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D. Wyllie · SciRah

Researcher profile · Semantic Scholar

D. Wyllie

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D. Wyllie — researcher profile on SciRah

h-index: 50
Works: 145
Citations: 9,107

Most-cited papers

Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability
B. Bilican, Andrea Serio, S. Barmada, A. Nishimura +16 more
2012Proceedings of the National Academy of Sciences of the United States of America352 citations Open access
Semantic Scholar
Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism
P. Hasel, O. Dando, Z. Jiwaji, P. Baxter +16 more
2017Nature Communications280 citations Open access
Semantic Scholar
Mitochondrial calcium uniporter Mcu controls excitotoxicity and is transcriptionally repressed by neuroprotective nuclear calcium signals
Jing Qiu, Yan-wei Tan, Anna M. Hagenston, Marc-André Martel +5 more
2013Nature Communications274 citations Open access
Semantic Scholar
Influence of GluN2 subunit identity on NMDA receptor function
D. Wyllie, M. Livesey, G. Hardingham
2013Neuropharmacology247 citations Open access
Semantic Scholar
GRIN2A-related disorders: genotype and functional consequence predict phenotype
V. Strehlow, H. Heyne, D. R. Vlaskamp, K. Marwick +65 more
2018Brain : a journal of neurology212 citations Open access
Semantic Scholar
The Subtype of GluN2 C-terminal Domain Determines the Response to Excitotoxic Insults
Marc-André Martel, T. Ryan, K. F. Bell, J. Fowler +8 more
2012Neuron196 citations Open access
Semantic Scholar
C9ORF72 repeat expansion causes vulnerability of motor neurons to Ca2+-permeable AMPA receptor-mediated excitotoxicity
B. T. Selvaraj, M. Livesey, Chenhao Zhao, J. Gregory +28 more
2018Nature Communications190 citations Open access
Semantic Scholar
Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2
K. F. Bell, Bashayer R. Al-Mubarak, Marc-André Martel, S. Mckay +15 more
2015Nature Communications187 citations Open access
Semantic Scholar
Suppression of the intrinsic apoptosis pathway by synaptic activity
Frédéric Léveillé, S. Papadia, M. Fricker, K. F. Bell +8 more
2010Journal of Neuroscience149 citations Open access
Semantic Scholar
Homeostasis of intrinsic excitability in hippocampal neurones: dynamics and mechanism of the response to chronic depolarization
Timothy O’Leary, Mark C. W. van Rossum, D. Wyllie
2010Journal of Physiology128 citations Open access
Semantic Scholar
Loss of β-III spectrin leads to Purkinje cell dysfunction recapitulating the behaviour and neuropathology of SCA5 in humans
E. Perkins, Yvonne L. Clarkson, N. Sabatier, D. Longhurst +9 more
2010Journal of Neuroscience122 citations Open access
Semantic Scholar
Conserved hippocampal cellular pathophysiology but distinct behavioural deficits in a new rat model of FXS
S. Till, Antonis Asiminas, A. Jackson, D. Katsanevaki +7 more
2015Human Molecular Genetics107 citations Open access
Semantic Scholar
Retinoid-independent motor neurogenesis from human embryonic stem cells reveals a medial columnar ground state
R. Patani, A. Hollins, T. Wishart, C. Puddifoot +9 more
2011Nature Communications97 citations Open access
Semantic Scholar
SynGAP isoforms exert opposing effects on synaptic strength
A. McMahon, M. Barnett, Timothy O’Leary, P. Stoney +8 more
2012Nature Communications96 citations Open access
Semantic Scholar
Cell-Type-Specific Translation Profiling Reveals a Novel Strategy for Treating Fragile X Syndrome
Sophie R. Thomson, Sang-Su Seo, S. Barnes, Susana R. Louros +7 more
2017Neuron86 citations Open access
Semantic Scholar
Maturation and electrophysiological properties of human pluripotent stem cell‐derived oligodendrocytes
M. Livesey, Dario Magnani, E. Cleary, Navneet A. Vasistha +9 more
2016Stem Cells85 citations Open access
Semantic Scholar
TCN 201 selectively blocks GluN2A-containing NMDARs in a GluN1 co-agonist dependent but non-competitive manner
S. Edman, S. Mckay, L. J. Macdonald, M. Samadi +3 more
2012Neuropharmacology82 citations Open access
Semantic Scholar
Neuronal homeostasis: time for a change?
Timothy O’Leary, D. Wyllie
2011Journal of Physiology79 citations Open access
Semantic Scholar
Sustained correction of associative learning deficits after brief, early treatment in a rat model of Fragile X Syndrome
Antonios Asiminas, A. Jackson, Susana R. Louros, S. Till +9 more
2019Science Translational Medicine72 citations Open access
Semantic Scholar
PGC-1α negatively regulates extrasynaptic NMDAR activity and excitotoxicity
C. Puddifoot, Marc-André Martel, Francesc X. Soriano, A. Camacho +3 more
2012Journal of Neuroscience66 citations Open access
Semantic Scholar
Typical development of synaptic and neuronal properties can proceed without microglia in the cortex and thalamus
M. O'Keeffe, Sam A. Booker, Darren Walsh, Mo-Si Li +23 more
2024bioRxiv56 citations Open access
Semantic Scholar
Altered dendritic spine function and integration in a mouse model of fragile X syndrome
Sam A. Booker, A. Domanski, O. Dando, A. Jackson +4 more
2018Nature Communications55 citations Open access
Semantic Scholar
Altered network properties in C9ORF72 repeat expansion cortical neurons are due to synaptic dysfunction
E. Perkins, K. Burr, Poulomi Banerjee, A. Mehta +10 more
2021Molecular Neurodegeneration53 citations Open access
Semantic Scholar
Input-Output Relationship of CA1 Pyramidal Neurons Reveals Intact Homeostatic Mechanisms in a Mouse Model of Fragile X Syndrome
Sam A. Booker, Laura Simões de Oliveira, Natasha J. Anstey, Zrinko Kozić +9 more
2020Cell Reports51 citations Open access
Semantic Scholar
Fragile X syndrome: from targets to treatments.
Lasani S. Wijetunge, S. Chattarji, D. Wyllie, P. Kind
2013Neuropharmacology51 citations
Semantic Scholar
Pro-death NMDA receptor signaling is promoted by the GluN2B C-terminus independently of Dapk1
Jamie McQueen, T. Ryan, S. Mckay, K. Marwick +10 more
2017eLife50 citations Open access
Semantic Scholar
Generation of Functional Neurons from Feeder-Free, Keratinocyte-Derived Equine Induced Pluripotent Stem Cells
Ruchi Sharma, M. Livesey, D. Wyllie, Chris Proudfoot +3 more
2014Stem Cells and Development48 citations
Semantic Scholar
Physiological Normoxia and Absence of EGF Is Required for the Long-Term Propagation of Anterior Neural Precursors from Human Pluripotent Cells
B. Bilican, M. Livesey, Ghazal Haghi, Jing Qiu +5 more
2014PLoS ONE48 citations Open access
Semantic Scholar
Cellular and synaptic phenotypes lead to disrupted information processing in Fmr1-KO mouse layer 4 barrel cortex
A. Domanski, Sam A. Booker, D. Wyllie, J. Isaac +1 more
2019Nature Communications47 citations Open access
Semantic Scholar
Postsynaptic GABABRs Inhibit L-Type Calcium Channels and Abolish Long-Term Potentiation in Hippocampal Somatostatin Interneurons.
Sam A. Booker, Desiree Loreth, Annabelle L Gee, M. Watanabe +4 more
2018Cell Reports46 citations Open access
Semantic Scholar
Recovery of NMDA receptor currents from MK-801 blockade is accelerated by Mg2+ and memantine under conditions of agonist exposure
S. Mckay, C. Bengtson, H. Bading, D. Wyllie +1 more
2013Neuropharmacology44 citations Open access
Semantic Scholar
Reversal of proliferation deficits caused by chromosome 16p13.11 microduplication through targeting NFκB signaling: An integrated study of patient-derived neuronal precursor cells, cerebral organoids and in vivo brain imaging
M. Johnstone, Navneet A. Vasistha, M. Barbu, O. Dando +18 more
2018Molecular Psychiatry42 citations Open access
Semantic Scholar
Evidence for evolutionary divergence of activity-dependent gene expression in developing neurons
Jing Qiu, Jamie McQueen, B. Bilican, Owen R. Dando +18 more
2016eLife37 citations Open access
Semantic Scholar
Loss of cerebellar glutamate transporters EAAT4 and GLAST differentially affects the spontaneous firing pattern and survival of Purkinje cells
E. Perkins, Yvonne L. Clarkson, D. Suminaite, A. Lyndon +5 more
2018Human Molecular Genetics34 citations Open access
Semantic Scholar
Maturation of AMPAR Composition and the GABAAR Reversal Potential in hPSC-Derived Cortical Neurons
M. Livesey, B. Bilican, Jing Qiu, N. Rzechorzek +5 more
2014Journal of Neuroscience33 citations Open access
Semantic Scholar
3-Fluoro-N-methyl-D-aspartic acid (3F-NMDA) stereoisomers as conformational probes for exploring agonist binding at NMDA receptors.
P. Chia, M. Livesey, A. Slawin, T. van Mourik +2 more
2012Chemistry33 citations
Semantic Scholar
Effect of a GRIN2A de novo mutation associated with epilepsy and intellectual disability on NMDA receptor currents and Mg(2+) block in cultured primary cortical neurons.
K. Marwick, P. Skehel, G. Hardingham, D. Wyllie
2015The Lancet30 citations
Semantic Scholar
NMDA receptor function in inhibitory neurons.
Sam A. Booker, D. Wyllie
2021Neuropharmacology29 citations
Semantic Scholar
Quantification of the Mg2+-induced potency shift of amantadine and memantine voltage-dependent block in human recombinant GluN1/GluN2A NMDARs.
H. J. Otton, A. L. McLean, M. A. Pannozzo, C. Davies +1 more
2011Neuropharmacology28 citations
Semantic Scholar
Functional properties of in vitro excitatory cortical neurons derived from human pluripotent stem cells
M. Livesey, Dario Magnani, G. Hardingham, S. Chandran +1 more
2015Journal of Physiology27 citations Open access
Semantic Scholar
Cortical neurons derived from human pluripotent stem cells lacking FMRP display altered spontaneous firing patterns
Shreya Das Sharma, Rakhi Pal, B. Reddy, Bhuvaneish T. Selvaraj +12 more
2020Molecular Autism26 citations Open access
Semantic Scholar
Author Correction: Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism
P. Hasel, Owen R. Dando, Z. Jiwaji, P. Baxter +16 more
2018Nature Communications25 citations Open access
Semantic Scholar
Functional assessment of triheteromeric NMDA receptors containing a human variant associated with epilepsy
K. Marwick, K. Hansen, P. Skehel, G. Hardingham +1 more
2019Journal of Physiology23 citations Open access
Semantic Scholar
Familial t(1;11) translocation is associated with disruption of white matter structural integrity and oligodendrocyte-myelin dysfunction
Navneet A. Vasistha, M. Johnstone, Samantha K. Barton, Steffen E. Mayerl +20 more
2019bioRxiv23 citations Open access
Semantic Scholar
Posterior cerebellar Purkinje cells in an SCA5/SPARCA1 mouse model are especially vulnerable to the synergistic effect of loss of β-III spectrin and GLAST
E. Perkins, D. Suminaite, Yvonne L. Clarkson, Sin-Kwan Lee +5 more
2016Human Molecular Genetics23 citations Open access
Semantic Scholar
Key roles of C2/GAP domains in SYNGAP1-related pathophysiology.
D. Katsanevaki, S. Till, I. Buller-Peralta, M. Nawaz +29 more
2024Cell Reports22 citations Open access
Semantic Scholar
Astrocytes mediate cell non-autonomous correction of aberrant firing in human FXS neurons
Shreya Das Sharma, B. Reddy, Rakhi Pal, Tuula E. Ritakari +6 more
2023Cell Reports21 citations Open access
Semantic Scholar
Investigating the utility of human embryonic stem cell-derived neurons to model ageing and neurodegenerative disease using whole-genome gene expression and splicing analysis
R. Patani, Patrick A. Lewis, D. Trabzuni, C. Puddifoot +8 more
2012Journal of Neurochemistry21 citations Open access
Semantic Scholar
Human embryonic stem cell-derived neurons as a tool for studying neuroprotection and neurodegeneration
G. Hardingham, R. Patani, P. Baxter, D. Wyllie +1 more
2010Molecular Neurobiology21 citations Open access
Semantic Scholar
Contribution of NMDA Receptors to Synaptic Function in Rat Hippocampal Interneurons
Sam A. Booker, Anna Sumera, P. Kind, D. Wyllie
2021eNeuro20 citations Open access
Semantic Scholar

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