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J. Murphy · SciRah

Researcher profile · Semantic Scholar

J. Murphy

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J. Murphy — researcher profile on SciRah

h-index: 28
Works: 101
Citations: 2,435

Most-cited papers

The cytosolic entry of diphtheria toxin catalytic domain requires a host cell cytosolic translocation factor complex
R. Ratts, H. Zeng, Eric A. Berg, C. Blue +4 more
2003Journal of Cell Biology197 citations Open access
Semantic Scholar
Mechanism of Diphtheria Toxin Catalytic Domain Delivery to the Eukaryotic Cell Cytosol and the Cellular Factors that Directly Participate in the Process
J. Murphy
2011Toxins191 citations Open access
Semantic Scholar
Structure of the metal-ion-activated diphtheria toxin repressor/ tox operator complex
A. White, Xiao-Chun Ding, J. Vanderspek, J. Murphy +1 more
1998Nature173 citations
Semantic Scholar
Erythrocyte metabolism. III. Relationship of energy metabolism and serum factors to the osmotic fragility following incubation
J. Murphy
1962145 citations
Semantic Scholar
The influence of pH and temperature on some physical properties of normal erythrocytes and erythrocytes from patients with hereditary spherecytosis
J. Murphy
1967142 citations
Semantic Scholar
Specific binding of the diphtheria tox regulatory element DtxR to the tox operator requires divalent heavy metal ions and a 9-base-pair interrupted palindromic sequence.
X. Tao, J. Boyd, J. Murphy
1992Proceedings of the National Academy of Sciences of the United States of America73 citations Open access
Semantic Scholar
The Gonococcal Fur Regulon: Identification of Additional Genes Involved in Major Catabolic, Recombination, and Secretory Pathways
Shite Sebastian, Sarika Agarwal, J. Murphy, C. Genco
2002Journal of Bacteriology66 citations Open access
Semantic Scholar
Bacteriophage Gene Products That Cause Human Disease
W. Bishai, J. Murphy
198858 citations
Semantic Scholar
Metal stoichiometry and functional studies of the diphtheria toxin repressor
M. M. Spiering, D. Ringe, J. Murphy, M. Marletta
2003Proceedings of the National Academy of Sciences of the United States of America55 citations Open access
Semantic Scholar
Molecular cloning, DNA sequence analysis, and characterization of the Corynebacterium diphtheriae dtxR homolog from Brevibacterium lactofermentum
J. A. Oguiza, Tao Xu, A. T. Marcos, Juan F. Martín +1 more
1995Journal of Bacteriology55 citations Open access
Semantic Scholar
The flocculation of algae with synthetic polymeric flocculants
R. Tilton, J. Murphy, J. K. Dixon
197255 citations
Semantic Scholar
Design and Synthesis of a Pan-Janus Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin.
Peter G. Jones, R. I. Storer, Y. Sabnis, Florian M Wakenhut +13 more
2017Journal of Medicinal Chemistry54 citations Open access
Semantic Scholar
A conserved motif in transmembrane helix 1 of diphtheria toxin mediates catalytic domain delivery to the cytosol
R. Ratts, C. Trujillo, A. Bharti, J. Vanderspek +2 more
2005Proceedings of the National Academy of Sciences of the United States of America53 citations Open access
Semantic Scholar
Diphtheria toxin fusion proteins.
F. Foss, M. Saleh, J. Krueger, J. Nichols +1 more
1998Current Topics in Microbiology and Immunology51 citations
Semantic Scholar
PROLONGATION OF CARDIAC ALLOGRAFT SURVIVAL IN MURINE RECIPIENTS TREATED WITH A DIPHTHERIA TOXIN RELATED INTERLEUKIN‐2 FUSION PROTEIN
R. Kirkman, P. Bacha, L. V. Barrett, S. Forte +2 more
1989Transplantation49 citations Open access
Semantic Scholar
High-level expression of a proteolytically sensitive diphtheria toxin fragment in Escherichia coli
W. Bishai, R. Rappuoli, J. Murphy
1987Journal of Bacteriology49 citations Open access
Semantic Scholar
Physical properties of red cells as related to effects in vivo. I. Increased rigidity of erythrocytes as measured by viscosity of cells altered by chemical fixation, sickling and hypertonicity.
T. H. Ham, R. Dunn, Richard W. Sayre, J. Murphy
1968Blood45 citations Open access
Semantic Scholar
SCLERODERMA WITH PULMONARY FIBROSIS
J. Murphy, P. Krainin, M. Gerson
194145 citations
Semantic Scholar
Identification of Immunologic and Pathologic Parameters of Death versus Survival in Respiratory Tularemia
Damiana Chiavolini, J. Alroy, C. A. King, P. Jorth +4 more
2007Infection and Immunity42 citations Open access
Semantic Scholar
Characterization of the Role of the Divalent Metal Ion-Dependent Transcriptional Repressor MntR in the Virulence of Staphylococcus aureus
Masaru Ando, Y. Manabe, P. Converse, E. Miyazaki +3 more
2003Infection and Immunity40 citations Open access
Semantic Scholar
Physical properties of red cells as related to effects in vivo. II. Effect of thermal treatment on rigidity of red cells, stroma and the sickle cell.
T. H. Ham, Richard W. Sayre, R. Dunn, J. Murphy
1968Blood38 citations Open access
Semantic Scholar
Genetic and biophysical studies of diphtheria toxin repressor (DtxR) and the hyperactive mutant DtxR(E175K) support a multistep model of activation.
J. Love, J. Vanderspek, Vedrana Marin, L. Guerrero +2 more
2004Proceedings of the National Academy of Sciences of the United States of America36 citations Open access
Semantic Scholar
Solution structure and peptide binding studies of the C-terminal src homology 3-like domain of the diphtheria toxin repressor protein.
Guangshun Wang, G. Wylie, P. Twigg, D. Caspar +2 more
1999Proceedings of the National Academy of Sciences of the United States of America36 citations Open access
Semantic Scholar
COPI coatomer complex proteins facilitate the translocation of anthrax lethal factor across vesicular membranes in vitro
Alfred G Tamayo, A. Bharti, C. Trujillo, R. Harrison +1 more
2008Proceedings of the National Academy of Sciences of the United States of America35 citations Open access
Semantic Scholar
Prolylpeptide binding by the prokaryotic SH3-like domain of the diphtheria toxin repressor: a regulatory switch.
G. Wylie, Vijayaraghavan Rangachari, E. Bienkiewicz, Vedrana Marin +4 more
2005Biochemistry35 citations
Semantic Scholar
Isolation and characterization of iron-independent positive dominant mutants of the diphtheria toxin repressor DtxR.
Li Sun, J. Vanderspek, J. Murphy
1998Proceedings of the National Academy of Sciences of the United States of America32 citations Open access
Semantic Scholar
Therapeutic targeting of regulatory T cells enhances tumor-specific CD8+ T cell responses in Epstein–Barr virus associated nasopharyngeal carcinoma
M. Fogg, J. Murphy, J. Lorch, M. Posner +1 more
2013Virology31 citations Open access
Semantic Scholar
Disulfide Bond Assignment in Human Interleukin-7 by Matrix-assisted Laser Desorption/Ionization Mass Spectroscopy and Site-directed Cysteine to Serine Mutational Analysis*
L. Cosenza, E. Sweeney, J. Murphy
1997Journal of Biological Chemistry31 citations Open access
Semantic Scholar
Suppressor Cell–Depleting Immunotherapy With Denileukin Diftitox is an Effective Host-Directed Therapy for Tuberculosis
Shashank Gupta, Laurene S. Cheung, Supriya Pokkali, K. Winglee +3 more
2017Journal of Infectious Diseases28 citations Open access
Semantic Scholar
Therapeutic targeting with DABIL‐4 depletes myeloid suppressor cells in 4T1 triple‐negative breast cancer model
S. Parveen, S. Siddharth, Laurene S. Cheung, Alok Kumar +4 more
2021Molecular Oncology27 citations Open access
Semantic Scholar
Corynebacterium diphtheriae: diphtheria toxin, the tox operon and its regulation by Fe2+-activation of apo-DtxR
S. Parveen, W. Bishai, J. Murphy
2019Microbiology spectrum27 citations Open access
Semantic Scholar
Neisseria meningitidis PorB, a Toll-Like Receptor 2 Ligand, Improves the Capacity of Francisella tularensis Lipopolysaccharide To Protect Mice against Experimental Tularemia
Damiana Chiavolini, S. Weir, J. Murphy, L. Wetzler
2008Clinical and Vaccine Immunology25 citations Open access
Semantic Scholar
Both Corynebacterium diphtheriae DtxR(E175K) and Mycobacterium tuberculosis IdeR(D177K) Are Dominant Positive Repressors of IdeR-Regulated Genes in M. tuberculosis
Y. Manabe, C. Hatem, A. Kesavan, J. Durack +1 more
2005Infection and Immunity25 citations Open access
Semantic Scholar
The src Homology 3-Like Domain of the Diphtheria Toxin Repressor (DtxR) Modulates Repressor Activation through Interaction with the Ancillary Metal Ion-Binding Site
J. Love, J. Vanderspek, J. Murphy
2003Journal of Bacteriology25 citations Open access
Semantic Scholar
INTERLEUKIN‐2-DIPHTHERIA TOXIN FUSION PROTEIN PROLONGS MURINE ISLET CELL ENGRAFTMENT
O. Pankewycz, James Mackie, R. Hassarjian, J. Murphy +2 more
1989Transplantation24 citations Open access
Semantic Scholar
Comparative model building of interleukin‐7 using interleukin‐4 as a template: A structural hypothesis that displays atypical surface chemistry in helix D important for receptor activation
L. Cosenza, A. Rosenbach, J. White, J. Murphy +1 more
2000Protein Science23 citations Open access
Semantic Scholar
Differential sensitivity of human myeloma cell lines and normal bone marrow colony forming cells to a recombinant diphtheria toxin‐interleukin 6 fusion protein
D. Chadwick, L. Jean, N. Jamal, H. Messner +2 more
1993British Journal of Haematology23 citations
Semantic Scholar
GRP78(BiP) facilitates the cytosolic delivery of anthrax lethal factor (LF) in vivo and functions as an unfoldase in vitro
Alfred G Tamayo, L. Slater, Julian Taylor-Parker, A. Bharti +3 more
2011Molecular Microbiology22 citations Open access
Semantic Scholar
Sequence of ligand binding and structure change in the diphtheria toxin repressor upon activation by divalent transition metals.
Vijayaraghavan Rangachari, Vedrana Marin, E. Bienkiewicz, Maria Semavina +4 more
2005Biochemistry21 citations
Semantic Scholar
Characterization and receptor specific toxicity of two diphtheria toxin‐related interleukin‐3 fusion proteins DAB389–mIL‐3 and DAB389–(Gly4Ser)2‐mIL‐3
D. Liger, J. Vanderspek, C. Gaillard, C. Cansier +3 more
1997FEBS Letters20 citations
Semantic Scholar
In vivo interferon-gamma induced changes in gene expression dramatically alter neutrophil phenotype
D. Ambruso, N. Briones, A. Baroffio, J. Murphy +5 more
2022PLoS ONE18 citations Open access
Semantic Scholar
‘ Identification of eIF 2 B g and eIF 2 g as cofactors of hepatitis C virus internal ribosome entry site-mediated translation using a functional genomics approach
Y. Manabe, B. Saviola, Li Sun, J. Murphy +1 more
200016 citations
Semantic Scholar
Conformational perturbation of interleukin‐2: A strategy for the design of cytokine analogs
B. Landgraf, Diane P. Williams, J. Murphy, Kendall A. Smith +1 more
1991Proteins: Structure, Function, and Bioinformatics16 citations
Semantic Scholar
Recent advances with Treg depleting fusion protein toxins for cancer immunotherapy.
Pankaj Kumar, Amit Kumar, S. Parveen, J. Murphy +1 more
2019Immunotherapy13 citations Open access
Semantic Scholar
DAB389 Interleukin-2 Receptor Binding Domain Mutations
J. Vanderspek, J. A. Sutherland, Monthakan Ratnarathorn, K. Howland +2 more
1996Journal of Biological Chemistry13 citations Open access
Semantic Scholar
T cell activation antigens: therapeutic implications.
John M. Williams, V. Kelley, R. Kirkman, N. Tilney +3 more
1987Immunological Investigations13 citations
Semantic Scholar
Trojan horse or proton force: Finding the right partner(s) for toxin translocation
C. Trujillo, R. Ratts, Alfred G Tamayo, R. Harrison +1 more
2006Neurotoxicity research12 citations
Semantic Scholar
Effective delivery of antisense peptide nucleic acid oligomers into cells by anthrax protective antigen
D. G. Wright, Ying Zhang, J. Murphy
2008Biochemical and Biophysical Research Communications - BBRC10 citations Open access
Semantic Scholar
Design and development of a novel genetic probe for the analysis of repressor-operator interactions.
J. Love, J. Murphy
2002Journal of Microbiological Methods10 citations
Semantic Scholar
Corynebacterium diphtheriae: Iron-Mediated Activation of DtxR and Regulation of Diphtheria Toxin Expression
J. Love, J. Murphy
20069 citations
Semantic Scholar

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