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R. Cao · SciRah

Researcher profile · Semantic Scholar

R. Cao

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R. Cao — researcher profile on SciRah

h-index: 17
Works: 70
Citations: 1,366

Most-cited papers

Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases
R. Guo, R. Cao, P. Liang, Tzu-Ping Ko +10 more
2007Proceedings of the National Academy of Sciences of the United States of America184 citations Open access
Semantic Scholar
Lipophilic Bisphosphonates as Dual Farnesyl/Geranylgeranyl Diphosphate Synthase Inhibitors: An X-ray and NMR Investigation
Yong-Hui Zhang, R. Cao, F. Yin, M. Hudock +20 more
2009Journal of the American Chemical Society174 citations Open access
Semantic Scholar
Diterpene Cyclases and the Nature of the Isoprene Fold
R. Cao, Yong-Hui Zhang, Francis M. Mann, Cancan Huang +9 more
2010Proteins: Structure, Function, and Bioinformatics146 citations Open access
Semantic Scholar
Antibacterial drug leads targeting isoprenoid biosynthesis
Wei Zhu, Yong-Hui Zhang, W. Sinko, M. Hensler +14 more
2012Proceedings of the National Academy of Sciences of the United States of America99 citations Open access
Semantic Scholar
Indirect Stimulation of Human Vγ2Vδ2 T cells Through Alterations in Isoprenoid Metabolism
Hong Wang, G. Sarikonda, K. Puan, Yoshimasa Tanaka +6 more
2011Journal of Immunology88 citations Open access
Semantic Scholar
Mechanism of action and inhibition of dehydrosqualene synthase
F. Lin, Chia-I Liu, Yi-Liang Liu, Yong-Hui Zhang +6 more
2010Proceedings of the National Academy of Sciences of the United States of America84 citations Open access
Semantic Scholar
Solid-state NMR, crystallographic, and computational investigation of bisphosphonates and farnesyl diphosphate synthase-bisphosphonate complexes.
J. Mao, Sujoy Mukherjee, Yong Zhang, R. Cao +8 more
2006Journal of the American Chemical Society83 citations
Semantic Scholar
Inhibition of Geranylgeranyl Diphosphate Synthase by Bisphosphonates: A Crystallographic and Computational Investigation
C. K. Chen, M. Hudock, Yong-Hui Zhang, R. Guo +11 more
2008Journal of Medicinal Chemistry79 citations Open access
Semantic Scholar
Lipophilic, pyridinium bisphosphonates are potent γδ T cell stimulators
Yong-Hui Zhang, R. Cao, F. Yin, F. Lin +8 more
2010Angewandte Chemie63 citations Open access
Semantic Scholar
Phosphonosulfonates Are Potent, Selective Inhibitors of Dehydrosqualene Synthase and Staphyloxanthin Biosynthesis in Staphylococcus aureus
Yong-Cheng Song, F. Lin, F. Yin, M. Hensler +8 more
2009Journal of Medicinal Chemistry58 citations Open access
Semantic Scholar
Applying Molecular Dynamics Simulations to Identify Rarely Sampled Ligand-bound Conformational States of Undecaprenyl Pyrophosphate Synthase, an Antibacterial Target
W. Sinko, C. de Oliveira, Sarah L. Williams, Adam W. van Wynsberghe +4 more
2011Chemical Biology and Drug Design49 citations Open access
Semantic Scholar
Non-Bisphosphonate Inhibitors of Isoprenoid Biosynthesis Identified via Computer-Aided Drug Design
Jacob D. Durrant, R. Cao, A. Gorfe, Wei Zhu +4 more
2011Chemical Biology and Drug Design46 citations Open access
Semantic Scholar
Enthalpy versus entropy-driven binding of bisphosphonates to farnesyl diphosphate synthase.
F. Yin, R. Cao, A. Goddard, Yong-Hui Zhang +1 more
2006Journal of the American Chemical Society42 citations
Semantic Scholar
Structures of a Potent Phenylalkyl Bisphosphonate Inhibitor Bound to Farnesyl and Geranylgeranyl Diphosphate Synthases
R. Cao, C. K. Chen, R. Guo, Andrew H.-J. Wang +1 more
2008Proteins: Structure, Function, and Bioinformatics40 citations Open access
Semantic Scholar
Head-to-Head Prenyl Tranferases: Anti-Infective Drug Targets
F. Lin, Yi-Liang Liu, Kai Li, R. Cao +4 more
2012Journal of Medicinal Chemistry23 citations Open access
Semantic Scholar
HIV-1 Integrase Inhibitor-Inspired Antibacterials Targeting Isoprenoid Biosynthesis
Yong-Hui Zhang, F. Lin, Kai Li, Wei Zhu +12 more
2012ACS Medicinal Chemistry Letters22 citations Open access
Semantic Scholar
Farnesyl diphosphate synthase inhibitors with unique ligand-binding geometries.
Yi-Liang Liu, R. Cao, Yang Wang, E. Oldfield
2015ACS Medicinal Chemistry Letters21 citations Open access
Semantic Scholar
Crystal Structure and Structural Mechanism of a Novel Anti-Human Immunodeficiency Virus and d-Amino Acid-Containing Chemokine
Dongxiang Liu, Navid Madani, Y. Li, R. Cao +14 more
2007Journal of Virology16 citations Open access
Semantic Scholar
Isolation, Structural Characterization and Neurotrophic Activity of Alkylamides from Zanthoxylum bungeanum
Yuan Wang, Zhong-Bin Liao, R. Cao, He Li +2 more
201715 citations Open access
Semantic Scholar
Activity of sulfonium bisphosphonates on tumor cell lines.
Yong-Hui Zhang, M. Hudock, K. Krysiak, R. Cao +4 more
2007Journal of Medicinal Chemistry15 citations Open access
Semantic Scholar
Oligomerization of BH4-truncated Bcl-x(L) in solution.
You-Li Wang, R. Cao, Dongxiang Liu, A. Chervin +3 more
2007Biochemical and Biophysical Research Communications - BBRC7 citations
Semantic Scholar
Crystal structure of chemically synthesized vMIP‐II
Ying Li, Dongxiang Liu, R. Cao, Santosh Kumar +5 more
2007Proteins: Structure, Function, and Bioinformatics6 citations Open access
Semantic Scholar
A chemical strategy to promote helical peptide-protein interactions involved in apoptosis.
Dongxiang Liu, Bin Yang, R. Cao, Ziwei Huang
2005Bioorganic & Medicinal Chemistry Letters4 citations Open access
Semantic Scholar
Indirect stimulation of human V{gamma}2V{delta}2 T cells through alterations in isoprenoid metabolism: implications for cancer immunotherapy
C. Morita, G. Sarikonda, K. Puan, Ju Feng +4 more
20111 citations
Semantic Scholar
T. brucei Farnesyl Diphosphate Synthase Complexed with Minodronate
R. Cao, J. Mao, Y. Gao, H. Robinson +3 more
20061 citations
Semantic Scholar
[1-Hydroxy-1-phosphono-2-(trimethylphosphonium-1-yl)ethyl]phosphonate monohydrate
R. Cao, M. Hudock, Yonghui Zhang, S. Wilson +1 more
20061 citations
Semantic Scholar
IDDF2023-ABS-0176 Characterization of volatile organic compounds produced by clostridium difficile using chromatography-mass spectrometry
R. Cao, Yi-Zhong Wang, Ting Zhang
2023Clinics in gastroenterology0 citations
Semantic Scholar
Crystal structure of human farnesyl diphosphate synthase in complex with BPH-1358
Y.-L. Liu, R. Cao, Y. Wang, E. Oldfield
20150 citations
Semantic Scholar
Crystal Structure of T. Brucei Farnesyl Diphosphate Synthase
R. Cao, Y.-L. Liu, E. Oldfield
20150 citations
Semantic Scholar
T. Brucei Farnesyl Diphosphate Synthase Complexed with Homorisedronate BPH-6
R. Cao, Y.-L. Liu, E. Oldfield
20150 citations
Semantic Scholar
T. Brucei Farnesyl Diphosphate Synthase Complexed with Bisphosphonate BPH-14
R. Cao, Y.-L. Liu, E. Oldfield
20150 citations
Semantic Scholar
Characterization and Immunostimulating Activity of Polysaccharide Isolated from Oat Bran
R. Cao, Jing-Jing Mao, Sang-Guan You
20140 citations
Semantic Scholar
Crystal Structure of E. coli undecaprenyl pyrophosphate synthase in complex with BPH-1299
R. Cao, Y.-L. Liu, E. Oldfield
20120 citations
Semantic Scholar
Structure of E. coli undecaprenyl diphosphate synthase complexed with BPH-1063
R. Cao, W. Zhu, Y. Zhang, E. Oldfield
20120 citations
Semantic Scholar
Crystal Structure of E. coli undecaprenyl pyrophosphate synthase in complex with BPH-1290
R. Cao, Y.-L. Liu, E. Oldfield
20120 citations
Semantic Scholar
Crystal Structure of E. coli undecaprenyl pyrophosphate synthase in complex with BPH-1100
R. Cao, Y.-L. Liu, E. Oldfield
20120 citations
Semantic Scholar
Crystal Structure of E. coli undecaprenyl pyrophosphate synthase in complex with BPH-1065
R. Cao, Y.-L. Liu, E. Oldfield
20120 citations
Semantic Scholar
Structure of Undecaprenyl Diphosphate synthase
R. Cao, E. Oldfield
20110 citations
Semantic Scholar
Indirect stimulation of human Vγ2Vδ2 T cells through alterations in isoprenoid metabolism: implications for cancer immunotherapy (48.14)
Craig T. Morita, G. Sarikonda, K. Puan, Jun Feng +4 more
2011Journal of Immunology0 citations
Semantic Scholar
T. Brucei Farnesyl Diphosphate Synthase Complexed with Bisphosphonate BPH-721
R. Cao, Y. Gao, H. Robinson, A. Goddard +1 more
20090 citations
Semantic Scholar
T. Brucei Farnesyl Diphosphate Synthase Complexed with Bisphosphonate BPH-461 and Isopentyl Diphosphate
R. Cao, Y. Gao, H. Robinson, A. Goddard +1 more
20090 citations
Semantic Scholar
T. Brucei Farnesyl Diphosphate Synthase Complexed with Bisphosphonate BPH-714
R. Cao, Y. Gao, H. Robinson, E. Oldfield
20090 citations
Semantic Scholar
T. Brucei Farnesyl Diphosphate Synthase Complexed with Bisphosphonate BPH-722
R. Cao, Y. Gao, H. Robinson, E. Oldfield
20090 citations
Semantic Scholar
T. Brucei Farnesyl Diphosphate Synthase Complexed with Bisphosphonate BPH-461
R. Cao, Y. Gao, H. Robinson, A. Goddard +1 more
20090 citations
Semantic Scholar
S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with BPH-806
K.-M. C. Chen, R. Guo, M. Hudock, R. Cao +2 more
20080 citations
Semantic Scholar
S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with inhibitor BPH-742
R. Guo, K.-M. C. Chen, Tzu-Ping Ko, R. Cao +3 more
20080 citations
Semantic Scholar
Experimental and Computational Study of Bisphosphonates Targeting Isoprenoid Biosynthesis Pathway
R. Cao
20080 citations
Semantic Scholar
T. Brucei Farnesyl Diphosphate Synthase Complexed with Bisphosphonate BPH-210
R. Cao, Y. Gao, E. Oldfield
20080 citations
Semantic Scholar
S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with BPH-28
R. Guo, K.-M. C. Chen, M. Hudock, R. Cao +2 more
20080 citations
Semantic Scholar
S. Cerevisiae Geranylgeranyl Pyrophosphate Synthase in Complex with BPH-715
R.-T. Guo, K.-M. C. Chen, R. Cao, E. Oldfield +1 more
20080 citations
Semantic Scholar

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