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Akira Kubota · SciRah

Researcher profile · Semantic Scholar

Akira Kubota

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Akira Kubota — researcher profile on SciRah

h-index: 21
Works: 55
Citations: 1,182

Most-cited papers

Role of pregnane X receptor and aryl hydrocarbon receptor in transcriptional regulation of pxr, CYP2, and CYP3 genes in developing zebrafish.
Akira Kubota, J. V. Goldstone, B. Lemaire, M. Takata +2 more
2015Toxicological Sciences63 citations Open access
Semantic Scholar
Ahr2-dependance of PCB126 effects on the swimbladder in relation to expression of CYP1 and cox-2 genes in developing zebrafish
Maria Jönsson, Akira Kubota, A. Timme-Laragy, B. Woodin +1 more
2012Toxicology and Applied Pharmacology63 citations Open access
Semantic Scholar
Functional Characterization of a Full Length Pregnane X Receptor, Expression in vivo, and Identification of PXR Alleles in Zebrafish (Danio rerio)
A. Bainy, Akira Kubota, J. V. Goldstone, Roger Lille‐Langøy +5 more
2013Aquatic Toxicology56 citations Open access
Semantic Scholar
Levels and toxicokinetic behaviors of PCDD, PCDF, and coplanar PCB congeners in common cormorants from Lake Biwa, Japan.
Akira Kubota, H. Iwata, S. Tanabe, K. Yoneda +1 more
2004Environmental Science and Technology56 citations
Semantic Scholar
Effect of Meropenem on Disposition Kinetics of Valproate and Its Metabolites in Rabbits
K. Yokogawa, Satsuki Iwashita, Akira Kubota, Y. Sasaki +6 more
2001Pharmaceutical Research54 citations
Semantic Scholar
Cytochrome P450 1A4 and 1A5 in common cormorant (Phalacrocorax carbo): evolutionary relationships and functional implications associated with dioxin and related compounds.
Akira Kubota, H. Iwata, Heather M. H. Goldstone, Eunyoung Kim +2 more
2006Toxicological Sciences52 citations Open access
Semantic Scholar
Role of the cyclooxygenase 2-thromboxane pathway in 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced decrease in mesencephalic vein blood flow in the zebrafish embryo.
H. Teraoka, Akira Kubota, W. Dong, Y. Kawai +5 more
2009Toxicology and Applied Pharmacology50 citations Open access
Semantic Scholar
Expression of cyclooxygenase 2 and cytosolic phospholipase A2 in the liver tissue of patients with chronic hepatitis and liver cirrhosis
Ji-Dong Cheng, Hiroyasu Imanishi, H. Iijima, S. Shimomura +4 more
200250 citations
Semantic Scholar
Organohalogen Compounds in Pet Dog and Cat: Do Pets Biotransform Natural Brominated Products in Food to Harmful Hydroxlated Substances?
H. Mizukawa, K. Nomiyama, S. Nakatsu, H. Iwata +8 more
2016Environmental Science and Technology48 citations
Semantic Scholar
Hepatic CYP1A induction by dioxin-like compounds, and congener-specific metabolism and sequestration in wild common cormorants from Lake Biwa, Japan.
Akira Kubota, H. Iwata, S. Tanabe, K. Yoneda +1 more
2005Environmental Science and Technology48 citations
Semantic Scholar
Biological effects of 6-formylindolo[3,2-b]carbazole (FICZ) in vivo are enhanced by loss of CYP1A function in an Ahr2-dependent manner
E. Wincent, Akira Kubota, A. Timme-Laragy, Maria Jönsson +2 more
2016Biochemical Pharmacology46 citations Open access
Semantic Scholar
Cytochrome P450 CYP2 genes in the common cormorant: evolutionary relationships with 130 diapsid CYP2 clan sequences and chemical effects on their expression
Akira Kubota, J. Stegeman, J. V. Goldstone, D. Nelson +3 more
2010Comparative biochemistry and physiology. Toxicology & pharmacology : CBP46 citations Open access
Semantic Scholar
The cytochrome P450 2AA gene cluster in zebrafish (Danio rerio); expression of CYP2AA1 and CYP2AA2 and response to phenobarbital-type inducers
Akira Kubota, A. Bainy, B. Woodin, J. V. Goldstone +1 more
2013Toxicology and Applied Pharmacology38 citations Open access
Semantic Scholar
Involvement of COX2-Thromboxane Pathway in TCDD-Induced Precardiac Edema in Developing Zebrafish
H. Teraoka, Y. Okuno, Daisuke Nijoukubo, Ayumi Yamakoshi +5 more
2014Aquatic Toxicology35 citations Open access
Semantic Scholar
Role of zebrafish cytochrome P450 CYP1C genes in the reduced mesencephalic vein blood flow caused by activation of AHR2
Akira Kubota, J. Stegeman, B. Woodin, T. Iwanaga +4 more
2011Toxicology and Applied Pharmacology34 citations Open access
Semantic Scholar
Malformation of certain brain blood vessels caused by TCDD activation of Ahr2/Arnt1 signaling in developing zebrafish
H. Teraoka, Akira Ogawa, Akira Kubota, J. Stegeman +2 more
2010Aquatic Toxicology33 citations Open access
Semantic Scholar
Developmental circulatory failure caused by metabolites of organophosphorus flame retardants in zebrafish, Danio rerio.
Jae Seung Lee, Y. Morita, Y. Kawai, A. Covaci +1 more
2019Chemosphere31 citations Open access
Semantic Scholar
Functional characterization of zebrafish cytochrome P450 1 family proteins expressed in yeast
J. Stegeman, Lars Behrendt, B. Woodin, Akira Kubota +4 more
2015Biochimica et Biophysica Acta30 citations Open access
Semantic Scholar
Transcriptional profiling of cytochrome P450 genes in the liver of adult zebrafish, Danio rerio.
Akira Kubota, Y. Kawai, Natsumi Yamashita, Jae Seung Lee +6 more
2019Journal of Toxicological Sciences26 citations Open access
Semantic Scholar
Identification, Modeling and Ligand Affinity of Early Deuterostome CYP51s, and Functional Characterization of Recombinant Zebrafish Sterol 14α-Demethylase
A. M. Morrison, J. V. Goldstone, D. Lamb, Akira Kubota +2 more
2013Biochimica et Biophysica Acta26 citations Open access
Semantic Scholar
Expression of cyclooxygenase 2 and cytosolic phospholipase A(2) in the liver tissue of patients with chronic hepatitis and liver cirrhosis.
Ji-Dong Cheng, Hiroyasu Imanishi, H. Iijima, S. Shimomura +4 more
2002Hepatology Research26 citations
Semantic Scholar
Dexamethasone-induced hepatomegaly and steatosis in larval zebrafish.
Guo-Jun Yin, Li-Ping Cao, Jin-Liang Du, Rui Jia +3 more
2017Journal of Toxicological Sciences20 citations Open access
Semantic Scholar
Congener‐specific toxicokinetics of polychlorinated dibenzo‐p‐dioxins, polychlorinated dibenzofurans, and coplanar polychlorinated biphenyls in black‐eared kites (Milvus migrans): Cytochrome P4501A—dependent hepatic sequestration
Akira Kubota, H. Iwata, S. Tanabe, K. Yoneda +1 more
2006Environmental Toxicology and Chemistry19 citations
Semantic Scholar
Cytochrome P450 20A1 in zebrafish: Cloning, regulation and potential involvement in hyperactivity disorders
B. Lemaire, Akira Kubota, Conor O'Meara, D. Lamb +3 more
2016Toxicology and Applied Pharmacology18 citations Open access
Semantic Scholar
Expression of two novel cytochrome P450 3A131 and 3A132 in liver and small intestine of domestic cats.
Kouichi Honda, T. Komatsu, Fumika Koyama, Akira Kubota +6 more
2011Journal of Veterinary Medical Science17 citations Open access
Semantic Scholar
TNT biodegradation and production of dihydroxylamino-nitrotoluene by aerobic TNT degrader Pseudomonas sp. strain TM15 in an anoxic environment
Akira Kubota, Toshinari Maeda, Nobuaki Nagafuchi, K. Kadokami +1 more
2008Biodegradation17 citations
Semantic Scholar
Alternative in vitro approach for assessing AHR-mediated CYP1A induction by dioxins in wild cormorant (Phalacrocorax carbo) population.
Leena Mol Thuruthippallil, Akira Kubota, Eunyoung Kim, H. Iwata
2013Environmental Science and Technology16 citations
Semantic Scholar
Estrogenic and growth inhibitory responses to organophosphorus flame retardant metabolites in zebrafish embryos.
Jae Seung Lee, Y. Kawai, Y. Morita, A. Covaci +1 more
2022Comparative biochemistry and physiology. Toxicology & pharmacology : CBP12 citations Open access
Semantic Scholar
Accumulation of dioxins and induction of cytochrome P450 1A4/1A5 enzyme activities in common cormorants from Lake Biwa, Japan: temporal trends and validation of national regulation on dioxins emission.
Akira Kubota, Michio X. Watanabe, Eunyoung Kim, K. Yoneda +2 more
2012Environmental Pollution12 citations
Semantic Scholar
Hepatic CYP1A induction by chlorinated dioxins and related compounds in the endangered black-footed albatross from the North Pacific.
Akira Kubota, Mafumi Watanabe, T. Kunisue, Eunyoung Kim +2 more
2010Environmental Science and Technology12 citations
Semantic Scholar
Alkoxyresorufin (methoxy-, ethoxy-, pentoxy- and benzyloxyresorufin) O-dealkylase activities by in vitro-expressed cytochrome P450 1A4 and 1A5 from common cormorant (Phalacrocorax carbo).
Akira Kubota, Eunyoung Kim, H. Iwata
2009Comparative biochemistry and physiology. Toxicology & pharmacology : CBP12 citations
Semantic Scholar
In vivo and in silico assessments of estrogenic potencies of bisphenol A and its analogs in zebrafish (Danio rerio): Validity of in silico approaches to predict in vivo effects.
Akira Kubota, M. Hirano, Y. Yoshinouchi, Xing Chen +6 more
2023Comparative biochemistry and physiology. Toxicology & pharmacology : CBP10 citations Open access
Semantic Scholar
Molecular cloning and expression of cytochrome P450 2D6 in the livers of domestic cats.
T. Komatsu, Kouichi Honda, Akira Kubota, T. Kitazawa +2 more
2010Journal of Veterinary Medical Science10 citations Open access
Semantic Scholar
One-step isolation and identification of hydroxylamino-dinitrotoluenes, unstable products from 2,4,6-trinitrotoluene metabolites, with thin-layer chromatography and laser time-of-flight mass spectrometry.
Toshinari Maeda, Nobuaki Nagafuchi, Akira Kubota, K. Kadokami +1 more
2006Journal of Chromatographic Science10 citations
Semantic Scholar
Protective effect of prostacyclin against pre-cardiac edema caused by 2,3,7,8-tetrachlorodibenzo-p-dioxin and a thromboxane receptor agonist in developing zebrafish.
Daisuke Nijoukubo, Yasuaki Tanaka, Y. Okuno, Guo-Jun Yin +4 more
2016Chemosphere9 citations
Semantic Scholar
Sex differences in the accumulation of chlorinated dioxins in the cormorant (Phalacrocorax carbo): implication of hepatic sequestration in the maternal transfer.
Akira Kubota, K. Yoneda, S. Tanabe, H. Iwata
2013Environmental Pollution9 citations
Semantic Scholar
Identification and functional characterization of novel feline cytochrome P450 2A
Gaku Okamatsu, T. Komatsu, Akira Kubota, T. Onaga +8 more
2015Xenobiotica; the fate of foreign compounds in biological systems7 citations
Semantic Scholar
Catalytic function of avian cytochrome P450 1A4 and 1A5 (CYP1A4 and CYP1A5) enzymes heterologously expressed using in vitro yeast system.
Akira Kubota, H. Iwata, Eunyoung Kim
2008Marine Environmental Research7 citations Open access
Semantic Scholar
Cytochrome P 450 1 A 4 and 1 A 5 in Common Cormorant ( Phalacrocorax carbo ) : Evolutionary Relationships and Functional Implications Associated with Dioxin and Related Compounds
Akira Kubota, H. Iwata, Heather M. H. Goldstone, Eunyoung Kim +2 more
20067 citations
Semantic Scholar
The evolution of UDP-glycosyl/glucuronosyltransferase 1E (UGT1E) genes in bird lineages is linked to feeding habits but UGT2 genes is not
Y. Kawai, Y. Ikenaka, M. Ishizuka, Akira Kubota
2018PLoS ONE6 citations Open access
Semantic Scholar
Enzymatic characterization of in vitro-expressed Baikal seal cytochrome P450 (CYP) 1A1, 1A2, and 1B1: implication of low metabolic potential of CYP1A2 uniquely evolved in aquatic mammals.
H. Iwata, Keisuke Yamaguchi, Y. Takeshita, Akira Kubota +4 more
2015Aquatic Toxicology6 citations
Semantic Scholar
Prostanoid Signaling Mediates Circulation Failure Caused by TCDD in Developing Zebrafish
H. Teraoka, Akira Kubota, Y. Kawai, T. Hiraga
20086 citations
Semantic Scholar
Hepatic transcriptional profile and tissue distribution of cytochrome P450 1-3 genes in the red-crowned crane Grus japonensis.
Y. Kawai, Kiwamu Itou, T. Yoshino, Hiroko Iima +2 more
2020Comparative biochemistry and physiology. Toxicology & pharmacology : CBP5 citations
Semantic Scholar
Efficient in vivo and in silico assessments of antiandrogenic potential in zebrafish.
Xing Chen, M. Hirano, H. Ishibashi, Jae Seung Lee +2 more
2022Comparative biochemistry and physiology. Toxicology & pharmacology : CBP4 citations Open access
Semantic Scholar
In vivo and in silico analyses of estrogenic potential of equine estrogens in medaka (Oryzias latipes).
H. Ishibashi, Masaya Uchida, M. Hirano, Taka Hayashi +6 more
2020Science of the Total Environment4 citations
Semantic Scholar
Differential display system with vertebrate-common degenerate oligonucleotide primers: uncovering genes responsive to dioxin in avian embryonic liver.
H. Teraoka, Shino Ito, Haruki Ikeda, Akira Kubota +5 more
2012Environmental Science and Technology4 citations
Semantic Scholar
Functioning adrenal black adenoma with pulmonary and cutaneous cryptococcosis: A case report and review of English literature
Sumio Takahashi, H. Iijima, Y. Moriwaki, T. Yamamoto +5 more
2001Journal of Endocrinological Investigation4 citations
Semantic Scholar
Crucial problem in rapid spectrophotometric determination of 2,4,6-trinitrotoluene and its breakthrough method.
Toshinari Maeda, Akira Kubota, Nobuaki Nagafuchi, K. Kadokami +1 more
2006Journal of Microbiological Methods3 citations Open access
Semantic Scholar
Evolutionary history of mammalian UDP-glucuronosyltransferase (UGT)1 and UGT2 families: the emergence of UGT2B subfamily in eutherians after the diversification of flowering plants
Y. Kawai, Kasumi Sano, Y. Ikenaka, S. Nakayama +3 more
2021bioRxiv2 citations Open access
Semantic Scholar
Identification of spontaneous conversion products of unstable 2,4,6-trinitrotoluene metabolites, hydroxylamino-dinitrotoluenes, by combination of thin-layer chromatography and laser time-of-flight mass spectrometry.
Toshinari Maeda, Nobuaki Nagafuchi, Akira Kubota, K. Kadokami +1 more
2007Journal of Chromatographic Science2 citations
Semantic Scholar

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