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J. Brodfuehrer · SciRah

Researcher profile · Semantic Scholar

J. Brodfuehrer

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J. Brodfuehrer — researcher profile on SciRah

h-index: 16
Works: 32
Citations: 1,248

Most-cited papers

Discovery of a potent and selective inhibitor of cyclin-dependent kinase 4/6.
P. Toogood, P. Harvey, J. Repine, D. Sheehan +10 more
2005Journal of Medicinal Chemistry490 citations Open access
Semantic Scholar
Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design.
Katherine L. Lee, C. Ambler, David R. Anderson, B. Boscoe +45 more
2017Journal of Medicinal Chemistry140 citations Open access
Semantic Scholar
Impact of physiological, physicochemical and biopharmaceutical factors in absorption and metabolism mechanisms on the drug oral bioavailability of rats and humans.
S. Hurst, Cho-Ming Loi, J. Brodfuehrer, A. El-Kattan
2007Expert Opinion on Drug Metabolism & Toxicology92 citations
Semantic Scholar
The IRAK4 kinase inhibitor PF-06650833 blocks inflammation in preclinical models of rheumatologic disease and in humans enrolled in a randomized clinical trial
Aaron Winkler, Wei-Yong Sun, Saurav De, Aiping Jiao +23 more
2021Arthritis & Rheumatology74 citations Open access
Semantic Scholar
Integrated oral bioavailability projection using in vitro screening data as a selection tool in drug discovery.
Chad L. Stoner, A. Cleton, Kjell Johnson, D. Oh +4 more
2004International journal of pharmaceutics64 citations
Semantic Scholar
Implementation of an ADME enabling selection and visualization tool for drug discovery.
Chad L. Stoner, E. Gifford, C. Stankovic, Christopher S. Lepsy +3 more
2004Journal of Pharmacy and Science45 citations
Semantic Scholar
Current advances in delivery of biotherapeutics across the blood-brain barrier.
M. Rajadhyaksha, T. Boyden, J. Liras, A. El-Kattan +1 more
2011Current Drug Discovery Technologies43 citations
Semantic Scholar
Evaluation of the human serum albumin column as a discovery screening tool for plasma protein binding.
Lisa Buchholz, C. Cai, L. Andress, A. Cleton +2 more
2002European Journal of Pharmaceutical Sciences29 citations
Semantic Scholar
Impact of physiological, physicochemical and biopharmaceutical factors in absorption and metabolism mechanisms on the drug oral bioavailability of rats and humans
S. Hurst, Cho-Ming Loi, J. Brodfuehrer, A. El-Kattan
200728 citations
Semantic Scholar
Antibacterial oxazolidinones possessing a novel C-5 side chain. (5R)-trans-3-[3-Fluoro-4- (1-oxotetrahydrothiopyran-4-yl)phenyl]-2- oxooxazolidine-5-carboxylic acid amide (PF-00422602), a new lead compound.
T. Poel, Richard C. Thomas, W. Adams, P. Aristoff +25 more
2007Journal of Medicinal Chemistry27 citations Open access
Semantic Scholar
Dystrophin and Mini-Dystrophin Quantification by Mass Spectrometry in Skeletal Muscle for Gene Therapy Development in Duchenne Muscular Dystrophy
V. Farrokhi, Jason Walsh, J. Palandra, J. Brodfuehrer +8 more
2021Gene Therapy26 citations Open access
Semantic Scholar
Quantitative Analysis of Target Coverage and Germinal Center Response by a CXCL13 Neutralizing Antibody in a T-Dependent Mouse Immunization Model
J. Brodfuehrer, A. Rankin, Jason M. Edmonds, S. Keegan +12 more
2013Pharmaceutical Research24 citations
Semantic Scholar
Rational approach to highly potent and selective apoptosis signal-regulating kinase 1 (ASK1) inhibitors.
F. Lovering, P. Morgan, C. Allais, A. Aulabaugh +18 more
2017European journal of medicinal chemistry23 citations Open access
Semantic Scholar
Assessment of the renal toxicity of novel anti-inflammatory compounds using cynomolgus monkey and human kidney cells.
H. Cai, A. Agrawal, D. Putt, M. Hashim +4 more
2009Toxicology18 citations
Semantic Scholar
The use of 1-aminobenzotriazole in differentiating the role of CYP-mediated first pass metabolism and absorption in limiting drug oral bioavailability: a case study.
A. El-Kattan, Julie Poe, Lisa Buchholz, H. Thomas +2 more
2008Drug Metabolism Letters18 citations
Semantic Scholar
Moving in Silico Screening into Practice: A Minimalist Approach to Guide Permeability Screening!!
Chad L. Stoner, M. Troutman, Hua Gao, Kjell Johnson +4 more
200618 citations
Semantic Scholar
An efficient approach for the rapid assessment of oral rat exposures for new chemical entities in drug discovery.
Hyo-Kyung Han, Nalini Sadagopan, G. Reichard, Udeni Yapa +4 more
2006Journal of Pharmacy and Science11 citations
Semantic Scholar
Pharmacokinetics of Clinafloxacin after Single and Multiple Doses
E. Randinitis, J. Brodfuehrer, I. Eiseman, A. Vassos
2001Antimicrobial Agents and Chemotherapy10 citations Open access
Semantic Scholar
A dose‐intensive regimen of 5‐fluorouracil for the treatment of metastatic colorectal carcinoma
E. Poplin, M. Kraut, Laurence Baker, J. Brodfuehrer +1 more
1991Cancer10 citations
Semantic Scholar
A Phase 1 Study to Assess Mass Balance and Absolute Bioavailability of Zimlovisertib in Healthy Male Participants Using a 14C‐Microtracer Approach
R. Singh, M. Dowty, M. Salganik, J. Brodfuehrer +4 more
2022Clinical pharmacology in drug development8 citations Open access
Semantic Scholar
Anatomical and Physiological Factors Affecting Oral Drug Bioavailability in Rats, Dogs, and Humans
A. El-Kattan, S. Hurst, J. Brodfuehrer, Cho-Ming Loi
20118 citations
Semantic Scholar
Mechanism-Based Pharmacokinetic/Pharmacodynamic Modeling of Rat Prefrontal Cortical Dopamine Response to Dual Acting Norepinephrine Reuptake Inhibitor and 5-HT1A Partial Agonist
C. Li, Li-Ming Zhang, T. Haske, A. Dounay +5 more
2012AAPS Journal6 citations Open access
Semantic Scholar
Understanding the clinical pharmacokinetics of a GABAA partial agonist by application of in vitro tools
Aarti Sawant, E. Miller, D. B. Duignan, J. Brodfuehrer +5 more
2010Xenobiotica; the fate of foreign compounds in biological systems6 citations
Semantic Scholar
Disposition and metabolism of the antitumor agent pyrazine-2-diazohydroxide in mouse and beagle dog
D. Moore, J. Brodfuehrer, Tracy J. Wilke, G. Powis
1988Cancer Chemotherapy and Pharmacology6 citations
Semantic Scholar
Modulation of the flavin-containing monooxygenase in guinea pigs by ascorbic acid and food restriction.
J. Brodfuehrer, V. Zannoni
1987Journal of NutriLife6 citations Open access
Semantic Scholar
Flavone acetic acid and plasma protein binding
J. Brodfuehrer, F. Valeriote, Kam-Leung Chan, L. Heilbrun +1 more
2004Cancer Chemotherapy and Pharmacology5 citations
Semantic Scholar
Pharmacokinetics and metabolism of the antitumor agent sulfamic acid 1,7-heptanediyl ester (sulfamic acid diester) in the mouse and beagle dog
J. Brodfuehrer, Tracy J. Wilke, G. Powis
1988Cancer Chemotherapy and Pharmacology5 citations
Semantic Scholar
Biomeasures and mechanistic modeling highlight PK/PD risks for a monoclonal antibody targeting Fn14 in kidney disease
Xiao-Ying Chen, V. Farrokhi, Pratap Singh, M. F. Ocaña +4 more
2018mAbs4 citations Open access
Semantic Scholar
Preclinical pharmacologic studies of the new antitumor agent carmethizole (NSC-602668) in the mouse and beagle dog
J. Brodfuehrer, Tracy J. Wilke, D. Kinder, G. Powis
2004Cancer Chemotherapy and Pharmacology2 citations
Semantic Scholar
Pharmacokinetics of Troglitazone in Patients with Renal Insufficiency
P. Knowlton, Cho-Ming Loi, A. Vassos, R. Blum +4 more
19992 citations
Semantic Scholar
Ascorbic Acid And The Flavin-containing Monooxygenase.
J. Brodfuehrer
19861 citations
Semantic Scholar
DMD - BIOMARKERS
V. Farrokhi, J. Walsh, J. Palandra, J. Brodfuehrer +6 more
2021Neuromuscular Disorders0 citations
Semantic Scholar

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A. El-Kattan×5
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A. El-Kattan — researcher profile on SciRah
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