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Helen Lee · SciRah

Researcher profile · Semantic Scholar

Helen Lee

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Helen Lee — researcher profile on SciRah

h-index: 25
Works: 55
Citations: 2,412

Most-cited papers

The effects of particle size and molecular targeting on the intratumoral and subcellular distribution of polymeric nanoparticles.
Helen Lee, H. Fonge, Bryan Hoang, R. Reilly +1 more
2010Molecular Pharmaceutics330 citations
Semantic Scholar
64Cu-MM-302 Positron Emission Tomography Quantifies Variability of Enhanced Permeability and Retention of Nanoparticles in Relation to Treatment Response in Patients with Metastatic Breast Cancer
Helen Lee, A. Shields, B. Siegel, K. Miller +13 more
2017Clinical Cancer Research248 citations Open access
Semantic Scholar
Formulation of drugs in block copolymer micelles: drug loading and release.
J. Liu, Helen Lee, Christine Allen
2006Current pharmaceutical design136 citations
Semantic Scholar
Therapeutic Opportunities with Pharmacological Inhibition of CD38 with Isatuximab
T. Martin, K. Corzo, M. Chiron, H. Van de Velde +9 more
2019Cells135 citations Open access
Semantic Scholar
In Vivo Distribution of Polymeric Nanoparticles at the Whole-Body, Tumor, and Cellular Levels
Helen Lee, Bryan Hoang, H. Fonge, R. Reilly +1 more
2010Pharmaceutical Research128 citations
Semantic Scholar
HER2-targeted liposomal doxorubicin displays enhanced anti-tumorigenic effects without associated cardiotoxicity.
Joe Reynolds, E. Geretti, B. Hendriks, Helen Lee +11 more
2012Toxicology and Applied Pharmacology112 citations
Semantic Scholar
Safety and Immunogenicity Study of NY-ESO-1b Peptide and Montanide ISA-51 Vaccination of Patients with Epithelial Ovarian Cancer in High-Risk First Remission
C. Diefenbach, S. Gnjatic, P. Sabbatini, C. Aghajanian +9 more
2008Clinical Cancer Research105 citations Open access
Semantic Scholar
Epidermal growth factor-conjugated poly(ethylene glycol)-block- poly(delta-valerolactone) copolymer micelles for targeted delivery of chemotherapeutics.
F. Zeng, Helen Lee, C. Allen
2006Bioconjugate chemistry103 citations
Semantic Scholar
Photodynamic priming mitigates chemotherapeutic selection pressures and improves drug delivery
Huang-Chiao Huang, I. Rizvi, Joyce F. Liu, Sriram Anbil +9 more
2017Cancer Research88 citations Open access
Semantic Scholar
Noninvasive monitoring of the fate of 111In-labeled block copolymer micelles by high resolution and high sensitivity microSPECT/CT imaging.
Bryan Hoang, Helen Lee, R. Reilly, C. Allen
2009Molecular Pharmaceutics88 citations
Semantic Scholar
Methoxy poly(ethylene glycol)-block-poly(delta-valerolactone) copolymer micelles for formulation of hydrophobic drugs.
Helen Lee, F. Zeng, M. Dunne, C. Allen
2005Biomacromolecules87 citations
Semantic Scholar
Antitumor Effects and Normal-Tissue Toxicity of 111In-Nuclear Localization Sequence-Trastuzumab in Athymic Mice Bearing HER-Positive Human Breast Cancer Xenografts
Danny L. Costantini, K. McLarty, Helen Lee, S. Done +2 more
2010Journal of Nuclear Medicine70 citations Open access
Semantic Scholar
Multiscale Kinetic Modeling of Liposomal Doxorubicin Delivery Quantifies the Role of Tumor and Drug-Specific Parameters in Local Delivery to Tumors
B. Hendriks, Joe Reynolds, S. Klinz, E. Geretti +6 more
2012CPT: Pharmacometrics & Systems Pharmacology64 citations Open access
Semantic Scholar
Cyclophosphamide-Mediated Tumor Priming for Enhanced Delivery and Antitumor Activity of HER2-Targeted Liposomal Doxorubicin (MM-302)
E. Geretti, S. Leonard, N. Dumont, Helen Lee +9 more
2015Molecular Cancer Therapeutics61 citations Open access
Semantic Scholar
Liposomal Irinotecan Accumulates in Metastatic Lesions, Crosses the Blood-Tumor Barrier (BTB), and Prolongs Survival in an Experimental Model of Brain Metastases of Triple Negative Breast Cancer
A. Mohammad, J. Griffith, C. Adkins, Neal Shah +6 more
2018Pharmaceutical Research58 citations Open access
Semantic Scholar
Apoptotic epidermal growth factor (EGF)-conjugated block copolymer micelles as a nanotechnology platform for targeted combination therapy.
Helen Lee, Meiduo Hu, R. Reilly, C. Allen
2007Molecular Pharmaceutics56 citations
Semantic Scholar
Companion Diagnostic 64Cu-Liposome Positron Emission Tomography Enables Characterization of Drug Delivery to Tumors and Predicts Response to Cancer Nanomedicines
Helen Lee, Daniel F. Gaddy, M. Ventura, Nicholas Bernards +6 more
2018Theranostics55 citations Open access
Semantic Scholar
Point of Care Nucleic Acid Testing for SARS-CoV-2 in Hospitalized Patients: A Clinical Validation Trial and Implementation Study
Dami A. Collier, S. Assennato, B. Warne, Nyaradzai Sithole +72 more
2020Cell Reports Medicine53 citations Open access
Semantic Scholar
Liposome formulation of a novel hydrophobic aryl-imidazole compound for anti-cancer therapy
Ju-Bo Liu, Helen Lee, M. Huesca, A. Young +1 more
2006Cancer Chemotherapy and Pharmacology47 citations
Semantic Scholar
A gradient-loadable (64)Cu-chelator for quantifying tumor deposition kinetics of nanoliposomal therapeutics by positron emission tomography.
Helen Lee, Jinzi Zheng, Daniel F. Gaddy, K. Orcutt +9 more
2015Nanomedicine : nanotechnology, biology, and medicine46 citations
Semantic Scholar
Formulation of olfactory-targeted microparticles with tamarind seed polysaccharide to improve nose-to-brain transport of drugs.
S. Yarragudi, R. Richter, Helen Lee, Greg F. Walker +3 more
2017Carbohydrate Polymers45 citations
Semantic Scholar
Intermolecular interactions and morphology of aqueous polymer/surfactant mixtures containing cationic chitosan and nonionic sorbitan esters.
J. Grant, Helen Lee, R. Liu, C. Allen
2008Biomacromolecules41 citations
Semantic Scholar
Synthesis and characterization of six-arm star poly(delta-valerolactone)-block-methoxy poly(ethylene glycol) copolymers.
F. Zeng, Helen Lee, M. Chidiac, C. Allen
2005Biomacromolecules37 citations
Semantic Scholar
Extended topoisomerase 1 inhibition through liposomal irinotecan results in improved efficacy over topotecan and irinotecan in models of small-cell lung cancer
S. Leonard, Helen Lee, Daniel F. Gaddy, S. Klinz +7 more
2017Anti-Cancer Drugs30 citations Open access
Semantic Scholar
Multifunctional block copolymer micelles for the delivery of 111In to EGFR-positive breast cancer cells for targeted Auger electron radiotherapy.
H. Fonge, Helen Lee, R. Reilly, C. Allen
2009Molecular Pharmaceutics30 citations
Semantic Scholar
Liposomal Irinotecan Achieves Significant Survival and Tumor Burden Control in a Triple Negative Breast Cancer Model of Spontaneous Metastasis.
Nicholas Bernards, M. Ventura, Inga B. Fricke, B. Hendriks +3 more
2018Molecular Pharmaceutics25 citations Open access
Semantic Scholar
Influence of molecular organization and interactions on drug release for an injectable polymer-lipid blend.
J. Grant, Helen Lee, P. Soo, Jaepyoung Cho +2 more
2008International journal of pharmaceutics21 citations
Semantic Scholar
Liposomal 64Cu-PET Imaging of Anti-VEGF Drug Effects on Liposomal Delivery to Colon Cancer Xenografts
S. Blocker, Kirk A. Douglas, L. Polin, Helen Lee +4 more
2017Theranostics18 citations Open access
Semantic Scholar
Polymeric Micelles for Formulation of Anti-Cancer Drugs
Helen Lee, P. Soo, Ju-Bo Liu, M. Butler +1 more
200618 citations
Semantic Scholar
Whole-body organ-level and kidney micro-dosimetric evaluations of 64Cu-loaded HER2/ErbB2-targeted liposomal doxorubicin (64Cu-MM-302) in rodents and primates
Daniel F. Gaddy, Helen Lee, Jinzi Zheng, D. Jaffray +2 more
2015EJNMMI Research17 citations Open access
Semantic Scholar
Rapid point of care nucleic acid testing for SARS-CoV-2 in hospitalised patients: a clinical trial and implementation study
Dami A. Collier, S. Assennato, B. Warne, N. Sithole +28 more
2020medRxiv15 citations Open access
Semantic Scholar
Relationship between composition and properties for stable chitosan films containing lipid microdomains
J. Grant, J. Tomba, Helen Lee, C. Allen
200710 citations
Semantic Scholar
Abstract P3-14-09: Preclinical Safety and Activity of MM-302, a HER2-Targeted Liposomal Doxorubicin Designed To Have an Improved Safety and Efficacy Profile over Approved Anthracyclines
T. Wickham, Joe Reynolds, D. Drummond, D. Kirpotin +13 more
20107 citations
Semantic Scholar
DNA damage with liposomal irinotecan (nal-IRI) in pancreatic cancer xenografts: Multimodal analysis of deposition characteristics.
S. Klinz, S. Leonard, N. Paz, Daniel F. Gaddy +3 more
20184 citations
Semantic Scholar
Deposition characteristics and resulting DNA damage patterns of liposomal irinotecan (nal-IRI) in pancreatic cancer xenografts.
S. Leonard, N. Paz, S. Klinz, Daniel F. Gaddy +3 more
20184 citations
Semantic Scholar
Abstract C90: HER2-targeted liposomal doxorubicin MM-302 has a favorable cardiosafety profile in preclinical models.
E. Geretti, Joe Reynolds, B. Hendriks, Isabelle Eckelhofer +10 more
20114 citations
Semantic Scholar
P1.07-006 Preclinical Support for Evaluation of Irinotecan Liposome Injection (nal-IRI, MM-398) in Small Cell Lung Cancer: Topic: Drug Treatment Alone and in Combination with Radiotherapy
S. Leonard, Helen Lee, S. Klinz, N. Paz +2 more
20173 citations Open access
Semantic Scholar
Abstract P4-15-04: Effect of pre-treatment with cyclophosphamide on MM-302 (HER2-targeted liposomal doxorubicin) deposition in HER2-positive metastatic breast cancer patients assessed by64Cu-MM-302 PET/CT
K. Miller, P. LoRusso, P. Munster, I. Krop +9 more
20153 citations
Semantic Scholar
Abstract LB040: Targeting CD38 and PD-1 with isatuximab (Isa) plus cemiplimab (Cemi) in patients (pts) with advanced malignancies: Results from a Phase 1/2 open-label, multicenter study
Chia-Chi Lin, P. Zucali, B. Carthon, T. Bauer +20 more
2021Clinical research2 citations
Semantic Scholar
Spinal cord cellular response to wear debris from metal-on-metal total disc replacements
Helen Lee
20162 citations
Semantic Scholar
Abstract 3637: MM-302, a HER2-targeted liposomal doxorubicin, shows binding/uptake and efficacy in HER2 2+ cells and xenograft models
S. Klinz, Isabelle Eckelhofer, Daniel F. Gaddy, E. Geretti +5 more
20112 citations
Semantic Scholar
The pharmacokinetics, normal tissue toxicity and anti-tumor effects of [111]In-NLS-trastuzumab in mice bearing HER2-overexpressing breast cancer xenografts
Danny L. Costantini, K. McLarty, Helen Lee, S. Done +2 more
20092 citations
Semantic Scholar
Abstract CT154: Isatuximab (Isa) plus atezolizumab (Atezo) in patients (pts) with advanced malignancies: Results from a Phase 1/2 open-label multicenter study
M. Villar, M. Simonelli, F. Eskens, M. Gil-Martin +27 more
2021Clinical Trials1 citations
Semantic Scholar
Abstract 5151: Nanoliposomal irinotecan (nal-IRI, MM-398) has greater anti-tumor activity than topotecan and irinotecan in mouse models of small cell lung cancer
S. Leonard, Daniel F. Gaddy, Helen Lee, S. Klinz +2 more
20171 citations
Semantic Scholar
Abstract OT3-02-14: A phase 1 study in patients with metastatic breast cancer to evaluate the feasibility of magnetic resonance imaging with ferrumoxytol as a potential biomarker for response to treatment with nanoliposomal irinotecan (nal-IRI, MM-398)
J. Sachdev, R. Ramanathan, N. Raghunand, C. Anders +11 more
20161 citations
Semantic Scholar
Abstract 4830: Preclinical anti-tumor activity of nanoliposomal irinotecan (Nal-IRI, MM-398) + 5-FU + oxaliplatin in pancreatic cancer
Daniel F. Gaddy, Helen Lee, N. Paz, S. Leonard +9 more
20161 citations
Semantic Scholar
Correction to: Longitudinal PET Imaging to Monitor Treatment Efficacy by Liposomal Irinotecan in Orthotopic Patient-Derived Pancreatic Tumor Models of High and Low Hypoxia
M. Ventura, Nicholas Bernards, R. D. de Souza, Inga B. Fricke +5 more
2021Molecular Imaging and Biology0 citations Open access
Semantic Scholar
Longitudinal PET Imaging to Monitor Treatment Efficacy by Liposomal Irinotecan in Orthotopic Patient-Derived Pancreatic Tumor Models of High and Low Hypoxia
M. Ventura, Nicholas Bernards, R. D. de Souza, Inga B. Fricke +5 more
2019Molecular Imaging and Biology0 citations Open access
Semantic Scholar
Abstract P6-12-16: Delivery and anti-tumor activity of nanoliposomal irinotecan (Nal-IRI, MM-398) in metastatic xenograft models of triple negative breast cancer
Helen Lee, M. Ventura, Nicholas Bernards, A. Mohammad +6 more
20170 citations
Semantic Scholar
Preclinical antitumor activity of nanoliposomal irinotecan (Nal-IRI, MM-398) and utilization as a foundation of front-line pancreatic cancer regimens.
Daniel F. Gaddy, Helen Lee, N. Paz, S. Leonard +10 more
20170 citations
Semantic Scholar

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