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J. Aragonés · SciRah

Researcher profile · Semantic Scholar

J. Aragonés

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J. Aragonés — researcher profile on SciRah

h-index: 36
Works: 77
Citations: 7,082

Most-cited papers

Substrate Fate in Activated Macrophages: A Comparison between Innate, Classic, and Alternative Activation
Juan-Carlos Rodríguez-Prados, P. Través, J. Cuenca, D. Rico +4 more
2010Journal of Immunology1,012 citations
Semantic Scholar
Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization
M. Mazzone, D. Dettori, Rodrigo Leite de Oliveira, S. Loges +21 more
2009Cell837 citations Open access
Semantic Scholar
Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism
J. Aragonés, Martin Schneider, K. V. Geyte, P. Fraisl +43 more
2008Nature Genetics500 citations Open access
Semantic Scholar
Induction of the mitochondrial NDUFA4L2 protein by HIF-1α decreases oxygen consumption by inhibiting Complex I activity.
Daniel Tello, E. Balsa, Barbara Acosta-Iborra, E. Fuertes-Yebra +11 more
2011Cell Metabolism370 citations Open access
Semantic Scholar
Inhibition of oxygen sensors as a therapeutic strategy for ischaemic and inflammatory disease
P. Fraisl, J. Aragonés, P. Carmeliet
2009Nature reviews. Drug discovery340 citations
Semantic Scholar
Oxygen sensors at the crossroad of metabolism.
J. Aragonés, P. Fraisl, M. Baes, P. Carmeliet
2009Cell Metabolism292 citations Open access
Semantic Scholar
Inhibition of hypoxia inducible factor hydroxylases protects against renal ischemia-reperfusion injury.
Peter W. S. Hill, D. Shukla, Maxine G. B. Tran, J. Aragonés +3 more
2008Journal of the American Society of Nephrology290 citations Open access
Semantic Scholar
Abnormal Sympathoadrenal Development and Systemic Hypotension in PHD3−/− Mice
T. Bishop, D. Gallagher, A. Pascual, C. Lygate +19 more
2008Molecular and Cellular Biology219 citations Open access
Semantic Scholar
Genetic evidence for a tumor suppressor role of HIF-2alpha.
T. Acker, A. Diez-Juan, J. Aragonés, M. Tjwa +15 more
2005Cancer Cell215 citations Open access
Semantic Scholar
HIF2α acts as an mTORC1 activator through the amino acid carrier SLC7A5.
A. Elorza, Ines Soro-Arnaiz, Florinda Meléndez-Rodríguez, Victoria Rodríguez-Vaello +15 more
2012Molecules and Cells207 citations Open access
Semantic Scholar
Pyrrolidine dithiocarbamate inhibits the production of interleukin-6, interleukin-8, and granulocyte-macrophage colony-stimulating factor by human endothelial cells in response to inflammatory mediators: modulation of NF-kappa B and AP-1 transcription factors activity.
C. Muñoz, D. Pascual-Salcedo, M. Castellanos, A. Alfranca +4 more
1996Blood187 citations Open access
Semantic Scholar
Loss or silencing of the PHD1 prolyl hydroxylase protects livers of mice against ischemia/reperfusion injury.
Martin F. Schneider, K. van Geyte, P. Fraisl, J. Kiss +18 more
2010Gastroenterology140 citations Open access
Semantic Scholar
c-Jun and Hypoxia-Inducible Factor 1 Functionally Cooperate in Hypoxia-Induced Gene Transcription
A. Alfranca, M. Gutiérrez, A. Vara, J. Aragonés +2 more
2002Molecular and Cellular Biology129 citations Open access
Semantic Scholar
Myocardial VHL-HIF Signaling Controls an Embryonic Metabolic Switch Essential for Cardiac Maturation.
I. Menendez-Montes, Beatriz Escobar, Beatriz Palacios, M. Gómez +7 more
2016Developmental Cell127 citations Open access
Semantic Scholar
Lack of Evidence for the Involvement of the Phosphoinositide 3-Kinase/Akt Pathway in the Activation of Hypoxia-inducible Factors by Low Oxygen Tension*
M. Álvarez-Tejado, A. Alfranca, J. Aragonés, A. Vara +2 more
2002Journal of Biological Chemistry124 citations Open access
Semantic Scholar
Evidence for the Involvement of Diacylglycerol Kinase in the Activation of Hypoxia-inducible Transcription Factor 1 by Low Oxygen Tension*
J. Aragonés, David R. Jones, Silvia Martín, M. A. S. Juan +5 more
2001Journal of Biological Chemistry114 citations Open access
Semantic Scholar
A Phase I Pharmacologic Study of Necitumumab (imc-11f8), a Fully Human Igg1 Monoclonal Antibody the Hif-1␣ Hypoxia Response in Tumor-infi Ltrating T Lymphocytes Induces Functional Cd137 (4-1bb) for Immunotherapy
Andreas G. Bader, David Brown, Matthew Winkler, A. Palazón +13 more
109 citations
Semantic Scholar
EFNA3 long noncoding RNAs induced by hypoxia promote metastatic dissemination
L. Gómez-Maldonado, M. Tiana, O. Roche, A. Prado-Cabrero +11 more
2014Oncogene107 citations Open access
Semantic Scholar
Inhibition of tumor angiogenesis by cannabinoids
Cristina Blázquez, M. Casanova, A. Planas, Teresa Gómez-del-Pulgar +6 more
2003The FASEB Journal106 citations
Semantic Scholar
Mitochondrial reprogramming through cardiac oxygen sensors in ischaemic heart disease.
S. Cadenas, J. Aragonés, M. O. Landázuri
2010Cardiovascular Research102 citations Open access
Semantic Scholar
HIF-2α-mediated induction of pulmonary thrombospondin-1 contributes to hypoxia-driven vascular remodelling and vasoconstriction
David Labrousse-Arias, Raquel Castillo-González, N. Rogers, Mar Torres-Capelli +5 more
2015Cardiovascular Research89 citations Open access
Semantic Scholar
Acute O2 sensing through HIF2α-dependent expression of atypical cytochrome oxidase subunits in arterial chemoreceptors
Alejandro Moreno-Domínguez, Patricia Ortega-Sáenz, Lin Gao, Olalla Colinas +8 more
2019Science Signaling87 citations
Semantic Scholar
Matrix-Binding Vascular Endothelial Growth Factor (VEGF) Isoforms Guide Granule Cell Migration in the Cerebellum via VEGF Receptor Flk1
Carmen Ruiz de Almodovar, Cathy Coulon, Paul Antoine Salin, Ellen Knevels +31 more
2010Journal of Neuroscience87 citations Open access
Semantic Scholar
HIF1α Suppresses Tumor Cell Proliferation through Inhibition of Aspartate Biosynthesis.
Florinda Meléndez-Rodríguez, Andrés A. Urrutia, Doriane Lorendeau, Gianmarco Rinaldi +23 more
2019Cell Reports83 citations Open access
Semantic Scholar
Macrophage Oxygen Sensing Modulates Antigen Presentation and Phagocytic Functions Involving IFN-γ Production through the HIF-1α Transcription Factor1
Barbara Acosta-Iborra, A. Elorza, I. Olazabal, N. Martín-Cófreces +6 more
2009Journal of Immunology82 citations Open access
Semantic Scholar
Role of Mitochondrial Complex IV in Age-Dependent Obesity.
Ines Soro-Arnaiz, Q. Li, Mar Torres-Capelli, Florinda Meléndez-Rodríguez +17 more
2016Cell Reports80 citations Open access
Semantic Scholar
Up-regulation of vascular endothelial growth factor receptor Flt-1 after endothelial denudation: role of transcription factor Egr-1.
Felipe Vidal, J. Aragonés, A. Alfranca, M. De Landázuri
2000Blood61 citations
Semantic Scholar
Targeting LAT1-mediated amino acid transport in innate and adaptive T cells efficiently controls skin inflammation.
D. Cibrian, Raquel Castillo-González, Nieves Fernández-Gallego, H. de la Fuente +11 more
2019Journal of Allergy and Clinical Immunology58 citations Open access
Semantic Scholar
Activation of HIF-prolyl Hydroxylases by R59949, an Inhibitor of the Diacylglycerol Kinase*
Elisa Temes, Silvia Martin-Puig, Barbara Acosta-Iborra, M. Castellanos +4 more
2005Journal of Biological Chemistry58 citations Open access
Semantic Scholar
From basic mechanisms to clinical applications in heart protection, new players in cardiovascular diseases and cardiac theranostics: meeting report from the third international symposium on “New frontiers in cardiovascular research”
H. Cabrera-Fuentes, J. Aragonés, J. Bernhagen, A. Boening +35 more
2016Basic Research in Cardiology57 citations Open access
Semantic Scholar
Specific oncolytic effect of a new hypoxia-inducible factor-dependent replicative adenovirus on von Hippel-Lindau-defective renal cell carcinomas.
Yolanda Cuevas, R. Hernández-Alcoceba, J. Aragonés, Salvador Naranjo-Suárez +5 more
2003Cancer Research49 citations
Semantic Scholar
Hypoxia-Inducible Factor 2-Dependent Pathways Driving Von Hippel–Lindau-Deficient Renal Cancer
Florinda Meléndez-Rodríguez, O. Roche, R. Sánchez-Prieto, J. Aragonés
2018Frontiers in Oncology48 citations Open access
Semantic Scholar
Synaptic activity‐induced glycolysis facilitates membrane lipid provision and neurite outgrowth
Marc Segarra-Mondejar, Sergi Casellas-Díaz, Marina Ramiro-Pareta, Claudia Müller-Sánchez +6 more
2018EMBO Journal45 citations Open access
Semantic Scholar
Neuregulin 4 Is a Novel Marker of Beige Adipocyte Precursor Cells in Human Adipose Tissue
F. Comas, C. Martínez, M. Sabater, F. Ortega +8 more
2019Frontiers in Physiology40 citations Open access
Semantic Scholar
Hypoxia‐inducible factor 2α drives hepatosteatosis through the fatty acid translocase CD36
Esther Rey, Florinda Meléndez-Rodríguez, Patricia Marañón, Miriam Gil-Valle +8 more
2020Liver international (Print)37 citations Open access
Semantic Scholar
Meeting report from the 2nd International Symposium on New Frontiers in Cardiovascular Research. Protecting the cardiovascular system from ischemia: between bench and bedside
H. Cabrera-Fuentes, C. Alba-Alba, J. Aragonés, J. Bernhagen +23 more
2015Basic Research in Cardiology37 citations Open access
Semantic Scholar
Metformin reduces macrophage HIF1α-dependent proinflammatory signaling to restore brown adipocyte function in vitro
Nuria Pescador, Vera Francisco, P. Vázquez, Eva María Esquinas +13 more
2021Redox Biology35 citations Open access
Semantic Scholar
CD69 is a direct HIF-1α target gene in hypoxia as a mechanism enhancing expression on tumor-infiltrating T lymphocytes
S. Labiano, Florinda Meléndez-Rodríguez, A. Palazón, Á. Teijeira +13 more
2017Oncoimmunology35 citations Open access
Semantic Scholar
Role of diacylglycerol induced by hypoxia in the regulation of HIF-1α activity
Elisa Temes, Silvia Martin-Puig, J. Aragonés, David R. Jones +3 more
200435 citations
Semantic Scholar
Role of the HIF oxygen sensing pathway in cell defense and proliferation through the control of amino acid metabolism.
Antonio Bouthelier, J. Aragonés
2020Biochimica et biophysica acta. Molecular cell research34 citations Open access
Semantic Scholar
Role Of Hif2α Oxygen Sensing Pathway In Bronchial Epithelial Club Cell Proliferation
Mar Torres-Capelli, G. Marsboom, Q. Li, Daniel Tello +6 more
2016Scientific Reports34 citations Open access
Semantic Scholar
Dithiocarbamates Trigger Differentiation and Induction of CD11c Gene through AP-1 in the Myeloid Lineage (*)
J. Aragonés, C. López-Rodríguez, Á. Corbí, P. D. del Arco +3 more
1996Journal of Biological Chemistry33 citations Open access
Semantic Scholar
Acute Vhl Gene Inactivation Induces Cardiac HIF-Dependent Erythropoietin Gene Expression
Marta Miró-Murillo, A. Elorza, Ines Soro-Arnaiz, Lucas Albacete-Albacete +8 more
2011PLoS ONE31 citations Open access
Semantic Scholar
HIF Oxygen Sensing Pathways in Lung Biology
Andrés A. Urrutia, J. Aragonés
2018Biomedicines28 citations Open access
Semantic Scholar
Age-dependent obesity and mitochondrial dysfunction
Q. Li, Ines Soro-Arnaiz, J. Aragonés
2017Adipocyte28 citations Open access
Semantic Scholar
Novel perspectives on the PHD-HIF oxygen sensing pathway in cardioprotection mediated by IPC and RIPC
Silvia Martin-Puig, Daniel Tello, J. Aragonés
2015Frontiers in Physiology28 citations Open access
Semantic Scholar
The association of the angiopoietin/Tie-2 system with the development of metastasis and leukocyte migration in neuroendocrine tumors.
N. Figueroa-Vega, A. Díaz, M. Adrados, C. Álvarez-Escolá +7 more
2010Endocrine-Related Cancer28 citations Open access
Semantic Scholar
Neuregulin 4 Downregulation Induces Insulin Resistance in 3T3-L1 Adipocytes through Inflammation and Autophagic Degradation of GLUT4 Vesicles
Francisco Díaz-Sáez, Carla Blanco-Sinfreu, Adrià Archilla-Ortega, David Sebastián +11 more
2021International Journal of Molecular Sciences23 citations Open access
Semantic Scholar
Reduced intracellular oxidative metabolism promotes firm adhesion of human polymorphonuclear leukocytes to vascular endothelium under flow conditions
M. Montoya, F. Luscinskas, M. D. del Pozo, J. Aragonés +1 more
1997European Journal of Immunology20 citations
Semantic Scholar
Novel antibodies directed against the human erythropoietin receptor: creating a basis for clinical implementation
P. Maxwell, Florinda Meléndez-Rodríguez, Kyle B. Matchett, J. Aragonés +21 more
2015British Journal of Haematology19 citations Open access
Semantic Scholar

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M. O. Landázuri×11
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M. O. Landázuri — researcher profile on SciRah
P. Carmeliet×9
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P. Carmeliet — researcher profile on SciRah
Florinda Meléndez-Rodríguez×7
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Florinda Meléndez-Rodríguez — researcher profile on SciRah
P. Maxwell×6
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Daniel Tello — researcher profile on SciRah

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A. Elorza — researcher profile on SciRah

Silvia Martin-Puig×6

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Silvia Martin-Puig — researcher profile on SciRah

F. Sánchez-Madrid×5

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F. Sánchez-Madrid — researcher profile on SciRah

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A. Alfranca — researcher profile on SciRah

M. De Landázuri×5

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M. De Landázuri — researcher profile on SciRah

Mar Torres-Capelli×5

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Mar Torres-Capelli — researcher profile on SciRah

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Q. Li — researcher profile on SciRah