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L. Randle · SciRah

Researcher profile · Semantic Scholar

L. Randle

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L. Randle — researcher profile on SciRah

h-index: 13
Works: 20
Citations: 1,016

Most-cited papers

Activation of hepatic Nrf2 in vivo by acetaminophen in CD‐1 mice
C. Goldring, N. Kitteringham, R. Elsby, L. Randle +7 more
2004Hepatology202 citations Open access
Semantic Scholar
Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver
N. Kitteringham, Azman Abdullah, J. Walsh, L. Randle +10 more
2010Journal of Proteomics180 citations Open access
Semantic Scholar
The hepatotoxic metabolite of acetaminophen directly activates the Keap1‐Nrf2 cell defense system
I. Copple, C. Goldring, R. Jenkins, Alvin J. L. Chia +4 more
2008Hepatology135 citations
Semantic Scholar
Isoquine and related amodiaquine analogues: a new generation of improved 4-aminoquinoline antimalarials.
P. O'Neill, A. Mukhtar, Paul A. Stocks, L. Randle +10 more
2003Journal of Medicinal Chemistry135 citations
Semantic Scholar
The Generation, Detection, and Effects of Reactive Drug Metabolites
A. Stachulski, T. Baillie, B. Park, R. Obach +14 more
2013Medicinal research reviews (Print)79 citations
Semantic Scholar
The Metabolism and Toxicity of Furosemide in the Wistar Rat and CD-1 Mouse: a Chemical and Biochemical Definition of the Toxicophore
D. Williams, D. Antoine, P. Butler, Russell Jones +6 more
2007Journal of Pharmacology and Experimental Therapeutics62 citations
Semantic Scholar
Investigation of the effect of a panel of model hepatotoxins on the Nrf2-Keap1 defence response pathway in CD-1 mice.
L. Randle, C. Goldring, C. Benson, Pete Metcalfe +3 more
2008Toxicology61 citations
Semantic Scholar
Development of a transactivator in hepatoma cells that allows expression of phase I, phase II, and chemical defense genes.
C. Goldring, N. Kitteringham, R. Jenkins, C. Lovatt +13 more
2006American Journal of Physiology - Cell Physiology43 citations
Semantic Scholar
Adaptation to acetaminophen exposure elicits major changes in expression and distribution of the hepatic proteome
R. Eakins, J. Walsh, L. Randle, R. Jenkins +13 more
2015Scientific Reports37 citations Open access
Semantic Scholar
α1‐Adrenoceptor antagonists prevent paracetamol‐induced hepatotoxicity in mice
L. Randle, J. Sathish, N. Kitteringham, I. Macdonald +2 more
200836 citations Open access
Semantic Scholar
alpha(1)-Adrenoceptor antagonists prevent paracetamol-induced hepatotoxicity in mice.
L. Randle, J. Sathish, N. Kitteringham, I. Macdonald +2 more
2008British Journal of Pharmacology15 citations
Semantic Scholar
Modelling the impact of changes in the extracellular environment on the cytosolic free NAD+/NADH ratio during cell culture
R. A. Kelly, J. Leedale, A. Harrell, D. Beard +3 more
2018PLoS ONE13 citations Open access
Semantic Scholar
Modulation of Antimalarial Activity at a Putative Bisquinoline Receptor In Vivo Using Fluorinated Bisquinolines.
Alistair J. Fielding, Valentina Lukinović, Philip G. Evans, Said Alizadeh-Shekalgourabi +13 more
2017Chemistry13 citations Open access
Semantic Scholar
Synthesis, Structural Determination, and Pharmacology of Putative Dinitroaniline Antimalarials
Alessio del Casino, Valentina Lukinović, R. Bhatt, L. Randle +6 more
2018ChemistrySelect5 citations Open access
Semantic Scholar
HPB O06 Developing a patient-derived model of cholangiocarcinoma using Precision Cut Tissue Slices (PCTS)
T. Gilbert, L. Randle, R. Díaz-Nieto, Robert M Jones +3 more
2022British Journal of Surgery1 citations
Semantic Scholar
Title: Modulation of Antimalarial Activity at a Putative Bisquinoline Receptor in vivo Using Fluorinated Bisquinolines Authors: Alistar
Philip G. Evans, R. Bisby, M. Drew, F. James +8 more
20170 citations
Semantic Scholar
Purpurogallin-A heme binding component of oak galls
A. Mehan, N. Migaz, N. Parikh, H. Truong +19 more
20150 citations
Semantic Scholar
O-PALMITOYL CHITOSAN-PEG MICELLES FOR AMPHOTERICIN B DELIVERY TO THE LUNG
T. Chavan, K. Taylor, I. Saleem, L. Randle +2 more
20130 citations
Semantic Scholar
AMPHIPHILIC POLYGAMMA GLUTAMIC ACID DERIVATIVES FOR THE DELIVERY OF AMIKACIN TO THE LUNG
T. Neelima, K. Taylor, I. Saleem, L. Randle +2 more
20130 citations
Semantic Scholar
Pharmacological and physiological protective mechanisms in chemical-induced hepatotoxicity.
L. Randle
20050 citations
Semantic Scholar

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