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T. Baasov · SciRah

Researcher profile · Semantic Scholar

T. Baasov

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T. Baasov — researcher profile on SciRah

h-index: 43
Works: 157
Citations: 4,654

Most-cited papers

Development of novel aminoglycoside (NB54) with reduced toxicity and enhanced suppression of disease-causing premature stop mutations
I. Nudelman, A. Rebibo-Sabbah, Marina Cherniavsky, V. Belakhov +6 more
2009Journal of Medicinal Chemistry193 citations Open access
Semantic Scholar
Synthetic aminoglycosides efficiently suppress cystic fibrosis transmembrane conductance regulator nonsense mutations and are enhanced by ivacaftor.
X. Xue, V. Mutyam, Li-Ping Tang, Silpak Biswas +12 more
2014American Journal of Respiratory Cell and Molecular Biology146 citations Open access
Semantic Scholar
Crystal structure and snapshots along the reaction pathway of a family 51 α‐L‐arabinofuranosidase
Klaus Hövel, D. Shallom, K. Niefind, V. Belakhov +4 more
2003142 citations Open access
Semantic Scholar
Repairing faulty genes by aminoglycosides: development of new derivatives of geneticin (G418) with enhanced suppression of diseases-causing nonsense mutations.
I. Nudelman, D. Glikin, B. Smolkin, Mariana Hainrichson +2 more
2010Bioorganic & Medicinal Chemistry130 citations
Semantic Scholar
Design, synthesis, and evaluation of novel fluoroquinolone-aminoglycoside hybrid antibiotics.
V. Pokrovskaya, V. Belakhov, Mariana Hainrichson, S. Yaron +1 more
2009Journal of Medicinal Chemistry123 citations
Semantic Scholar
Dual-acting hybrid antibiotics: a promising strategy to combat bacterial resistance
V. Pokrovskaya, T. Baasov
2010Expert Opinion on Drug Discovery112 citations
Semantic Scholar
Designer aminoglycosides: the race to develop improved antibiotics and compounds for the treatment of human genetic diseases.
Mariana Hainrichson, I. Nudelman, T. Baasov
2008Organic and biomolecular chemistry109 citations
Semantic Scholar
A comparative evaluation of NB30, NB54 and PTC124 in translational read-through efficacy for treatment of an USH1C nonsense mutation
Tobias Goldmann, N. Overlack, Fabian Möller, V. Belakhov +4 more
2012EMBO Molecular Medicine107 citations Open access
Semantic Scholar
Attenuation of Nonsense-Mediated mRNA Decay Enhances In Vivo Nonsense Suppression
K. Keeling, Dan Wang, Yanying Dai, Srinivasan Murugesan +7 more
2013PLoS ONE105 citations Open access
Semantic Scholar
Designer Aminoglycosides That Selectively Inhibit Cytoplasmic Rather than Mitochondrial Ribosomes Show Decreased Ototoxicity
E. Shulman, V. Belakhov, G. Wei, Ann Kendall +4 more
2013Journal of Biological Chemistry101 citations Open access
Semantic Scholar
Biochemical characterization and identification of the catalytic residues of a family 43 beta-D-xylosidase from Geobacillus stearothermophilus T-6.
D. Shallom, M. Leon, Tsafrir Bravman, A. Ben-David +6 more
2005Biochemistry101 citations
Semantic Scholar
Readthrough of nonsense mutations in Rett syndrome: evaluation of novel aminoglycosides and generation of a new mouse model
C. Brendel, V. Belakhov, H. Werner, Eike Wegener +4 more
2010Journal of molecular medicine98 citations Open access
Semantic Scholar
Targeting Nonsense Mutations in Diseases with Translational Read-Through-Inducing Drugs (TRIDs)
Kerstin Nagel-Wolfrum, Fabian Möller, Inessa Penner, T. Baasov +1 more
2016BioDrugs96 citations
Semantic Scholar
Characterization of new-generation aminoglycoside promoting premature termination codon readthrough in cancer cells
L. Bidou, Olivier Bugaud, V. Belakhov, T. Baasov +1 more
2017RNA Biology91 citations Open access
Semantic Scholar
Redesign of aminoglycosides for treatment of human genetic diseases caused by premature stop mutations.
I. Nudelman, A. Rebibo-Sabbah, Dalia Shallom-Shezifi, Mariana Hainrichson +3 more
2006Bioorganic & Medicinal Chemistry Letters89 citations
Semantic Scholar
The Designer Aminoglycoside NB84 Significantly Reduces Glycosaminoglycan Accumulation Associated with MPS I-H in the Idua-W392X Mouse
Dan Wang, V. Belakhov, Jeyakumar Kandasamy, T. Baasov +4 more
2011Molecular Genetics and Metabolism80 citations Open access
Semantic Scholar
In vitro and ex vivo suppression by aminoglycosides of PCDH15 nonsense mutations underlying type 1 Usher syndrome
A. Rebibo-Sabbah, I. Nudelman, Zubair M. Ahmed, T. Baasov +1 more
2007Human Genetics79 citations
Semantic Scholar
Suppression of CFTR premature termination codons and rescue of CFTR protein and function by the synthetic aminoglycoside NB54
S. Rowe, Peter A. Sloane, Li-Ping Tang, Kyle Backer +8 more
2011Journal of molecular medicine77 citations Open access
Semantic Scholar
Increased Selectivity towards Cytoplasmic versus Mitochondrial Ribosome Confers Improved Efficiency of Synthetic Aminoglycosides in Fixing Damaged Genes: A Strategy for Treatment of Genetic Diseases Caused by Nonsense Mutations
Jeyakumar Kandasamy, Dana Atia-Glikin, E. Shulman, Katya Shapira +3 more
2012Journal of Medicinal Chemistry66 citations Open access
Semantic Scholar
A snapshot of enzyme catalysis using electrospray ionization mass spectrometry.
Zhili Li, A. Sau, S. Shen, C. Whitehouse +2 more
2003Journal of the American Chemical Society65 citations
Semantic Scholar
Detailed kinetic analysis of a family 52 glycoside hydrolase: a beta-xylosidase from Geobacillus stearothermophilus.
Tsafrir Bravman, Gennady Zolotnitsky, V. Belakhov, G. Shoham +3 more
2003Biochemistry63 citations
Semantic Scholar
Differential Selectivity of Natural and Synthetic Aminoglycosides towards the Eukaryotic and Prokaryotic Decoding A Sites
J. Kondo, Mariana Hainrichson, I. Nudelman, Dalia Shallom-Shezifi +4 more
2007ChemBioChem61 citations
Semantic Scholar
New inducible genetic method reveals critical roles of GABA in the control of feeding and metabolism
Fan-Tao Meng, Yong Han, D. Srisai, V. Belakhov +5 more
2016Proceedings of the National Academy of Sciences of the United States of America59 citations Open access
Semantic Scholar
Dual effect of synthetic aminoglycosides: antibacterial activity against Bacillus anthracis and inhibition of anthrax lethal factor.
M. Fridman, V. Belakhov, Lac V. Lee, Fu-Sen Liang +2 more
2005Angewandte Chemie59 citations
Semantic Scholar
Beneficial read-through of a USH1C nonsense mutation by designed aminoglycoside NB30 in the retina.
Tobias Goldmann, A. Rebibo-Sabbah, N. Overlack, I. Nudelman +5 more
2010Investigative Ophthalmology and Visual Science58 citations
Semantic Scholar
Crystal Structures of Geobacillus stearothermophilus α-Glucuronidase Complexed with Its Substrate and Products
G. Golan, D. Shallom, A. Teplitsky, G. Zaide +6 more
2004Journal of Biological Chemistry58 citations Open access
Semantic Scholar
Biotransformations of propenylbenzenes by an Arthrobacter sp. and its t-anethole blocked mutants.
E. Shimoni, T. Baasov, U. Ravid, Y. Shoham
2003Journal of Biotechnology53 citations
Semantic Scholar
Identification of the Catalytic Residues in Family 52 Glycoside Hydrolase, a β-Xylosidase from Geobacillus stearothermophilus T-6*
Tsafrir Bravman, V. Belakhov, Dmitry Solomon, G. Shoham +3 more
2003Journal of Biological Chemistry52 citations Open access
Semantic Scholar
Long-Term Nonsense Suppression Therapy Moderates MPS I-H Disease Progression
Gwen Gunn, Yanying Dai, M. Du, V. Belakhov +5 more
2013Molecular Genetics and Metabolism50 citations Open access
Semantic Scholar
A new class of branched aminoglycosides: pseudo-pentasaccharide derivatives of neomycin B.
M. Fridman, V. Belakhov, S. Yaron, T. Baasov
2003Organic Letters50 citations
Semantic Scholar
Ex Vivo Treatment with a Novel Synthetic Aminoglycoside NB54 in Primary Fibroblasts from Rett Syndrome Patients Suppresses MECP2 Nonsense Mutations
M. Vecsler, B. Ben Zeev, I. Nudelman, Y. Anikster +5 more
2011PLoS ONE49 citations Open access
Semantic Scholar
Covalently linked kanamycin - Ciprofloxacin hybrid antibiotics as a tool to fight bacterial resistance.
M. Shavit, V. Pokrovskaya, V. Belakhov, T. Baasov
2017Bioorganic & Medicinal Chemistry48 citations
Semantic Scholar
One-pot synthesis of glucosamine oligosaccharides.
M. Fridman, Dmitry Solomon, S. Yogev, T. Baasov
2002Organic Letters48 citations
Semantic Scholar
Aminoglycosides Affect Intracellular Salmonella enterica Serovars Typhimurium and Virchow
O. Menashe, Elena Kaganskaya, T. Baasov, S. Yaron
2008Antimicrobial Agents and Chemotherapy47 citations Open access
Semantic Scholar
Branched aminoglycosides: biochemical studies and antibacterial activity of neomycin B derivatives.
Mariana Hainrichson, V. Pokrovskaya, Dalia Shallom-Shezifi, M. Fridman +4 more
2005Bioorganic & Medicinal Chemistry39 citations
Semantic Scholar
Design of Novel Aminoglycoside Derivatives with Enhanced Suppression of Diseases-Causing Nonsense Mutations.
Narayana Murthy Sabbavarapu, M. Shavit, Yarden Degani, B. Smolkin +2 more
2016ACS Medicinal Chemistry Letters36 citations Open access
Semantic Scholar
When Proteins Start to Make Sense: Fine-tuning Aminoglycosides for PTC Suppression Therapy
M. Shalev, T. Baasov
2014MedChemComm34 citations Open access
Semantic Scholar
Structural basis for selective targeting of leishmanial ribosomes: aminoglycoside derivatives as promising therapeutics
M. Shalev, H. Rozenberg, B. Smolkin, A. Nasereddin +7 more
2015Nucleic Acids Research33 citations Open access
Semantic Scholar
Identification of the molecular attributes required for aminoglycoside activity against Leishmania
M. Shalev, J. Kondo, Dmitry Kopelyanskiy, C. Jaffe +2 more
2013Proceedings of the National Academy of Sciences of the United States of America33 citations Open access
Semantic Scholar
Crystal structure and snapshots along the reaction pathway of a family 51 alpha-L-arabinofuranosidase.
Klaus Hövel, D. Shallom, K. Niefind, V. Belakhov +4 more
2003EMBO Journal32 citations
Semantic Scholar
Inhibition mode of a bisubstrate inhibitor of KDO8P synthase: a frequency-selective REDOR solid-state and solution NMR characterization.
L. Kaustov, Shifi Kababya, V. Belakhov, T. Baasov +2 more
2003Journal of the American Chemical Society30 citations
Semantic Scholar
A Reciprocal Single Mutation Affects the Metal Requirement of 3-Deoxy-d-manno-2-octulosonate-8-phosphate (KDO8P) Synthases from Aquifex pyrophilus and Escherichia coli*
S. Shulami, C. Furdui, N. Adir, Y. Shoham +2 more
2004Journal of Biological Chemistry29 citations Open access
Semantic Scholar
Aminoglycosides redesign strategies for improved antibiotics and compounds for treatment of human genetic diseases.
V. Pokrovskaya, I. Nudelman, Jeyakumar Kandasamy, T. Baasov
2010Methods in Enzymology28 citations
Semantic Scholar
Synthesis and evaluation of a mechanism-based inhibitor of KDO8P synthase.
V. Belakhov, Ekaterina Dovgolevsky, E. Rabkin, S. Shulami +2 more
2002Carbohydrate Research28 citations
Semantic Scholar
Structure-toxicity relationship of aminoglycosides: correlation of 2'-amine basicity with acute toxicity in pseudo-disaccharide scaffolds.
Lilach Chen, Mariana Hainrichson, Dmitry Bourdetsky, A. Mor +2 more
2008Bioorganic & Medicinal Chemistry24 citations
Semantic Scholar
Repairing faulty genes by aminoglycosides: Identification of new pharmacophore with enhanced suppression of disease-causing nonsense mutations
Jeyakumar Kandasamy, Dana Atia-Glikin, V. Belakhov, T. Baasov
201123 citations
Semantic Scholar
Overexpression and Initial Characterization of the Chromosomal Aminoglycoside 3′-O-Phosphotransferase APH(3′)-IIb from Pseudomonas aeruginosa
Mariana Hainrichson, O. Yaniv, Marina Cherniavsky, I. Nudelman +3 more
2006Antimicrobial Agents and Chemotherapy23 citations Open access
Semantic Scholar
A Hybrid Drug Limits Resistance by Evading the Action of the Multiple Antibiotic Resistance Pathway.
Kathy K. Wang, Laura Stone, T. D. Lieberman, M. Shavit +2 more
2016Molecular biology and evolution22 citations Open access
Semantic Scholar
Aminoglycoside-Induced Premature Stop Codon Read-Through of Mucopolysaccharidosis Type I Patient Q70X and W402X Mutations in Cultured Cells.
Makoto Kamei, Karissa Kasperski, M. Fuller, E. Parkinson-Lawrence +5 more
2014JIMD Reports21 citations Open access
Semantic Scholar
Development of generic immunoassay for the detection of a series of aminoglycosides with 6′-OH group for the treatment of genetic diseases in biological samples
M. Shalev, Jeyakumar Kandasamy, Nir Skalka, V. Belakhov +2 more
2012Journal of Pharmaceutical and Biomedical Analysis18 citations Open access
Semantic Scholar

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