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Haruhisa Inoue · SciRah

Researcher profile · Semantic Scholar

Haruhisa Inoue

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Haruhisa Inoue — researcher profile on SciRah

h-index: 41
Works: 175
Citations: 10K

Most-cited papers

Induced pluripotent stem cell technology: a decade of progress
Yanhong Shi, Haruhisa Inoue, Joseph C. Wu, S. Yamanaka
2016Nature reviews. Drug discovery1,348 citations Open access
Semantic Scholar
Human iPS cell-derived dopaminergic neurons function in a primate Parkinson’s disease model
Tetsuhiro Kikuchi, A. Morizane, D. Doi, Hiroaki Magotani +12 more
2017Nature610 citations
Semantic Scholar
Induced Pluripotent Stem Cells and Their Use in Human Models of Disease and Development.
Peter Karagiannis, Kazutoshi Takahashi, M. Saito, Y. Yoshida +10 more
2019Physiological Reviews311 citations
Semantic Scholar
The Src/c-Abl pathway is a potential therapeutic target in amyotrophic lateral sclerosis
K. Imamura, Y. Izumi, Akira Watanabe, Kayoko Tsukita +32 more
2017Science Translational Medicine234 citations Open access
Semantic Scholar
Engineering the AAVS1 locus for consistent and scalable transgene expression in human iPSCs and their differentiated derivatives.
Fabian Oceguera-Yañez, Shin-Il Kim, Tomoko Matsumoto, Ghee Wan Tan +7 more
2016Methods222 citations Open access
Semantic Scholar
iPSC-Based Compound Screening and In Vitro Trials Identify a Synergistic Anti-amyloid β Combination for Alzheimer's Disease.
T. Kondo, K. Imamura, Misato Funayama, Kayoko Tsukita +11 more
2017Cell Reports187 citations Open access
Semantic Scholar
Focal Transplantation of Human iPSC-Derived Glial-Rich Neural Progenitors Improves Lifespan of ALS Mice
T. Kondo, Misato Funayama, Kayoko Tsukita, A. Hotta +8 more
2014Stem Cell Reports146 citations Open access
Semantic Scholar
Vulnerability of Purkinje Cells Generated from Spinocerebellar Ataxia Type 6 Patient-Derived iPSCs.
Y. Ishida, H. Kawakami, H. Kitajima, Ayaka Nishiyama +3 more
2016Cell Reports97 citations Open access
Semantic Scholar
Modeling the Early Phenotype at the Neuromuscular Junction of Spinal Muscular Atrophy Using Patient-Derived iPSCs
Michiko Yoshida, S. Kitaoka, Naohiro Egawa, Mayu Yamane +10 more
2015Stem Cell Reports97 citations Open access
Semantic Scholar
High molecular weight amyloid β1‐42 oligomers induce neurotoxicity via plasma membrane damage
Taro Yasumoto, Y. Takamura, Mayumi Tsuji, T. Watanabe-Nakayama +10 more
2019The FASEB Journal85 citations
Semantic Scholar
Calcium dysregulation contributes to neurodegeneration in FTLD patient iPSC-derived neurons
K. Imamura, N. Sahara, N. Kanaan, Kayoko Tsukita +14 more
2016Scientific Reports84 citations Open access
Semantic Scholar
TDP-43 stabilises the processing intermediates of mitochondrial transcripts
Keiichi Izumikawa, Yuko Nobe, Harunori Yoshikawa, Hideaki Ishikawa +13 more
2017Scientific Reports72 citations Open access
Semantic Scholar
Prenatal neurogenesis induction therapy normalizes brain structure and function in Down syndrome mice
Akiko Nakano-Kobayashi, Tomonari Awaya, I. Kii, Yuto Sumida +6 more
2017Proceedings of the National Academy of Sciences of the United States of America71 citations Open access
Semantic Scholar
In Vitro Modeling of Blood-Brain Barrier with Human iPSC-Derived Endothelial Cells, Pericytes, Neurons, and Astrocytes via Notch Signaling
K. Yamamizu, Mio Iwasaki, Hitomi Takakubo, Takumi Sakamoto +7 more
2017Stem Cell Reports49 citations Open access
Semantic Scholar
Prediction Model of Amyotrophic Lateral Sclerosis by Deep Learning with Patient Induced Pluripotent Stem Cells
K. Imamura, Yuichiro Yada, Y. Izumi, M. Morita +9 more
2021Annals of Neurology46 citations Open access
Semantic Scholar
Induced pluripotent stem cell–based Drug Repurposing for Amyotrophic lateral sclerosis Medicine (iDReAM) study: protocol for a phase I dose escalation study of bosutinib for amyotrophic lateral sclerosis patients
K. Imamura, Y. Izumi, H. Banno, R. Uozumi +17 more
2019BMJ Open42 citations Open access
Semantic Scholar
Genetic and pharmacological correction of aberrant dopamine synthesis using patient iPSCs with BH4 metabolism disorders
Taizo Ishikawa, K. Imamura, T. Kondo, Y. Koshiba +8 more
2016Human Molecular Genetics41 citations Open access
Semantic Scholar
Safety and tolerability of bosutinib in patients with amyotrophic lateral sclerosis (iDReAM study): A multicentre, open-label, dose-escalation phase 1 trial
K. Imamura, Y. Izumi, M. Nagai, K. Nishiyama +17 more
2022EClinicalMedicine40 citations Open access
Semantic Scholar
Antisense Oligonucleotides Reduce RNA Foci in Spinocerebellar Ataxia 36 Patient iPSCs
K. Matsuzono, K. Imamura, Nagahisa Murakami, Kayoko Tsukita +7 more
2017Molecular Therapy: Nucleic Acids39 citations Open access
Semantic Scholar
Idiopathic Parkinson's disease patient‐derived induced pluripotent stem cells function as midbrain dopaminergic neurons in rodent brains
Tetsuhiro Kikuchi, A. Morizane, D. Doi, K. Okita +5 more
2017Journal of Neuroscience Research36 citations Open access
Semantic Scholar
Multimodal Imaging for DREADD-Expressing Neurons in Living Brain and Their Application to Implantation of iPSC-Derived Neural Progenitors
Bin Ji, Hiroyuki Kaneko, T. Minamimoto, Haruhisa Inoue +15 more
2016Journal of Neuroscience35 citations Open access
Semantic Scholar
Simple Derivation of Spinal Motor Neurons from ESCs/iPSCs Using Sendai Virus Vectors
Kazuya Goto, K. Imamura, Kenichi Komatsu, K. Mitani +7 more
2017Molecular Therapy: Methods & Clinical Development34 citations Open access
Semantic Scholar
Induction of inverted morphology in brain organoids by vertical-mixing bioreactors
S. N. Dang, K. Imamura, Ikuyo Inoue, Ryotaro Kabai +8 more
2021Communications Biology31 citations Open access
Semantic Scholar
Galectin 3–binding protein suppresses amyloid-β production by modulating β-cleavage of amyloid precursor protein
Tsuneyoshi Seki, M. Kanagawa, Kazuhiro Kobayashi, H. Kowa +5 more
2020Journal of Biological Chemistry31 citations Open access
Semantic Scholar
microRNA-33 maintains adaptive thermogenesis via enhanced sympathetic nerve activity
Takahiro Horie, T. Nakao, Y. Miyasaka, Tomohiro Nishino +29 more
2021Nature Communications27 citations Open access
Semantic Scholar
TDP-43 regulates cholesterol biosynthesis by inhibiting sterol regulatory element-binding protein 2
Naohiro Egawa, Y. Izumi, Hidefumi Suzuki, I. Tsuge +16 more
2022Scientific Reports26 citations Open access
Semantic Scholar
A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model
Naomi Tsuburaya, Kengo Homma, T. Higuchi, Andrii G. Balia +18 more
2018Nature Communications26 citations Open access
Semantic Scholar
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients
T. Kondo, N. Hara, S. Koyama, Yuichiro Yada +8 more
2022Nature Aging25 citations
Semantic Scholar
Repurposing bromocriptine for Aβ metabolism in Alzheimer’s disease (REBRAnD) study: randomised placebo-controlled double-blind comparative trial and open-label extension trial to investigate the safety and efficacy of bromocriptine in Alzheimer’s disease with presenilin 1 (PSEN1) mutations
T. Kondo, H. Banno, T. Okunomiya, Yoko Amino +28 more
2021BMJ Open24 citations Open access
Semantic Scholar
Human iPS cell-derived mural cells as an in vitro model of hereditary cerebral small vessel disease
Yumi Yamamoto, K. Kojima, Daisuke Taura, M. Sone +14 more
2020Molecular Brain23 citations Open access
Semantic Scholar
iPSC screening for drug repurposing identifies anti‐RNA virus agents modulating host cell susceptibility
K. Imamura, Yasuteru Sakurai, Takako Enami, R. Shibukawa +8 more
2021FEBS Open Bio22 citations Open access
Semantic Scholar
Nasal vaccine delivery attenuates brain pathology and cognitive impairment in tauopathy model mice
Hiroki Takeuchi, K. Imamura, Bin Ji, Kayoko Tsukita +16 more
2020npj Vaccines21 citations Open access
Semantic Scholar
Modeling Neurological Disorders with Human Pluripotent Stem Cell-Derived Astrocytes
Mika Suga, T. Kondo, Haruhisa Inoue
2019International Journal of Molecular Sciences21 citations Open access
Semantic Scholar
A simplified and sensitive method to identify Alzheimer's disease biomarker candidates using patient-derived induced pluripotent stem cells (iPSCs).
K. Shirotani, Kazuya Matsuo, S. Ohtsuki, Takeshi Masuda +7 more
2017Journal of Biochemistry (Tokyo)19 citations
Semantic Scholar
Proteasome impairment in neural cells derived from HMSN-P patient iPSCs
Nagahisa Murakami, K. Imamura, Y. Izumi, Naohiro Egawa +6 more
2017Molecular Brain19 citations Open access
Semantic Scholar
Cytoplasmic aggregates of dynactin in iPSC-derived tyrosine hydroxylase-positive neurons from a patient with Perry syndrome.
Takayasu Mishima, Taizo Ishikawa, K. Imamura, T. Kondo +7 more
2016Parkinsonism & Related Disorders19 citations
Semantic Scholar
Functional evaluation of PDGFB-variants in idiopathic basal ganglia calcification, using patient-derived iPS cells
Shin-ichiro Sekine, M. Kaneko, Masaki Tanaka, Y. Ninomiya +20 more
2019Scientific Reports16 citations Open access
Semantic Scholar
Mutant α-synuclein causes death of human cortical neurons via ERK1/2 and JNK activation
Hidefumi Suzuki, Naohiro Egawa, K. Imamura, Takayuki Kondo +7 more
2024Molecular Brain14 citations Open access
Semantic Scholar
ALS, a cellular whodunit on motor neuron degeneration.
Peter Karagiannis, Haruhisa Inoue
2020Molecular and cellular neurosciences13 citations
Semantic Scholar
A second pedigree with amyloid-less familial Alzheimer's disease harboring an identical mutation in the amyloid precursor protein gene (E693delta).
Y. Kutoku, Y. Ohsawa, R. Kuwano, T. Ikeuchi +5 more
2015Internal medicine13 citations Open access
Semantic Scholar
DNA damage in embryonic neural stem cell determines FTLDs’ fate via early-stage neuronal necrosis
Hidenori Homma, Hikari Tanaka, Meihua Jin, Xiaocen Jin +22 more
2021Life Science Alliance12 citations Open access
Semantic Scholar
Cellular analysis of SOD1 protein-aggregation propensity and toxicity: a case of ALS with slow progression harboring homozygous SOD1-D92G mutation
M. Sawamura, K. Imamura, Rie Hikawa, Takako Enami +12 more
2022Scientific Reports11 citations Open access
Semantic Scholar
Analysis of neural crest cells from Charcot–Marie–Tooth disease patients demonstrates disease-relevant molecular signature
F. Kitani-Morii, K. Imamura, T. Kondo, R. Ohara +8 more
2017NeuroReport11 citations
Semantic Scholar
One-step induction of photoreceptor-like cells from human iPSCs by delivering transcription factors
Yuki Otsuka, K. Imamura, A. Oishi, T. Kondo +8 more
2022iScience10 citations Open access
Semantic Scholar
MiR-33a is a therapeutic target in SPG4-related hereditary spastic paraplegia human neurons.
Fumiko Nakazeki, I. Tsuge, Takahiro Horie, K. Imamura +21 more
2019Clinical science10 citations Open access
Semantic Scholar
Erratum to: Modeling Alexander disease with patient iPSCs reveals cellular and molecular pathology of astrocytes
T. Kondo, Misato Funayama, Michiyo Miyake, Kayoko Tsukita +5 more
2016Acta Neuropathologica Communications10 citations Open access
Semantic Scholar
Prediction of Compound Bioactivities Using Heat-Diffusion Equation
T. Hidaka, K. Imamura, Takeshi Hioki, T. Takagi +8 more
2020Patterns9 citations Open access
Semantic Scholar
Evaluation of Toxic Amyloid β42 Oligomers in Rat Primary Cerebral Cortex Cells and Human iPS-derived Neurons Treated with 10-Me-Aplog-1, a New PKC Activator
K. Murakami, Mayuko Yoshimura, Shota Nakagawa, T. Kume +3 more
2020International Journal of Molecular Sciences9 citations Open access
Semantic Scholar
Establishment of human induced pluripotent stem cell line from a patient with Angelman syndrome carrying the deletion of maternal chromosome 15q11.2-q13.
Takeshi Niki, K. Imamura, Takako Enami, M. Kinoshita +1 more
2019Stem Cell Research9 citations Open access
Semantic Scholar
Simple derivation of skeletal muscle from human pluripotent stem cells using temperature‐sensitive Sendai virus vector
Ghee Wan Tan, T. Kondo, K. Imamura, Mika Suga +7 more
2021Journal of Cellular and Molecular Medicine8 citations Open access
Semantic Scholar

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