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W. W. ten Bokkel Huinink · SciRah

Researcher profile · Semantic Scholar

W. W. ten Bokkel Huinink

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W. W. ten Bokkel Huinink — researcher profile on SciRah

h-index: 56
Works: 277
Citations: 12K

Most-cited papers

Topotecan versus paclitaxel for the treatment of recurrent epithelial ovarian cancer.
W. W. ten Bokkel Huinink, M. Gore, J. Carmichael, A. Gordon +11 more
1997Journal of Clinical Oncology663 citations
Semantic Scholar
Increased oral bioavailability of topotecan in combination with the breast cancer resistance protein and P-glycoprotein inhibitor GF120918.
C. M. Kruijtzer, J. Beijnen, H. Rosing, W. W. ten Bokkel Huinink +4 more
2002Journal of Clinical Oncology475 citations
Semantic Scholar
Phase I clinical and pharmacokinetic study of PNU166945, a novel water-soluble polymer-conjugated prodrug of paclitaxel
J. M. Meerum Terwogt, W. W. ten Bokkel Huinink, J. Schellens, M. Schot +6 more
2001Anti-Cancer Drugs257 citations
Semantic Scholar
Importance of bleomycin in combination chemotherapy for good-prognosis testicular nonseminoma: a randomized study of the European Organization for Research and Treatment of Cancer Genitourinary Tract Cancer Cooperative Group.
R. de Wit, G. Stoter, S. Kaye, D. Sleijfer +5 more
1997Journal of Clinical Oncology244 citations
Semantic Scholar
Intraperitoneal cisplatin with regional hyperthermia in advanced ovarian cancer: pharmacokinetics and cisplatin-DNA adduct formation in patients and ovarian cancer cell lines.
P. V. D. van de Vaart, N. van der Vange, F. Zoetmulder, A. van Goethem +5 more
1998European Journal of Cancer243 citations
Semantic Scholar
Chemotherapy in advanced ovarian cancer: four systematic meta-analyses of individual patient data from 37 randomized trials. Advanced Ovarian Cancer Trialists' Group.
K. Aabo, M. Adams, P. Adnitt, D. Alberts +53 more
1998British Journal of Cancer238 citations Open access
Semantic Scholar
Coadministration of oral cyclosporin A enables oral therapy with paclitaxel.
J. M. Meerum Terwogt, M. Malingré, J. Beijnen, W. W. ten Bokkel Huinink +5 more
1999Clinical Cancer Research210 citations
Semantic Scholar
Coadministration of cyclosporine strongly enhances the oral bioavailability of docetaxel.
M. Malingré, D. J. Richel, J. H. Beijnen, H. Rosing +4 more
2001Journal of Clinical Oncology201 citations
Semantic Scholar
Doxorubicin versus doxorubicin and cisplatin in endometrial carcinoma: definitive results of a randomised study (55872) by the EORTC Gynaecological Cancer Group.
F. V. van Wijk, M. Aapro, G. Bolis, B. Chevallier +38 more
2003Annals of Oncology200 citations Open access
Semantic Scholar
Phase I and pharmacological study of daily oral administration of perifosine (D-21266) in patients with advanced solid tumours.
M. Crul, H. Rosing, G. D. de Klerk, R. Dubbelman +6 more
2002European Journal of Cancer171 citations
Semantic Scholar
Four cycles of BEP vs four cycles of VIP in patients with intermediate-prognosis metastatic testicular non-seminoma: a randomized study of the EORTC Genitourinary Tract Cancer Cooperative Group. European Organization for Research and Treatment of Cancer.
R. de Wit, G. Stoter, D. Sleijfer, J. Neijt +4 more
1998British Journal of Cancer148 citations Open access
Semantic Scholar
Co-administration of GF120918 significantly increases the systemic exposure to oral paclitaxel in cancer patients
M. Malingré, J. Beijnen, H. Rosing, F. Koopman +4 more
2001British Journal of Cancer142 citations Open access
Semantic Scholar
Co-administration of cyclosporin enables oral therapy with paclitaxel.
J. M. Meerum Terwogt, J. Beijnen, W. W. ten Bokkel Huinink, H. Rosing +1 more
1998The Lancet123 citations
Semantic Scholar
Phase I and pharmacokinetic study of SPI-77, a liposomal encapsulated dosage form of cisplatin
J. M. Meerum Terwogt, G. Groenewegen, D. Pluim, M. Maliepaard +8 more
2002Cancer Chemotherapy and Pharmacology119 citations
Semantic Scholar
A phase I and pharmacokinetic study of MAG-CPT, a water-soluble polymer conjugate of camptothecin
N. E. Schoemaker, C. van Kesteren, H. Rosing, S. Jansen +10 more
2002British Journal of Cancer113 citations Open access
Semantic Scholar
Long-term survival in a phase III, randomised study of topotecan versus paclitaxel in advanced epithelial ovarian carcinoma.
W. W. ten Bokkel Huinink, S. Lane, G. Ross
2004Annals of Oncology111 citations Open access
Semantic Scholar
Clinical activity and benefit of irinotecan (CPT-11) in patients with colorectal cancer truly resistant to 5-fluorouracil (5-FU).
E. Van Cutsem, D. Cunningham, W. W. ten Bokkel Huinink, C. Punt +16 more
1999European Journal of Cancer111 citations Open access
Semantic Scholar
Controlled multicentre study of the influence of subcutaneous recombinant human erythropoietin on anaemia and transfusion dependency in patients with ovarian carcinoma treated with platinum-based chemotherapy
W. W. ten Bokkel Huinink, Cam de Swart, DW van Toorn, G. Morack +10 more
1998Medical Oncology98 citations
Semantic Scholar
Phase I and pharmacokinetic study of oral paclitaxel.
M. Malingré, J. M. Meerum Terwogt, J. H. Beijnen, H. Rosing +7 more
2000Journal of Clinical Oncology92 citations
Semantic Scholar
Clinical evidence for topotecan-paclitaxel non--cross-resistance in ovarian cancer.
Martin Gore, W. W. ten Bokkel Huinink, James Carmichael, A. Gordon +11 more
2001Journal of Clinical Oncology91 citations
Semantic Scholar
A phase I/II and pharmacokinetic study of irinotecan in combination with capecitabine as first-line therapy for advanced colorectal cancer.
D. Rea, J. Nortier, W. W. ten Bokkel Huinink, S. Falk +9 more
2005Annals of Oncology80 citations Open access
Semantic Scholar
Single-agent gemcitabine: an active and better tolerated alternative to standard cisplatin-based chemotherapy in locally advanced or metastatic non-small cell lung cancer.
W. W. ten Bokkel Huinink, B. Bergman, A. Chemaissani, W. Dornoff +11 more
1999Lung Cancer75 citations
Semantic Scholar
The co-solvent Cremophor EL limits absorption of orally administered paclitaxel in cancer patients
MM Malingré, J. Schellens, O. van Tellingen, M. Ouwehand +7 more
2001British Journal of Cancer74 citations Open access
Semantic Scholar
Extensive cytoreductive surgery combined with intra-operative intraperitoneal perfusion with cisplatin under hyperthermic conditions (OVHIPEC) in patients with recurrent ovarian cancer: a feasibility pilot.
N. van der Vange, A. van Goethem, F. Zoetmulder, M. Kaag +3 more
2000European Journal of Surgical Oncology74 citations
Semantic Scholar
Phase II trial of topically applied miltefosine solution in patients with skin-metastasized breast cancer
J. M. M. Terwogt, I. A. M. Mandjes, H. Sindermann, J. H. Beijnen +1 more
1999British Journal of Cancer72 citations Open access
Semantic Scholar
Pharmacokinetics and metabolism of docetaxel administered as a 1-h intravenous infusion
H. Rosing, V. Lustig, L. V. van Warmerdam, M. Huizing +5 more
2000Cancer Chemotherapy and Pharmacology71 citations
Semantic Scholar
Oral topotecan: bioavailability and effect of food co-administration
V. Herben, H. Rosing, W. W. ten Bokkel Huinink, D. M. van Gortel-van Zomeren +5 more
1999British Journal of Cancer69 citations Open access
Semantic Scholar
Initial experience with treatment of human B cell lymphoma with anti-CD19 monoclonal antibody
A. Hekman, A. Honselaar, W. Vuist, J. Sein +5 more
2005Cancer Immunology and Immunotherapy64 citations
Semantic Scholar
Hepatic metabolism of paclitaxel and its impact in patients with altered hepatic function.
V. R. Panday, M. Huizing, P. Willemse, A. de Graeff +3 more
1997Seminars in Oncology62 citations
Semantic Scholar
Phase I and pharmacokinetic study of E7070, a novel chloroindolyl sulfonamide cell-cycle inhibitor, administered as a one-hour infusion every three weeks in patients with advanced cancer.
E. Raymond, W. W. ten Bokkel Huinink, J. Taïeb, J. Beijnen +6 more
2002Journal of Clinical Oncology59 citations
Semantic Scholar
Phase I and pharmacokinetic study of irinotecan administered as a low-dose, continuous intravenous infusion over 14 days in patients with malignant solid tumors.
V. Herben, J. Schellens, M. Swart, G. Gruia +3 more
1999Journal of Clinical Oncology56 citations
Semantic Scholar
Bio-analysis of docetaxel and hydroxylated metabolites in human plasma by high-performance liquid chromatography and automated solid-phase extraction.
H. Rosing, V. Lustig, F. Koopman, W. W. ten Bokkel Huinink +1 more
1997Journal of Chromatography B: Biomedical Sciences and Applications50 citations
Semantic Scholar
Serum alpha-fetoprotein surge after the initiation of chemotherapy for non-seminomatous testicular cancer has an adverse prognostic significance.
R. de Wit, L. Collette, R. Sylvester, P. D. de Mulder +6 more
1998British Journal of Cancer46 citations Open access
Semantic Scholar
Safety and efficacy of patupilone in patients with advanced ovarian, primary fallopian, or primary peritoneal cancer: a phase I, open-label, dose-escalation study.
W. W. ten Bokkel Huinink, J. Šufliarský, W. M. Smit, S. Špánik +5 more
2009Journal of Clinical Oncology45 citations
Semantic Scholar
The use of the Calvert formula to determine the optimal carboplatin dosage
L. V. van Warmerdam, S. Rodenhuis, W. W. ten Bokkel Huinink, R. Maes +1 more
2005Journal of Cancer Research and Clinical Oncology44 citations Open access
Semantic Scholar
Phase I and pharmacologic study of the combination of paclitaxel, cisplatin, and topotecan administered intravenously every 21 days as first-line therapy in patients with advanced ovarian cancer.
V. Herben, V. R. Panday, D. J. Richel, J. Schellens +7 more
1999Journal of Clinical Oncology43 citations
Semantic Scholar
Pharmacokinetics of 4′-epi-doxorubicin in man
H. Weenen, J. Lankelma, P. G. M. Penders, J. Mcvie +3 more
2004Investigational new drugs38 citations
Semantic Scholar
Phase II and pharmacological study of oral paclitaxel (Paxoral) plus ciclosporin in anthracycline-pretreated metastatic breast cancer
H. Helgason, C. M. Kruijtzer, A. Huitema, S. Marcus +5 more
2006British Journal of Cancer37 citations Open access
Semantic Scholar
Pharmacokinetics of carboplatin after intraperitoneal administration
F. Elferink, W. V. D. van der Vijgh, I. Klein, W. W. ten Bokkel Huinink +2 more
2004Cancer Chemotherapy and Pharmacology36 citations
Semantic Scholar
Limited-sampling models for anticancer agents
L. V. van Warmerdam, W. W. ten Bokkel Huinink, Robert A. A. Maes, J. H. Beijnen
2005Journal of Cancer Research and Clinical Oncology33 citations Open access
Semantic Scholar
A randomised phase II multicentre trial of irinotecan (CPT-11) using four different schedules in patients with metastatic colorectal cancer
N. E. Schoemaker, I. Kuppens, V. Moiseyenko, B. Glimelius +18 more
2004British Journal of Cancer32 citations Open access
Semantic Scholar
Cisplatin, doxorubicin and ifosfamide in carcinosarcoma of the female genital tract. A phase II study of the European Organization for Research and Treatment of Cancer Gynaecological Cancer Group (EORTC 55923).
R. V. van Rijswijk, J. Vermorken, N. Reed, G. Favalli +13 more
2003European Journal of Cancer32 citations
Semantic Scholar
Urinary and fecal excretion of topotecan in patients with malignant solid tumours
V. Herben, N. E. Schoemaker, H. Rosing, Desiree M. van Zomeren +5 more
2002Cancer Chemotherapy and Pharmacology32 citations
Semantic Scholar
The effect of different doses of cyclosporin A on the systemic exposure of orally administered paclitaxel
M. Malingré, J. Beijnen, H. Rosing, F. Koopman +6 more
2001Anti-Cancer Drugs32 citations
Semantic Scholar
Phase I/II dose-escalation trial of patupilone every 3 weeks in patients with relapsed/refractory ovarian cancer
W. M. Smit, J. Šufliarský, S. Špánik, M. Wagnerová +6 more
200531 citations
Semantic Scholar
Clinical pharmacokinetics of camptothecin topoisomerase I inhibitors.
V. Herben, J. Beijnen, W. W. ten Bokkel Huinink, J. Schellens
1998Pharmacy World & Science31 citations
Semantic Scholar
Phase I study of an oral formulation of irinotecan administered daily for 14 days every 3 weeks in patients with advanced solid tumours
N. E. Schoemaker, I. E. Kuppens, W. W. ten Bokkel Huinink, P. Lefebvre +4 more
2005Cancer Chemotherapy and Pharmacology30 citations
Semantic Scholar
Tumour marker concentration at the start of chemotherapy is a stronger predictor of treatment failure than marker half-life: a study in patients with disseminated non-seminomatous testicular cancer.
R. de Wit, R. Sylvester, C. Tsitsa, P. D. de Mulder +7 more
1997British Journal of Cancer30 citations Open access
Semantic Scholar
Experience with independent radiological review during a topotecan trial in ovarian cancer.
S. Gwyther, G. Bolis, M. Gore, W. W. ten Bokkel Huinink +4 more
1997Annals of Oncology30 citations Open access
Semantic Scholar
Phase I study of Brequinar sodium (NSC 368390) in patients with solid malignancies
G. Schwartsmann, P. Dodion, J. Vermorken, W. W. ten Bokkel Huinink +8 more
2004Cancer Chemotherapy and Pharmacology28 citations Open access
Semantic Scholar

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H. Rosing×16
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H. Rosing — researcher profile on SciRah
J. Beijnen×12
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J. Beijnen — researcher profile on SciRah
J. Schellens×10
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J. Schellens — researcher profile on SciRah
F. Koopman×6
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F. Koopman — researcher profile on SciRah

×6

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J. Schellens — researcher profile on SciRah

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M. Schot — researcher profile on SciRah

J. M. Meerum Terwogt×5

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J. M. Meerum Terwogt — researcher profile on SciRah

O. van Tellingen×5

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O. van Tellingen — researcher profile on SciRah

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J. Beijnen — researcher profile on SciRah

J. Vermorken×5

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J. Vermorken — researcher profile on SciRah

M. Malingré×5

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M. Malingré — researcher profile on SciRah

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M. Swart — researcher profile on SciRah