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Sophia B. Georghiou · SciRah

Researcher profile · Semantic Scholar

Sophia B. Georghiou

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Sophia B. Georghiou — researcher profile on SciRah

h-index: 18
Works: 47
Citations: 1,245

Most-cited papers

Evaluation of Genetic Mutations Associated with Mycobacterium tuberculosis Resistance to Amikacin, Kanamycin and Capreomycin: A Systematic Review
Sophia B. Georghiou, Marisa M Magaña, R. Garfein, D. Catanzaro +2 more
2012PLoS ONE266 citations Open access
Semantic Scholar
Rapid Drug Susceptibility Testing of Drug-Resistant Mycobacterium tuberculosis Isolates Directly from Clinical Samples by Use of Amplicon Sequencing: a Proof-of-Concept Study
R. Colman, Julia M. Anderson, D. Lemmer, Erik Lehmkuhl +10 more
2016Journal of Clinical Microbiology87 citations Open access
Semantic Scholar
Xpert MTB/XDR: a 10-Color Reflex Assay Suitable for Point-of-Care Settings To Detect Isoniazid, Fluoroquinolone, and Second-Line-Injectable-Drug Resistance Directly from Mycobacterium tuberculosis-Positive Sputum
Yuan Cao, Heta Parmar, R. Gaur, D. Lieu +10 more
2020Journal of Clinical Microbiology85 citations Open access
Semantic Scholar
Detection of isoniazid, fluoroquinolone, ethionamide, amikacin, kanamycin, and capreomycin resistance by the Xpert MTB/XDR assay: a cross-sectional multicentre diagnostic accuracy study.
A. Penn-Nicholson, Sophia B. Georghiou, N. Ciobanu, Mubin Kazi +10 more
2021Lancet. Infectious Diseases (Print)76 citations Open access
Semantic Scholar
Bacillus thuringiensis Cry5B Protein Is Highly Efficacious as a Single-Dose Therapy against an Intestinal Roundworm Infection in Mice
Yan Hu, Sophia B. Georghiou, A. Kelleher, R. Aroian
2010PLoS Neglected Tropical Diseases69 citations Open access
Semantic Scholar
Tuberculosis Treatment Monitoring and Outcome Measures: New Interest and New Strategies
J. Heyckendorf, Sophia B. Georghiou, Nicole Frahm, N. Heinrich +7 more
2022Clinical Microbiology Reviews66 citations Open access
Semantic Scholar
Correlating rrs and eis promoter mutations in clinical isolates of Mycobacterium tuberculosis with phenotypic susceptibility levels to the second line injectables
Priti Kambli, K. Ajbani, C. Nikam, M. Sadani +6 more
2015International Journal of Mycobacteriology55 citations Open access
Semantic Scholar
The epidemiology, transmission, diagnosis, and management of drug-resistant tuberculosis-lessons from the South African experience.
K. Naidoo, R. Perumal, H. Cox, B. Mathema +7 more
2024Lancet. Infectious Diseases (Print)51 citations
Semantic Scholar
Performance Comparison of Three Rapid Tests for the Diagnosis of Drug-Resistant Tuberculosis
A. Catanzaro, T. Rodwell, D. Catanzaro, R. Garfein +13 more
2015PLoS ONE45 citations Open access
Semantic Scholar
Evaluating culture-free targeted next-generation sequencing for diagnosing drug-resistant tuberculosis: a multicentre clinical study of two end-to-end commercial workflows
R. Colman, M. Seifert, A. De la Rossa, Sophia B. Georghiou +11 more
2024Lancet. Infectious Diseases (Print)44 citations Open access
Semantic Scholar
Defining Multidrug-Resistant Tuberculosis: Correlating GenoType MTBDRplus Assay Results with Minimum Inhibitory Concentrations
Priti Kambli, K. Ajbani, M. Sadani, C. Nikam +6 more
2015Diagnostic microbiology and infectious disease30 citations Open access
Semantic Scholar
Determination of MICs of Levofloxacin for Mycobacterium tuberculosis with gyrA Mutations
Priti Kambli, K. Ajbani, C. Nikam, A. Khillari +6 more
2015The International Journal of Tuberculosis and Lung Disease30 citations Open access
Semantic Scholar
Updating the approaches to define susceptibility and resistance to anti-tuberculosis agents: implications for diagnosis and treatment
Sophia B. Timothy C. Alexei Said H. Kanchan Jan-Willem Da Georghiou Rodwell Korobitsyn Abbadi Ajbani Alffena, Sophia B. Georghiou, T. Rodwell, A. Korobitsyn +124 more
2022European Respiratory Journal29 citations Open access
Semantic Scholar
Comparative Analytical Evaluation of Four Centralized Platforms for the Detection of Mycobacterium tuberculosis Complex and Resistance to Rifampicin and Isoniazid
M. de Vos, L. Scott, A. David, A. Trollip +7 more
2020Journal of Clinical Microbiology29 citations Open access
Semantic Scholar
MTBDRplus and MTBDRsl Assays: Absence of Wild-Type Probe Hybridization and Implications for Detection of Drug-Resistant Tuberculosis
M. Seifert, Sophia B. Georghiou, D. Catanzaro, C. Rodrigues +5 more
2016Journal of Clinical Microbiology25 citations Open access
Semantic Scholar
Analytical performance of the Xpert MTB/XDR® assay for tuberculosis and expanded resistance detection.
Sophia B. Georghiou, A. Penn-Nicholson, M. de Vos, A. Macé +10 more
2021Diagnostic microbiology and infectious disease22 citations Open access
Semantic Scholar
On the Consequences of Poorly Defined Breakpoints for Rifampin Susceptibility Testing of Mycobacterium tuberculosis Complex
C. Köser, Sophia B. Georghiou, T. Schön, M. Salfinger
2021Journal of Clinical Microbiology22 citations Open access
Semantic Scholar
Designing molecular diagnostics for current tuberculosis drug regimens
Sophia B. Georghiou, M. de Vos, Kavindhran Velen, P. Miotto +6 more
2023Emerging Microbes and Infections20 citations Open access
Semantic Scholar
Commentary: what is the role of the EUCAST reference method for MIC testing of the Mycobacterium tuberculosis complex?
T. Schön, C. Köser, J. Werngren, M. Viveiros +12 more
2020Clinical Microbiology and Infection18 citations Open access
Semantic Scholar
Guidance for Studies Evaluating the Accuracy of Rapid Tuberculosis Drug-Susceptibility Tests.
Sophia B. Georghiou, S. Schumacher, T. Rodwell, R. Colman +10 more
2019Journal of Infectious Diseases17 citations Open access
Semantic Scholar
Increased Tuberculosis Patient Mortality Associated with Mycobacterium tuberculosis Mutations Conferring Resistance to Second-Line Antituberculous Drugs
Sophia B. Georghiou, M. Seifert, D. Catanzaro, R. Garfein +1 more
2017Journal of Clinical Microbiology16 citations Open access
Semantic Scholar
A Performance Evaluation of MTBDRplus (version 2) for the Diagnosis of Multidrug-resistant Tuberculosis
M. Seifert, K. Ajbani, Sophia B. Georghiou, D. Catanzaro +6 more
2016The International Journal of Tuberculosis and Lung Disease16 citations Open access
Semantic Scholar
Impact of Fluoroquinolone Use on Mortality Among a Cohort of Patients With Suspected Drug-Resistant Tuberculosis
M. Seifert, Sophia B. Georghiou, R. Garfein, D. Catanzaro +1 more
2017Clinical Infectious Diseases15 citations Open access
Semantic Scholar
Accuracy of the Truenat MTB-RIF Dx assay for detection of rifampicin resistance-associated mutations.
Sophia B. Georghiou, N. Gomathi, P. Rajendran, V. Nagalakshmi +7 more
2021Tuberculosis13 citations
Semantic Scholar
Redefining MTBDRplus test results: What do indeterminate results actually mean?
C. Nikam, Ronak Patel, M. Sadani, K. Ajbani +7 more
2016The International Journal of Tuberculosis and Lung Disease12 citations Open access
Semantic Scholar
Shedding light on the performance of a pyrosequencing assay for drug-resistant tuberculosis diagnosis
Sophia B. Georghiou, M. Seifert, S. Lin, D. Catanzaro +7 more
2016BMC Infectious Diseases12 citations Open access
Semantic Scholar
Developing biomarker assays to accelerate tuberculosis drug development: defining target product profiles
Stephen H. Gillespie, A. DiNardo, Sophia B. Georghiou, W. Sabiiti +12 more
2024The Lancet Microbe10 citations Open access
Semantic Scholar
Targeted next-generation sequencing for drug-resistant tuberculosis diagnosis: implementation considerations for bacterial load, regimen selection and diagnostic algorithm placement
Sophia B. Georghiou, N. Tukvadze, C. Rodrigues, S. V. Omar +7 more
2025BMJ Global Health9 citations Open access
Semantic Scholar
In silico evaluation of WHO-endorsed molecular methods to detect drug resistant tuberculosis
A. Brankin, M. Seifert, Sophia B. Georghiou, T. Walker +3 more
2022Scientific Reports8 citations Open access
Semantic Scholar
Comparative accuracy of the REBA MTB MDR and Hain MTBDRplus line probe assays for the detection of multidrug-resistant tuberculosis: A multicenter, non-inferiority study
Joshua Havumaki, D. Hillemann, N. Ismail, S. Omar +4 more
2017PLoS ONE8 citations Open access
Semantic Scholar
Triage test for all-oral drug-resistant tuberculosis (DR-TB) regimen: a phase IV study to assess effectiveness, feasibility, acceptability and cost-effectiveness of the Xpert MTB/XDR assay for rapid triage and treatment of DR-TB
K. Naidoo, A. Naidoo, A. Abimiku, E. Tiemersma +23 more
2024BMJ Open7 citations Open access
Semantic Scholar
Equivalence of the GeneXpert System and GeneXpert Omni System for tuberculosis and rifampicin resistance detection
Sophia B. Georghiou, R. Alagna, D. Cirillo, S. Carmona +2 more
2021PLoS ONE5 citations Open access
Semantic Scholar
Molecular diagnostic tests for isoniazid-resistant tuberculosis: a scoping review.
Thi Mai Nguyen, E. L. MacLean, Xiaomei Zhang, Sophia B. Georghiou +6 more
2026The Lancet Microbe4 citations Open access
Semantic Scholar
Clinical evaluation of the Xpert MTB/XDR assay for rapid detection of isoniazid, fluoroquinolone, ethionamide and second-line drug resistance: A cross-sectional multicentre diagnostic accuracy study
A. Penn-Nicholson, Sophia B. Georghiou, N. Ciobanu, Mubin Kazi +10 more
2021medRxiv4 citations Open access
Semantic Scholar
Laboratory Evaluation of a Lateral-Flow Cell for Molecular Detection of First-Line and Second-Line Antituberculosis Drug Resistance
D. Catanzaro, R. Colman, Yvonne Linger, Sophia B. Georghiou +8 more
2020Journal of Clinical Microbiology4 citations Open access
Semantic Scholar
Corrigendum to “Correlating rrs and eis promoter mutations in clinical isolates of Mycobacterium tuberculosis with phenotypic susceptibility levels to the second-line injectables” [Int. J. Mycobacteriol. 5(1) 2016 1–6]*
Priti Kambli, K. Ajbani, C. Nikam, M. Sadani +6 more
2016International Journal of Mycobacteriology4 citations Open access
Semantic Scholar
MTBDR plus and MTBDR sl Assays: Absence of Wild-Type Probe Hybridization and Implications for Detection of Drug-Resistant Tuberculosis
M. Seifert, Sophia B. Georghiou, D. Catanzaro, Camilla Rodrigues +5 more
20164 citations
Semantic Scholar
Performance of a Pyrosequencing Platform in Diagnosing Drug-resistant Extrapulmonary Tuberculosis Specimens in India
Sophia B. Georghiou, K. Ajbani, Camilla Rodrigues, T. Rodwell
2016The International Journal of Tuberculosis and Lung Disease4 citations Open access
Semantic Scholar
The ahpC c−54t compensatory mutation is not always a valid surrogate for isoniazid resistance in Mycobacterium tuberculosis
Viktória Szél, J. Phelan, Sophia B. Georghiou, D. L. Dolinger +4 more
2025Antimicrobial Agents and Chemotherapy3 citations Open access
Semantic Scholar
Inclusion of patient-centered, non-microbiological endpoints and biomarkers in tuberculosis drug trials
A. DiNardo, W. Sabiiti, Stephen H. Gillespie, Sophia B. Georghiou +14 more
2025Frontiers in Antibiotics2 citations Open access
Semantic Scholar
Evaluation of the microscopic observation drug susceptibility assay for the detection of first and second-line drug susceptibility for Mycobacterium tuberculosis.
D. Catanzaro, A. Trollip, M. Seifert, Sophia B. Georghiou +4 more
2017European Respiratory Journal2 citations Open access
Semantic Scholar
TB Diagnostic Pipeline
Sophia B. Georghiou
20171 citations
Semantic Scholar
Correction: Inclusion of patient-centered, non-microbiological endpoints and biomarkers in tuberculosis drug trials
A. DiNardo, W. Sabiiti, Stephen H. Gillespie, Sophia B. Georghiou +14 more
2026Frontiers in Antibiotics0 citations Open access
Semantic Scholar
"I love this gory business": The Art of Female Hedonism in the Poetry of Chelsey Minnis and Sara Peters
Sophia B. Georghiou
2025Writing in Practice0 citations
Semantic Scholar
Clinical evaluation of the Xpert MTB/XDR assay for rapid detection of isoniazid, 1 fluoroquinolone, ethionamide and second-line drug resistance: A cross-sectional 2 multicentre diagnostic accuracy study
A. Penn-Nicholson, Sophia B. Georghiou, N. Ciobanu, M. Bhalla +10 more
20210 citations
Semantic Scholar
Molecular diagnostics for drug-resistant tuberculosis: Can genetic tests replace conventional diagnostics as predictors of drug resistance and clinical outcome?
Sophia B. Georghiou
20160 citations
Semantic Scholar
An investigation into the anthelmintic properties and synergistic potential of Cry5B
Sophia B. Georghiou
20100 citations
Semantic Scholar

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