Skip to content

Home Search Authors Pakistan News Saved

SciRah

SciRah does not host or store research papers. Results come live from free, official scholarly APIs, and every paper links back to its original source.

Data sources

OpenAlex
Semantic Scholar
Crossref
CORE
arXiv
PubMed

Privacy policy Terms of service

R. Myerowitz · SciRah

Researcher profile · Semantic Scholar

R. Myerowitz

Share profile

R. Myerowitz — researcher profile on SciRah

h-index: 19
Works: 38
Citations: 1,995

Most-cited papers

The major defect in Ashkenazi Jews with Tay-Sachs disease is an insertion in the gene for the alpha-chain of beta-hexosaminidase.
R. Myerowitz, F. Costigan
1988Journal of Biological Chemistry212 citations Open access
Semantic Scholar
Suppression of autophagy permits successful enzyme replacement therapy in a lysosomal storage disorder—murine Pompe disease
N. Raben, Cynthia Schreiner, R. Baum, S. Takikita +8 more
2010Autophagy167 citations Open access
Semantic Scholar
Aptamer-based endocytosis of a lysosomal enzyme
Chi-Hong B. Chen, Ken Dellamaggiore, C. Ouellette, C. Sedano +7 more
2008Proceedings of the National Academy of Sciences of the United States of America162 citations Open access
Semantic Scholar
Molecular pathophysiology in Tay-Sachs and Sandhoff diseases as revealed by gene expression profiling.
R. Myerowitz, D. Lawson, H. Mizukami, Yi-De Mi +2 more
2002Human Molecular Genetics161 citations
Semantic Scholar
Splice junction mutation in some Ashkenazi Jews with Tay-Sachs disease: evidence against a single defect within this ethnic group.
R. Myerowitz
1988Proceedings of the National Academy of Sciences of the United States of America134 citations Open access
Semantic Scholar
A deletion involving Alu sequences in the beta-hexosaminidase alpha-chain gene of French Canadians with Tay-Sachs disease.
R. Myerowitz, N. Hogikyan
1987Journal of Biological Chemistry133 citations Open access
Semantic Scholar
Defects in calcium homeostasis and mitochondria can be reversed in Pompe disease
Jeong-A Lim, Li-Shu Li, O. Kakhlon, R. Myerowitz +1 more
2015Autophagy110 citations Open access
Semantic Scholar
Human beta-hexosaminidase alpha chain: coding sequence and homology with the beta chain.
R. Myerowitz, R. Piekarz, E. Neufeld, T. Shows +1 more
1985Proceedings of the National Academy of Sciences of the United States of America109 citations Open access
Semantic Scholar
Autophagy and Mitochondria in Pompe Disease: Nothing is so New as What Has Long Been Forgotten*
N. Raben, A. Wong, E. Ralston, R. Myerowitz
2012American Journal of Medical Genetics. Part C, Seminars in Medical Genetics108 citations Open access
Semantic Scholar
Different mutations in Ashkenazi Jewish and non-Jewish French Canadians with Tay-Sachs disease.
R. Myerowitz, N. Hogikyan
1986Science97 citations
Semantic Scholar
Tay‐Sachs disease‐causing mutations and neutral polymorphisms in the Hex A gene
R. Myerowitz
1997Human Mutation93 citations Open access
Semantic Scholar
Impaired autophagy: The collateral damage of lysosomal storage disorders
R. Myerowitz, R. Puertollano, N. Raben
2020EBioMedicine66 citations Open access
Semantic Scholar
Maturation of alpha-L-iduronidase in cultured human fibroblasts.
R. Myerowitz, E. Neufeld
1981Journal of Biological Chemistry55 citations Open access
Semantic Scholar
The role of glycosidically bound mannose in the assimilation of beta-galactosidase by generalized gangliosidosis fibroblasts.
V. Hieber, Jack J. Distler, R. Myerowitz, R. Schmickel +1 more
1976Biochemical and Biophysical Research Communications - BBRC55 citations Open access
Semantic Scholar
The mannose 6-phosphate receptor of Chinese Hamster ovary cells. Isolation of mutants with altered receptors.
A. R. Robbins, R. Myerowitz, R. Youle, G. Murray +1 more
1981Journal of Biological Chemistry53 citations Open access
Semantic Scholar
Murine Muscle Cell Models for Pompe Disease and Their Use in Studying Therapeutic Approaches
S. Takikita, R. Myerowitz, K. Zaal, N. Raben +1 more
2009Molecular Genetics and Metabolism42 citations Open access
Semantic Scholar
cDNA clone for the alpha-chain of human beta-hexosaminidase: deficiency of alpha-chain mRNA in Ashkenazi Tay-Sachs fibroblasts.
R. Myerowitz, R. Proia
1984Proceedings of the National Academy of Sciences of the United States of America41 citations Open access
Semantic Scholar
Pompe disease: Shared and unshared features of lysosomal storage disorders
Jeong-A Lim, O. Kakhlon, Li-Shu Li, R. Myerowitz +1 more
2015Rare Diseases38 citations Open access
Semantic Scholar
The mannose 6-phosphate receptor of Chinese hamster ovary cells. Compartmentalization of acid hydrolases in mutants with altered receptors.
A. R. Robbins, R. Myerowitz
1981Journal of Biological Chemistry36 citations Open access
Semantic Scholar
Global gene expression in a type 2 Gaucher disease brain.
R. Myerowitz, H. Mizukami, K. Richardson, L. Finn +2 more
2004Molecular Genetics and Metabolism18 citations
Semantic Scholar
The values and limits of an in vitro model of Pompe disease
S. Takikita, R. Myerowitz, Cynthia Schreiner, R. Baum +2 more
2009Autophagy15 citations Open access
Semantic Scholar
Evidence for the Involvement of Glu-355 in the Catalytic Action of Human β-Hexosaminidase B*
M. Pennybacker, C. Schuette, B. Liessem, Stefan T. Hepbildikler +5 more
1997Journal of Biological Chemistry14 citations Open access
Semantic Scholar
Fine assignment of beta-hexosaminidase A alpha-subunit on 15q23-q24 by high resolution in situ hybridization.
K. Takeda, H. Nakai, Hisashi Hagiwara, Keiya Tada +3 more
1990Tohoku journal of experimental medicine14 citations Open access
Semantic Scholar
An unusual genotype in an Ashkenazi Jewish patient with Tay‐Sachs disease
S. Shore, J. Tomczak, E. Grebner, R. Myerowitz
1992Human Mutation13 citations Open access
Semantic Scholar
Synthesis of a human lysosomal enzyme, beta-hexosaminidase B, using the baculovirus expression system.
J. A. Boose, C. Tifft, Richard L. Proia, R. Myerowitz
1990Protein Expression and Purification12 citations
Semantic Scholar
Studies of lysosomal enzyme biosynthesis in cultured cells.
R. Myerowitz, April R. Robbins, R. Proia, G. Sahagian +2 more
1983Methods in Enzymology12 citations
Semantic Scholar
A gel electrophoretic assay for detecting the insertion defect in Ashkenazi Jewish carriers of Tay-Sachs disease.
S. Shore, R. Myerowitz
1990Analytical Biochemistry9 citations
Semantic Scholar
Selective noncompetitive assimilation of bovine testicular beta-galactosidase and bovine liver beta-glucuronidase by generalized gangliosidosis fibroblasts.
Virginia Hieber, Jack J. Distler, R. Myerowitz, R. Schmickel +1 more
1980Journal of Clinical Investigation6 citations Open access
Semantic Scholar
Polymerase chain reaction-generated heteroduplexes from Ashkenazi Tay-Sachs carriers with an insertion mutation can be detected on agarose gels.
S. Shore, R. Myerowitz
1990American Journal of Human Genetics5 citations
Semantic Scholar
Specific chemical modification of the readily nitrated tyrosine of the RTEM β-lactamase and of bacillus cereus β-lactamase I
B. Wolozin, R. Myerowitz, R. Pratt
19823 citations
Semantic Scholar
12. The search for the genetic lesion in Ashkenazi Jews with classic Tay-Sachs disease
R. Myerowitz
20012 citations
Semantic Scholar
The search for the genetic lesion in Ashkenazi Jews with Classic Tay-Sachs disease.
R. Myerowitz
2001Advances in Genetics1 citations
Semantic Scholar
cDNA clone for the a-chain of human f3-hexosaminidase: Deficiency of a-chain mRNA in Ashkenazi Tay-Sachs fibroblasts
R. Myerowitz, R. Proia
19991 citations
Semantic Scholar
Correction of accumulation of sulfate-containing compounds in cultured generalized gangliosidosis fibroblasts by beta-galactosidase.
J. Distler, V. Hieber, R. Schmickel, R. Myerowitz +1 more
1975Birth defects original article series1 citations
Semantic Scholar
139. Remarkable reversal of pathology in Pompe mice by conversion of Type II to Type I muscle fibers by transgenic expression of PGC-1 alpha
S. Takikita, R. Myerowitz, R. Baum, Cynthia Schreiner +3 more
20090 citations
Semantic Scholar
Specific chemical modification of the readily nitrated tyrosine of the RTEM beta-lactamase and of bacillus cereus beta-lactamase I. The role of the tyrosine in beta-lactamase catalysis.
B. Wolozin, R. Myerowitz, R. Pratt
1982Biochimica et Biophysica Acta0 citations
Semantic Scholar
Human , B-hexosaminidase a chain : Coding sequence and homology with the f 8 chain ( lysosomal enzyme / Tay-Sachs disease / cDNA sequencing / second mRNA / chromosomal loalization )
R. Myerowitz, R. Piekarz, E. Neufeld, B. Thomas +2 more
0 citations
Semantic Scholar
Autophagic Punctum The values and limits of an in vitro model of Pompe disease
S. Takikita, R. Myerowitz, Cynthia Schreiner, R. Baum +2 more
0 citations
Semantic Scholar

Frequent co-authors

Invite them to SciRah by sharing their profile.

N. Raben×9
Invite
N. Raben — researcher profile on SciRah
R. Proia×6
Invite
R. Proia — researcher profile on SciRah
S. Takikita×5
Invite
S. Takikita — researcher profile on SciRah
P. Plotz×5
Invite
P. Plotz — researcher profile on SciRah

×5

Invite

E. Neufeld — researcher profile on SciRah

Cynthia Schreiner×4

Invite

Cynthia Schreiner — researcher profile on SciRah

Invite

R. Baum — researcher profile on SciRah

Invite

C. Tifft — researcher profile on SciRah

G. W. Jourdian×3

Invite

G. W. Jourdian — researcher profile on SciRah

Invite

S. Shore — researcher profile on SciRah

Invite

E. Ralston — researcher profile on SciRah

Invite

H. Mizukami — researcher profile on SciRah