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T. Karlberg · SciRah

Researcher profile · Semantic Scholar

T. Karlberg

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T. Karlberg — researcher profile on SciRah

h-index: 33
Works: 240
Citations: 3,621

Most-cited papers

Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors
E. Wahlberg, T. Karlberg, E. Kouznetsova, N. Markova +11 more
2012Nature Biotechnology478 citations
Semantic Scholar
Structural Basis for Potency and Promiscuity in Poly(ADP-ribose) Polymerase (PARP) and Tankyrase Inhibitors
A. Thorsell, T. Ekblad, T. Karlberg, Mirjam Löw +5 more
2016Journal of Medicinal Chemistry331 citations Open access
Semantic Scholar
Structural basis for the allosteric inhibitory mechanism of human kidney-type glutaminase (KGA) and its regulation by Raf-Mek-Erk signaling in cancer cell metabolism
K. Thangavelu, C. Pan, T. Karlberg, Ganapathy Balaji +5 more
2012Proceedings of the National Academy of Sciences of the United States of America198 citations Open access
Semantic Scholar
Recognition of mono-ADP-ribosylated ARTD10 substrates by ARTD8 macrodomains.
Alexandra H. Forst, T. Karlberg, Nicolas Herzog, A. Thorsell +10 more
2013Structure138 citations Open access
Semantic Scholar
Comparative Structural Analysis of Human DEAD-Box RNA Helicases
Patrick Schütz, T. Karlberg, S. van den Berg, R. Collins +9 more
2010PLoS ONE125 citations Open access
Semantic Scholar
Structural basis for the interaction between tankyrase-2 and a potent Wnt-signaling inhibitor.
T. Karlberg, N. Markova, Ida Johansson, Martin Hammarström +3 more
2010Journal of Medicinal Chemistry121 citations Open access
Semantic Scholar
Crystal Structures of the ATPase Domains of Four Human Hsp70 Isoforms: HSPA1L/Hsp70-hom, HSPA2/Hsp70-2, HSPA6/Hsp70B', and HSPA5/BiP/GRP78
M. Wiśniewska, T. Karlberg, L. Lehtiö, Ida Johansson +3 more
2010PLoS ONE107 citations Open access
Semantic Scholar
Engineering Af1521 improves ADP-ribose binding and identification of ADP-ribosylated proteins
K. Nowak, Florian Rosenthal, T. Karlberg, Mareike Bütepage +10 more
2020Nature Communications77 citations Open access
Semantic Scholar
Structural biology of the writers, readers, and erasers in mono- and poly(ADP-ribose) mediated signaling
T. Karlberg, M. Langelier, J. Pascal, H. Schüler
2013Molecular Aspects of Medicine71 citations Open access
Semantic Scholar
A Potent and Selective PARP11 Inhibitor Suggests Coupling between Cellular Localization and Catalytic Activity.
I. T. Kirby, A. Kojic, Moriah R. Arnold, A. Thorsell +6 more
2018Cell Chemical Biology60 citations Open access
Semantic Scholar
System-wide identification and prioritization of enzyme substrates by thermal analysis
A. Saei, C. Beusch, P. Sabatier, J. A. Wells +14 more
2021Nature Communications57 citations Open access
Semantic Scholar
PARP inhibitor with selectivity toward ADP-ribosyltransferase ARTD3/PARP3.
Anders E. G. Lindgren, T. Karlberg, A. Thorsell, Mareike Hesse +9 more
2013ACS Chemical Biology55 citations Open access
Semantic Scholar
Small Molecule Microarray Based Discovery of PARP14 Inhibitors.
Bo Peng, A. Thorsell, T. Karlberg, H. Schüler +1 more
2017Angewandte Chemie52 citations
Semantic Scholar
Towards small molecule inhibitors of mono-ADP-ribosyltransferases.
T. Ekblad, Anders E. G. Lindgren, C. D. Andersson, Rémi Caraballo +6 more
2015European journal of medicinal chemistry49 citations Open access
Semantic Scholar
Discovery of ligands for ADP-ribosyltransferases via docking-based virtual screening.
C. D. Andersson, T. Karlberg, T. Ekblad, Anders E. G. Lindgren +9 more
2012Journal of Medicinal Chemistry44 citations Open access
Semantic Scholar
14-3-3 proteins activate Pseudomonas exotoxins-S and -T by chaperoning a hydrophobic surface
T. Karlberg, P. Hornyák, A. Pinto, Stefina Milanova +13 more
2018Nature Communications42 citations Open access
Semantic Scholar
Design, synthesis and evaluation of potent and selective inhibitors of mono-(ADP-ribosyl)transferases PARP10 and PARP14.
J. Holechek, R. Lease, A. Thorsell, T. Karlberg +6 more
2018Bioorganic & Medicinal Chemistry Letters36 citations Open access
Semantic Scholar
Crystal structure of human RNA helicase A (DHX9): structural basis for unselective nucleotide base binding in a DEAD-box variant protein.
Patrick Schütz, E. Wahlberg, T. Karlberg, Martin Hammarström +3 more
2010Journal of Molecular Biology35 citations Open access
Semantic Scholar
Design, Synthesis, Crystallographic Studies, and Preliminary Biological Appraisal of New Substituted Triazolo[4,3-b]pyridazin-8-amine Derivatives as Tankyrase Inhibitors
P. Liscio, A. Carotti, S. Asciutti, T. Karlberg +7 more
2014Journal of Medicinal Chemistry33 citations Open access
Semantic Scholar
Biochemical Discrimination between Selenium and Sulfur 1: A Single Residue Provides Selenium Specificity to Human Selenocysteine Lyase
R. Collins, Annika Johansson, T. Karlberg, N. Markova +9 more
2012PLoS ONE31 citations Open access
Semantic Scholar
Crystal Structure of Human ADP-ribose Transferase ARTD15/PARP16 Reveals a Novel Putative Regulatory Domain*
T. Karlberg, A. Thorsell, Å. Kallas, H. Schüler
2012Journal of Biological Chemistry29 citations Open access
Semantic Scholar
Design and synthesis of potent inhibitors of the mono(ADP-ribosyl)transferase, PARP14.
Kristen A. Upton, M. Meyers, A. Thorsell, T. Karlberg +7 more
2017Bioorganic & Medicinal Chemistry Letters25 citations Open access
Semantic Scholar
Bacterial ferrochelatase turns human: Tyr13 determines the apparent metal specificity of Bacillus subtilis ferrochelatase
M. Hansson, T. Karlberg, Christopher A. G. Söderberg, S. Rajan +4 more
2011JBIC Journal of Biological Inorganic Chemistry17 citations Open access
Semantic Scholar
Chemical probes to study ADP-ribosylation: synthesis and biochemical evaluation of inhibitors of the human ADP-ribosyltransferase ARTD3/PARP3.
Anders E. G. Lindgren, T. Karlberg, T. Ekblad, S. Spjut +8 more
2013Journal of Medicinal Chemistry13 citations Open access
Semantic Scholar
Sister Chromatid Cohesion Establishment Factor ESCO1 Operates by Substrate-Assisted Catalysis.
E. Kouznetsova, Takaharu Kanno, T. Karlberg, A. Thorsell +4 more
2016Structure10 citations Open access
Semantic Scholar
System-wide Identification of Enzyme Substrates by Thermal Analysis (SIESTA)
A. Saei, C. Beusch, P. Sabatier, J. A. Wells +12 more
2018bioRxiv7 citations Open access
Semantic Scholar
Human steroidogenic acute regulatory protein
L. Lehtiö, M. Siponen, C. Arrowsmith, Hans Berglund +29 more
20104 citations
Semantic Scholar
SIESTA as a universal unbiased proteomics approach for identification and prioritization of enzyme substrates
A. Saei, C. Beusch, P. Sabatier, J. A. Wells +14 more
20212 citations Open access
Semantic Scholar
Correction to "Structural Basis for Potency and Promiscuity in Poly(ADP-ribose) Polymerase (PARP) and Tankyrase Inhibitors".
A. Thorsell, T. Ekblad, T. Karlberg, Mirjam Löw +5 more
2019Journal of Medicinal Chemistry1 citations Open access
Semantic Scholar
Human PARP1 (ARTD1) - Catalytic domain in complex with inhibitor ME0527
T. Karlberg, A. Thorsell, Anders E. G. Lindgren, M. Moche +5 more
20191 citations
Semantic Scholar
HUMAN ARTD1 (PARP1) - CATALYTIC DOMAIN IN COMPLEX WITH INHIBITOR TALAZOPARIB
T. Karlberg, A. Thorsell, T. Ekblad, Mirjam M. Klepsch +4 more
20151 citations
Semantic Scholar
Human Mitochondrial endo-exonuclease
M. Welin, M. Moche, C. Arrowsmith, Hans Berglund +16 more
20121 citations
Semantic Scholar
Crystal Structure of Human 8-oxo-dGTPase (MTH1)
L. Trésaugues, M. Siponen, C. Arrowsmith, H. Berglund +24 more
20111 citations
Semantic Scholar
Crystal structure of the NTF2 domain of Ras GTPase-activating protein-binding protein 1
M. Welin, L. Trésaugues, C. Arrowsmith, H. Berglund +24 more
20111 citations
Semantic Scholar
Crystal structure of human S-adenosyl homocysteine hydrolase-like 1 protein
M. Wiśniewska, M. Siponen, C. Arrowsmith, H. Berglund +22 more
20101 citations
Semantic Scholar
Human PARP10 (ARTD10), catalytic fragment in complex with 3-aminobenzamide and citrate
T. Karlberg, A. Thorsell, H. Schüler
20190 citations
Semantic Scholar
Crystal structure of in vitro evolved Af1521
T. Karlberg, A. Thorsell, K. Nowak, M. Hottiger +1 more
20190 citations
Semantic Scholar
Human PARP14 (ARTD8), catalytic fragment in complex with inhibitor ITK6
T. Karlberg, A. Thorsell, I. T. Kirby, R. Sreenivasan +2 more
20190 citations
Semantic Scholar
Human PARP16 (ARTD15) IN COMPLEX WITH EB-47
T. Karlberg, A. Pinto, A. Thorsell, H. Schüler
20190 citations
Semantic Scholar
Human PARP14 (ARTD8), catalytic fragment in complex with inhibitor ITK1
T. Karlberg, A. Thorsell, I. T. Kirby, R. Sreenivasan +2 more
20190 citations
Semantic Scholar
Human PARP16 (ARTD15) IN COMPLEX WITH CARBA-NAD
T. Karlberg, A. Pinto, A. Thorsell, H. Schüler
20190 citations
Semantic Scholar
Exoenzyme S from Pseudomonas aeruginosa in complex with human 14-3-3 protein beta, tetrameric crystal form
T. Karlberg, A. Pinto, P. Hornyák, K. Nareoja +1 more
20180 citations
Semantic Scholar
A Potent and Selective PARP 11 Inhibitor Suggests Coupling betweenCellular Localization andCatalytic Activity Graphical
I. T. Kirby, A. Kojic, Moriah R. Arnold, A. Thorsell +5 more
20180 citations
Semantic Scholar
Exoenzyme S from Pseudomonas aeruginosa in complex with human 14-3-3 protein beta, trimeric crystal form bound to Carba-NAD
T. Karlberg, A. Pinto, P. Hornyák, A. Thorsell +2 more
20180 citations
Semantic Scholar
Yersinia YscU C-terminal fragment in complex with a synthetic compound
T. Karlberg, A. Thorsell, O. Ho, Naresh Sunduru +3 more
20180 citations
Semantic Scholar
Exoenzyme S from Pseudomonas aeruginosa in complex with human 14-3-3 protein beta, trimeric crystal form in complex with STO1101
T. Karlberg, A. Pinto, P. Hornyák, A. Thorsell +2 more
20180 citations
Semantic Scholar
Exoenzyme T from Pseudomonas aeruginosa in complex with human 14-3-3 protein beta, tetrameric crystal form bound to STO1101
T. Karlberg, A. Pinto, P. Hornyák, A. Thorsell +2 more
20180 citations
Semantic Scholar
Exoenzyme S from Pseudomonas aeruginosa in complex with human 14-3-3 protein beta, trimeric crystal form
T. Karlberg, A. Pinto, P. Hornyák, A. Thorsell +2 more
20180 citations
Semantic Scholar
Targeting dissociation of the substrate specificity switch protein YscU in the Yersinia type III secretion system with small molecules
O. Ho, Frédéric H. Login, P. Rogne, T. Edgren +7 more
20170 citations
Semantic Scholar
Human PARP14 (ARTD8), catalytic fragment in complex with an N-aryl piperazine inhibitor
T. Karlberg, A. Thorsell, H. Schüler
20170 citations
Semantic Scholar

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