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T. Grünewald · SciRah

Researcher profile · Semantic Scholar

T. Grünewald

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T. Grünewald — researcher profile on SciRah

h-index: 31
Works: 132
Citations: 5,464

Most-cited papers

Sarcoma classification by DNA methylation profiling
C. Koelsche, D. Schrimpf, D. Stichel, M. Sill +107 more
2021Nature Communications469 citations Open access
Semantic Scholar
Sarcoma treatment in the era of molecular medicine
T. Grünewald, M. Alonso, S. Avnet, A. Banito +38 more
2020EMBO Molecular Medicine271 citations Open access
Semantic Scholar
Single-cell transcriptomic analyses provide insights into the developmental origins of neuroblastoma
Selina Jansky, A. Sharma, V. Körber, Andrés Quintero +11 more
2021Nature Genetics257 citations
Semantic Scholar
Novel antigen-presenting cell imparts Treg-dependent tolerance to gut microbiota
B. Akagbosu, Zakieh Tayyebi, Gayathri Shibu, Yoselin A. Paucar Iza +19 more
2022Nature243 citations Open access
Semantic Scholar
Ewing Sarcoma—Diagnosis, Treatment, Clinical Challenges and Future Perspectives
S. Zöllner, J. Amatruda, S. Bauer, S. Collaud +14 more
2021Journal of Clinical Medicine233 citations Open access
Semantic Scholar
PHGDH heterogeneity potentiates cancer cell dissemination and metastasis
Matteo Rossi, P. Altea-Manzano, Margherita Demicco, Ginevra Doglioni +47 more
2022Nature209 citations Open access
Semantic Scholar
Endogenous T-cell receptor promotes in vivo persistence of CD19-CAR-T cells compared to a CRISPR/Cas9-mediated T-cell receptor knockout CAR
D. Stenger, Tanja A. Stief, Theresa Kaeuferle, Semjon Willier +11 more
2020Blood156 citations Open access
Semantic Scholar
A palmitate-rich metastatic niche enables metastasis growth via p65 acetylation resulting in pro-metastatic NF-κB signaling
P. Altea-Manzano, Ginevra Doglioni, Ya-Wen Liu, Alejandro M. Cuadros +46 more
2023Nature Cancer140 citations Open access
Semantic Scholar
In Vivo Evidence for Serine Biosynthesis-Defined Sensitivity of Lung Metastasis, but Not of Primary Breast Tumors, to mTORC1 Inhibition
Gianmarco Rinaldi, E. Pranzini, Joke van Elsen, D. Broekaert +12 more
2020Molecules and Cells102 citations Open access
Semantic Scholar
Systematic multi-omics cell line profiling uncovers principles of Ewing sarcoma fusion oncogene-mediated gene regulation
M. F. Orth, D. Surdez, Tobias Faehling, Anna C. Ehlers +21 more
2021bioRxiv69 citations Open access
Semantic Scholar
DNA methylation profiling distinguishes Ewing-like sarcoma with EWSR1-NFATc2 fusion from Ewing sarcoma
C. Koelsche, M. Kriegsmann, F. Kommoss, D. Stichel +17 more
2019Journal of Cancer Research and Clinical Oncology66 citations Open access
Semantic Scholar
Oncogenic hijacking of a developmental transcription factor evokes vulnerability toward oxidative stress in Ewing sarcoma
A. Marchetto, S. Ohmura, M. F. Orth, M. Knott +21 more
2020Nature Communications56 citations Open access
Semantic Scholar
STAG Mutations in Cancer.
L. Romero-Pérez, D. Surdez, E. Brunet, O. Delattre +1 more
2019Trends in Cancer53 citations
Semantic Scholar
DNA methylation-based profiling of uterine neoplasms: a novel tool to improve gynecologic cancer diagnostics
F. Kommoss, D. Stichel, D. Schrimpf, M. Kriegsmann +21 more
2019Journal of Cancer Research and Clinical Oncology46 citations Open access
Semantic Scholar
Targeting the undruggable: exploiting neomorphic features of fusion oncoproteins in childhood sarcomas for innovative therapies
M. Knott, Tilman L. B. Hölting, S. Ohmura, T. Kirchner +2 more
2019Cancer Metastasis Review45 citations Open access
Semantic Scholar
mTORC1 regulates cell survival under glucose starvation through 4EBP1/2-mediated translational reprogramming of fatty acid metabolism
Tal Levy, Kai Voeltzke, Laura Hruby, Khawla Alasad +27 more
2024Nature Communications43 citations Open access
Semantic Scholar
A comparative view on the expression patterns of PD-L1 and PD-1 in soft tissue sarcomas
M. F. Orth, Veit L. Buecklein, E. Kampmann, M. Subklewe +10 more
2020Cancer Immunology and Immunotherapy40 citations Open access
Semantic Scholar
Translational evidence for RRM2 as a prognostic biomarker and therapeutic target in Ewing sarcoma
S. Ohmura, A. Marchetto, M. F. Orth, Jing Li +16 more
2021Molecular Cancer39 citations Open access
Semantic Scholar
Oncogenic chimeric transcription factors drive tumor-specific transcription, processing, and translation of silent genomic regions.
J. Vibert, O. Saulnier, Céline Collin, Floriane Petit +25 more
2022Molecules and Cells34 citations Open access
Semantic Scholar
Prion-like domain mediated phase separation of ARID1A promotes oncogenic potential of Ewing’s sarcoma
Yong Ryoul Kim, Jaegeon Joo, Hee-Jung Lee, Chaelim Kim +14 more
2024Nature Communications30 citations Open access
Semantic Scholar
Small round cell sarcomas
F. Cidre-Aranaz, S. Watson, J. Amatruda, Takuro Nakamura +4 more
2022Nature Reviews Disease Primers30 citations
Semantic Scholar
Teacher-student collaborated multiple instance learning for pan-cancer PDL1 expression prediction from histopathology slides
Darui Jin, Shangying Liang, Artem Shmatko, Alexander Arnold +4 more
2024bioRxiv29 citations Open access
Semantic Scholar
Hippo pathway effectors YAP1/TAZ induce an EWS–FLI1‐opposing gene signature and associate with disease progression in Ewing sarcoma
Pablo Rodríguez-Núñez, L. Romero-Pérez, A. T. Amaral, P. Puerto-Camacho +6 more
2019Journal of Pathology28 citations Open access
Semantic Scholar
MHC Class I-Restricted TCR-Transgenic CD4+ T Cells Against STEAP1 Mediate Local Tumor Control of Ewing Sarcoma In Vivo
S. J. Schober, M. Thiede, H. Gassmann, Carolin Prexler +9 more
2020Cells26 citations Open access
Semantic Scholar
High Specificity of BCL11B and GLG1 for EWSR1-FLI1 and EWSR1-ERG Positive Ewing Sarcoma
M. F. Orth, Tilman L. B. Hölting, Marlene Dallmayer, F. Wehweck +23 more
2020Cancers22 citations Open access
Semantic Scholar
Therapeutic targeting of the PLK1-PRC1-axis triggers cell death in genomically silent childhood cancer
Jing Li, S. Ohmura, A. Marchetto, M. F. Orth +19 more
2021Nature Communications21 citations Open access
Semantic Scholar
Oncofusion-driven de novo enhancer assembly promotes malignancy in Ewing sarcoma via aberrant expression of the stereociliary protein LOXHD1
Qu Deng, Ramakrishnan Natesan, F. Cidre-Aranaz, Shehbeel Arif +15 more
2021bioRxiv21 citations Open access
Semantic Scholar
Eukaryotic translation initiation factor 4E binding protein 1 (EIF4EBP1) expression in glioblastoma is driven by ETS1- and MYBL2-dependent transcriptional activation
Laura Hauffe, D. Picard, J. Musa, M. Remke +4 more
2022Cell Death Discovery19 citations Open access
Semantic Scholar
Single-cell division tracing and transcriptomics reveal cell types and differentiation paths in the regenerating lung
Leila R. Martins, L. Sieverling, Michelle Michelhans, Chiara Schiller +7 more
2024Nature Communications18 citations Open access
Semantic Scholar
Integrative clinical transcriptome analysis reveals TMPRSS2‐ERG dependency of prognostic biomarkers in prostate adenocarcinoma
J. S. Gerke, M. F. Orth, Y. Tolkach, L. Romero-Pérez +17 more
2019International Journal of Cancer18 citations Open access
Semantic Scholar
Pan-Cancer Analysis of Mitochondria Chaperone-Client Co-Expression Reveals Chaperone Functional Partitioning
Geut Galai, Hila Ben-David, Liron Levin, M. F. Orth +4 more
2020Cancers17 citations Open access
Semantic Scholar
MondoA drives malignancy in B-ALL through enhanced adaptation to metabolic stress
A. Sipol, Erik Hameister, Bu-Sheng Xue, Julia Hofstetter +20 more
2021Blood13 citations Open access
Semantic Scholar
Integrative gene network and functional analyses identify a prognostically relevant key regulator of metastasis in Ewing sarcoma
F. Cidre-Aranaz, Jing Li, Tilman L. B. Hölting, M. F. Orth +25 more
2022Molecular Cancer12 citations Open access
Semantic Scholar
EIF4EBP1 is transcriptionally upregulated by MYCN and associates with poor prognosis in neuroblastoma
Kai Voeltzke, K. Scharov, C. Funk, Alisa Kahler +11 more
2021bioRxiv12 citations Open access
Semantic Scholar
Advancing sarcoma diagnostics with expanded DNA methylation-based classification
N. Jäger, D. Reuss, M. Sill, D. Schrimpf +105 more
2025medRxiv11 citations
Semantic Scholar
Patient-derived tumoroids from CIC::DUX4 rearranged sarcoma identify MCL1 as a therapeutic target
W. Breunis, E. Brack, Anna C. Ehlers, Ingrid Bechtold +21 more
2025Nature Communications10 citations Open access
Semantic Scholar
Recurrent and Refractory Ewing Sarcoma Phase I/II Trials: Current Perspective From the Euro-Ewing Consortium.
A. Juan-Ribelles, A. Félix, N. Benavent, Josep Escrivá-Fernández +11 more
2025JCO Precision Oncology10 citations Open access
Semantic Scholar
Expression of the EWSR1-FLI1 fusion oncogene in pancreas cells drives pancreatic atrophy and lipomatosis.
L. Fahr, Yoshiaki Sunami, N. Maeritz, K. Steiger +8 more
2020Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]10 citations Open access
Semantic Scholar
Leukemia escape in immune desert: intraocular relapse of pediatric pro-B-ALL during systemic control by CD19-CAR T cells
Semjon Willier, Johannes Raedler, Franziska Blaeschke, D. Stenger +8 more
2020Journal for ImmunoTherapy of Cancer9 citations Open access
Semantic Scholar
Interaction between somatic mutations and germline variants contributes to clinical heterogeneity in cancer
J. Musa, T. Grünewald
2019Molecular & Cellular Oncology9 citations Open access
Semantic Scholar
Advancing Preclinical Biology for Ewing Sarcoma: An International Effort
F. D. Dela Cruz, Elizabeth A. Stewart, D. Surdez, Jessica D. Daley +25 more
2025Molecular Cancer Therapeutics8 citations Open access
Semantic Scholar
The Transcription Factor FEZF1, a Direct Target of EWSR1-FLI1 in Ewing Sarcoma Cells, Regulates the Expression of Neural-Specific Genes
L. García-García, E. Fernández-Tabanera, Saint T. Cervera, Raquel M. Melero-Fernández de Mera +5 more
2021Cancers8 citations Open access
Semantic Scholar
Subversion of mRNA degradation pathways by EWSR1::FLI1 represents a therapeutic vulnerability in Ewing sarcoma
Bartimée Galvan, Loïc Ongena, Jonathan Bruyr, Gregory Fettweis +21 more
2025Nature Communications7 citations Open access
Semantic Scholar
Identification of Germline FOXE1 and Somatic MAPK Pathway Gene Alterations in Patients with Malignant Struma Ovarii, Cleft Palate and Thyroid Cancer
Carolina Pires, A. Saramago, M. Moura, Jing Li +8 more
2024International Journal of Molecular Sciences7 citations Open access
Semantic Scholar
SOX6: a double-edged sword for Ewing sarcoma
A. Marchetto, T. Grünewald
2020Molecular & Cellular Oncology7 citations Open access
Semantic Scholar
Somatic gene delivery faithfully recapitulates a molecular spectrum of high-risk sarcomas
R. Imle, Daniel Blösel, Felix K. F. Kommoss, Sara Placke +28 more
2025Nature Communications6 citations Open access
Semantic Scholar
High content-imaging drug synergy screening identifies specific senescence-related vulnerabilities of mesenchymal neuroblastomas
Sonja Herter, M. Emperador, Kyriaki Smyrilli, Daniela Kocher +13 more
2025Cell Death and Disease5 citations Open access
Semantic Scholar
Author Correction: PHGDH heterogeneity potentiates cancer cell dissemination and metastasis
Matteo Rossi, P. Altea-Manzano, Margherita Demicco, Ginevra Doglioni +47 more
2022Nature5 citations Open access
Semantic Scholar
The GIST of it all: management of gastrointestinal stromal tumors (GIST) from the first steps to tailored therapy. A bibliometric analysis
J. Musa, Sarah M. Kochendoerfer, F. Willis, Christine Sauerteig +6 more
2024Langenbeck's archives of surgery (Print)4 citations Open access
Semantic Scholar
A single-sample workflow for joint metabolomic and proteomic analysis of clinical specimens
H. Gegner, Thomas Naake, Karim Aljakouch, Aurélien J. F. Dugourd +11 more
2023bioRxiv4 citations Open access
Semantic Scholar

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