein FATZ-1 (d91-FATZ-1 construct) in complex with half dimer of alpha-actinin-2
A. Sponga, J. Arolas, A. Chamorro, G. Mlynek +6 more
20210 citations
Semantic Scholar
Crystal structure of sarcomeric protein FATZ-1 (mini-FATZ-1 construct) in complex with rod domain of alpha-actinin-2
A. Sponga, J. Arolas, A. Chamorro, G. Mlynek +6 more
20210 citations
Semantic Scholar
Crystal structure of sarcomeric protein FATZ-1 (d91-FATZ-1 construct) in complex with rod domain of alpha-actinin-2
A. Sponga, J. Arolas, A. Chamorro, G. Mlynek +6 more
20210 citations
Semantic Scholar
Order from disorder in the sarcomere: FATZ forms a fuzzy complex and phase-separated macromolecular condensates with α-actinin
A. Sponga, J. Arolas, Thomas C. Schwarz, C. Jeffries +23 more
2021Acta Crystallographica Section A: Foundations and Advances0 citations Open access
Semantic Scholar
Structural Insights into the Disease-Causing Mutant α-Actinin 4 K255E Bound to F-Actin
Wei-Li Zheng, J. Arolas, Slobodan Vujin, K. Djinović-Carugo +1 more
2019Biophysical Journal0 citations Open access
Semantic Scholar
Structure of the α-actinin actin-binding domain/F-actin complex
Slobodan Vujin, Wei-Li Zheng, J. Arolas, Eneda Höllerl +6 more
2019Acta Crystallographica Section A: Foundations and Advances0 citations Open access
Semantic Scholar
Fuzzy sarcomeric Z-disk complex: α-actinin-FATZ
K. Djinović-Carugo, Antonio Sponga, Ariadna Rodriguez Chamorro, Euripedes de Ribeiro +4 more
20160 citations Open access
Semantic Scholar
Structure of karilysin propeptide and catalytic MMP domain
M. Lopez-pelegrin, M. Ksiazek, A. Karim, T. Guevara +3 more
20150 citations
Semantic Scholar

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F. Avilés×22
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S. Ventura×12
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F. Gomis-Rüth×10
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J. Lorenzo — researcher profile on SciRah

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